UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A
Proxy Statement Pursuant to Section 14(a) of the
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Soliciting Material Pursuant tounder §240.14a-12

Seattle Genetics, Inc.

SEATTLE GENETICS, INC.

(Name of Registrant as Specified Inin Its Charter)


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NOTICE OF 2020 ANNUAL MEETING AND
PROXY STATEMENT
ANNUAL MEETING
Friday, May 15, 2020
11:00 a.m. at Seattle Genetics
Corporate Headquarters Building 3
21823 – 30th Drive SE
Bothell, Washington 98021 seattle genetics



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Dear Fellow Shareholders:

Seattle Genetics had a remarkable year in 2019 and entered 2020 as a multi-product oncology company. First, in collaboration with our partner Takeda, ADCETRIS® global sales exceeded $1 billion for the first time. ADCETRIS is an important medicine around the world for the treatment of patients with certain types of lymphoma. Second, we and our collaborator Astellas received FDA accelerated approval of PADCEVTM (enfortumab vedotin-ejfv) for adult patients with previously treated locally advanced or metastatic urothelial cancer, potentially changing the treatment paradigm for these patients with a high unmet need. The approval expanded our commercial portfolio and will diversify our revenues from product sales, adding to a strong ADCETRIS base. And third, we reported positive results from our tucatinibHER2CLIMB-01 pivotal trial, which supported marketing applications in the United States, Europe and other countries to treat patients with metastatic HER2-positive breast cancer. These submissions position tucatinib to be our third commercial product, if approved, and allow us to offer a new treatment option to thousands of patients globally who are in need of better therapies. In addition, we believe ADCETRIS, PADCEV and tucatinib have other therapeutic opportunities and are investing in broad development programs.

We also continue to invest in research and development as it is the engine for our future growth. We are advancing a robust pipeline of new product candidates in clinical trials, with a focus onfirst-in-class orbest-in-class targeted therapies for cancer. The investment and execution of our strategy to develop and bring innovative therapies to market benefit patients and are the foundation for a sustainable business that we believe will result in long-term shareholder value.

In 2019, we augmented our investor relations activities with a proactive shareholder engagement effort focused on corporate governance and executive compensation. Our discussions and the feedback we received from investors provided valuable information for senior management and our Board of Directors in their planning and decision making. The discussions led to several changes to our executive compensation and corporate governance practices, which are described in this proxy statement. We look forward to continuing this valuable dialogue.

We hope that you will participate in the Annual Meeting, either by attending and voting in person or by voting via the internet, by telephone or by mail as described in this proxy statement as promptly as possible. Your vote is important.

Sincerely,
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Clay B. Siegall, Ph.D.

Chairman, President and

Chief Executive Officer

April 2, 2020

                  
Filing Party:

                     
Date Filed:



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April 5, 2019
Dear Seattle Genetics Stockholders:
On behalf of Seattle Genetics, Inc., I cordially invite you to attend our 2019 Annual Meeting of Stockholders to be held on Monday, May 20, 2019, at 11:00 a.m., local time, at our principal offices located in Building 3 at 21823 – 30th Drive SE, Bothell, Washington 98021.
Details of the business to be conducted at the Annual Meeting are given in the Notice of Annual Meeting of Stockholders and the proxy statement.
We are using the Internet as our primary means of furnishing proxy materials to stockholders. Most stockholders will not receive paper copies of our proxy materials. We will instead send these stockholders a notice with instructions for accessing the proxy materials and voting via the Internet. The notice also provides information on how stockholders may obtain paper copies of our proxy materials if they so choose.
Your vote is important. Whether or not you plan to attend the Annual Meeting, it is important that your shares are represented. Please read the proxy statement and vote via the Internet, over the telephone or, if you received a paper proxy card or voting instruction form by mail, by marking, dating, signing and returning the proxy card or voting instruction form, as promptly as possible. Of course, if you attend the Annual Meeting, you will have the right to vote your shares in person.
On behalf of the Board of Directors, I would like to express our appreciation for your continued interest in Seattle Genetics. We look forward to seeing you at the Annual Meeting.

2020 NOTICE OF ANNUAL MEETING OF SHAREHOLDERS

 Sincerely,Meeting Date:May 15, 2020Meeting Place:*

Seattle Genetics, Inc.

Building 3, 21823 – 30th Drive SE

Bothell, WA 98021

 
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Meeting Time:11:00 a.m. (Pacific)
 
Clay B. Siegall, Ph.D.
President and Chief Executive Officer
Record Date:

March 19, 2020
















YOUR VOTE IS IMPORTANT
You may vote your shares via the Internet, over the telephone or, if you received a paper proxy card or voting instruction form by mail, by marking, dating and signing the proxy card or voting instruction form and mailing it promptly in the return envelope provided.

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21823 – 30TH DRIVE SE
BOTHELL, WA 98021
NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
To Be Held May 20, 2019
The 2019 Annual Meeting of Stockholders, or the Annual Meeting, of Seattle Genetics, Inc., or the Company, a Delaware corporation, will be held on Monday, May 20, 2019 at 11:00 a.m. local time at the principal offices of Seattle Genetics located in Building 3 at 21823 – 30th Drive SE, Bothell, Washington 98021 for the following purposes:
(1)To elect the three nominees for Class III director named in the accompanying proxy statement to hold office until the Company’s 2022 Annual Meeting of Stockholders.
(2)To ratify the appointment of PricewaterhouseCoopers LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2019.
(3)To approve the amendment and restatement of the Seattle Genetics, Inc. Amended and Restated 2000 Employee Stock Purchase Plan, or the ESPP, to increase the aggregate number of shares of common stock authorized for issuance thereunder by 1,000,000 shares and to allow for the participation in the ESPP by our non-U.S. based employees.
(4)To approve, on an advisory basis, the compensation of the Company’s named executive officers as disclosed in the accompanying proxy statement.
(5)To transact such other business as may properly come before the Annual Meeting and any adjournment or postponement thereof.
You can find more information about each of these items, including the nominees for directors, in the accompanying proxy statement.
The Board of Directors has fixed the close of business on March 22, 2019 as the record date for determining the stockholders entitled to notice of and to

VOTING METHODS

Your vote at the Annual Meeting and at any adjournment or postponement thereof.

We cordially invite all stockholders to attend the Annual Meeting in person. However, whetheris very important. Whether or not you expect to attend the Annual Meeting in person, please ensure your representation and the presence of a quorum at the Annual Meeting by voting via one of the Internet, over the telephone or, if you received a paper proxy card or voting instruction form by mail, by marking, dating, signing and returning the proxy card or voting instruction formmethods listed below, as promptly as possible in the return envelope provided.possible. If you are an owner of record as of the record date, you may vote via any of the Internet, overfollowing methods:

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Via the Internet:Call Toll-Free:Mail Signed Proxy Card
www.envisionreports.com/SGEN1-800-652-VOTE (8683)

Using the Provided

Postage-Paid Envelope

If you are a beneficial owner of shares held through a broker, bank or other owner of record, you must follow the telephone or by sending in your proxy card or voting instruction form, but then decide to attendinstructions you receive from the Annual Meetingowner of record to vote your shares in person, you may still do so. Your proxy is revocable in accordance withshares.

MEETING AGENDA

The purposes of the procedures describedmeeting are to:

1.

Elect the three nominees for Class I director named in the accompanying proxy statement to hold office until Seattle Genetics’ 2023 Annual Meeting of Shareholders.

2.

Approve, on an advisory basis, the compensation of Seattle Genetics’ named executive officers as disclosed in the accompanying proxy statement.

3.

Approve the amendment and restatement of the Seattle Genetics, Inc. Amended and Restated 2007 Equity Incentive Plan to, among other things, increase the aggregate number of shares of common stock authorized for issuance thereunder by 6,000,000 shares.

4.

Ratify the appointment of PricewaterhouseCoopers LLP as Seattle Genetics’ independent registered public accounting firm for the fiscal year ending December 31, 2020.

5.

Transact such other business as may properly come before the Annual Meeting and any adjournment or postponement thereof.

You can find more information about each of these items, including the nominees for directors, in the accompanying proxy statement. Please note that if your shares are held in an account by your broker, bank, or other nominee and you wish to vote at the Annual Meeting, you must notify your broker, bank or other nominee and obtain the proper documentation.

By Order of the Board of Directors,
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Jean I. Liu

CORPORATE SECRETARY

APRIL 2, 2020

*We are monitoring the emerging public health impact of the coronavirus outbreak (COVID-19). The health andwell-being of our employees and shareholders are paramount. If public health developments warrant, we may need to change the location of the Annual Meeting or switch to a virtual meeting format. Any such change will be announced via press release and the filing of additional soliciting materials with the SEC.

YOUR VOTE IS IMPORTANT TO US.

PLEASE EXERCISE YOUR SHAREHOLDER RIGHT TO VOTE.

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                 Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting of Shareholders to be Held on May 15, 2019: The proxy statement and annual report to shareholders are available at http://www.edocumentview.com/SGEN.


Jean I. Liu
Corporate Secretary
Bothell, Washington

TABLE OF CONTENTS

PROXY STATEMENT SUMMARY1 
April 5,

PROPOSAL NO. 1

ELECTION OF DIRECTORS

8
NOMINEES FOR THE BOARD OF DIRECTORS AND CONTINUING DIRECTORS9
CORPORATE GOVERNANCE14

Director Independence

14

Board Leadership Structure

14

Director Commitments

15

Board Committees

16

Board and Committee Meetings and Attendance

17

Board Risk Oversight

17

Compensation Committee Process and Procedures

18

Board Refreshment

18

Criteria for Board Membership and Nomination Process

18

Shareholder Director Nominations and Recommendations

19

Communications with the Board of Directors

20

Majority Voting in Uncontested Elections

20

Board Classification

20

Succession Planning

21

Corporate Governance Guidelines

21

Stock Ownership Guidelines

21

Code of Conduct and Business Ethics

21

Whistleblower Policy

21

Prohibitions on Hedging, Pledging and Short-Term Speculative Trading

22

Corporate Responsibility

23
DIRECTOR COMPENSATION24
EXECUTIVE OFFICERS28

EXECUTIVE OFFICER PROFILES

28
PROPOSAL NO. 2
ADVISORY VOTE ON EXECUTIVE COMPENSATION 29
COMPENSATION OF EXECUTIVE OFFICERS30

A MESSAGE FROM THE COMPENSATION COMMITTEE

30

COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

56

SUMMARY COMPENSATION TABLE

57

GRANTS OF PLAN-BASED AWARDS

58

EMPLOYMENT AGREEMENTS AND ARRANGEMENTS

59

OUTSTANDING EQUITY AWARDS AT FISCALYEAR-END

63

OPTION EXERCISES AND STOCK VESTED

65

CEO PAY RATIO

65

POTENTIAL PAYMENTS UPON TERMINATION ORCHANGE-IN-CONTROL

67
CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS71
EQUITY COMPENSATION PLAN INFORMATION72
SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT73
PROPOSAL NO. 3
APPROVAL OF THE AMENDMENT AND RESTATEMENT OF THE SEATTLE GENETICS, INC. AMENDED AND RESTATED 2007 EQUITY INCENTIVE PLAN75
PROPOSAL NO. 4
RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM86
AUDIT COMMITTEE REPORT88
FREQUENTLY ASKED QUESTIONS AND OTHER INFORMATION89
APPENDIX A: SEATTLE GENETICS, INC. AMENDED AND RESTATED 2007 EQUITY INCENTIVE PLANA-1 

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YOUR VOTE IS IMPORTANT
You may vote your shares via the Internet, over the telephone or, if you received a paper proxy card or voting instruction form by mail, by marking, dating and signing the proxy card or voting instruction form and mailing it promptly in the return envelope provided.


Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting of Stockholders to be Held on May 20, 2019

PROXY STATEMENT SUMMARY

The following summary highlights certain information contained elsewhere in Building 3 at 21823 – 30th Drive SE, Bothell, Washington 98021.

Thethis proxy statement and annual report to stockholders are available at
http://www.edocumentview.com/SGEN

SEATTLE GENETICS, INC.
PROXY STATEMENT FOR THE
2019 ANNUAL MEETING OF STOCKHOLDERS
To Be Held May 20, 2019
Our Boarddoes not contain all of Directors is soliciting proxies for the 2019 Annual Meeting of Stockholders. Thisinformation you should consider. You should read the entire proxy statement contains important information for you to consider when deciding how to vote on the matters broughtcarefully before the meeting. Please read it carefully.
The Board has set the close of business on March 22, 2019 as the record date for the Annual Meeting. Stockholders of record who owned our common stock on that date are entitled to vote at and attend the Annual Meeting. Each share of common stock is entitled to one vote. There were 160,954,666 shares of common stock outstanding on the record date. voting.

2020 MEETING INFORMATION

Meeting Date:May 15, 2020Meeting Place:

Seattle Genetics, Inc.

Building 3, 21823 – 30th Drive SE

Bothell, WA 98021

Meeting Time:11:00 a.m. (Pacific)
Record Date:

March 19, 2020

VOTING MATTERS

Proposals

Board Vote
Recommendation
  See Page Number  
for More Detail

PROPOSAL NO. 1

Election of Class I directors

FOR EACH
NOMINEE

Page 8

PROPOSAL NO. 2

Advisory vote on the compensation of our named executive officers

FOR

Page 29

PROPOSAL NO. 3

Amendment and restatement of the Seattle Genetics, Inc. Amended and Restated 2007 Equity Incentive Plan, or the 2007 Equity Plan, to, among other things, increase the aggregate number of shares of common stock authorized for issuance thereunder by 6,000,000 shares

FOR

Page 75

PROPOSAL NO. 4

Ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm

FOR

Page 86

Our proxy materials, which include this proxy statement and our 20182019 annual report, are first being mailed or made available to stockholdersshareholders on or about April 5,2, 2020.

COMPANY OVERVIEW

Seattle Genetics is a global, multi-product biotechnology company that discovers, develops and commercializes transformative medicines targeting cancer to make a meaningful difference in people’s lives. We are commercializing ADCETRIS® for the treatment of several types of CD30-expressing lymphomas and PADCEVTM for the treatment of certain metastatic urothelial cancers. In addition, we have submitted marketing applications for tucatinib, our small molecule tyrosine kinase inhibitor, for patients with metastatic HER2-positive breast cancer. We are also advancing a pipeline of novel therapies for solid tumors and blood-related cancers designed to address unmet medical needs and improve treatment outcomes for patients. Many of our programs, including ADCETRIS and PADCEV, are based on our proprietary antibody-drug conjugate, or ADC, technology that utilizes the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells.

2020 PROXY STATEMENT1


  PROXY STATEMENT SUMMARY

BUSINESS HIGHLIGHTS

2019 was a transformational year during which Seattle Genetics achieved record revenues driven by continued growth of ADCETRIS product sales, increasing royalty revenues and significant progress by our collaborators that triggered several milestone payments. ADCETRIS product sales in the U.S. and Canada were $628 million in 2019, an increase of 32% over 2018, and more than double product sales in 2017. In 2020, we expect continued net sales growth of ADCETRIS, and are continuing to invest in clinical trials to further expand this important global brand.

We also realized our goal of becoming a multi-product company. In December 2019, approximately three months before the target action date, we and our partner Astellas received FDA accelerated approval of PADCEV for the treatment of previously treated metastatic urothelial cancer. Prior to approval, these patients had limited treatment options. We are also conducting additional trials to potentially expand PADCEV’s use to first-line metastatic disease and to earlier stages of bladder cancer as well as outside of bladder cancer in a range of other solid tumors. PADCEV received Breakthrough Therapy designation, or BTD, from the FDA for previously treated metastatic urothelial cancer prior to its approval and more recently received BTD for its use in combination with Merck’s Keytruda® in the first-line setting.

Additionally, in late 2019 and early 2020, we submitted marketing applications for tucatinib in the United States, Europe and other countries for the treatment of patients with metastatic HER2-positive breast cancer based on positive results from the HER2CLIMB-01 trial. The results demonstrated that the tucatinib-containing regimen improved progression-free survival, or PFS,

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overall survival and PFS in patients with brain metastases, along with a manageable safety profile in patients with previously treated locally advanced or metastatic HER2-positive breast cancer. TheHER2CLIMB-01 data supported BTD from the FDA and the PDUFA target action date is August 20, 2020. This positions tucatinib to be our third commercial product, if approved. We are also conducting a broad tucatinib development program, including the phase 3HER2CLIMB-02 trial for first- or second-line metastatic HER2-positive breast cancer and a potentially pivotal phase 2 trial in metastatic HER2-positive colorectal cancer.

We also continue to advance our pipeline, and in 2019 we and our partner Genmab completed enrollment in a pivotal trial of tisotumab vedotin for patients with metastatic cervical cancer. We expect to report topline data in the first half of 2020 that, if positive, could support an accelerated approval pathway with the FDA.

We continue to invest in the development of our earlier-stage pipeline with ongoing clinical trials and advancement of several new product candidates into clinical development in 2019. ThisWe have also licensed our ADC technology to other companies, which generates milestone payments and royalties to us. In 2019 and early 2020, Genentech/Roche received approval in the U.S. and the European Union for their product PolivyTM, an ADC using our technology, in the U.S. and the European Union for which we receive royalties on global sales.

As we enter 2020, we are well-positioned to continue our progress. And, while the global impact of the COVID-19 pandemic is evolving, we remain committed to delivering innovative medicines that improve outcomes for people living with cancer.

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PROXY STATEMENT SUMMARY  

BOARD OF DIRECTORS AND NOMINEES SNAPSHOT

The names of the nominees and of the directors whose terms of office will continue after the Annual Meeting, their ages as of April 2, 2020, and certain other information about them are set forth below. For more detailed information about the background of each of our directors, please see “Nominees for the Board of Directors and Continuing Directors”, below.

Director Nominee

 Age Director
Since
 Term
Expires
 Principal Occupation Audit Compensation Nominating &
Corporate
Governance

David W. Gryska

 64 2005 2020 Former Executive Vice President and Chief Financial Officer of Incyte Corporation ¡    

John A. Orwin

 55 2014 2020 President and Chief Executive Officer of Atreca, Inc.    

Alpna H. Seth, Ph.D.

 56 2018 2020 Chief Executive Officer and President of Proneurotech Inc.   

Director

                     

Felix J. Baker, Ph.D.

Lead Independent Director

 51 2003 2021 Founder andCo-Managing Member of Baker Bros. Advisors LP   ¡ 

Srinivas Akkaraju, M.D., Ph.D.

 52 2003 2022 Founder and Managing General Partner of Samsara BioCapital      

Marc E. Lippman, M.D.

 75 2000 2022 Professor of Oncology at Georgetown University Medical Center’s Lombardi Comprehensive Cancer Center     

Clay B. Siegall, Ph.D.

 59 1997 2021 President, Chief Executive Officer and Chairman of the Board of Seattle Genetics, Inc.      

Nancy A. Simonian, M.D.

 59 2012 2021 Chief Executive Officer of Syros Pharmaceuticals, Inc.     ¡

Daniel G. Welch

 62 2007 2022 Former Chairman, Chief Executive Officer and President of InterMune, Inc.     

¡ = Committee Chair

       

BOARD COMPOSITION

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2020 PROXY STATEMENT3


PROXY STATEMENT SUMMARY  

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GOVERNANCE HIGHLIGHTS

Our Board of Directors is committed to building long-term shareholder value and maintaining sound corporate governance practices. We highlight some of our corporate governance practices below.

Number of directors

9

Percentage of directors who are independent

89%

Directors who attended at least 75% of board and committee meetings

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Strong and active lead independent director

100% independent audit, compensation and nominating and corporate governance committees

Board and committees may engage outside advisors independent of management

Annual Board self-evaluations

Active shareholder engagement program

Corporate governance guidelines

Majority voting in uncontested elections

Corporate governance guidelines formalize the consideration of diversity factors for director nominees

All employees, officers and directors must adhere to a Code of Conduct and Business Ethics

4

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PROXY STATEMENT SUMMARY  

SHAREHOLDER ENGAGEMENT

In 2019, we conducted a proactive shareholder outreach program to solicit feedback and better understand investor perspectives on operational, governance and executive compensation matters. We held discussions with a number of our shareholders in the spring before the Annual Meeting and once again in late fall. Our cross-functional team that participated in these discussions to address investors’ specific focus areas included executives from our Investor Relations, Human Resources and Legal departments as well as our Chief Financial Officer. In addition, Dr. Baker, our Lead Independent Director, who also serves as Chair of the Compensation Committee, participated in some of these discussions. Feedback from these engagement activities was shared with management and our Board of Directors to inform our goal of aligning Company interests with those of our shareholders. Investor feedback is important to us, and we are committed to continuing to engage with our shareholders in the future to understand and consider their views.

2019 SHAREHOLDER ENGAGEMENT EFFORT

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SHAREHOLDER FEEDBACK

In 2019, these discussions covered a wide range of topics, including:

executive compensation

our voting standard for director elections

director overboarding
the role of our lead independent director

enhanced proxy statement disclosure

diversity of our Board of Directors

OUTCOMES OF ENGAGEMENT

The feedback from thesay-on-pay vote and discussions with shareholders led to changes in 2019 to our executive compensation program and corporate governance practices, as described below.

  Executive
  Compensation

  Incorporated performance-based equity awards into our CEO’s long-term incentive program

  Adopted a clawback policy for executives

  Enhanced our scrutiny ofpay-for-performance alignment in making compensation decisions

  Corporate
  Governance

  Adopted majority vote standard in uncontested director elections

  Revised our policy on outside board commitments

  Enhanced the authority and responsibilities of our lead independent director

  Increased our disclosure on diversity at the Company

  Enhanced the information provided in our proxy statement

2020 PROXY STATEMENT5


PROXY STATEMENT SUMMARY  

2019 COMPENSATION HIGHLIGHTS

We endeavor to maintain sound executive compensation policies and practices consistent with our executive compensation philosophy. The following table highlights some of our executive compensation policies and practices, which are structured to drive performance and align our executives’ interests with our shareholders’ long-term interests. For more detailed information, please see the discussion under “Compensation Discussion and Analysis—Our Executive Compensation Practices.”

WHAT WE DOWHAT WE DON’T DO

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Pay for Performance

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No Special Health or Welfare Benefits for Executives

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Significant Portion of Compensation is at Risk

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No Post-Employment TaxGross-Ups

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Double-Trigger Vesting

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Prohibition on Hedging and Pledging

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Independent Compensation Committee

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No Stock Option Repricing

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Independent Compensation Advisor Reports Directly to the Compensation Committee

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Annual Market Review of Executive Compensation

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Stock Ownership Guidelines for Directors and Executive Officers

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Multi-Year Vesting Requirements

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AnnualSay-on-Pay Vote

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Active Shareholder Engagement Program

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Clawback Policy

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Cap on Annual Cash Bonuses

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Minimize Inappropriate Risk Taking

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Competitive Peer Group

6

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PROXY STATEMENT SUMMARY  

ALIGNMENT OF CEO PAY TO TOTAL SHAREHOLDER RETURN

We design our executive compensation program to align pay with company performance, and as highlighted in the charts below, there is strong alignment between the two. The charts below compare our CEO’s total compensation and our annual total shareholder return, or TSR, over theone-year and three-year periods ended December 31, 2019 to the CEO total compensation and annual TSR of our compensation peer group over theone-year and three-year periods ended December 31, 2018, annual reportwhich are the most recent periods for which data was available to the Compensation Committee when making pay decisions in August 2019. For more information on the Internet at http://www.edocumentview.com/SGEN.

our pay elements and our compensation decision making process, including our compensation peer group, please see “Executive Compensation—Compensation Discussion and Analysis—Principal Elements of Pay” and “Executive Compensation—Compensation Discussion and Analysis —Compensation-Setting Process” below.

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CERTAIN DEFINED TERMS

In this proxy statement:

Proxy Statement:

“We,” “us,” “our”, the “Company” and “Seattle Genetics” refer to Seattle Genetics, Inc.; and its wholly-owned subsidiaries on a consolidated basis;

“Annual Meeting” means our 20192020 Annual Meeting of Stockholders;Shareholders;

“Board of Directors” or “Board” means our Board of Directors; and

“SEC” means the Securities and Exchange Commission.

We summarize below important information with respect to the Annual Meeting.
TIME AND PLACE OF THE ANNUAL MEETING
The Annual Meeting is being held on Monday, May 20, 2019, at 11:00 a.m. local time at our principal offices located in Building 3 at 21823 – 30th Drive SE, Bothell, Washington 98021. Directions to our principal offices may be found at www.seattlegenetics.com.
All stockholders who owned shares of our stock as of March 22, 2019, the record date, may attend and vote on the proposals considered at the Annual Meeting.
PURPOSE OF THE PROXY MATERIALS
Our Board of Directors is soliciting your proxy to vote at the Annual Meeting, including at any adjournments or postponements of the Annual Meeting. This proxy statement describes the proposals on which we would like you, as a stockholder, to vote. It also gives you information on these proposals so that you can make an informed decision, information you may find useful in determining how to vote and information regarding voting procedures.
INTERNET AVAILABILITY OF PROXY MATERIALS
In accordance with the rules of the Securities and Exchange Commission, or SEC, we are using the Internet as our primary means of furnishing proxy materials to stockholders. Consequently, most stockholders will not receive paper copies of our proxy materials. We will instead send these stockholders a Notice of Internet Availability of Proxy Materials, or the Notice, with instructions for accessing the proxy materials, including our proxy statement and 2018 annual report, and voting via the Internet. The Notice also provides information on how stockholders may obtain paper copies of our proxy materials if they so choose. This makes the proxy distribution process more efficient and less costly, and helps conserve natural resources.
PROPOSALS TO BE VOTED ON AT THIS YEAR’S ANNUAL MEETING AND BOARD RECOMMENDATIONS
At the Annual Meeting, there are four matters scheduled for a vote:
the election of the three nominees for Class III director named in this proxy statement to hold office until our 2022 Annual Meeting of Stockholders;
the ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2019;
the approval of the amendment and restatement of the Seattle Genetics, Inc. Amended and Restated 2000 Employee Stock Purchase Plan, or the ESPP, to increase the aggregate number of shares of common stock authorized for issuance thereunder by 1,000,000 shares and to allow for the participation in the ESPP by our non-U.S. based employees; and

the approval, on an advisory basis, of the compensation of our named executive officers as disclosed in this proxy statement.
The Board of Directors recommends a vote “FOR” all of the nominees named herein for director and a vote “FOR” each of the other proposals.
VOTING VIA THE INTERNET, BY TELEPHONE OR BY MAIL
Stockholders whose shares are registered with our transfer agent, Computershare, Inc., in their own name are record holders also known as stockholders of record. As an alternative to voting in person at the Annual Meeting, a record holder may vote via the Internet, over telephone or, for those stockholders who receive a paper proxy card in the mail, by mailing a completed proxy card.
For those record holders who receive a paper proxy card, instructions for voting via the Internet, over the telephone or by mail are set forth on the proxy card. If you are a stockholder who elects to vote by mail, you should sign and mail the proxy card in the addressed, postage paid envelope that was enclosed with the proxy materials, and your shares will be voted at the Annual Meeting in the manner you direct.
Stockholders whose shares are not registered in their own name with Computershare, Inc. are beneficial holders of shares held in street name. Such shares may be held in an account at a bank or at a brokerage firm (your record holder). As the beneficial holder, you have the right to direct your record holder on how to vote your shares, and you will receive instructions from your record holder that must be followed in order for your record holder to vote your shares per your instructions. Many banks and brokerage firms have a process for their beneficial holders to provide instructions via the Internet or by telephone. If Internet or telephone voting is unavailable from your record holder, please complete and return the voting instruction form in the addressed, postage paid envelope provided. If your shares are held beneficially in street name and you have not given your record holder voting instructions, your record holder will not be able to vote your shares with respect to any matter other than ratification of the appointment of Seattle Genetics’ independent registered public accounting firm as explained in more detail below.
For those stockholders who receive a Notice, the Notice provides information on how to access your proxy materials on the Internet, which contains instructions on how to vote via the Internet or by telephone. If you received a Notice, you can request a printed copy of your proxy materials by following the instructions contained in the Notice.
VOTING IN PERSON AT THE ANNUAL MEETING
If you are a stockholder of record, you may vote in person at the Annual Meeting. Whether or not you plan to attend the Annual Meeting, we urge you to vote by proxy to ensure your vote is counted. You may still attend the Annual Meeting and vote in person even if you have already voted by proxy. If your shares are held in street name, your shares may be voted by you in person at the Annual Meeting only if you obtain a legal proxy from your record holder giving you the right to vote such shares in person at the Annual Meeting.
REVOCATION OF PROXIES
You may revoke or change a previously delivered proxy at any time before the final vote at the Annual Meeting. If you are the record holder of your shares, you may revoke your proxy in any one of the following ways:
You may submit another properly completed proxy card with a later date.
You may grant a subsequent proxy over the telephone or via the Internet.
You may send a timely written notice that you are revoking your proxy to our Corporate Secretary at 21823 – 30th Drive SE, Bothell, Washington 98021.
2020 PROXY STATEMENT7


You may attend the Annual Meeting and vote in person. Simply attending the Annual Meeting will not, by itself, revoke your proxy.
Your most recent proxy card or telephone or Internet proxy is the one that is counted.
If your shares are held by your broker, bank or other agent as a nominee or agent, you should follow the instructions provided by your broker, bank or other agent.
MULTIPLE SETS OF PROXY MATERIALS
If you receive more than one set of proxy materials, or more than one Notice or a combination thereof, your shares may be registered in more than one name or are registered in different accounts. Please follow the voting instructions on each set of proxy materials or Notices to ensure that all of your shares are voted.

QUORUM REQUIREMENT
Shares are counted as present at the Annual Meeting if a stockholder of record either:
is present and votes in person at the Annual Meeting; or
has properly voted by proxy.
The holders of a majority of our issued and outstanding shares of common stock entitled to vote as of the record date must be present at the Annual Meeting (either in person or by proxy) in order to hold the Annual Meeting and conduct business. This is called a “quorum.”
VOTING INSTRUCTIONS; ABSTENTIONS AND BROKER NON-VOTES
If you are the record holder of your shares, you must vote by proxy or attend the Annual Meeting in person in order to vote on the proposals. If the shares you own are held in “street name” by a brokerage firm, your brokerage firm, as the record holder of your shares, is required to vote your shares according to your instructions. In order to vote your shares, you will need to follow the directions your brokerage firm provides you. Many brokers also offer the option of voting via the Internet or over the telephone, instructions for which would be provided by your brokerage firm on your voting instruction form. Under the current rules that govern brokers, if you do not give instructions to your brokerage firm, it will still be able to vote your shares, but only with respect to proposals for which it has discretionary voting authority. A “broker non-vote” occurs when a broker or other holder of record holding shares for a beneficial owner submits a proxy for the Annual Meeting but does not vote on a particular proposal because that holder does not have discretionary voting power with respect to that proposal and has not received instructions from the beneficial owner.
The election of directors (Proposal No. 1), the amendment and restatement of the ESPP (Proposal No. 3) and the advisory vote on the compensation of our named executive officers (Proposal No. 4) are proposals for which brokers do not have discretionary voting authority. If you do not instruct your broker how to vote with respect to these proposals, your broker may not vote with respect to these proposals and those non-votes will be counted as “broker non-votes.” The ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm (Proposal No. 2) is considered to be discretionary and your brokerage firm will be able to vote on Proposal No. 2 even if it does not receive instructions from you, so long as it holds your shares in its name.
Abstentions and broker non-votes will be treated as shares present for the purpose of determining the presence of a quorum for the transaction of business at the Annual Meeting. Abstentions and broker non-votes are not counted for the purpose of determining the number of votes cast and will therefore not have any effect with respect to any of the proposals.
We encourage you to provide instructions to your brokerage firm by voting your proxy. This ensures that your shares will be voted at the Annual Meeting.
REQUIRED VOTES
Assuming that a quorum is present at the Annual Meeting, the following votes will be required:
With respect to the election of Class III directors (Proposal No. 1), the three nominees receiving the highest number of FOR votes (from the holders of shares present in person or represented by proxy) will be elected as directors.
With respect to the ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm (Proposal No. 2), approval will require the affirmative vote of a majority of the votes cast in person or by proxy at the Annual Meeting.
With respect to the vote on the amendment and restatement of the ESPP to increase the aggregate number of shares of common stock authorized for issuance thereunder by 1,000,000 shares and to allow for the participation in the ESPP by our non-U.S. based employees (Proposal No. 3), approval will require the affirmative vote of a majority of the votes cast in person or by proxy at the Annual Meeting.
With respect to the advisory vote on the compensation of our named executive officers as disclosed in this proxy statement (Proposal No. 4), approval will require the affirmative vote of a majority of the votes cast in person or by proxy at the Annual Meeting.
We believe that the procedures to be used by the Inspector of Election to count the votes are consistent with Delaware law concerning voting of shares and determination of a quorum.
VOTE SOLICITATIONS
The Board of Directors of Seattle Genetics is soliciting your proxy to vote your shares at the Annual Meeting. We will bear the entire cost of this solicitation of proxies, including the preparation, assembly, printing, and mailing of the Notice, this proxy statement, the proxy card and any additional solicitation material that we may provide to our stockholders. In addition to

these proxy materials, our directors, officers and other employees may contact you by telephone, via the Internet, in person or otherwise to obtain your proxy. Our directors, officers and other employees will not receive any additional compensation for assisting in the solicitation. We will also request brokerage firms, nominees, custodians and fiduciaries to forward proxy materials to the beneficial owners. We will reimburse these entities and our transfer agent for their reasonable out-of-pocket expenses in forwarding proxy materials.
VOTING PROCEDURES
Votes cast by proxy or in person at the Annual Meeting will be tabulated by a representative of Computershare, Inc., our transfer agent, who will act as the Inspector of Election. The Inspector of Election will also determine whether a quorum is present at the Annual Meeting.
Shares properly voted by proxy will be voted at the Annual Meeting. If you specify a choice with respect to any matter to be acted on, the shares will be voted in accordance with that specified choice. If you are the record holder of your shares and you do not specify your vote on each proposal individually when voting via the Internet or over telephone, or if you sign and return a proxy card without giving specific voting instructions, then your shares will be voted as follows:
FOR all of the director nominees named herein (Proposal No. 1);
FOR the ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm (Proposal No. 2);
FOR the approval of the amendment and restatement of the ESPP to increase the aggregate number of shares of common stock authorized for issuance thereunder by 1,000,000 shares and to allow for the participation in the ESPP by our non-U.S. based employees (Proposal No. 3); and
FOR the approval of the compensation of our named executive officers as disclosed in this proxy statement (Proposal No. 4).
If any other matter is properly presented at the Annual Meeting, it is the intention of the persons named in the accompanying proxy, referred to in this proxy statement as the “proxy holders,” to vote on those matters in accordance with their best judgment.
PUBLICATION OF VOTING RESULTS
We will announce preliminary voting results at the Annual Meeting. We will publish the final results in a current report on Form 8-K, which we expect to file with the SEC within four business days of the Annual Meeting. If final voting results are not available to us in time to file a Form 8-K within four business days after the meeting, we intend to file a Form 8-K to publish preliminary results and, within four business days after the final results are known to us, file an additional Form 8-K to publish the final results. You can obtain a copy of any of these filings on our website at www.seattlegenetics.com, by contacting our Investor Relations Department at (425) 527-4000, by calling the SEC at (800) 732-0330 for information regarding its public reference room or through the EDGAR system at www.sec.gov.
OTHER BUSINESS
We do not know of any business to be considered at the Annual Meeting other than the proposals described in this proxy statement. If any other business is properly presented at the Annual Meeting, the proxy holders have the authority to vote on such matters at their discretion.
PROPOSALS FOR 2020 ANNUAL MEETING
To have your proposal included in our proxy statement for the 2020 Annual Meeting, you must submit your proposal in writing by December 7, 2019 to Jean I. Liu, Corporate Secretary, Seattle Genetics, 21823 – 30th Drive SE, Bothell, Washington 98021, and you must comply with all applicable requirements of Rule 14a-8 promulgated under the Securities Exchange Act of 1934, as amended, or the Exchange Act. However, if the 2020 Annual Meeting is not held between April 20, 2020 and June 19, 2020, then the deadline will be a reasonable time prior to the time we begin to print and send our proxy materials.
Stockholders wishing to submit proposals or director nominations for our 2020 Annual Meeting that are not to be included in our proxy statement must give timely written notice to our Corporate Secretary in accordance with our bylaws. To be “timely,” written notice must be received by our Corporate Secretary at the above address no earlier than January 21, 2020 and no later than February 20, 2020; provided, however, that in the event the date of the 2020 Annual Meeting is not scheduled to be held between April 20, 2020 and June 19, 2020, then such notice must be received by the later of the 90th day prior to the date of the 2020 Annual Meeting or the 10th day following the date on which public announcement or disclosure of the date of the 2020 Annual Meeting is first made. However, in the event that the number of directors to be elected to the Board of Directors is increased and either all of the nominees for director or the size of the increased Board of Directors is not publicly announced or disclosed by Seattle Genetics on or prior to February 10, 2020, a stockholder’s notice to our Corporate Secretary

will also be considered timely, but only with respect to nominees for any new positions created by such increase, if the stockholder’s notice is delivered to our Corporate Secretary at the above address not later than the close of business on the 10th day following the first date all of such nominees or the size of the increased Board of Directors has been publicly announced or disclosed by Seattle Genetics. We also advise you to review our bylaws, which contain additional requirements about advance notice of stockholder proposals and director nominations, including attendance requirements. A stockholder’s notice to our Corporate Secretary must set forth the information required by our bylaws with respect to each nominee or matter the stockholder proposes to bring before the 2020 Annual Meeting, and must be updated not later than ten days after the record date for the determination of stockholders entitled to vote at 2020 Annual Meeting to provide any material changes in the foregoing information. The person presiding at the 2020 Annual Meeting may determine, if the facts warrant, that a nominee or matter has not been properly brought before the meeting and, therefore, may not be considered at the meeting. In addition, the proxy solicited by the Board of Directors for the 2020 Annual Meeting will confer discretionary voting authority with respect to (i) any proposal presented by a stockholder at that meeting for which Seattle Genetics has not been provided with timely notice and (ii) any proposal made in accordance with our bylaws, if the 2020 proxy statement briefly describes the matter and how management proxy holders intend to vote on it, if the stockholder does not comply with the requirements of Rule 14a-4(c)(2) promulgated under the Exchange Act.

PROPOSAL NO. 1

ELECTION OF DIRECTORS

Our Fourth Amended and Restated Certificate of Incorporation provides that the Board of Directors is divided into three approximately equal classes with staggered three-year terms. As a result, approximately one-thirdterms, as shown in the table below:

Director Nominee

 

 

Class

 

 

Age*

 

 

Position

 

 

Director
Since

 

 

Current
Term
Expires

 

 

 

Expiration
of Term
for Which
Nominated

 

David W. Gryska

 I 64 Director 2005 2020 2023

John A. Orwin

 I 55 Director 2014 2020 2023

Alpna H. Seth, Ph.D.

 I 56 Director 2018 2020 2023

 

Director

                  

Felix J. Baker, Ph.D.

 II 51 Lead Independent Director 2003 2021  

Clay B. Siegall, Ph.D.

 II 59 President, CEO and Chairman of the Board 1997 2021  

Nancy A. Simonian, M.D.

 II 59 Director 2012 2021  

Srinivas Akkaraju, M.D., Ph.D.

 III 52 Director 2003 2022  

Marc E. Lippman, M.D.

 III 75 Director 2000 2022  

Daniel G. Welch

 III 62 Director 2007 2022  

*

Ages as of April 2, 2020

If elected at the Annual Meeting, each of the total numberabove director nominees would serve until the 2023 Annual Meeting of directors will beShareholders and until the director’s successor is elected every year.

Vacancies onand has qualified, or, if sooner, until the Board may be filled only by persons elected bydirector’s death, resignation or removal.

As this is an uncontested election, each nominee for director must receive a majority of the remaining directors or by the affirmative vote of the holders of a majority of the voting power of the then outstanding shares of our voting stock, provided that newly created directorships resulting from any increasevotes cast in order to be elected, meaning the number of directors will, unless the Board determines by resolution that any such directorships shall be filled by stockholders, be filled only by a majority of the remaining directors. A director elected by the Board to fill a vacancy (including a vacancy created by an increase inshares voted “for” each nominee must exceed the number of directors) will serve for the remainder of the full term of the class of directors in which the vacancy occurred.

The total number of directors constituting the whole Board of Directors is presently set at nine members. The Class III directors, whose terms expire at the Annual Meeting, are Srinivas Akkaraju, Marc Lippman and Daniel Welch. The Class I directors, whose terms of office expire at the 2020 Annual Meeting, are David Gryska, John Orwin and Alpna Seth. The Class II directors, whose terms of office expire at the 2021 Annual Meeting are Felix Baker, Clay Siegall and Nancy Simonian. Our stockholders only elect one class of directors at each annual meeting. The other classes continue to serve for the remainder of their three-year terms.
Srinivas Akkaraju, Marc Lippman and Daniel Welch have been recommended by the Nominating and Corporate Governance Committee of the Board of Directors for election at the Annual Meeting and have been nominated by the Board for election at the Annual Meeting as Class III directors for three-year terms expiring at the 2022 Annual Meeting. Drs. Akkaraju and Lippman and Mr. Welch were previously elected by the stockholders as Class III directors. Director nominees are elected by receiving the greatest number of votes cast for their election by holders of common stock that are present in person or represented by proxy at the meeting. Although the election of directors at the Annual Meeting is uncontested and directors are elected by a plurality of votes cast, and we therefore expect that each of the named nominees for director will be elected at the Annual Meeting,shares voted “against” such nominee.

In addition, under our Corporate Governance Guidelines, any nominee for director who receives a greater number of votes “against” his or her election than votes “for” such election is required to submit an offer of resignation for consideration by the Nominating and Corporate Governanace Committee, or the Governance Committee if such nominee for director (in an uncontested election) receives a greater number of votes “withheld” from his or her election than votes “for” such election.Committee. In such case, the Nominating and Corporate Governance Committee will then consider all of the relevant facts and circumstances and recommend to the full Board the action to be taken with respect to such offer of resignation. Shares represented by executed proxies will be voted, if authority to do so is not withheld, for the election of the three nominees named herein. In the event that

If any nominee should beis unavailable for election as a result ofdue to an unexpected occurrence, such shares will be voted for the election of such substitute nominees as the Nominating and Corporate Governance Committee may propose. Proxies may not be voted for a greater number of persons than the number of nominees named. Each person nominated for election has consented to being named as a nominee in this proxy statement and has agreed to serve if elected, and management has no reason to believe that any nominee will be unable to serve.

  LOGO   

The Board recommends a voteFOR all three of the nominees for director named above.

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NOMINEES FOR THE BOARD OF DIRECTORS AND CONTINUING DIRECTORS  


NOMINEES FOR THE BOARD OF DIRECTORS AND CONTINUING DIRECTORS

The names of the nominees and of the directors whose terms of office will continue after the Annual Meeting, their ages as of April 5, 2019,2, 2020, and certain other information about them are set forth below. The Nominating and Corporate Governance Committee seeks to assemble a Board that, as a group, provides a significant composite mix of experience, knowledge and abilities that will allow the Board to fulfill its responsibilities. To that end, the Nominating and Corporate Governance Committee has identified and evaluated nominees in the broader context of the Board’s overall composition, with the goal of recruiting and retaining members who complement and strengthen the skills of the other members of the Board and who also exhibit integrity, collegiality, sound business judgment and other qualities that the Nominating and Corporate Governance Committee views as critical to effective functioning of the Board. The brief biographies below includeSuch information as of the date of this proxy statement, regardingincludes the specific and particular experience, qualifications, attributes or skills of each nominee and continuing director that led the Nominating and Corporate Governance Committee and the Board to believe that such nominee or continuing director should continue to serve on the Board as of the date of this proxy statement.

Director Nominee Age
 Company Positions/Offices Director Since Term Expires
Srinivas Akkaraju, M.D., Ph.D. 51
 Director July 2003 2019
Marc E. Lippman, M.D. (1)
 74
 Director June 2000 2019
Daniel G. Welch (2)
 61
 Director June 2007 2019
         
Continuing Directors Age
 Company Positions/Offices Director Since Term Expires
David W. Gryska (3)
 63
 Director March 2005 2020
John A. Orwin (2) (3)
 54
 Director January 2014 2020
Alpna Seth, Ph.D. (3)
 55
 Director March 2018 2020
Felix Baker, Ph.D. (1) (2)
 50
 Lead Independent Director July 2003 2021
Clay B. Siegall, Ph.D. 58
 President, Chief Executive Officer and Chairman of the Board December 1997 2021
Nancy A. Simonian, M.D. (1)
 58
 Director March 2012 2021
_____________________

DIRECTOR NOMINEE PROFILES

(1)Current

 DAVID W. GRYSKA                                                                                                               INDEPENDENT  

KEY QUALIFICATIONSRECENT EXPERIENCE

Age: 64

Director Since:
2005

Term Expires:
2020

Committees:

•  Audit (Chair)   

Mr. Gryska has years of experience as Chief Financial Officer at Incyte Corporation, Celgene Corporation, Scios, Inc., and Cardiac Pathways Corporation. He brings to the Board valuable and relevant experience as a senior financial executive at life sciences and biotechnology companies engaged in financings, global expansion and other strategic transactions. He also has extensive knowledge of accounting principles and financial reporting rules and regulations, tax compliance and oversight of the financial reporting processes of several large, publicly-traded corporations, which assists Mr. Gryska in fulfilling his duties as chair of our Audit Committee.

Incyte Corporation, a publicly-traded biopharmaceutical company

  Executive Vice President and Chief Financial Officer (2014-2018; retired)

Myrexis, Inc., a publicly-traded biotechnology company

  Chief Operating Officer and Interim Chief Executive Officer (2012)

Celgene Corporation, a publicly-traded biopharmaceutical company

  Senior Vice President and Chief Financial Officer (2006-2010)

OTHER PUBLIC COMPANY BOARDS

  PDL BioPharma, Inc.

  Aerie Pharmaceuticals, Inc.

2020 PROXY STATEMENT9


  NOMINEES FOR THE BOARD OF DIRECTORS AND CONTINUING DIRECTORS

DIRECTOR NOMINEE PROFILES

 JOHN A. ORWIN                                                                                                                 INDEPENDENT  

KEY QUALIFICATIONSRECENT EXPERIENCE

Age: 55

Director Since:
2014

Term Expires:
2020

Committees:

•  Compensation

•  Audit

Mr. Orwin has many years of experience as a senior executive at leading pharmaceutical and biotechnology companies, including Atreca, Inc., Relypsa, Inc., Affymax, Inc., Genentech, Inc., and Johnson & Johnson. This gives him a strong understanding of the biotechnology industry and the challenges we must meet in order to continue developing and commercializing ADCETRIS, PADCEV and our product candidates.

Atreca, Inc., a publicly-traded biopharmaceutical company

  President and Chief Executive Officer(2018-present)

Relypsa, Inc., now an affiliate of Vifor Pharma AG, a Swiss-listed public company

  Chief Executive Officer (2013-2017)

Affymax, Inc., a biotechnology company

  Board member (2011-2014)

  Chief Executive Officer (2011-2013)

  President and Chief Operating Officer (2010-2011)

Genentech, Inc., now a member of the NominatingRoche Group

  Vice President and Corporate Governance Committee.then Senior Vice President of the BioOncology Business Unit (2005-2010)

OTHER PUBLIC COMPANY BOARDS

Current

  Atreca, Inc.

  Retrophin, Inc.

Past 5 Years

  Array BioPharma Inc.

 ALPNA H. SETH, PH.D.                                                                                                      INDEPENDENT  

KEY QUALIFICATIONSRECENT EXPERIENCE

Age: 56

Director Since:
2018

Term Expires:
2020

Committees:      

•  Audit

Dr. Seth has over 20 years of global experience in the biotechnology industry. Having held a range of leadership roles around the globe, Dr. Seth brings a breadth of experience in drug development, commercial, international operations and general management.

Proneurotech Inc., a private biotechnology company

  Chief Executive Officer and President(2019-present)

Vir Biotechnology, Inc., a private biopharmaceutical company

  Chief Operating Officer (2017-2019)

Biogen, Inc., a publicly-traded biotechnology company

  Senior Vice President and Global Head of the Biosimilars Global Business Unit (2014-2017)

  Range of leadership roles in business development, drug development and commercial (1998-2014)

OTHER PUBLIC COMPANY BOARDS

  Bio-Techne Corporation

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NOMINEES FOR THE BOARD OF DIRECTORS AND CONTINUING DIRECTORS  

CONTINUING DIRECTOR PROFILES

FELIX J. BAKER, PH.D.                                                                   LEAD INDEPENDENT DIRECTOR

KEY QUALIFICATIONSRECENT EXPERIENCE

Age: 51

Director Since:
2003

Term Expires:
2021

Committees:

•  Compensation (Chair)

•  Governance

As a board member and investor in many successful biotechnology companies, Dr. Baker is able to draw on his experience and vision in investing in and building companies to add significant value to Board of Directors discussions and company strategy.

Baker Bros. Advisors LP, a biotechnology investment firm

  Founder andCo-Managing Member(2000-present)

OTHER PUBLIC COMPANY BOARDS

Current

  Alexion Pharmaceuticals, Inc.

  Kiniksa Pharmaceuticals, Ltd.

  Kodiak Sciences Inc.

Past 5 Years

  Synageva BioPharma Corp.

  Genomic Health, Inc.

SRINIVAS AKKARAJU, M.D., PH.D.                                                                                   INDEPENDENT  

KEY QUALIFICATIONSRECENT EXPERIENCE

Age: 52

Director Since:
2003

Term Expires:
2022

Dr. Akkaraju has a strong scientific background coupled with extensive experience in private equity and venture capital investing from his work at J.P. Morgan, Panorama Capital, New Leaf Venture Partners, Sofinnova Ventures and Samsara BioCapital. This combination allows for Dr. Akkaraju to thoroughly understand our technology and provide strong business and strategic expertise.

Samsara BioCapital, a venture capital firm

  Founder and Managing General Partner(2017-present)

Sofinnova Ventures, a venture capital firm

  General Partner (2013-2016)

New Leaf Venture Partners, an investment firm

  Managing Director (2009-2013)

OTHER PUBLIC COMPANY BOARDS

Current

  Intercept Pharmaceuticals, Inc.

  Syros Pharmaceuticals, Inc.

  Aravive, Inc.

Past 5 Years

  Principia Biopharma, Inc.

  aTyr Pharma, Inc.

  ZS Pharma Inc.

2020 PROXY STATEMENT11


  NOMINEES FOR THE BOARD OF DIRECTORS AND CONTINUING DIRECTORS

CONTINUING DIRECTOR PROFILES

MARC E. LIPPMAN, M.D.                                                                                                INDEPENDENT

KEY QUALIFICATIONSRECENT EXPERIENCE

Age: 75

Director Since:
2000

Term Expires:
2022

Committees:

•  Governance

Dr. Lippman’s extensive experience in treating patients and conducting oncology research at the National Cancer Institute and at the medical schools of the University of Miami, the University of Michigan and Georgetown University provides an important patient perspective and focus on innovation in our development of targeted oncology therapies.

Georgetown University Medical Center’s Lombardi Comprehensive Cancer Center

  Professor of Oncology (2018-present)

University of Miami Leonard M. Miller School of Medicine

  Kathleen and Stanley Glaser Professor of Medicine and Chairman of the Department of Medicine (2017-2018)

  Deputy Director of the Sylvester Comprehensive Cancer Center (2008-2017)

OTHER PUBLIC COMPANY BOARDS

  None

CLAY B. SIEGALL, PH.D.                                                                           CHAIRMAN OF THE BOARD

KEY QUALIFICATIONSRECENT EXPERIENCE

Age: 59

Director Since:
1997

Term Expires:
2021

Dr. Siegall’s experience in founding and building Seattle Genetics is integral to our success and our mission. His scientific understanding along with his corporate vision and operational knowledge provide strategic insights to our Board of Directors.

Seattle Genetics, Inc.

  Chairman of the Board (2004-present)

  Chief Executive Officer (2002-present)

  President (2000-present)

  Chief Scientific Officer (1997-2002)

  Co-founder (1997-present)

OTHER PUBLIC COMPANY BOARDS

Current

  Ultragenyx Pharmaceutical Inc.

Past 5 Years

  Alder BioPharmaceuticals, Inc.

  Mirna Therapeutics, Inc.

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NOMINEES FOR THE BOARD OF DIRECTORS AND CONTINUING DIRECTORS  

CONTINUING DIRECTOR PROFILES

NANCY A. SIMONIAN, M.D.                                                                                            INDEPENDENT

KEY QUALIFICATIONSRECENT EXPERIENCE

Age: 59

Director Since:
2012

Term Expires:
2021

Committees:

•  Governance (Chair)

As a current and former senior executive of several other biotechnology companies, including Syros Pharmaceuticals, Inc., Millennium Pharmaceuticals, Inc. and Biogen, Dr. Simonian possesses a strong understanding of the biotechnology industry and the development and commercialization of our product candidates. Her knowledge of late-stage product development, as former Chief Medical Officer of Millennium Pharmaceuticals, Inc., and her understanding of patient perspectives, as a medical doctor, bring important insights to our Board of Directors.

Syros Pharmaceuticals, Inc., a publicly-traded life sciences company

  Chief Executive Officer (2012-present)

Millennium Pharmaceuticals, Inc., an affiliate of The Takeda Oncology Company

  Chief Medical Officer (2006-2011)

OTHER PUBLIC COMPANY BOARDS

Current

  Evelo Biosciences

  Syros Pharmaceuticals

DANIEL G. WELCH                                                                                                               INDEPENDENT  

KEY QUALIFICATIONSRECENT EXPERIENCE

Age: 62

Director Since:
2007

Term Expires:
2022

Committees:

•  Compensation      

Mr. Welch’s global commercial background and strong senior executive experience at a wide range of biotechnology companies, including previously serving as Chairman and Chief Executive Officer of two publicly-traded biotechnology companies, InterMune, Inc. and Triangle Pharmaceuticals, Inc. gives him insight into strategy and planning for a biopharmaceutical company that is valuable to our senior management and our Board of Directors.

Sofinnova Ventures, a venture capital firm

  Executive Partner (2015-2018; retired)

InterMune, Inc., a publicly-traded biotechnology company

  Chief Executive Officer and President(2003-2014)

  Chairman of the Board (2007-2014)

OTHER PUBLIC COMPANY BOARDS

Current

  Intercept Pharmaceuticals, Inc.

  Ultragenyx Pharmaceuticals, Inc. (Chairman of the Board)

Past 5 Years

  Hyperion Therapeutics

  Avexis, Inc.

2020 PROXY STATEMENT13


CORPORATE GOVERNANCE

CORPORATE GOVERNANCE

Our Board of Directors is committed to building long-term shareholder value and maintaining sound corporate governance practices. In furtherance of this commitment, we regularly monitor developments in the area of corporate governance and review our processes, policies and procedures in light of such developments.

DIRECTOR INDEPENDENCE; AUDIT COMMITTEE FINANCIAL EXPERT

Our Board of Directors has determined that all of our directors are independent directors within the meaning of Rule 5605(a)(2) Current memberof the Nasdaq listing standards, except for Clay B. Siegall, our President and Chief Executive Officer. In making this determination, our Board of Directors considered Dr. Baker’s role as aCo-Managing Member of Baker Brothers Investments, and the relationship Seattle Genetics has with Baker Brothers Investments and affiliated entities as significant shareholders in making the determination that Dr. Baker is independent.

Our Board of Directors has also determined that all of the members of the Compensation Committee.

(3)     Current memberCommittee currently serving are independent under the additional criteria for members of the Compensation Committee under the Nasdaq listing standards. In the case of Dr. Baker, our Board of Directors determined that, given his affiliation with our largest shareholder, his interests are aligned with other shareholders in seeking an appropriate executive compensation program for Seattle Genetics. In addition, the Board of Directors has determined that all of the members of the Audit Committee.
Committee are independent within the meaning of Rules 5605(c)(2)(A)(i) and (ii) of the Nasdaq listing standards and that Mr. Gryska is an audit committee financial expert as defined in Item 407(d)(5)(ii) ofRegulation S-K.There are no family relationships among any of the directors or executive officers of Seattle Genetics.

DIRECTOR NOMINEE PROFILES
Srinivas Akkaraju, M.D., Ph.D.BOARD LEADERSHIP STRUCTURE

Our Board of Directors has chosen to combine the principal executive officer and Board chairman positions and, in addition, has appointed a separate lead independent director. Dr. AkkarajuSiegall has served as oneour principal executive officer and Board chairman since 2004. At the present time, the independent directors believe that Dr. Siegall’sin-depth knowledge of our operations and vision for our development make him the best-qualified director to serve as Board chairman. We believe that combining the positions of chief executive officer and Board chairman provides a single, clear chain of command to execute our strategic initiatives and business plans. In addition, we believe that a combined chief executive officer/Board chairman is better positioned to act as a bridge between management and the Board, facilitating the regular flow of information. We also believe that it is advantageous to have a Board chairman with an extensive history with and knowledge of Seattle Genetics (as is the case with our chief executive officer) as compared to an independent Board chairman with less direct involvement.

Under our Corporate Governance Guidelines, when the Board chairman also serves as our chief executive officer or as another executive officer of Seattle Genetics, the Board may designate an independent director who acts as a lead independent director. The position of lead independent director has been structured to serve as an effective balance to a combined chief executive officer/Board chairman. In addition, we believe that having a lead independent director, who is independent of management, creates an environment that is more conducive to objective evaluation and oversight of management’s performance, increasing management accountability and improving the ability of the Board of Directors to monitor whether management’s actions are in the best interests of Seattle Genetics and its shareholders. Since February 2005, Felix J. Baker has served as the lead independent director of the Board. His formal and informal duties include, among others:

providing leadership to the Board complementary to the Board chairman;

working with the Board chairman and Corporate Secretary to set the agenda for Board meetings;

serving as the principal liaison between the independent directors and the Board chairman;

calling meetings of the independent directors;

chairing meetings of independent directors without management present;

chairing Board meetings if the Board chairman is not in attendance;

if requested by shareholders, ensuring that he is available, when appropriate, for consultation and direct communication; and

reviewing and providing input on Board meeting schedules.

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In addition, as chair of our Compensation Committee, Dr. Baker provides additional oversight of management by leading the annual evaluation of the pay and performance of our chief executive officer and our other executive officers.

DIRECTOR COMMITMENTS

Our Board believes that all members of the Board must have sufficient time and attention to devote to Board duties and to otherwise fulfill the responsibilities required of directors. Over the past year, our Governance Committee reviewed institutional and proxy advisory firms’ policies on director time commitments and reviewed the policies of peers and other public companies. We also discussed this topic during investor engagements.

Based on this information, our Governance Committee and Board revised our Corporate Governance Guidelines as outlined below. All of our directors since July 2003. Dr. Akkaraju is a founder and Managing General Partner of Samsara BioCapital. Previously,are in compliance with our policy.

Director who also serves as a Section 16 executive officer of a public company

£2 public company boards in addition to our Board unless approved in advance by our Board

  Director who is not an Executive Officer

£4 public company boards in addition to our Board unless approved in advance by the Board

Non-employee directors are required to notify the Governance Committee if they:

retire from April 2013 to February 2016, Dr. Akkaraju served as a General Partner of Sofinnova Ventures. From January 2009 to April 2013, Dr. Akkaraju served as Managing Director of New Leaf Venture Partners. From August 2006 to December 2008, Dr. Akkaraju served as a Managing Directortheir executive positions at Panorama Capital, LLC, a private equity firm founded byoutside companies

change the former venture capital investment team of J.P. Morgan Partners, LLC, a private equity division of JPMorgan Chase & Co. Panorama Capital advised J.P. Morgan Partners as to its investment in Seattle Genetics. Prior to co-founding Panorama Capital, he was with J.P. Morgan Partners, which he joined in April 2001 and of which heposition they held when they became a Partner in January 2005. From October 1998 to April 2001, he was in Business and Corporate Development at Genentech, Inc. (now a member of the Roche Group),Board

join the board of a biotechnology company, most recentlyprivate or public company.

The Governance Committee will review the appropriateness of continued Board membership under the circumstances and the affected director will be expected to act in accordance with the Governance Committee’s recommendation.

In recommending to the full Board the re-election of Mr. Orwin, the members of the Governance Committee considered the Company’s policy as Senior Manager. Prior to joining Genentech, Dr. Akkaraju waswell as the policies at a graduate student at Stanford University, where he receivedfew of the Company’s major shareholders regarding the number of outside boards on which an M.D. and a Ph.D. in Immunology. He received his undergraduate degrees in Biochemistry and Computer Science from Rice University.active CEO should participate. In addition to Seattle Genetics, Dr. Akkarajuour Board, Mr. Orwin serves as a director of Intercept Pharmaceuticals, Inc., Syros Pharmaceuticals, Inc., Principia Biopharma, Inc. and Aravive, Inc., publicly-traded biotechnology companies. Previously, Dr. Akkaraju served as a director on the boards of aTyr Pharma, Inc., Barrier Therapeutics, Inc., Eyetech Pharmaceuticals, Inc., ZS Pharma Inc., Versartis, Inc., which merged with Aravive Biologics, Inc.directors of two other public companies: Retrophin and formed Aravive, Inc., and Synageva Biopharma Corp., all publicly-traded biotechnology companies, and Amarin Corporation plc, a foreign publicly-traded biotechnology company. Dr. Akkaraju has a strong scientific background coupled with extensive experience in private equity and venture capital investing from his work at J.P. Morgan, Panorama Capital, New Leaf, Sofinnova and Samsara. This combination allows for Dr. Akkaraju to thoroughly understand our technology and provide strong business and strategic expertise.


Marc E. Lippman, M.D. Dr. Lippman has served as one of our directors since June 2000. Since July 2018, Dr. Lippman has served as Professor of Oncology at Georgetown University Medical Center's Lombardi Comprehensive Cancer Center. From October 2017 to July 2018, Dr. Lippman served as the Kathleen and Stanley Glaser Professor of Medicine and Chairman of the Department of Medicine at the University of Miami Leonard M. Miller School of Medicine. From January 2008 to October 2017, Dr. Lippman served as the Deputy Director of the Sylvester Comprehensive Cancer Center of University of Miami Leonard M. Miller School of Medicine. Previously, from February 2001 to May 2007 he served as the John G. Searle Professor and Chairman of the Department of Internal Medicine at the University of Michigan School of Medicine. Previously, Dr. Lippman was the Director of the Lombardi Cancer Research Center from July 1988 to February 2001, Professor and Chairman of the Department of Oncology from July 1999 to February 2001 and Professor of Medicine at Georgetown University Medical School in Washington, D.C. from July 1988 to February 2001. He also served as Chief of the Division of Hematology-Oncology at Georgetown University Medical School from July 1995 to February 2001. He was Head of the Medical Breast Cancer Section of the Medicine Branch of the National Cancer Institute from July 1976 to July 1988. Dr. Lippman has authored over 500 peer-reviewed publications and one of the standard texts on breast cancer. He received a B.A., magna cum laude, from Cornell and an M.D. from YaleAtreca, where he was electedalso serves as CEO and President.

Our Governance Committee and Board believe that Mr. Orwin has demonstrated, and will continue to Alpha Omega Alpha. Dr. Lippman’s extensive experience in treating patientsdemonstrate, the ability to dedicate sufficient time to carry out his Board duties effectively and conducting oncology research at the National Cancer Institute and at the medical schools of the University of Miami, the University of Michigan and Georgetown University provides an important patient perspective and focus on innovation in our development of antibody-based therapies.

Daniel G. Welch Mr. Welch has served as one of our directors since June 2007. From January 2015 to February 2018, Mr. Welch served as an Executive Partner of Sofinnova Ventures, a venture capital firm. Mr. Welch served as Chief Executive Officer and President of InterMune, Inc., a formerly publicly-traded biotechnology company, from September 2003 until InterMune’s acquisition by Roche Holdings in September 2014, and, from May 2007 to October 2014, he servedbelieves that it is in the additional role of Chairman of the Board of InterMune. Before joining InterMune, he was Chairman and Chief Executive Officer of Triangle Pharmaceuticals from 2002 to 2003, which was acquired by Gilead in 2003. Prior toCompany’s best interest that he was President of Biopharmaceuticals at Elan Corporation from 2000continue to 2002. During his tenure at Elan he was responsible for its U.S. commercial operations, international subsidiaries, R&D and diagnostics businesses. From 1987 to 2000, Mr. Welch served in various senior management roles at Sanofi-Synthelabo, now Sanofi-Aventis, including Vice President of Worldwide Marketing and Chief Operating Officer of the U.S. business. Mr. Welch holds a B.S. from the University of Miami and an M.B.A. from the University of North Carolina. In addition to Seattle Genetics, Mr. Welch servesserve as a director of Intercept Pharmaceuticals, Inc. and Chairman offor the Board at Ultragenyx Pharmaceuticals, Inc., both publicly-traded biotechnology companies. Since August 2018, Mr. Welch has served as Executive Chairman of Levo Therapeutics, a private biotechnology firm. Previously, he served as a Director of Hyperion Therapeutics until its acquisition by Horizon Pharma in 2015 and Chairman of the Board of Avexis, Inc. until its acquisition by Novartis Pharmaceuticals in 2018. Mr. Welch’s global commercial background and strong senior executive experience at a wide range of biotechnology companies, including previously serving as Chairman and Chief Executive Officer of two publicly-traded biotechnology companies, gives him insight into the strategy and planning for a biopharmaceutical company that is valuable to our senior management as well as the other members of our Board of Directors.
following reasons:




THE BOARD RECOMMENDS A VOTE FOR ALL THREE OF
THE NOMINEES FOR DIRECTOR NAMED ABOVE.

CONTINUING DIRECTOR PROFILES
Felix Baker, Ph.D. Dr. Baker has served as one of our directors since July 2003 and as our lead independent director since February 2005. Dr. Baker is Co-Managing Member of Baker Bros. Advisors LP. Dr. Baker and his brother, Julian Baker, started their fund management careers in 1994 when they co-founded a biotechnology investing partnership with the Tisch Family. In 2000, they founded Baker Bros. Advisors LP. Dr. Baker holds a B.S. and a Ph.D. in Immunology from Stanford University, where he also completed two years of medical school. In addition to Seattle Genetics, Dr. Baker currently serves as a director of Alexion Pharmaceuticals, Inc. and Genomic Health, Inc., both of which are publicly-traded biotechnology companies. In addition, Dr. Baker previously served as a director of Ardea BioScience, Inc., AnorMED Inc., Conjuchem, Inc., Neurogen Corporation, Synageva BioPharma Corp. and Trimeris, Inc., all of which were publicly-traded companies during Dr. Baker’s service as a director. As a board member and investor in many successful biotechnology companies, Dr. Baker is able to draw on his experience and vision in investing in and building companies to add significant value to Board of Directors discussions and company strategy.
David W. Gryska Mr. Gryska has served as one of our directors since March 2005. From October 2014 through December 2018, Mr. Gryska served as Executive Vice President and Chief Financial Officer of Incyte Corporation, a publicly-traded biopharmaceutical company. From May 2012 to December 2012, Mr. Gryska served as Chief Operating Officer and from August 2012 to December 2012, interim Chief Executive Officer of Myrexis Inc., a publicly-traded biotechnology company. From December 2006 to October 2010, he served as Senior Vice President and Chief Financial Officer of Celgene Corporation. From October 2004 to December 2006, he was a principal at Strategic Consulting Group, where he provided strategic consulting to early-stage biotechnology companies. Mr. Gryska served at Scios, Inc., a biopharmaceutical company, as Senior Vice President and Chief Financial Officer from November 2000 to October 2004, and as Vice President of Finance and Chief Financial Officer from December 1998 to November 2000. Scios was acquired by Johnson & Johnson in 2003. From 1993 to December 1998, he served as Vice President, Finance and Chief Financial Officer at Cardiac Pathways Corporation, a medical device company which was later acquired by Boston Scientific Corporation. Prior to Cardiac Pathways, Mr. Gryska served as a partner at Ernst & Young LLP, an accounting firm. During his eleven years at Ernst & Young LLP, he focused on technology industries, with an emphasis on biotechnology and healthcare companies. Mr. Gryska holds a B.A. in accounting and finance from Loyola University and an M.B.A. from Golden Gate University. In addition to Seattle Genetics, Mr. Gryska serves on the board of PDL BioPharma, Inc. and Aerie Pharmaceuticals, Inc., both publicly-traded biotechnology companies. With his years of experience as Chief Financial Officer, at Incyte Corporation, Celgene, Scios, and Cardiac Pathways, Mr. Gryska brings to the Board of Directors valuable and relevant experience as a senior financial executive at life sciences and biotechnology companies dealing with financings, mergers, acquisitions and global expansion and other strategic transactions. He also has extensive knowledge of accounting principles and financial reporting rules and regulations, tax compliance and oversight of the financial reporting processes of several large, publicly-traded corporations, which assists Mr. Gryska in fulfilling his duties as chair of our Audit Committee.
John A. Orwin

Mr. Orwin has served as oneon our Board for over six years and has assured our Board that he is fully committed to continuing to dedicate the appropriate amount of our directors since January 2014. Mr. Orwin currently serves as the President and Chief Executive Officer of Atreca, Inc., a private biotechnology company. From June 2013time to June 2017, he served as Chief Executive Officer and member of the board of Relypsa, Inc., now an affiliate of Vifor Pharma AG, a Swiss-listed public company. Prior to Relypsa, Mr. Orwin served as President and Chief Operating Officer of Affymax, Inc., a biotechnology company, from April 2010 to January 2011, as its Chief Executive Officer from February 2011 through May 2013 and as a member of its board of directors from February 2011 to November 2014. From 2005 to April 2010, Mr. Orwin served as Vice President and then Senior Vice President of the BioOncology Business Unit at Genentech, Inc. (now a member of the Roche Group), a biotechnology company, where he was responsible for all marketing, sales, business unit operations and pipeline brand management for Genentech’s oncology portfolio in the United States. From 2001 to 2005, Mr. Orwin served in various executive-level positions at Johnson & Johnson, a life sciences company, overseeing oncology therapeutic commercial and portfolio expansion efforts in the U.S. Prior to such roles, Mr. Orwin held senior marketing and sales positions at various life sciences and pharmaceutical companies, including Alza Corporation (acquired by Johnson & Johnson), Sangstat Medical Corporation (acquired by Genzyme), Rhone-Poulenc Rorer Pharmaceuticals, Inc. (merged with Sanofi-Aventis) and Schering-Plough Corporation (merged with Merck). Mr. Orwin servesfulfill his duties as a member of the Board and Compensation Committee.

Mr. Orwin’s experience in senior management positions in the pharmaceutical industry provides significant industry knowledge and commercial, operational and management expertise to our Board. His experience on the boards of directors of Array BioPharma Inc.other public companies will continue to benefit us by providing him with insight and experience that enhances his value to our Board.

Mr. Orwin’s attendance record demonstrates his commitment to our board, participating in 100% of Retrophin, Inc., both publicly-traded biopharmaceutical companies. Board meetings and 100% of Compensation committee meetings for the past three years.

Mr. Orwin is consistently prepared and has exemplary participation at meetings of the Board and Compensation Committee, and he contributes significantly to discussions and decision making. He is also s served onappropriately engaged with management and the boardother members of directorsthe Board outside of NeurogesX, Inc.,meetings of the Board and Compensation Committee.

Each of Atreca and Retrophin is a biopharmaceuticalpharmaceutical company until July 2013.headquartered in California. Mr. Orwin received an M.B.A. from New York University and a B.A. from Rutgers University. Mr. Orwin’s many years of experience as a senior executive gives him a strong understanding of the biotechnology industry and the challenges we must meet in order to continue developing and commercializing ADCETRIS and our product candidates.

Alpna Seth, Ph.D. Dr. Seth has served as one of our directors since March 2018. From July 2017 to January 2019, Dr. Seth served as the Chief Operating Officer of Vir Biotechnology, Inc., a publicly-traded biopharmaceutical company. Prior to joining Vir in July 2017, Dr. Seth was Senior Vice President and Global Head of the Biosimilars Global Business Unit for Biogen, Inc. headquartered in Zug, Switzerland since 2014. For the period from 1998 through July 2017, Dr. Seth held a range of leadership roles at Biogen in business development, drug development and commercial, including founding Managing

Director of Biogen Idec India and Program Executive for several of Biogen’s major cross-functional drug development programs and product launches. Dr. Seth serves as a memberattended 100% of the board meetings of directorsRetrophin since he joined the board in 2017. He has also attended 100% of Bio-Techne Corporation, a publicly-traded biotechnology company. Dr. Seth holds a Ph.D.the board and committee meetings of Atreca since he joined in Biochemistry2018. As reported in their respective annual reports on Form 10-K for the year ended December 31, 2019, Atreca and Molecular Biology from UniversityRetrophin had only 113 and 221 full-time employees, respectively, as of Massachusetts Medical Schoolthe dates specified therein.

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Mr. Orwin does not serve on the boards of any privately-held companies and conducted her post-doctoral research at Harvard University in Immunology and Structural Biology, both as a Howard Hughes Medical Institute Fellow. She is also a 2002 graduateresult his only other director commitments are limited to Atreca and Retrophin.

Based on all of the Advanced Management Program at Harvard Business School. Dr. Seth brings a breadthabove considerations, our Governance Committee and Board believe that Mr. Orwin’s re-election is in the best interest of experience in drug development, commercial, international operations and general management.

Clay B. Siegall, Ph.D. Dr. Siegall co-founded Seattle Genetics in 1997. He has served as our Chief Executive Officer since November 2002, as our President since June 2000, as one of our directors since December 1997 and as our Board chairman since March 2004. Dr. Siegall also served as our Chief Scientific Officer from December 1997 until November 2002. Prior to co-founding Seattle Genetics, Dr. Siegall was with the Bristol-Myers Squibb Pharmaceutical Research Institute from 1991 to 1997, most recently as a Principal Scientist. From 1988 to 1991, Dr. Siegall was a Staff Fellow/Biotechnology Fellow at the National Cancer Institute, National Institutes of Health. Dr. Siegall received a Ph.D. in Genetics from George Washington University and a B.S. in Zoology from the University of Maryland. Genetics.

In addition to Seattle Genetics, Dr. Siegall serves as a director of Ultragenyx Pharmaceutical Inc. and Alder BioPharmaceuticals, Inc., both publicly-traded biotechnology companies. He served as a director of Mirna Therapeutics, Inc., also a publicly-traded biotechnology company from 2013 to 2016. Dr. Siegall’s experience in founding and building Seattle Genetics is integral to our success and our mission. His scientific understanding along with his corporate vision and operational knowledge provide strategic guidance to our management team and the Board, of Directors.

Nancy A. Simonian, M.D. Dr. Simonian has served as one of our directors since March 2012. Since July 2012, Dr. Simonian has served as the Chief Executive Officer of Syros Pharmaceuticals, Inc., a publicly-traded life science company focused on gene control therapeutics. From 2001 to October 2011, Dr. Simonian was with Millennium Pharmaceuticals, Inc., an affiliate of The Takeda Oncology Company, most recently serving as Chief Medical Officer and Senior Vice President of Clinical, Medical and Regulatory Affairs. From 1995 to 2001, Dr. Simonian was at Biogen (now Biogen Idec) and most recently served as Vice President of Clinical Research where she was responsible for clinical development and medical affairs of the neurology and oncology pipeline, including Avonex® and Tysabri®. Dr. Simonian serves on the boards of directors of two other public companies: Evelo Biosciences, Inc., or Evelo, and Syros Pharmaceuticals, both publicly-traded biotechnology companies, andInc., or Syros, where she also serves on the board of the Biotechnology Innovation Organization (BIO)as CEO and the Damon Runyan Foundation. She previously servedPresident. However, our Board does not believe that Dr. Simonian’s outside boards or other commitments negatively impact her ability to devote sufficient time and attention to her duties as a director of ArQule, Inc., a publicly-traded biotechnology company,Seattle Genetics based on her perfect attendance record both at our Board and Governance Committee meetings and at Evelo and Syros board meetings, and the Personalized Medicine Coalition. Priorhigh quality of her contributions to joiningour Board and her leadership of our Governance Committee. In addition, the pharmaceutical industry,perspective and experience that Dr. Simonian wascontinues to gain through both her role as a pharmaceutical company CEO and her leadership on two other pharmaceutical company boards enhances her ability to provide insightful and strategic contributions as a director of Seattle Genetics.

BOARD COMMITTEES

The Board has a standing Audit Committee, Compensation Committee and Governance Committee, each of which is made up solely of independent directors. Each of these committees operates under a written charter setting forth the functions and responsibilities of the committee, which is available on our website at www.seattlegenetics.com.

AUDIT COMMITTEE

Chair:

David W. Gryska

Other Members:

John A. Orwin

Alpna H. Seth

KEY FUNCTIONS

  appoint and establish the fees for our independent registered public accounting firm;

  review and approve the procedures we use to prepare our periodic and annual reports;

  review and discuss with management and our independent auditor our quarterly earnings release, financial statements, and related periodic SEC filings;

  review our critical accounting policies and critical audit matters;

  review the independence of the independent registered public accounting firm in accordance with the Public Company Accounting Oversight Board;

  monitor the effectiveness of the audit effort; and

  oversee our financial and accounting organization and our system of internal accounting controls.

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COMPENSATION COMMITTEE

Chair:

Felix J. Baker

Other Members:

John A. Orwin

Daniel G. Welch

KEY FUNCTIONS

  review and advise the Board regarding the performance of the CEO and other executive officers;

  review overall corporate performance against goals and determine corporate payout factor used for annual executive and nonexecutive bonuses;

  review and determine the compensation to be paid to the Company’s executive officers;

  establish and administer our policies regarding annual executive salaries, cash incentives and long-term equity incentives;

  oversee our equity plans, long-term incentive plans, executive bonus plan and other compensation policies, plans and programs;

  review with management our Compensation Discussion and Analysis; and

  review the compensation paid to our directors.

GOVERNANCE COMMITTEE

Chair:

Nancy A. Simonian

Other Members:

Felix J. Baker

Marc E. Lippman

KEY FUNCTIONS

  identify and evaluate individuals qualified to serve as members of the Board of Directors and consider board composition, including evaluating incumbent directors forre-election;

  recommend nominees to the Board for election as directors of Seattle Genetics and appointment as members of the committees of the Board of Directors;

  develop and make recommendations to the Board regarding the Company’s Corporate Governance Guidelines and provide oversight with respect to corporate governance and ethical conduct; and

  oversee an annual evaluation of the performance of the Board.

BOARD AND COMMITTEE MEETINGS AND ATTENDANCE

The Board met seven times and acted by written consent one time during 2019. On at least a quarterly basis, the Board meets in executive sessions of independent directors without management present. During 2019, the Audit Committee held six meetings, the Compensation Committee held seven meetings and acted by written consent three times and the Governance Committee met once and acted by written consent one time. Each of our directors attended at least 75% of the aggregate of Board and applicable committee meetings on which he or she served during 2019.

Although we do not have a formal policy regarding attendance by members of the Board of Directors at our Annual Meetings of Shareholders, directors are encouraged to attend. However, due to scheduling conflicts we held a meeting of the Board of Directors two weeks prior to our 2019 annual meeting of shareholders and as a result, with the exception of Dr. Siegall, none of our directors then serving attended the 2019 annual meeting of shareholders.

BOARD RISK OVERSIGHT

Our Board of Directors has overall responsibility for risk oversight with a focus on the facultymost significant risks facing Seattle Genetics. Throughout the year, the Board and the committees to which it has delegated responsibility dedicate a portion of Massachusettstheir meetings to reviewing and discussing specific risk topics in greater detail. Strategic and operational risks are presented and discussed in the context of the Chief Executive Officer’s report on operations to the Board at regularly scheduled Board meetings and at presentations to the Board and its committees by the respective

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committee chairs, our Chief Financial Officer, our General HospitalCounsel and Harvard Medical SchoolExecutive Vice President, Legal Affairs, and other officers. In addition, management periodically reports to the Board on enterprise risk management. Our Board also retains responsibility for assessment of succession-related risks and succession planning.

The Board has delegated responsibility for the oversight of specific risks to Board committees as follows:

  Audit Committee

  Reviews and oversees risks related to cybersecurity and compliance matters, including but not limited to, Foreign Corrupt Practices Act compliance.

  Reviews and oversees related-party transactions on behalf of Seattle Genetics.

  Compensation

  Committee

  Evaluates the risks and rewards associated with our compensation philosophy and programs.

  Reviews and approves compensation programs with features that mitigate risk without diminishing the  incentive nature of the compensation. For more detail see “Compensation of Executive Officers—Compensation Discussion and Analysis—Compensation and Risk,” below in this proxy statement.

  Discusses with management the procedures that have been put in place to identify and mitigate potential  risks in compensation.

  Governance

  Committee

  Oversees risks related to Seattle Genetics’ governance structure and processes, board composition,  refreshment and committee leadership.

In addition, our General Counsel and Executive Vice President, Legal Affairs works with our committees and Board to develop risk identification, risk management and risk mitigation strategies and reports periodically to the Board and the committees on Seattle Genetics’ risk profile and various management and mitigation strategies.

COMPENSATION COMMITTEE PROCESS AND PROCEDURES

Information on the Compensation Committee’s processes and procedures for consideration of executive compensation are addressed in “Compensation Discussion and Analysis” below. For information regarding our processes and procedures for the consideration and determination of director compensation, please see “Director Compensation” below. In accordance with its charter, the Compensation Committee may delegate any of its authority or responsibility as appropriate, except to the extent inconsistent with any applicable laws and rules, including the Nasdaq listing standards. Our compensation committee does not, however, delegate any of its functions to others in determining or recommending executive or director compensation.

BOARD REFRESHMENT

Under our Corporate Governance Guidelines, our Governance Committee is responsible for assessing the appropriate balance of experience, skills and characteristics required of the Board. In this regard, our Governance Committee identifies and evaluates individuals qualified to serve as Board members, including evaluating incumbent directors forre-election, and recommends to the Board nominees for election as directors. On an assistant professorannual basis, our Governance Committee assesses the qualities, experiences, skills and attributes that qualify each director to be a member of neurology. She receivedthe Board in light of our business structure and long-term strategy and assesses the committee’s effectiveness in diversifying the Board. Our Governance Committee also oversees an annual Board self-evaluation process. Director responses are collated into a B.A.summary by an outside third party, and the results are discussed with the full Board.

CRITERIA FOR BOARD MEMBERSHIP AND NOMINATION PROCESS

The Governance Committee assesses many characteristics and diversity considerations when reviewing director candidates and these characteristics are set forth in Biology from Princeton Universityour Corporate Governance Guidelines. Among the characteristics to be considered are:

professional background,

depth and an M.D. from the Universitybreadth of Pennsylvania Medical School. As a current and former senior executive of several other biotechnology companies, Dr. Simonian possesses a strong experience,

wisdom,

sound business judgment,

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integrity,

collegiality,

ability to make independent analytical inquiries,

understanding of the Company’s business environment,

familiarity with the biotechnology industry,

willingness to devote adequate time to Board duties,

the interplay of the candidate’s experience and skills with those of other Board members, and

the extent to which a candidate would be a desirable addition to the Board and any committees of the Board.

In determining whether to recommend a director forre-election, the Governance Committee also considers the director’s past attendance at meetings and participation in and contributions to the activities of the Board and its committees, as well as the nature and time involved in a director’s service on other boards. In 2019, we amended our Corporate Governance Guidelines to provide that the Governance Committee seeks nominees with:

a broad range of experience, viewpoints, professions, skills, geographic representations and backgrounds and

a diversity of race, ethnicity, gender, age and culture.

We believe that the backgrounds and qualifications of our directors, considered as a group, should provide a significant composite mix of experience, knowledge and abilities that will allow the Board to fulfill its responsibilities and should represent an appropriate balance between institutional knowledge and fresh perspectives.

The Governance Committee identifies nominees by first evaluating the current members of the Board willing to continue in service. Current members of the Board with skills and experience that are relevant to our business and who are willing to continue in service are considered forre-nomination. If there is a vacancy on the Board as a result of a resignation or otherwise, or if the Board decides not to nominate a member forre-election or decides to add a member to the Board, the Governance Committee identifies the desired skills and experience of a new nominee in light of the criteria above and the Board’s needs. Current members of the Board are asked to submit suggestions as to individuals meeting the criteria described above.

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SHAREHOLDER DIRECTOR NOMINATIONS AND RECOMMENDATIONS

In accordance with our bylaws and applicable law, nominations for directors may be made by any shareholder of record entitled to vote for the election of directors at shareholder meetings held for such purpose. The requirements a shareholder must follow for nominating persons for election as directors are set forth in our bylaws and under the heading “Frequently Asked Questions and Other Information—When are proposals and nominations due for the 2021 Annual Meeting?” below in this proxy statement.

The Governance Committee will also consider director candidates recommended by shareholders. In order to recommend director candidates to the Governance Committee, shareholders should follow the procedures in our bylaws for director nominations. If a shareholder complies with these procedures for recommending persons for

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election as directors, the Governance Committee will conduct the appropriate and necessary inquiries into the backgrounds, qualifications and skills of the recommended candidates and, in the exercise of the Governance Committee’s independent judgment in accordance with the policies and procedures adopted in the Governance Committee’s charter, will determine whether to recommend the candidate(s) recommended by the shareholders to the Board for inclusion in the list of candidates for election as directors at the next shareholder meeting held to elect directors. The Governance Committee does not intend to alter the manner in which it evaluates director candidates based on whether or not the candidate was recommended by a shareholder.

COMMUNICATIONS WITH THE BOARD OF DIRECTORS

Our Board of Directors currently does not have a formal process for shareholders to send communications to the Board of Directors. Nevertheless, efforts are made to ensure that the views of shareholders are heard by the Board or individual directors, as applicable, and that appropriate responses are provided to shareholders on a timely basis. The Board does not recommend that formal communication procedures be adopted at this time because it believes that informal communications are sufficient to communicate questions, comments and observations that could be useful to the Board. Shareholders wishing to formally communicate with the Board of Directors may send communications directly to Seattle Genetics, Inc., Attention: Investor Relations, 21823 – 30th Drive SE, Bothell, Washington 98021, and the communication will be forwarded, as appropriate. If the communication regards a shareholder proposal to be considered at an annual meeting of shareholders, the methods and timing for submitting a shareholder proposal are covered under the heading “Frequently Asked Questions and Other Information—When are proposals and nominations due for the 2021 Annual Meeting?”

MAJORITY VOTING IN UNCONTESTED ELECTIONS

In January 2020, the Board amended and restated our bylaws to implement a majority voting standard in uncontested director elections, instead of plurality voting. Under the Amended and Restated Bylaws, in uncontested elections, a director must be elected by a majority of the votes cast with respect to the election of such director (meaning the number of shares voted “for” such nominee’s election must exceed the number of votes cast “against” his or her election) at any meeting for the election of directors at which a quorum is present. However, in the event of a contested election of directors, directors shall be elected by the highest number of votes, or a plurality of votes, cast.

In addition, under our Corporate Governance Guidelines, any nominee for director who receives a greater number of votes “against” his or her election than votes “for” such election is required to submit an offer of resignation for consideration by the Governance Committee. In such case, the Governance Committee will then consider all of the relevant facts and circumstances and recommend to the full Board the action to be taken with respect to such offer of resignation.

BOARD CLASSIFICATION

The Board believes that there is no single approach to corporate governance that is appropriate for all companies and that the key consideration in determining whether to implement a particular governance practice is whether that practice promotes the interests of shareholders, taking into account the specific circumstances of Seattle Genetics. While the Board acknowledges that declassification proposals have received popular support, the Board has reviewed the rationale for its current classified structure and continues to believe that a classified board is the appropriate board structure for Seattle Genetics at this time and is in the best interest of our shareholders for the reasons set forth below:

Long-Term Focus. The Board believes that a classified board encourages directors to look to the long-term best interest of Seattle Genetics and our shareholders by strengthening the independence ofnon-employee directors against the often short-term focus of certain investors and special interests.

Continuity of Board Leadership. A classified board allows for a greater amount of stability and continuity, providing institutional perspective and knowledge both to management and other directors in a time of rapid growth and transformation for Seattle Genetics. In addition, the development and commercialization of pharmaceuticals is complex and requires significant expertise. By its very nature, a classified board ensures that at any given time there will be experienced directors serving on our Board who are fully immersed in and knowledgeable about our highly technical business, including our relationships with our current and potential strategic partners, as well as the competition, opportunities, risks and challenges that exist in the biotechnology and pharmaceutical industries. Each year the Governance Committee reviews the qualifications and performance of the directors prior to nominating

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CORPORATE GOVERNANCE

them to stand forre-election. We believe the benefit of a classified board to Seattle Genetics and our shareholders comes not from continuity alone—but rather from the continuity of highly qualified, engaged and knowledgeable directors focused on long-term shareholder interests.

Unsolicited Takeover Protection. A classified board can reduce vulnerability to potential abusive takeover tactics by encouraging persons seeking control of Seattle Genetics to negotiate with the Board and thereby better positioning the Board to negotiate effectively on behalf of all shareholders. Because less than a majority of directors stand for election at each annual meeting under a classified board structure, a hostile bidder could not simply replace a majority of the Board at a single annual meeting with directors aligned with the hostile bidder’s own interests, thereby gaining control of Seattle Genetics without paying a fair market price to all shareholders. Rather, in the interests of fairness to shareholders as a whole, having a classified board encourages the hostile bidder to negotiate directly with the Board on a potential transaction.

In sum, Seattle Genetics has benefited from the independence and continuity of experienced leadership provided by our Board of Directors under the classified structure, and we must meetbelieve these factors have been critical drivers of the significant growth in shareholder value that Seattle Genetics has generated over time.

SUCCESSION PLANNING

Succession planning is an important part of planning for the long-term success of our business. Under our Corporate Governance Guidelines, our Board is responsible for CEO succession planning, and they discuss CEO and executive officer performance and succession in executive session. In addition, our CEO and senior executives discuss future candidates for leadership positions at all levels within our organization.

CORPORATE GOVERNANCE GUIDELINES

As a part of the Board’s commitment to building long-term shareholder value and maintaining sound corporate governance, the Board has adopted a set of Corporate Governance Guidelines, which guides the operation of the Board and its committees. Our Corporate Governance Guidelines cover, among other topics, Board composition, structure and functioning, including our director resignation policy, Board membership criteria, director independence, Board self-evaluations, committees of the Board, Board access to management and independent advisers, stock ownership guidelines for members of the Board and our executive officers, and succession and leadership development. A copy of the Corporate Governance Guidelines can be viewed on our website at www.seattlegenetics.com.

STOCK OWNERSHIP GUIDELINES

Our Corporate Governance Guidelines include stock ownership guidelines for our directors and executive officers. For more information about these guidelines, please see “Director Compensation—Director Stock Ownership Guidelines” and “Compensation of Executive Officers—Compensation Discussion and Analysis—Stock Ownership Guidelines” below.

CODE OF CONDUCT AND BUSINESS ETHICS

The Board of Directors has adopted a Code of Conduct and Business Ethics, or the Code of Ethics, for all directors, officers and employees of Seattle Genetics, Inc. A copy of the Code of Ethics can be viewed on our website at www.seattlegenetics.com. We intend to satisfy the disclosure requirement under Item 5.05 of Form8-K regarding an amendment to, or waiver from, a provision of the Code of Ethics by posting such information on our website at the website address specified above.

WHISTLEBLOWER POLICY

Seattle Genetics has adopted a Whistleblower Policy applicable to its employees that provides for protection from retaliation or discrimination by Seattle Genetics due to reporting issues relating to concerns involving questionable accounting or auditing matters and compliance with applicable laws and regulations.

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CORPORATE GOVERNANCE

PROHIBITIONS ON HEDGING, PLEDGING AND SHORT-TERM SPECULATIVE TRANSACTIONS

Under the terms of our insider trading policy, no employees (including executive officers) of Seattle Genetics or its subsidiaries, members of our Board or consultants who know or have access to material information regarding Seattle Genetics that has not been fully disclosed to the public may engage in any hedging or monetization transactions relating to Seattle Genetics or its securities, including through the use of financial instruments such as prepaid variable forwards, equity swaps, collars and exchange funds, nor may any of these persons engage in short-term speculative transactions involving Seattle Genetics securities (or derivatives of Seattle Genetics securities), including short sales and the buying and selling of put or call options. In addition, none of these persons may hold Seattle Genetics securities in a margin account or otherwise pledge Seattle Genetics securities as collateral for a loan.

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CORPORATE GOVERNANCE

CORPORATE RESPONSIBILITY

At Seattle Genetics, we are committed to developing transformative medicines for patients with cancer in a socially responsible and sustainable manner. We are dedicated to providing patients access to our medicines and education about their disease. We also believe that fostering a culture of inclusion with diverse perspectives and operating with integrity are key to our success. We continue to support the community both locally and through nonprofits that are dedicated to patients and advancing research. Finally, as grow, we are striving to limit our environmental impact and operate in an increasingly sustainable manner.

    LOGO

PATIENTS

    LOGO

EMPLOYEES & COMMUNITY

    LOGO

ENVIRONMENT
Providing patients with safe and effective medicines as well as supporting patient advocacy and education through philanthropic donationsContinuing to be an employer of choice by promoting an inclusive and rewarding workplace and being a good corporate citizen in the communities where we operateSeeking to operate our business in a sustainable manner and aligning with suppliers that we believe share our vision

  Assisting patients with access to our medicines through financial reimbursement support through our SeaGen Secure program

  Supporting patient advocacy organizations to help patients learn more about their disease states and find a community

  Improving patients’ lives through scientific excellence by seeking to develop therapies for areas of significant unmet need

  Working to ensure that our supply chain meets or exceeds good manufacturing practices (GMP) as well as U.S. Food & Drug Administration, European Medicines Agency, Occupational Health and Safety Act (OHSA) and Environmental Protection Agency (EPA) standards

  Continuing to foster a diverse and inclusive workforce at all levels. As of the end of 2019:

o   57% of our workforce was female and 30% were racially/ethnically diverse

o   38% of our leadership (Executive Director and above) were female and 18% were racially/ethnically diverse

  Proactively seeking feedback from employees, including a 97% completion rate of the 2019 Employee Engagement survey

o   97% of those responding agreed that the Company’s values are important for achieving our mission of improving lives of people with cancer and 94% are personally committed to fulfilling our vision

  Expanding philanthropic and volunteer opportunities in support of environmental, cancer and other nonprofits through our Employee Impact Committee

  Educating our employees on adherence to our Code of Conduct and Business Ethics and seeking partners who share our Standards for Suppliers

  Focusing on improving energy, water and waste management practices

  Enhancing a sustainability reporting framework with specific targets for reducing our water and energy use, carbon emissions and waste

  Continuing to make available and promote to employees environmentally friendly options such as alternative commute options and electric vehicle charging stations

  Implementing and maintaining a risk management process and internal controls designed to comply with our policy on Environmental, Health and Safety (EHS) management. Identifying and seeking to manage EHS risks and issues in line with principles of good governance and tiered accountability.

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DIRECTOR COMPENSATION

DIRECTOR COMPENSATION

The responsibility for reviewing director compensation and recommending changes to the Board is vested in the Compensation Committee per its charter. The Compensation Committee reviews our director compensation against the director compensation of our peer group companies annually, as described below under “—Processes and Procedures for Determining Director Compensation”.

CASH COMPENSATION

Ournon-employee directors receive an annual cash retainer for service on the Board, plus reimbursement forout-of-pocket expenses incurred in connection with attendance at Board and Board committee meetings, as well as additional retainers for service as our Lead Independent Director or service on committees of the Board. In March 2019, on the recommendation of the Compensation Committee based on a review of our peer group companies, the retainers for service on the Board and Board committees were revised as follows:

Service

  

Previous Annual Cash

Compensation

   

                         

  

New Annual Cash  

Compensation  

 

Non-Employee Director

   $50,000       $55,000  

Lead Independent Director

   $25,000      $37,500  

    Chair   Member       Chair   Member   

Audit Committee

  $20,000   $10,000     $25,000   $12,000  

Compensation Committee

  $15,000   $8,000     $20,000   $10,000  

Governance Committee

  $10,000   $5,000     $15,000   $6,500  

In January 2020, on the recommendation of the Compensation Committee based on a review of our peer group companies, the annual cash retainer for service as anon-employee director was further revised from $55,000 to $60,000 and the annual retainer for service as Chair of the Compensation Committee was further revised from $20,000 to $22,000.

If anon-employee director has not served on the Board or a Board committee for the full year, the Board and any applicable Board committee retainers will be prorated for the portion of the year served.

EQUITY COMPENSATION

Our Board has established a policy of providing each newnon-employee director of Seattle Genetics an initial grant of stock options and restricted stock units, or RSUs, under our 2007 Equity Plan. These initial awards are granted effective on the date on which a recipient first becomes anon-employee director of Seattle Genetics. In addition, effective on the date of each annual meeting of shareholders, eachnon-employee director receives an annual grant of stock options and RSUs under the 2007 Equity Plan if, on such date, he or she has served on the Board for at least six months prior to such date. In 2019, on the recommendation of the Compensation Committee based on a review of our peer group companies, our Board revised its policy regarding the initial and annual grants tonon-employee directors to provide value-based awards instead of share-based awards, which we provided in the past.

    Target Value of
Option Award (1)
   

Target Value of

RSU Award(2)

   Total Target  
Value of Award  
 

Initial grant

   $300,000    $300,000    $600,000  

Annual grant

   $200,000    $200,000    $400,000  
(1)

The actual number of shares underlying each option grant is calculated based on an approximation of the target award value based on the average stock price during the 30 calendar days preceding the effective date of the grant and using the Black Scholes methodology for stock option valuation.

(2)

The actual number of shares underlying each RSU grant is calculated by dividing the target value of the RSU award by the average stock price during the 30 calendar days preceding the effective date of the grant.

In 2019, each of ournon-employee directors received an annual option grant to purchase 7,038 shares of common stock and an annual RSU grant covering 2,963 shares of common stock, effective on the date of our 2019 annual meeting.

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DIRECTOR COMPENSATION

The exercise price of options granted to our directors is equal to the fair market value of our common stock on the Nasdaq Global Select Market on the effective date of grant. Options granted tonon-employee directors under the 2007 Equity Plan and the 2000 Directors’ Stock Option Plan, or the Directors’ Plan, have ten year terms and remain exercisable for up to three months following the grantee’s termination of service, unless such termination is a result of death or disability, in which case the options remain exercisable for up to a twelve-month period (or such lesser period as is determined by the Board).

The initial option grants vest as to 25% of the underlying shares on the first anniversary of the grant date and ratably thereafter on a monthly basis until such grant is fully vested on the fourth anniversary of the grant date, and the initial RSU grant vests as to 25% per year over a four year period on the anniversaries of the vesting commencement date, subject in both cases to continued service. The annual option and RSU awards made to each of our eligible directors in 2019 will vest on May 20, 2020. In addition, allnon-employee directors would receive full acceleration of vesting of any outstanding options or RSU awards under the 2007 Equity Plan and the Directors’ Plan, as applicable, immediately prior to a change in control of Seattle Genetics.

DIRECTOR STOCK OWNERSHIP GUIDELINES

In order to developalign the interests of the directors with Seattle Genetics’ shareholders, our Corporate Governance Guidelines state that allnon-employee directors should, not later than December 31st of the year during which the applicable director achieves his or her fifth anniversary as anon-employee director, own, directly or indirectly, a number of shares of Seattle Genetics common stock with a value not less than three times the annual cash retainer paid by Seattle Genetics to such director for service on the Board, and commercializethereafter such director should continue to own a number of shares with such value until he or she is no longer a director. The Compensation Committee used December 31, 2019 as the date to assess compliance with these director ownership guidelines. All of our product candidates.non-employee directors serving as of such date were in compliance with these guidelines or had not yet reached the applicable deadline for compliance.

PROCESSES AND PROCEDURES FOR DETERMINING DIRECTOR COMPENSATION

In January 2019, Compensia, Inc., or Compensia, our Compensation Committee’s compensation consultant at that time, conducted an analysis to compare our director compensation to the director compensation of the peer group of companies approved by our Compensation Committee, with input from senior management and Compensia, in August 2018. For additional information on this peer group, please see “Compensation of Executive Officers—Compensation Discussion and Analysis—Compensation-Setting Process—Competitive Positioning”.

Compensia concluded that cash compensation paid to ournon-employee directors was generally below the 50th percentile of our peer group medians. As a result of this analysis, in February 2019, our Compensation Committee recommended that the cash compensation for ournon-employee directors be increased to approximate the 50th percentile of cash compensation received by members of the boards of directors of our peer companies, and in March 2019, the Board approved this recommended change, resulting in the revised cash compensation effective in March 2019 described above.

With regard to equity compensation for ournon-employee board of directors, Compensia concluded that the practice of delivering initial and annual board grants by denominating the number of shares to be delivered can lead to variance in the value of these grants year to year based on our share price at the time of grant, and can result in grants to Board members that vary from the intended 50th percentile of equity compensation paid by peer group companies. Following this review, our Compensation Committee recommended to the Board that equity grants tonon-employee directors be determined based on a target value and that such target values approximate the 50th percentile of equity compensation paid to directors of our peer companies. In March 2019, the Board adopted these recommendations, resulting in the revised equity grant policies described above.

In December 2019, Radford, our Compensation Committee’s new compensation consultant, conducted an analysis to compare our director compensation to the director compensation of the peer group of companies approved by our Compensation Committee, with input from senior management and Radford in July 2019. For additional information on this peer group, please see “Compensation of Executive Officers—Compensation Discussion and Analysis—Compensation-Setting Process—Competitive Positioning”. Radford concluded that the annual cash retainer paid to our non-employee directors and the annual cash retainer for service as Chair of the Compensation Committee were below the 50th percentile of our peer group medians. As a result of this analysis, in December 2019, our Compensation Committee recommended that these annual cash retainers be increased to approximate the 50th

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DIRECTOR COMPENSATION

percentile of cash compensation received by members of the boards of directors of our peer companies, and in January 2020, the Board approved this recommended change, resulting in the revised cash compensation effective in January 2020 described above.

In addition, as further described in Proposal No. 3, the 2007 Equity Plan as amended by the Board in March 2020, or the Restated 2007 Equity Plan, includes a limit on the amount ofnon-employee director compensation under the Restated 2007 Equity Plan. Under the Restated 2007 Equity Plan, the aggregate value of all compensation granted or paid to any individual solely for service as anon-employee director of the Board of Directors with respect to any calendar year may not exceed $1,000,000 in total value, calculating the value of any stock awards based on the grant date fair value of such awards for financial reporting purposes), or, with respect to the calendar year in which anon-employee director is first appointed or elected to the Board, $1,500,000. This limit is not intended to serve as an increase in the annual amount ofnon-employee director compensation; rather, it is proposed for the purpose of limiting the amount of compensation the Board can approve fornon-employee directors each year.

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DIRECTOR COMPENSATION TABLE

The following table sets forth all of the compensation awarded to or earned by each person who served as anon-employee director during 2019. Dr. Siegall, our only employee director, receives no compensation for Board service but is reimbursed for reasonable and customary travel expenses. Dr. Siegall’s compensation is described under “Compensation of Executive Officers” below.

Name

  

Fees Earned or

Paid in Cash in 2019(1)

$

   

Stock Awards(2)

$

   

Option Awards(3)

$

   

Total 

$ 

 

Srinivas Akkaraju, M.D., Ph.D.(4)(12)

   54,325    190,758    176,223    421,306  

Felix J. Baker, Ph.D.(5)(12)

   115,760    190,758    176,223    482,741  

David W. Gryska(6)(12)

   78,650    190,758    176,223    445,631  

Marc E. Lippman, M.D.(7)(12)

   60,623    190,758    176,223    427,604  

John A. Orwin(8)(12)

   75,785    190,758    176,223    442,766  

Alpna H. Seth, Ph.D.(9)(12)

   66,055    190,758    176,223    433,036  

Nancy A. Simonian, M.D.(10)(12)

   68,650    190,758    176,223    435,631  

Daniel G. Welch(11)(12)

   64,055    190,758    176,223    431,036  

(1)

Fees paid in cash for Board and Committee services reflect a portion paid at the current fee retainers, reflecting the changes made during March 2019 as discussed above, and a portion paid at the fee retainers paid prior to the change.

(2)

The amounts in this column represent the aggregate full grant date fair value of RSU awards granted during 2019 in accordance with FASB ASC Topic 718 with no estimate for future forfeitures, which value is based on the closing price of our common stock on the date of grant of May 20, 2019.

(3)

The amounts in this column represent the aggregate full grant date fair value of options granted during 2019 calculated in accordance with FASB ASC Topic 718 with no estimate for future forfeitures. For information regarding the assumptions used in calculating these amounts, see Note 16 of the Notes to the Consolidated Financial Statements included in our Annual Report on Form10-K for the year ended December 31, 2019. The option awards amounts represent the grant date fair value of options granted on May 20, 2019.

(4)

The fees earned by Dr. Akkaraju consisted of a $54,325 retainer for Board service.

(5)

Dr. Baker served as our lead independent director, chairman of our Compensation Committee and a member of our Governance Committee in 2019. The fees earned included a $54,325 retainer for Board service, a $35,812 retainer for service as the lead independent director, a $19,325 retainer for service as the chairman of our Compensation Committee, and a $6,298 retainer for service as a member of our Governance Committee.

(6)

Mr. Gryska served as chairman of our Audit Committee in 2019. The fees earned included a $54,325 retainer for Board service and a $24,325 retainer for service as chairman of our Audit Committee during 2019.

(7)

Dr. Lippman served as a member of our Governance Committee in 2019. The fees earned included a $54,325 retainer for Board service and a $6,298 retainer for service as a member of our Governance Committee.

(8)

Mr. Orwin served as a member of our Audit Committee and our Compensation Committee in 2019. The fees earned included a $54,325 retainer for Board service, a $11,730 retainer for service as a member of the Audit Committee, and a $9,730 retainer for service as a member of the Compensation Committee.

(9)

Dr. Seth served as a member of our Audit Committee in 2019. The fees earned included a $54,325 retainer for Board service and $11,730 retainer for service as a member of the Audit Committee.

(10)

Dr. Simonian served as chair of our Governance Committee in 2019. The fees earned included a $54,325 retainer for Board service and a $14,325 retainer for service as chair of our Governance Committee.

(11)

Mr. Welch served as a member of our Compensation Committee in 2019. The fees earned included a $54,325 retainer for Board service and a $9,730 retainer for service as a member of our Compensation Committee.

(12)

As of December 31, 2019, ournon-employee directors listed in the table above held outstanding stock awards and options, as follows:

Name

  

Number of Shares

Underlying

Outstanding Restricted

Stock Units

   

Number of Shares   

Subject to   

Outstanding Options   

 

Srinivas Akkaraju, M.D., Ph.D.

   2,963    79,078   

Felix J. Baker, Ph.D.

   2,963    114,078   

David W. Gryska

   2,963    94,078   

Marc E. Lippman, M.D.

   2,963    79,078   

John A. Orwin

   2,963    56,578   

Alpna H. Seth, Ph.D.

   8,713    21,288   

Nancy A. Simonian, M.D.

   2,963    86,578   

Daniel G. Welch

   2,963    111,078   

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EXECUTIVE OFFICERS

EXECUTIVE OFFICERS

The executive officers of Seattle Genetics who are not also directors of Seattle Genetics, their ages as of April 5, 2019,2, 2020, and certain other information about them are set forth below:

Non-Director Executive Officers

  Age
  Company Positions/Offices

Todd E. Simpson

  58
59
  Chief Financial Officer

Roger D. Dansey, M.D.

  62
63
  Chief Medical Officer

Vaughn B. Himes, Ph.D.

  58
59
  Chief Technical Officer

Jean I. Liu

  50
51
  Executive Vice President, Legal Affairs, and General Counsel

EXECUTIVE OFFICER PROFILES

Todd E. Simpson Mr. Simpson has served as our Chief Financial Officer since October 2005. Previously, Mr. Simpson served from October 2001 to October 2005 as Vice President, Finance & Administration and Chief Financial Officer of Targeted Genetics Corporation, a biotechnology company. From January 1996 to October 2001, Mr. Simpson served as Vice President, Finance & Administration and CFO of Aastrom Biosciences, Inc., a biotechnology company. From August 1995 to December 1995, he served as Treasurer of Integra LifeSciences Corporation, a biotechnology company, which acquired Telios Pharmaceuticals, Inc., in August 1995. From 1992 until its acquisition by Integra, he served as Vice President of Finance and CFO of Telios and in various other finance-related positions. Mr. Simpson is a certified public accountant (inactive), and from 1983 to


1992 he practiced public accounting with the firm of Ernst & Young LLP. Mr. Simpson currently serves on the board of directors of Aquinox Pharmaceuticals,Neoleukin Therapeutics, Inc., a publicly-traded pharmaceuticalbiotechnology company. Mr. Simpson received a B.S. in Accounting and Computer Science from Oregon State University.

Roger D. Dansey, M.DDr. Dansey has served as our Chief Medical Officer since May 2018. Prior to that, Dr. Dansey served as Senior Vice President, Clinical Oncology Research at Merck & Co. from January 2015 through April 2018. While at Merck, Dr. Dansey was Therapeutic Area Head for Late Stage Oncology and was responsible for the ongoing registration efforts for KEYTRUDA®KEYTRUDA® (pembrolizumab) across multiple tumor types. Prior to Merck, from August 2013 to December 2014, Dr. Dansey served as the Vice President, Oncology Clinical Research at Gilead Sciences, Inc. Dr. Dansey previously worked at Amgen in roles of increasing responsibility in Amgen'sAmgen’s oncology and hematology therapeutic areas, including as the Global Development Leader for XGEVA®. Dr. Dansey received his Medical Degrees from the University of Witwatersrand, Johannesburg, South Africa.

Vaughn B. Himes, Ph.D. Dr. Himes has served as our Chief Technical Officer since August 2016. Dr. Himes joined Seattle Genetics as Executive Vice President, Technical Operations in April 2009 and served as our Executive Vice President, Technical Operations and Process Science from July 2012 until August 2016. Previously, Dr. Himes was with ZymoGenetics, Inc. from November 2005 to March 2009, most recently as Senior Vice President, Technical Operations where his responsibilities included commercial and clinical manufacturing, supply chain and logistics, quality control and process development. From March 2003 to October 2005, he was Vice President, Manufacturing at Corixa, Inc. Prior to that, he held Vice President positions in manufacturing and development at Targeted Genetics and Genovo,Inc. Dr. Himes received a B.A. in Chemistry from Pomona College in California and a Ph.D. in Chemical Engineering from the University of Minnesota.

Jean I. Liu, J.D. Ms. Liu has served as our General Counsel, Executive Vice President, Legal Affairs and Corporate Secretary since November 2014. Prior to that, she served as Vice President and General Counsel of Halozyme Therapeutics, Inc., a publicly-traded biotechnology company, from November 2011 to November 2014. From 1998 to 2011, she was with Durect Corporation, a publicly-traded biotechnology company, where she served in positions of increasing responsibility, including most recently Chief Legal Officer and Corporate Secretary. Prior to Durect, Ms. Liu was with the law firms of Pillsbury, Madison & Sutro (now Pillsbury Winthrop) and Venture Law Group where she focused on broad areas of legal advisory for early stage companies, including technology transfer, licensing, patents, and copyright and trademark litigation. Ms. Liu received her B.S. in Cellular and Molecular Biology with highest distinction from the University of Michigan, her M.S. in Biology from Stanford University and her J.D. from Columbia University where she was a Harlan Fiske Stone Scholar.


INDEPENDENCE OF THE BOARD OF DIRECTORS
As required under the listing standards of The Nasdaq Stock Market, or Nasdaq, a majority of the members of a listed company’s board of directors must qualify as “independent” as defined in Rule 5605(a)(2) of the Nasdaq listing standards, as affirmatively determined by the board of directors. Our Board of Directors consults with our internal and outside counsel to ensure that the Board of Directors’ determinations are consistent with all relevant laws and regulations regarding the definition of “independent,” including those set forth in pertinent Nasdaq listing standards.
Management has reviewed the directors’ responses to a questionnaire asking about their transactions, relationships and arrangements with Seattle Genetics (and those of their immediate family members) and other potential conflicts of interest. Other than as described in this paragraph, these questionnaires did not disclose any transactions, relationships or arrangements that could impact the independence of our directors. After reviewing this information, our Board of Directors has determined that all of our directors are independent directors within the meaning of the applicable Nasdaq listing standards except for Clay B. Siegall, our President and Chief Executive Officer. The Board of Directors also considered Dr. Baker’s role as a Co-Managing Member of Baker Brothers Investments, and the relationship Seattle Genetics has with Baker Brothers Investments and affiliated entities as significant stockholders in making the determination that Dr. Baker is independent. The Board of Directors also considered Dr. Simonian’s past employment with Takeda and the relationship Seattle Genetics has with Takeda for development of ADCETRIS® (brentuximab vedotin) in making the determination that Dr. Simonian is independent.
BOARD LEADERSHIP STRUCTURE AND RISK OVERSIGHT
Board Leadership Structure
Our Board of Directors has chosen to combine the principal executive officer and Board chairman positions and, in addition, has appointed a separate lead independent director. Dr. Siegall has served as our principal executive officer and Board chairman since 2004. At the present time, the independent directors believe that Dr. Siegall’s in-depth knowledge of our operations and vision for our development make him the best-qualified director to serve as Board chairman. We believe that combining the positions of chief executive officer and Board chairman provides a single, clear chain of command to execute our strategic initiatives and business plans. In addition, we believe that a combined chief executive officer/Board chairman is better positioned to act as a bridge between management and the Board, facilitating the regular flow of information. We also

believe that it is advantageous to have a Board chairman with an extensive history with and knowledge of Seattle Genetics (as is the case with our chief executive officer) as compared to an independent Board chairman with less direct involvement.
The position of lead independent director has been structured to serve as an effective balance to a combined chief executive officer/Board chairman. In addition, we believe that having a lead independent director, who is independent of management, creates an environment that is more conducive to objective evaluation and oversight of management’s performance, increasing management accountability and improving the ability of the Board of Directors to monitor whether management’s actions are in the best interests of Seattle Genetics and its stockholders. Since February 2005, Felix Baker has served as the lead independent director of the Board. His duties include, among others:
providing leadership to the Board complementary to the Board chairman;
working with the Board chairman and Corporate Secretary to set the agenda for Board meetings;
chairing regular meetings of independent directors without management present; and
chairing Board meetings if the Board chairman is not in attendance.
Board Risk Oversight
Our Board of Directors has overall responsibility for risk oversight with a focus on the most significant risks facing Seattle Genetics. Throughout the year, the Board and the committees to which it has delegated responsibility dedicate a portion of their meetings to reviewing and discussing specific risk topics in greater detail. Strategic and operational risks are presented and discussed in the context of the Chief Executive Officer’s report on operations to the Board at regularly scheduled Board meetings and at presentations to the Board and its committees by the respective committee chairmen, our Chief Financial Officer, our General Counsel and Executive Vice President, Legal Affairs, and other officers.
The Board has delegated responsibility for the oversight of specific risks to Board committees as follows:
The Audit Committee oversees Seattle Genetics’ risk policies and processes relating to our financial statements and financial reporting processes, as well as healthcare compliance risks, key credit risks, liquidity risks, market risks and the guidelines, policies and processes for monitoring and mitigating those risks. In fulfilling this role, the Audit Committee conducts a quarterly risk-assessment process and reports its finding to the full Board of Directors. The Audit Committee also reviews and oversees related party transactions on behalf of Seattle Genetics.
The Compensation Committee evaluates the risks and rewards associated with our compensation philosophy and programs. As discussed in more detail below in this proxy statement under the heading “Compensation of Executive Officers—Compensation Discussion and Analysis—Compensation and Risk,” the Compensation Committee reviews and approves compensation programs with features that mitigate risk without diminishing the incentive nature of the compensation. Management discusses with the Compensation Committee the procedures that have been put in place to identify and mitigate potential risks in compensation.
The Nominating and Corporate Governance Committee oversees risks related to Seattle Genetics’ governance structure and processes. In addition, our General Counsel and Executive Vice President, Legal Affairs works with our committees and Board to develop risk identification, risk management and risk mitigation strategies and reports periodically to the Board and the committees on Seattle Genetics’ risk profile and various management and mitigation strategies.

MEETINGS AND COMMITTEES OF THE BOARD OF DIRECTORS
During 2018, the Board met five times and acted by written consent four times. On at least a quarterly basis, the Board meets in executive sessions of independent directors without management present. The Board has several committees, including an Audit Committee, a Compensation Committee and a Nominating and Corporate Governance Committee. During 2018, each of our directors attended at least 75% of the aggregate of Board and applicable committee meetings on which he or she served during 2018 for the period that he or she was a director or committee member.
Information about the Compensation Committee
Felix Baker (chairman), John Orwin and Daniel Welch serve as the members of our Compensation Committee. The Board of Directors has determined that all of the members of the Compensation Committee currently serving are “independent” as that term is defined in Rule 5605(a)(2) of the Nasdaq listing standards. In making this determination, our Board of Directors concluded that, based on its consideration of factors specifically relevant to determining whether any such director has a relationship to Seattle Genetics that is material to that director’s ability to be independent from management in connection with the duties of a compensation committee member, no member of the Compensation Committee has a relationship that would impair that member’s ability to make independent judgments about our executive compensation. In particular, our Board of

Directors considered, among other things, the source of each member’s compensation, including compensation paid to such member by us, and also considered Dr. Baker’s role as a Co-Managing Member of Baker Brothers Investments, and the relationship Seattle Genetics has with Baker Brothers Investments and affiliated entities as significant stockholders and determined that such compensation and affiliation, as applicable, would not impair the applicable member’s ability to make independent judgments about our executive compensation. In the case of Dr. Baker, our Board of Directors determined that, given his affiliation with our largest stockholder, his interests are aligned with other stockholders in seeking an appropriate executive compensation program for Seattle Genetics.
The Compensation Committee held four meetings and acted by written consent five times during 2018. The functions of the Compensation Committee are to establish and administer our policies regarding annual executive salaries, cash incentives and long-term equity incentives. The Compensation Committee also administers our 1998 Stock Option Plan, Amended and Restated 2007 Equity Incentive Plan, or the 2007 Equity Plan, and our ESPP, as well as our Senior Executive Annual Bonus Plan and special long-term incentive plans. The Compensation Committee also reviews with management our Compensation Discussion and Analysis and considers whether to recommend that it be included in proxy statements and other filings, and reviews the compensation paid to our directors. The Compensation Committee operates under a written charter setting forth the functions and responsibilities of the committee. A copy of the Compensation Committee charter can be viewed on our website at www.seattlegenetics.com. Under its charter, the Compensation Committee has the authority, in its sole discretion, to retain (or obtain the advice of) any compensation consultant, legal counsel or other adviser to assist it in the performance of its duties. In addition, under its charter, the Compensation Committee may form, and delegate authority to, subcommittees as appropriate. The Compensation Committee also has the direct responsibility for the appointment, compensation and oversight of the work of any advisers retained or engaged by the Compensation Committee. Finally, the Compensation Committee has the sole authority to approve the reasonable fees and the other terms and conditions of the engagement of any such advisor, including authority to terminate the engagement. We must provide for appropriate funding, as determined by the Compensation Committee, for the payment of reasonable compensation to any such adviser retained by the Compensation Committee.
For information regarding our processes and procedures for the consideration and determination of executive and director compensation, please see “Compensation of Executive Officers—Compensation Discussion and Analysis” and “—Director Compensation,” respectively.
Information about the Audit Committee
David Gryska (chairman), John Orwin and Alpna Seth serve as the members of our Audit Committee. Mr. Welch served on the Audit Committee until May 30, 2018. The Board of Directors has determined that all of the members of the Audit Committee are “independent” within the meaning of Rules 5605(c)(2)(A)(i) and (ii) of the Nasdaq listing standards. The Board of Directors has determined that Mr. Gryska is an “audit committee financial expert” as defined in Item 407(d)(5)(ii) of Regulation S-K.
The Audit Committee held six meetings during 2018 and acted by written consent three times during 2018. Among its responsibilities, the Audit Committee appoints and establishes the fees for our independent registered public accounting firm, reviews and approves the procedures we use to prepare our periodic reports, reviews our critical accounting policies, reviews the independence of the independent registered public accounting firm, monitors the effectiveness of the audit effort and oversees our financial and accounting organization and our system of internal accounting controls. The Audit Committee operates under a written charter setting forth the functions and responsibilities of the committee, which is reviewed annually and amended as necessary by the Audit Committee and the Board of Directors to ensure compliance with all applicable laws and regulations, including the Sarbanes-Oxley Act of 2002 and corporate governance standards adopted by Nasdaq. A copy of the Audit Committee charter can be viewed on our website at www.seattlegenetics.com.
Information about the Nominating and Corporate Governance Committee
Nancy Simonian (chair), Felix Baker and Marc Lippman serve as the members of our Nominating and Corporate Governance Committee. The Board of Directors has determined that all of the members of the Nominating Committee are “independent” as that term is defined in Rule 5605(a)(2) of the Nasdaq listing standards.
The Nominating and Corporate Governance Committee met once during 2018 and acted by written consent twice during 2018. The Nominating and Corporate Governance Committee is responsible for identifying individuals qualified to serve as members of the Board of Directors, recommending nominees to the Board for election as directors of Seattle Genetics and as members of the committees of the Board of Directors, as well as developing and making recommendations to the Board’s Corporate Governance Guidelines and providing oversight with respect to corporate governance and ethical conduct. The Nominating and Corporate Governance Committee operates under a written charter setting forth the functions and responsibilities of the committee. A copy of the Nominating and Corporate Governance Committee charter can be viewed on our website at www.seattlegenetics.com.

The Nominating and Corporate Governance Committee assesses many characteristics and diversity considerations when reviewing director candidates and these characteristics are set forth in our Corporate Governance Guidelines. Among the characteristics to be considered are such person’s professional background, business experience, judgment and integrity, familiarity with the biotechnology industry, applicable expertise and the interplay of the candidate’s experience and skills with those of other Board members. In determining whether to recommend a director for re-election, the Nominating and Corporate Governance Committee also considers the director’s past attendance at meetings and participation in and contributions to the activities of the Board and its committees, as well as the nature and time involved in a director’s service on other boards. The Nominating and Corporate Governance Committee seeks nominees with a broad diversity of experience, professions, skills, geographic representation and backgrounds; however, the Nominating and Corporate Governance Committee does not assign specific weights to particular criteria and no particular criterion is necessarily applicable to all prospective nominees. We believe that the backgrounds and qualifications of our directors, considered as a group, should provide a significant composite mix of experience, knowledge and abilities that will allow the Board to fulfill its responsibilities. Nominees are not discriminated against on the basis of age, race, religion, national origin, sexual orientation, disability or any other basis proscribed by law.
The Nominating and Corporate Governance Committee identifies nominees by first evaluating the current members of the Board willing to continue in service. Current members of the Board with skills and experience that are relevant to our business and who are willing to continue in service are considered for re-nomination. If there is a vacancy on the Board as a result of a resignation or otherwise, or if the Board decides not to nominate a member for re-election or decides to add a member to the Board, the Nominating and Corporate Governance Committee identifies the desired skills and experience of a new nominee in light of the criteria above and the Board’s needs. Current members of the Board are asked to submit suggestions as to individuals meeting the criteria described above. To date, we have not engaged third parties to identify or evaluate or assist in identifying potential nominees, although we may in the future decide to retain a third-party search firm.
In accordance with our bylaws and applicable law, nominations for directors may be made by any stockholder of record entitled to vote for the election of directors at stockholder meetings held for such purpose. The requirements a stockholder must follow for nominating persons for election as directors are set forth in our bylaws and under the heading “Proposals for 2020 Annual Meeting.” The Nominating and Corporate Governance Committee will also consider director candidates recommended by stockholders. In order to recommend director candidates to the Nominating and Corporate Governance Committee, stockholders should follow the procedures in our bylaws for director nominations. If a stockholder complies with these procedures for recommending persons for election as directors, the Nominating and Corporate Governance Committee will conduct the appropriate and necessary inquiries into the backgrounds, qualifications and skills of the recommended candidates and, in the exercise of the Nominating and Corporate Governance Committee’s independent judgment in accordance with the policies and procedures adopted in the Nominating and Corporate Governance Committee’s charter, will determine whether to recommend the candidate(s) recommended by the stockholders to the Board for inclusion in the list of candidates for election as directors at the next stockholder meeting held to elect directors. The Nominating and Corporate Governance Committee does not intend to alter the manner in which it evaluates director candidates based on whether or not the candidate was recommended by a stockholder.
Annual Meeting Attendance
Although we do not have a formal policy regarding attendance by members of the Board of Directors at our Annual Meetings of Stockholders, directors are encouraged to attend. However, due to scheduling conflicts we held a meeting of the Board of Directors two weeks prior to our 2018 annual meeting of stockholders and, with the exception of Dr. Siegall, none of our directors then serving attended the 2018 annual meeting of stockholders.

CERTAIN OTHER CORPORATE GOVERNANCE MATTERS
Communications with the Board of Directors
Our Board of Directors currently does not have a formal process for stockholders to send communications to the Board of Directors. Nevertheless, efforts are made to ensure that the views of stockholders are heard by the Board or individual directors, as applicable, and that appropriate responses are provided to stockholders on a timely basis. The Board does not recommend that formal communication procedures be adopted at this time because it believes that informal communications are sufficient to communicate questions, comments and observations that could be useful to the Board. Stockholders wishing to formally communicate with the Board of Directors may send communications directly to Seattle Genetics, Inc., Attention: Investor Relations, 21823 – 30th Drive SE, Bothell, Washington 98021, and the communication will be forwarded, as appropriate. If the communication regards a stockholder proposal to be considered at an annual meeting of stockholders, the methods and timing for submitting a stockholder proposal are covered under the heading “Proposals for 2020 Annual Meeting.”

Corporate Governance Guidelines
As a part of the Board’s commitment to building long-term stockholder value with an emphasis on corporate governance, the Board has adopted a set of Corporate Governance Guidelines, which guides the operation of the Board and its committees. Our Corporate Governance Guidelines cover, among other topics, Board composition, structure and functioning, Board membership criteria, director independence, Board self-evaluations, committees of the Board, Board access to management and independent advisers, stock ownership guidelines for members of the Board and our executive officers, and succession and leadership development. A copy of the Corporate Governance Guidelines can be viewed on our website at www.seattlegenetics.com.
Code of Ethics
The Board of Directors has adopted a Code of Conduct and Business Ethics, or the Code of Ethics, for all directors, officers and employees of Seattle Genetics, Inc. A copy of the Code of Ethics can be viewed on our website at www.seattlegenetics.com. We intend to satisfy the disclosure requirement under Item 5.05 of Form 8-K regarding an amendment to, or waiver from, a provision of the Code of Ethics by posting such information on our website at the website address specified above.
Whistleblower Policy
Seattle Genetics has adopted a Whistleblower Policy applicable to its employees that provides for protection from retaliation or discrimination by Seattle Genetics due to reporting issues relating to concerns involving questionable accounting or auditing matters and compliance with applicable laws and regulations.

DIRECTOR COMPENSATION
Cash Compensation. Our non-employee directors received an annual retainer of $50,000 in 2018 for their service on the Board, plus reimbursement for out-of-pocket expenses incurred in connection with attendance at Board and Board committee meetings, and our lead independent director received an additional retainer of $25,000 in 2018. Our non-employee directors also received the following additional annual retainers for service on committees of the Board in 2018:
Committee Chair Member
Audit Committee $20,000
 $10,000
Compensation Committee $15,000
 $8,000
Nominating and Corporate Governance Committee $10,000
 $5,000
If a non-employee director has not served on the Board or a Board committee for the full year, the Board and any applicable Board committee retainers may be prorated for the portion of the year served.
In March 2019, on the recommendation of the Compensation Committee based on a review of our peer group companies, the retainer for Board service was increased by $5,000 to $55,000, the retainer for service as the lead independent director was increased by $12,500 to $37,500 and committee service retainers were also revised. Retainers for service on committees of the Board effective in March 2019 are as follows:
Committee Chair Member
Audit Committee $25,000
 $12,000
Compensation Committee $20,000
 $10,000
Nominating and Corporate Governance Committee $15,000
 $6,500

Equity Compensation. Our Board has established a policy of providing each person who becomes a non-employee director of Seattle Genetics an initial nonstatutory stock option to purchase shares of our common stock and an initial restricted stock unit, or RSU, grant under our 2007 Equity Plan. These initial awards are granted on the date on which a recipient first becomes a non-employee director of Seattle Genetics. In 2018, non-employee directors were eligible for an initial nonstatutory stock option to purchase 14,250 shares of common stock and an initial RSU grant covering 5,750 shares of common stock. This initial option grant vests as to 25% of the underlying shares on the first anniversary of the grant date and ratably thereafter on a monthly basis until such grant is fully vested on the fourth anniversary of the grant date, and the initial RSU award vests in full on the third anniversary of the grant date, subject in both cases to continued service. In connection with her appointment to our Board effective March 15, 2018, Dr. Seth was granted a nonstatutory stock option to purchase 14,250 shares of common stock and a RSU grant covering 5,750 shares of common stock.

In 2019, on the recommendation of the Compensation Committee based on a review of our peer group companies, our Board revised its policy regarding the initial grants to non-employee directors joining our Board. Non-employee directors who join our Board in or after March 2019 will be eligible to receive equity grants equal in value to $600,000, consisting of an initial option to purchase shares of our common stock and an initial RSU grant each valued at $300,000. The number of shares underlying each option grant will be based on an approximation of $300,000 of grant date fair value, using the Black Scholes methodology for stock options. The number of shares underlying each RSU grant will be calculated by dividing $300,000 by the average stock price during the 30 calendar days preceding the date on which the newly appointed director’s grant becomes effective. The initial option grant will vest as to 25% of the underlying shares on the first anniversary of the grant date and ratably thereafter on a monthly basis until such grant is fully vested on the fourth anniversary of the grant date, and the initial RSU grant will vest as to 25% per year over a four year period on the anniversary of the vesting commencement date, subject in both cases to continued service.
In addition, effective on the date of each annual meeting of stockholders, each non-employee director is granted an annual nonstatutory stock option to purchase shares of common stock and an annual RSU grant under the 2007 Equity Plan if, on such date, he or she had served on the Board for at least six months. In 2018, with the exception of Dr. Seth, each of our non-employee directors received an annual option to purchase 9,260 shares of common stock and an annual RSU grant covering 3,700 shares of common stock, effective on the date of our 2018 annual meeting. Dr. Seth was not eligible to receive an annual director grant because she had not yet been serving as a director for six months on the annual meeting date.
In 2019, on the recommendation of the Compensation Committee based on a review of our peer group companies, our Board revised its policy regarding annual equity grants to our non-employee directors to provide a value-based award instead of a share-based award. Effective on the date of the 2019 Annual Meeting and subject to continued service until that date, each of our nonemployee directors will be eligible to receive annual equity grants equal in value to $400,000, consisting of an option grant to purchase shares of our common stock and an RSU grant under our 2007 Equity Plan each valued at $200,000. The number of shares underlying each option grant will be based on an approximation of $200,000 of grant date fair value, using the Black Scholes methodology for stock options. The number of shares underlying each RSU grant will be calculated by dividing $200,000 by the average stock price during the 30 calendar days preceding the date of the Annual Meeting. The value of these annual equity grants was set at the median of our peer group, as further described below.
The annual option award and annual RSU awards made to each of our eligible directors in 2018 will vest on May 18, 2019. In addition, all non-employee directors would receive full acceleration of vesting of any outstanding options or RSU awards under the 2007 Equity Plan and the 2000 Directors’ Stock Option Plan, as applicable, immediately prior to a change in control of Seattle Genetics. The exercise price of options granted to our directors is equal to the fair market value of our common stock on the Nasdaq Global Select Market on the effective date of grant. Options granted to non-employee directors under the 2007 Equity Plan and the Directors’ Plan have ten year terms and remain exercisable for up to three months following the grantee’s termination of service, unless such termination is a result of death or disability, in which case the options remain exercisable for up to a twelve-month period (or such lesser period as is determined by the Board).
In order to align the interests of the directors with Seattle Genetics’ stockholders, our Corporate Governance Guidelines state that all non-employee directors should, not later than December 31st of the year during which the applicable director achieves his or her fifth anniversary as a non-employee director, own, directly or indirectly, a number of shares of Seattle Genetics common stock with a value not less than three times the annual cash retainer paid by Seattle Genetics to such director for service on the Board, and thereafter such director should continue to own a number of shares with such value until he or she is no longer a director. The Nominating and Corporate Governance Committee used December 31, 2018 as the date to assess compliance with these director ownership guidelines. All of our non-employee directors serving as of such date were in compliance with these guidelines or had not yet reached the applicable deadline for compliance.

Processes and Procedures for Determining Director Compensation. Effective as of February 9, 2018, the responsibility for reviewing director compensation and recommending changes to the Board is vested in the Compensation Committee per its charter.
In 2018, the Compensation Committee did not review or make any changes to director compensation in light of the historical practice of reviewing director compensation levels bi-annually but determined to review director compensation in early 2019.
In January 2019, Compensia, Inc., or Compensia, our Compensation Committee's compensation consultant, conducted a survey to compare our director compensation to the director compensation of our peer group companies. As of the date this analysis was performed, these peer companies had a median market capitalization of approximately $8 billion, as compared to our market capitalization of approximately $9.5 billion, median 12-month revenue of approximately $452 million, as compared to our 12-month revenue of approximately $482 million, and a median of 715 employees, as compared to our 1,100 employees. This peer group consisted of:

Agios Pharmaceuticals, Inc. 
Clovis Oncology, Inc.

28
 Neurocrine Biosciences, Inc.
Alexion Pharmaceuticals, Inc.

LOGO

  Exelixis, Inc. Sarepta Therapeutics, Inc.
Alkermes plc

Incyte Corporation

Tesaro, Inc.
Alnylam Pharmaceuticals, Inc.


Ionis Pharmaceuticals, Inc.United Therapeutics, Inc.
BioMarin Pharmaceutical, Inc.

Jazz Pharmaceuticals plc
Vertex Pharmaceuticals Incorporated

bluebird bio, Inc.Nektar Therapeutics



Compensia concluded that cash compensation paid to our non-employee directors was generally at or below the twenty-fifth percentile of our peer group medians. As a result of the survey, in February 2019, our Compensation Committee recommended that the cash compensation for our non-employee directors be increased to approximate the 50th percentile of cash compensation received by members of the boards of directors of our peer companies, and in March 2019, the Board approved this recommended change, resulting in the revised cash compensation effective in March 2019 described above.
With regard to equity compensation for our non-employee board of directors, Compensia concluded that the practice of delivering initial and annual board grants by denominating the number of shares to be delivered can lead to variance in the value of these grants year to year based on our share price at the time of grant, and can result in grants to Board members that vary from the intended 50th percentile of equity compensation paid by peer group companies. Following this review, our Compensation Committee recommended that equity grants to non-employee directors be determined based on a target value and that such target values approximate the 50th percentile of equity compensation paid to directors of our peer companies. In March 2019, the Board adopted these recommendations, resulting in the revised equity grant policies described above.
The Compensation Committee also decided to conduct an annual review of director compensation instead of a bi-annual review, which had been the historical practice.
Director Compensation Table. The following table sets forth all of the compensation awarded to or earned by each person who served as a non-employee director during 2018. Dr. Siegall, our only employee director, receives no compensation for Board service but is reimbursed for reasonable and customary travel expenses. Dr. Siegall’s compensation is described under “Compensation of Executive Officers” below.
Name 
Fees Earned or
Paid in Cash in 2018
 
Stock Awards (1)
 
Option Awards (2)
 Total
Srinivas Akkaraju, M.D., Ph.D. (3) (11)
 $50,000
 $210,049
 $204,627
 $464,676
Felix Baker, Ph.D. (4) (11)
 $95,000
 $210,049
 $204,627
 $509,676
David W. Gryska (5) (11)
 $70,000
 $210,049
 $204,627
 $484,676
Marc E. Lippman, M.D. (6) (11)
 $55,000
 $210,049
 $204,627
 $469,676
John A. Orwin (7) (11)
 $68,000
 $210,049
 $204,627
 $482,676
Alpna Seth, Ph.D. (8) (11)
 $45,810
 $331,660
 $351,177
 $728,647
Nancy A. Simonian, M.D. (9) (11)
 $60,000
 $210,049
 $204,627
 $474,676
Daniel G. Welch (10) (11)
 $62,148
 $210,049
 $204,627
 $476,824
_____________________
(1)

The amounts in this column represent the aggregate full grant date fair value of RSU awards granted during 2018 in accordance with FASB ASC Topic 718 with no estimate for future forfeitures, which value is based on the closing price of our common stock on the date of grant.

(2)The amounts in this column represent the aggregate full grant date fair value of options granted during 2018 calculated in accordance with FASB ASC Topic 718 with no estimate for future forfeitures. For information regarding the assumptions used in calculating these amounts, see Note 16 of the Notes to the Consolidated Financial Statements included in our Annual Report on Form 10-K for the year ended December 31, 2018.
(3)The fees earned by Dr. Akkaraju consist of a $50,000 retainer for Board service. The stock awards amount represents the grant date fair value of RSU awards granted on May 18, 2018. The option awards amount represents the grant date fair value of an option granted on May 18, 2018.
(4)Dr. Baker served as our lead independent director, chairman of our Compensation Committee and a member of our Nominating and Corporate Governance Committee in 2018. The fees earned include a $50,000 retainer for Board service, a $25,000 retainer for service as the lead independent director, a $15,000 retainer for service as the chairman of our Compensation Committee, and a $5,000 retainer for service as a member of our Nominating and Corporate Governance Committee. The stock awards amount represents the grant date fair value of RSU awards granted on May 18, 2018. The option awards amount represents the grant date fair value of an option granted on May 18, 2018.
(5)Mr. Gryska served as chairman of our Audit Committee in 2018. The fees earned include a $50,000 retainer for Board service and a $20,000 retainer for service as chairman of our Audit Committee during 2018. The stock awards amount represents the grant date fair value of RSU awards granted on May 18, 2018. The option awards amount represents the grant date fair value of an option granted on May 18, 2018.
(6)Dr. Lippman served as a member of our Nominating and Corporate Governance Committee in 2018. The fees earned by Dr. Lippman consist of a $50,000 retainer for Board service and a $5,000 retainer for service as a member of our Nominating and Corporate Governance Committee. The stock awards amount represents the grant date fair value of RSU awards granted on May 18, 2018. The option awards amount represents the grant date fair value of an option granted on May 18, 2018.
(7)Mr. Orwin served as a member of our Audit Committee and our Compensation Committee in 2018. The fees earned include a $50,000 retainer for Board service and $18,000 in retainers for service as a member of the Audit Committee and Compensation Committee. The stock awards amount represents the grant date fair value of RSU awards granted on May 18, 2018. The option awards amount represents the grant date fair value of an option granted on May 18, 2018.
(8)Dr. Seth served as a member of our Audit Committee for a portion of 2018. The fees earned include a $39,958 retainer for Board service and $5,852 retainer for service as a member of the Audit Committee, both of which have been prorated. The stock awards amount represents the grant date fair value of RSU awards granted on March 15, 2018. The option awards amount represents the grant date fair value of an option granted on March 15, 2018.
(9)Dr. Simonian served as chair of our Nominating and Corporate Governance Committee in 2018. The fees earned include a $50,000 retainer for Board service and a $10,000 retainer for service as a member and chair of our Nominating and Corporate Governance Committee. The stock awards amount represents the grant date fair value of RSU awards granted on May 18, 2018. The option awards amount represents the grant date fair value of an option granted on May 18, 2018.
(10)Mr. Welch served as a member of our Compensation Committee in 2018, and as a member of our Audit Committee for a portion of 2018. The fees earned include a $50,000 retainer for Board service and $12,148 in retainers for service as a member of our Audit Committee and Compensation Committee. Mr. Welch's fee for the Audit Committee was prorated.The stock awards amount represents the grant date fair value of RSU awards granted on May 18, 2018. The option awards amount represents the grant date fair value of an option granted on May 18, 2018.
(11)As of December 31, 2018, our non-employee directors listed in the table above held outstanding stock awards and options, as follows:
Name 
Number of Shares
Underlying
Outstanding Restricted
Stock Units
 
Number of Shares
Subject to
Outstanding Options
Srinivas Akkaraju, M.D., Ph.D. 3,700
 89,540
Felix Baker, Ph.D. 3,700
 117,040
David W. Gryska 3,700
 107,040
Marc E. Lippman, M.D. 3,700
 109,540
John A. Orwin 3,700
 49,540
Alpna Seth, Ph.D. 5,750
 14,250
Nancy A. Simonian, M.D. 3,700
 79,540
Daniel G. Welch 3,700
 104,040

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
The following table sets forth information as of March 1, 2019 (except as noted) regarding the beneficial ownership of our common stock by each director (including each nominee for director), by each person or group of affiliated persons known to us to beneficially own five percent or more of our outstanding common stock, by each named executive officer and by all executive officers and directors as a group. Unless otherwise indicated, the address of the individuals and entities below is c/o Seattle Genetics, Inc., 21823 – 30th Drive SE, Bothell, WA 98021.
Name and Address 
Total Common
Stock Equivalents (1)
 
Percent of Common
Stock Equivalents (2)
Felix J. Baker, Ph.D. (3)
Baker Bros. Advisors LP and Affiliates (3)
667 Madison Avenue, 21st Floor
New York, NY 10065
 51,399,776
 31.9%
Wellington Management Company (4)
280 Congress Street
Boston, MA 02210



 15,139,436
 9.4%
PRIMECAP Management Company (5)
177 E. Colorado Blvd., 11th Floor
Pasadena, CA 91105
 14,141,275
 8.8%
Capital International Investors (6)
11100 Santa Monica Blvd., 16th Floor
Los Angeles, CA 90025
 14,696,952
 9.1%
The Vanguard Group (7)
100 Vanguard Blvd
Malvern, PA 19355
 9,244,948
 5.7%
BlackRock, Inc. (8)
55 East 52nd Street
New York, NY 10055
 9,104,981
 5.7%
T. Rowe Price Associates, Inc (9)
100 E. Pratt Street
Baltimore, MD 21202
 8,074,740
 5.0%
Clay B. Siegall, Ph.D. (10)
 2,095,655
 1.3%
Todd E. Simpson (11)
 385,147
 *
Roger D. Dansey, M.D. 
 *
Vaughn B. Himes, Ph.D. (12)
 394,767
 *
Darren Cline (13)
 132,236
 *
Srinivas Akkaraju, M.D., Ph.D. (14)
 113,785
 *
David W. Gryska (15)
 134,130
 *
Marc E. Lippman, M.D. (16)
 222,430
 *
John A Orwin (17)
 58,380
 *
Alpna Seth, Ph.D. (18)
 3,859
 *
Nancy A. Simonian, M.D. (19)
 88,380
 *
Daniel G. Welch (20)
 160,880
 *
All directors and executive officers as a group (21)
 55,347,041
 33.8%
_______________________
* Less than one percent
(1)Beneficial ownership is determined in accordance with SEC rules. In computing the beneficial ownership we have included shares for which the named person has sole or shared power over voting or investment decisions. The number of shares of common stock beneficially owned includes common stock which the named person has the right to acquire, through option exercise or otherwise, within 60 days after March 1, 2019.
(2)Percentage of common stock equivalents is based on a total of 160,804,232 shares of common stock outstanding as of March 1, 2019. For each named person, the percentage ownership includes common stock that the person has the right to acquire within 60 days after March 1, 2019, as described in Footnote 1. However, such shares are not deemed outstanding with respect to the calculation of ownership percentage for any other person. In some cases, beneficial ownership calculations for five percent or greater stockholders are based solely on publicly-filed Schedules 13D or

13G, which five percent or greater stockholders are required to file with the SEC, and which generally set forth ownership interests as of December 31, 2018 unless otherwise provided.
(3)The indicated ownership is based on (i) a Schedule 13D/A filed with the SEC by the reporting persons on May 2, 2018 and (ii) a Form 4 filed with the SEC by the reporting persons on May 18, 2018. According to the Schedule 13D/A and the Form 4, the shares reported in the table as beneficially owned by the reporting persons includes 45,757,886 shares held by Baker Brothers Life Sciences, L.P. , or Life Sciences, 5,220,074 shares held by 667, L.P., or 667, 18,243 shares held by FBB2, LLC, or FBB2, 12,678 shares held by FBB3, LLC, or FBB3, 107,511 shares held by Felix J. Baker, 107,504 shares held by Julian C. Baker, 50,000 shares issued to Felix J. Baker as a result of the exercise of options and 18,100 shares issued to Felix J. Baker upon the vesting of restricted stock units. This number also includes 107,780 shares of common stock issuable upon exercise of options held by Felix J. Baker that are exercisable within 60 days of March 1, 2019 held by Felix J. Baker that vest within 60 days of March 1, 2019. According to the Schedule 13D/A and the Form 4, Baker Bros. Advisors LP, or the Adviser, serves as the Investment Adviser to Life Sciences and 667, or collectively the Baker Funds. Baker Bros. Advisors (GP) LLC, or the Adviser GP, is the Adviser’s sole general partner. Julian C. Baker and Felix J. Baker are principals of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Baker Funds, and may be deemed to have the power to vote or direct the vote of and the power to dispose or direct the disposition of such securities. In addition, according to the Schedule 13D/A, the Adviser has voting and investment power over the options, RSU awards and common stock held by Felix J. Baker, and the Adviser GP, as well as Felix J. Baker and Julian C. Baker as principals of the Adviser GP, may be deemed to have the power to vote or direct the vote of and the power to dispose or direct the disposition of, the options, RSU awards and common stock held by Felix J. Baker. In addition, according to the Schedule 13D/A, Julian C. Baker and Felix J. Baker are also the sole managers of FBB2 and FBB3 and as such may be deemed to be beneficial owners of shares of common stock held by FBB2 and FBB3 and may be deemed to have the power to vote or direct the vote and dispose or direct the disposition of those shares.
(4)The indicated ownership is based solely on a Schedule 13G filed with the SEC by the reporting person on February 12, 2019. Wellington Management Group LLP, Wellington Group Holdings LLP, Wellington Investment Advisors Holdings LLP and Wellington Management Company LLP, or collectively, Wellington, beneficially own 15,139,436 shares of our common stock that are owned of record by clients of one or more investment advisers directly or indirectly owned by Wellington Management Group LLP. The Schedule 13G filed by the reporting person provides information as of December 31, 2018 and, consequently, the beneficial ownership of the reporting person may have changed between December 31, 2018 and March 1, 2019.
(5)The indicated ownership is based solely on a Schedule 13G/A filed with the SEC by the reporting person on February 8, 2019. According to the Schedule 13G/A, PRIMECAP Management Company has sole voting power over 10,421,400 shares of common stock and sole dispositive power over 14,141,275 shares of common stock. The Schedule 13G/A filed by the reporting person provides information as of December 31, 2018 and, consequently, the beneficial ownership of the reporting person may have changed between December 31, 2018 and March 1, 2019.
(6)The indicated ownership is based solely on a Schedule 13G/A filed with the SEC by the reporting person on February 14, 2019. According to the Schedule 13G/A, Capital International Investors has sole voting power over 13,921,847 shares of common stock and sole dispositive power over 14,696,952 shares of common stock. The Schedule 13G/A filed by the reporting person provides information as of December 31, 2018 and, consequently, the beneficial ownership of the reporting person may have changed between December 31, 2018 and March 1, 2019.
(7)The indicated ownership is based solely on a Schedule 13G/A filed with the SEC by the reporting person on February 13, 2019. According to the Schedule 13G/A, The Vanguard Group has sole voting power over 82,635 shares of common stock and sole dispositive power over 9,136,552 shares of common stock. The Schedule 13G/A filed by the reporting person provides information as of December 31, 2018 and, consequently, the beneficial ownership of the reporting person may have changed between December 31, 2018 and March 1, 2019.
(8)The indicated ownership is based solely on a Schedule 13G filed with the SEC by the reporting person on February 8, 2019. According to the Schedule 13G, BlackRock Inc, has sole voting power over 8,422,296 shares of common stock and sole dispositive power over 9,104,981 shares of common stock. The Schedule 13G filed by the reporting person provides information as of December 31, 2018 and, consequently, the beneficial ownership of the reporting person may have changed between December 31, 2018 and March 1, 2019.
(9)The indicated ownership is based solely on a Schedule 13G/A filed with the SEC by the reporting person on February 14, 2019. According to the Schedule 13G/A, T. Rowe Price Associates, Inc. has sole voting power over 2,221,094 shares of common stock and sole dispositive power over 8,074,740 shares of common stock. The Schedule 13G/A filed by the reporting person provides information as of December 31, 2018 and, consequently, the beneficial ownership of the reporting person may have changed between December 31, 2018 and March 1, 2019.
(10)Includes 1,598,223 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2019.
(11)Includes 252,582 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2019.

(12) Includes 281,991 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2019.
(13) Includes 111,324 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2019.
(14) Includes 80,280 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2019.
(15) Includes 92,780 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2019.
(16) Includes 97,780 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2019.
(17) Includes 40,280 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2019.
(18) Includes 3,859 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2019.
(19)Includes 70,280 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2019.
(20) Includes 94,780 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2019.
(21) Includes 2,964,814 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2019.

SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE
Section 16(a) of the Exchange Act requires our directors, our executive officers and persons who own more than ten percent of our common stock to file initial reports of ownership and changes in ownership of our common stock. These reporting persons are required by SEC regulations to furnish us with copies of all Section 16 reports they file. To our knowledge, based primarily on our review of the copies of such reports received or written representations from certain of these reporting persons that no other reports were required, we believe that during the fiscal year ended December 31, 2018, all of these reporting persons complied with all applicable filing requirements.

PROPOSAL NO. 2

RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED
PUBLIC ACCOUNTING FIRM
Our Audit Committee has selected PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2019. PricewaterhouseCoopers LLP has served as our independent registered public accounting firm since June 1998. A representative of PricewaterhouseCoopers LLP is expected to be present at the Annual Meeting. This representative will have an opportunity to make a statement and will be available to respond to appropriate questions.
Stockholder ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm is not required by our bylaws or other governing documents. However, the Board is submitting the appointment of PricewaterhouseCoopers LLP to the stockholders for ratification as a matter of good corporate governance. While the Audit Committee is not bound by a vote either for or against the proposal, it will consider a vote against PricewaterhouseCoopers LLP by the stockholders in selecting our independent registered public accounting firm in the future. Even if the stockholders do ratify the appointment, the Audit Committee in its discretion may direct the appointment of a different independent registered public accounting firm at any time during the year if it believes that such a change would be in the best interests of Seattle Genetics and its stockholders.
Stockholder approval of this Proposal No. 2 will require the affirmative vote of a majority of the votes cast in person or by proxy at the Annual Meeting.

ON BEHALF OF THE AUDIT COMMITTEE, THE BOARD RECOMMENDS A VOTE FOR

THIS PROPOSAL NO. 2

Independent Registered Public Accounting Firm Fees
PricewaterhouseCoopers LLP served as our independent registered public accounting firm for 2017 and 2018 and their aggregate fees for services rendered were as follows:
Type of Fees 2018 2017
Audit Fees $1,543,000
 $1,418,000
Audit-Related Fees 
 70,000
Tax Fees 
 
All Other Fees 2,700
 2,700
Total Fees $1,545,700
 $1,490,700
Audit Fees. Audit fees represent fees for professional services provided in connection with the audit of our financial statements and review of our quarterly financial statements and audit services provided in connection with other statutory or regulatory filings. In 2018, these fees also included services to support the acquisition of Cascadian Therapeutics, Inc., and in 2017, these fees included service to support our Oracle Enterprise Resource Planning, or ERP, software implementation, the acquisition of a pharmaceutical manufacturing facility in Bothell, Washington and the Immunomedics transaction.
Audit-Related Fees. Audit-related fees consist of fees billed for assurance and related services that are reasonably related to the performance of the audit or review of our financial statements and are not reported under “Audit Fees.” There were no audit-related fees billed to Seattle Genetics for services rendered during 2018. In 2017, these fees related to support of our Oracle ERP implementation.
Tax Fees. Tax fees principally included tax compliance, tax advice and tax planning fees. There were no tax fees billed to Seattle Genetics for services rendered during 2018 or 2017.
All Other Fees. All other fees include any fees billed that are not audit, audit related, or tax fees. In 2018 and 2017, these fees related to accounting research software.
Pre-Approval Policies and Procedures
In October 2006, the Audit Committee adopted an Audit and Audit-Related Services Pre-Approval Policy, or the Policy, which sets forth the procedures and the conditions pursuant to which services proposed to be performed by the independent registered public accounting firm may be pre-approved. Proposed services either may be pre-approved by the Audit Committee without consideration of specific case-by-case services (i.e., general pre-approval) or require the specific pre-approval of the Audit Committee (i.e., specific pre-approval). The Audit Committee believes that the combination of these two approaches has resulted in an effective and efficient procedure to pre-approve services performed by the independent registered public accounting firm. As set forth in the Policy, unless a type of service has received general pre-approval, it will require specific pre-approval by the Audit Committee if it is to be provided by the independent registered public accounting firm. Any proposed services exceeding pre-approved cost levels or budgeted amounts will also require specific pre-approval by the Audit Committee. In addition, the Audit Committee has delegated to the Chair of the Audit Committee the authority to pre-approve services not prohibited by the Policy to be performed by our independent registered public accounting firm and associated fees up to $25,000, provided that the Chair is required to report any decision to pre-approve such audit-related or non-audit services and fees to the full Audit Committee for ratification at its next regular meeting. All audit-related and non-audit related services performed by our independent registered public accounting firm in 2018 were pre-approved.

AUDIT COMMITTEE REPORT (1)
The Audit Committee of the Board of Directors is currently comprised of three independent directors and operates under a written charter originally adopted by the Board of Directors in March 2001, which charter is reviewed on an annual basis and amended as necessary by the Board of Directors upon recommendation by the Audit Committee.
The members of the Audit Committee are currently David Gryska (chairman), John Orwin and Alpna Seth. Each of the members of the Audit Committee is an “independent director” as currently defined in Rules 5605(c)(2)(A)(i) and (ii) of the Nasdaq listing standards and Rule 10A-3 of the Exchange Act. The Board of Directors has also determined that David Gryska is an “audit committee financial expert” as described in applicable rules and regulations of the SEC.
The Audit Committee appoints an accounting firm as our independent registered public accounting firm. The independent registered public accounting firm is responsible for performing an independent audit of our financial statements in accordance with the standards of the Public Company Accounting Oversight Board, or the PCAOB, and issuing a report thereon. Management is responsible for our internal controls and the financial reporting process. The Audit Committee is responsible for monitoring and overseeing these processes.
The Audit Committee held six meetings and acted by written consent three times during 2018. The meetings were designed to provide information to the Audit Committee necessary for it to conduct its oversight function of the external financial reporting activities and audit process of Seattle Genetics, and to facilitate and encourage communication between the Audit Committee, management and our independent registered public accounting firm, PricewaterhouseCoopers LLP. Management represented to the Audit Committee that our financial statements were prepared in accordance with accounting principles generally accepted in the United States of America. The Audit Committee reviewed and discussed the audited financial statements for 2018 with management and the independent registered public accounting firm. The Audit Committee also instructed the independent registered public accounting firm that the Audit Committee expects to be advised if there are any subjects that require special attention.
The Audit Committee discussed with the independent registered public accounting firm the matters required to be discussed by Auditing Standard No. 16, Communications with Audit Committees, as adopted by the PCAOB.
The Audit Committee has also received the written disclosures and the letter from the independent registered public accounting firm, PricewaterhouseCoopers LLP, required by applicable requirements of the PCAOB regarding the independent registered public accounting firm’s communications with the Audit Committee concerning independence, and has discussed with PricewaterhouseCoopers LLP that firm’s independence.
Based on its review of the audited financial statements and the various discussions noted above, the Audit Committee recommended to the Board of Directors that the audited financial statements and the audited assessment of internal control over financial reporting be included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2018.
The Audit Committee of the Board of Directors of Seattle Genetics, Inc.:
David Gryska (chair)
John Orwin
Alpna Seth
______________
(1)The material in this report is not “soliciting material,” is not deemed “filed” with the SEC and is not to be incorporated by reference in any filing of Seattle Genetics under the Securities Act of 1933, as amended, or the Securities Act, or the Exchange Act, whether made before or after the date hereof and irrespective of any general incorporation language in any such filing.

PROPOSAL NO. 3
APPROVAL OF THE AMENDMENT AND RESTATEMENT OF
THE SEATTLE GENETICS, INC.
AMENDED AND RESTATED 2000 EMPLOYEE STOCK PURCHASE PLAN

The Board of Directors believes it is in the best interests of the Company to encourage stock ownership by employees of the Company. The Board has approved, subject to your approval, the amendment and restatement of the Seattle Genetics, Inc. 2000 Employee Stock Purchase Plan, or the ESPP, including increasing the number of shares of our Common Stock available for issuance under the ESPP by 1,000,000 shares from 1,896,190 shares to 2,896,190 shares, which represents less than 1% of our outstanding shares as of March 1, 2019.
In addition, the ESPP has been amended and restated to allow for the participation of employees of our foreign subsidiaries and affiliates under a “Non-423 Component” which does not qualify for the tax treatment of Section 423 of the Internal Revenue Code, or the Code. The ESPP also has been amended and restated to address changes in applicable law, to improve the Company’s ability to administer the ESPP, to implement other best practices and to eliminate provisions that are no longer relevant.
If approved by our stockholders, the ESPP will become immediately effective. If our stockholders do not approve the ESPP, the specific amendments that were approved by our Board that require stockholder approval will not become effective. Namely, the amendments relating to the authorization of additional shares and the extension of the ESPP to employees of foreign subsidiaries and affiliates will not become effective. All other amendments to the ESPP that were approved by our Board that do not require stockholder approval will continue in effect, and we may continue to issue shares purchased by employees under the ESPP until the existing available pool of 278,901 shares is exhausted.
The Board recommends that you vote for approval of the Amended ESPP.
We refer to the ESPP as amended as the Amended ESPP. The Board believes that it is in the best interests of the Company and our stockholders to approve the Amended ESPP because it provides a broad-based plan to U.S. employees, and in the future, global employees, to become long-term stockholders through the purchase of shares of Seattle Genetics’ Common Stock on favorable terms. The Board believes that the ability to offer this type of global program and to maintain an adequate reserve of shares under the Amended ESPP is an important factor in attracting, motivating and retaining qualified officers and employees essential to our success and in aligning their long-term interests with those of the stockholders.
The principal features of the Amended ESPP are summarized below. This summary is qualified in its entirety, however, by reference to the full text of the Amended ESPP, which is attached to this proxy statement as Appendix A.
Material Changes to the ESPP
The following summary highlights the proposed material changes to the Amended ESPP. For purposes of this Proxy Statement, “Administrator” means our Board of Directors or its Compensation Committee.
• Increase the number of shares authorized for issuance under the Amended ESPP to 2,896,190
• Prior to its amendment in March 2019, the ESPP provided for participation only by employees of the Company and its subsidiaries in compliance with the requirements of Section 423 of the Code. With the amendments, the Company may offer participation in the Amended ESPP to employees of our foreign subsidiaries and affiliates and may create rules, procedures or sub-plans which are designed to meet tax, securities law or other Company compliance objectives in particular locations outside the United States, which offerings may be made under the Non-423 Component of the Amended ESPP and therefore may not comply with the requirements of Section 423 of the Code.
• The definition of employees eligible to participate in the Amended ESPP has been revised to reflect the full scope of permissible exclusions under Section 423 of the Code, including with respect to employees resident outside the United States, while retaining flexibility for the Company to continue operating the Amended ESPP under its pre-existing eligibility requirements.
• Various updates have been made to the Amended ESPP to reflect amendments to the Treasury Regulations under Section 423 of the Code, including to provide for the offering of the Amended ESPP through separate offerings at separate subsidiary corporations, the terms of which need not be identical.

Summary of Material Provisions of the ESPP
Authorization of Additional Shares
As of March 1, 2019, 1,617,289 shares had been purchased under the ESPP and only 278,901 shares remained available for purchase. We estimate that the existing pool of 278,901 shares will be issued and purchased by employees for the purchase periods that occur through January 31, 2020. Accordingly, there is the possibility that, without this amendment, there would be insufficient authorized shares for all issuances before the 2020 Annual Meeting. We believe that with the approval of the additional authorized shares, there will be sufficient shares for purchases under the ESPP until 2021, or beyond, depending on the participation rates and the price of our Common Stock
Purpose of the Amended ESPP
The purpose of the Amended ESPP is to provide eligible employees with an opportunity to purchase our Common Stock.
The options to purchase Common Stock granted under the Amended ESPP are intended to be treated as either (i) options granted under an “employee stock purchase plan,” as that term is defined in Section 423 of the Code (i.e., the “423 Component” of the Amended ESPP), or (ii) options granted under an employee stock purchase plan that is not subject to the terms and conditions of Section 423 of the Code (i.e., the “Non-423 Component” of the Amended ESPP). The Administrator will retain the discretion to grant options under either the 423 Component or the Non-423 Component of the Amended ESPP.
Administration
Our Board administers the Amended ESPP unless it delegates administration to a committee. The Board has delegated the administration of the Amended ESPP to our Compensation Committee. Nevertheless, the Board has the final power to determine all questions of policy and expediency that may arise in the administration of the Amended ESPP. The Administrator has, among other authority, the authority to interpret the Amended ESPP, determine all questions as to eligibility to participate including whether employees will participate in an offering under the 423 Component of the Amended ESPP or under the Non-423 Component, determine all terms and conditions of options granted under the Amended ESPP, amend outstanding options to the extent permitted by the Amended ESPP and, for options granted under the 423 Component, to adopt such rules and regulations for administering the Amended ESPP as it may deem necessary to comply with the requirements of Section 423 of the Code. Further, the Administrator may adopt rules or procedures relating to the operation and administration of the Amended ESPP to accommodate the specific requirements of local laws of jurisdictions outside the United States, including (without limitation) with respect to eligibility to participate, handling of payroll deductions, making of contributions to the Amended ESPP (including in forms other than payroll deductions), establishment of bank or trust accounts to hold participating employee contributions, payment of interest, conversion of local currency, obligations to pay payroll tax, withholding procedures and handling of issuances of shares of Common Stock.
Eligibility
Generally, any individual in an employee-employer relationship with the Company or with a subsidiary or affiliate that has been designated by the Administrator as participating in the Amended ESPP is eligible to participate in the Amended ESPP offerings. However, the Administrator, in its discretion may determine on a uniform basis for an offering that employees shall not be eligible to participate if they: (i) have not completed at least two (2) years of service since their last hire date (or such lesser period of time as may be determined by the ESPP Administrator in its discretion), (ii) customarily work not more than twenty (20) hours per week, (iii) customarily work not more than five (5) months per calendar year, (iv) are highly compensated employees within the meaning of Section 414(q) of the Code, or (v) are highly compensated employees within the meaning of Section 414(q) of the Code with compensation above a certain level or are officers subject to the disclosure requirements of Section 16(a) of the Exchange Act. Directors of the Company who are not employees of the Company are not eligible to participate in the Amended ESPP. Further, no employee may participate in the Amended ESPP if immediately after we grant the employee a purchase right, such employee would have voting power over 5% or more of our outstanding capital stock.
As of March 1, 2019, approximately 1,300 employees were eligible to participate in the current ESPP.
Eligible employees who are citizens or resident of a jurisdiction outside the U.S. may be excluded from participation in the Amended ESPP if their participation is prohibited under local laws or if complying with local laws would cause an offering under the 423 Component to fail to qualify under Section 423 of the Code. In the case of an offering under the Non-423 Component, an eligible employee may be excluded from participation in the Amended ESPP or an offering if the Administrator has determined that participation of such eligible employees is not advisable or practicable for any reason.


Offerings and Payroll Deductions
 The Amended ESPP is implemented through a series of offerings of purchase rights to eligible employees. The Board has the authority to set the terms and frequency of offerings, which may be overlapping or consecutive, provided that no offering may have a duration exceeding 27 months. Unless otherwise determined by the Board, consecutive six-month offerings commence on each February 1 and August 1, with purchase dates on July 31 and January 31, respectively. The Amended ESPP provides that unless otherwise determined by the Board the current offering will be followed by an offering that will commence on August 1, 2019 and will end on January 31, 2020. An offering may be terminated by the Board under certain circumstances.
To participate in the Amended ESPP, an employee must complete the enrollment process which indicates the percentage amount to be deducted from his or her eligible compensation and applied to the purchase of the shares on the purchase date. In addition to regular payroll deductions, the Administrator may allow participating employees to make contributions to purchase shares under the Amended ESPP using alternative payment methods, including by check. The contribution amount may be up to 20% of eligible compensation or such other amount as approved by the Administrator. Contributions are credited to an account kept by the Company in the name of each participating employee, which does not bear interest.
An employee may withdraw from participation in an offering at any time up to ten days before a purchase date by completing the electronic withdrawal process (or by completing such other process as the Administrator may specify). Upon withdrawal from the Amended ESPP, all of the contributions credited to the participating employee’s account will be paid promptly to the participating employee and the participating employee’s option for the current period will be automatically terminated.
An employee’s participation ends automatically on termination of his or her employment.
Stock Purchases
On a purchase date, the accumulated contributions of each participating employee shall be used to purchase the maximum number of whole shares of Common Stock determined by dividing the purchase price into the balance of the participating employee’s account. The purchase price per share is equal to the lower of:
85% of the fair market value of a share on the first day of the offering; or
85% of the fair market value of a share on the purchase date.
The fair market value is the closing sales price (rounded up where necessary to the nearest whole cent) for our shares (or the closing bid, if no sales were reported) as quoted on the Nasdaq Global Select Market on the date of determination, as reported in such source as the Board deems reliable. As of March 22, 2019, the last reported sale price of our common stock as quoted on the Nasdaq Global Select Market was $73.99 per share.
Any money remaining in a participating employee’s account representing a fractional share shall remain in the participating employee’s account to be used in the next offering period along with new contributions in the next offering period.
Other Limitations
A participant’s right to purchase our common stock under the Amended ESPP, plus any other purchase plans that may be established by Seattle Genetics or its affiliates, is limited. An employee may not accrue the right to purchase stock at a rate of more than $25,000 of the fair market value of our common stock for each calendar year in which the purchase right is outstanding. We determine the fair market value of our common stock, for the purpose of this limitation, as of the first day of an offering. Additionally, no employee may purchase more than 2,000 shares in any offering.
Transferability
Options granted under the Amended ESPP are not transferable by a participating employee other than by will or by the laws of descent and distribution, and are exercisable during the participating employee’s lifetime only by the participating employee.
Changes to Capital Structure
In the event that there is a specified type of change in our capital structure, such as a stock split, appropriate adjustments will be made to (i) the number of shares reserved under the Amended ESPP, and (ii) the number of shares and purchase limits of all outstanding purchase rights.
Corporate Transactions
In the event of certain significant corporate transactions, as described in the Amended ESPP, the surviving or acquiring corporation will either assume or substitute outstanding purchase rights. If the surviving or acquiring corporation refuses to

assume or substitute such purchase rights, then, as determined by the Board in its discretion, such rights may continue in full force and effect or the participants’ accumulated contributions may be used to purchase shares of our common stock immediately prior to such corporate transaction, and such purchase rights will terminate immediately thereafter.
Duration, Amendment and Termination
The Board of Directors may suspend or terminate the Amended ESPP at any time. The Board of Directors may amend the Amended ESPP at any time. However, no amendment will be effective unless approved by our stockholders to the extent such stockholder approval is necessary for the Amended ESPP to satisfy the requirements of Rule 16b-3 under the Exchange Act, any Nasdaq or other securities exchange listing requirements or other applicable law or regulation, or with respect to the 423 Component of the Amended ESPP, the requirements of Section 423 of the Code. Rights granted before amendment or termination of the Amended ESPP will not be impaired by such amendment or termination, except as expressly provided in the Amended ESPP.
Certain U.S. Federal Tax Consequences
The following summary briefly describes U.S. federal income tax consequences of rights under the Amended ESPP, but is not a detailed or complete description of all U.S. federal tax laws or regulations that may apply, and does not address any local, state or other country laws. Therefore, no one should rely on this summary for individual tax compliance, planning or decisions. Participants in the Amended ESPP should consult their own professional tax advisors concerning tax aspects of rights under the Amended ESPP. The discussion below concerning tax deductions that may become available to us under U.S. federal tax law is not intended to imply that we will necessarily obtain a tax benefit or asset from those deductions. Taxation of equity-based payments in other countries is complex, does not generally correspond to U.S. federal tax laws, and is not covered by the summary below.
423 Component
Options to purchase shares granted under the 423 Component of the Amended ESPP are intended to qualify for favorable federal income tax treatment associated with options granted under an employee stock purchase plan which qualifies under the provisions of Section 423(b) of the Internal Revenue Code. Under these provisions, no income will be taxable to a participating employee until the shares purchased under the Amended ESPP are sold or otherwise disposed of. If the shares are disposed of within two years from the option grant date (i.e., the beginning of the offering period or, if later, the date the participating employee entered the offering period) or within one year from the purchase date of the shares, a transaction referred to as a “disqualifying disposition,” the participating employee will realize ordinary income in the year of such disposition equal to the difference between the fair market value of the stock on the purchase date and the purchase price. The amount of such ordinary income will be added to the participating employee’s basis in the shares, and any additional gain or resulting loss recognized on the disposition of the shares after such basis adjustment will be a capital gain or loss. A capital gain or loss will be long-term if the participating employee holds the shares for more than one year after the purchase date.
If the stock purchased under the Amended ESPP is sold (or otherwise disposed of) more than two years after the option grant date and more than one year after the stock is transferred to the participating employee, then the lesser of (i) the excess of the sale price of the stock at the time of disposition over the purchase price, and (ii) the excess of the fair market value of the stock as of the first date of the offering period over the purchase price (determined as of the first date of the offering period) will be treated as ordinary income. The amount of such ordinary income will be added to the participating employee’s basis in the shares, and any additional gain or resulting loss recognized on the disposition of the shares after such basis adjustment will be long-term capital gain or loss. If the sale price is less than the purchase price, no ordinary income will be reported.
The Company generally will be entitled to a deduction in the year of a disqualifying disposition equal to the amount of ordinary income realized by the participating employee as a result of such disposition, subject to the satisfaction of any tax-reporting obligations. In all other cases, no deduction is allowed.
Non-423 Component
If the option is granted under the Non-423 Component, then the amount equal to the difference between the fair market value of the stock on the purchase date and the purchase price will be treated as ordinary income at the time of such purchase. In such instances, the amount of such ordinary income will be added to the participating employee’s basis in the shares, and any additional gain or resulting loss recognized on the disposition of the shares after such basis adjustment will be a capital gain or loss. A capital gain or loss will be long-term if the participating employee holds the shares for more than one year after the purchase date.
The Company generally will be entitled to a deduction in the year of purchase equal to the amount of ordinary income realized by the participating employee as a result of such disposition, subject to the satisfaction of any tax-reporting obligations. For U.S. participating employees, FICA/FUTA taxes will be due in relation to ordinary income earned as a result of participation in the Non-423 Offering.

Past Participation in the ESPP
The table below sets forth the number of shares purchased by each of our named executive officers and other employees of the Company and designated subsidiaries under the ESPP, including all executive officers as a group since the inception of the ESPP through March 1, 2019. Non-employee directors are not eligible to participate in the ESPP.
ESPP
Name and positionNumber of shares
Clay B. Siegall, Ph.D., President and CEO0
Todd E. Simpson, Chief Financial Officer13,013
Roger D. Dansey, M.D., Chief Medical Officer359
Vaughn B. Himes, Ph.D., Chief Technical Officer1,921
Darren Cline, Executive Vice President, Commercial3,932
All current executive officers as a group19,225
All current directors who are not executive officers as a groupN/A
Each nominee for election as a director:N/A
Srinivas Akkaraju, M.D., Ph. D.N/A
Marc E. Lippman, M.D.N/A
Daniel G. WelchN/A
Each associate of any executive officers, current directors or director nomineesN/A
Each other person who received or is to receive 5% of purchase rightsN/A
All employees, including all current officers who are not executive officers, as a group2,795,101

New ESPP Benefits
The amounts of future purchases under the ESPP are not determinable because participation is voluntary, participation levels depend on each participating employee’s elections and the restrictions of Section 423 of the Code and the Amended ESPP, and the per share purchase price will depend on the future value of the Common Stock.
Vote Required
The affirmative vote of the holders of a majority of the shares of Common Stock present in person or by proxy at the Annual Meeting and entitled to vote is required to approve the Amended ESPP.
THE BOARD RECOMMENDS A VOTE FOR THIS PROPOSAL NO. 3


PROPOSAL NO. 4
ADVISORY VOTE ON EXECUTIVE COMPENSATION
Under the Dodd-Frank Wall Street Reform and Consumer Protection Act, or the Dodd-Frank Act, and

Pursuant to Section 14A of the Exchange Act, our stockholders are entitled to vote to approve, on an advisory (non-binding) basis, the compensation of our Chief Executive Officer, Chief Financial Officer and our three other most highly compensated executive officers during the year ended December 31, 2018, or,collectively, the named executive officers, as disclosed in this proxy statement in accordance with the SEC’s rules. This non-binding advisory vote is commonly referred to as a “say-on-pay” vote.

At last year’s annual meeting, we provided our stockholders with the opportunityask shareholders to cast an advisory vote regardingto approve the compensation of our named executive officers as disclosed in the proxy statement for the 2018 Annual Meeting of Stockholders. At the 2018 Annual Meeting of Stockholders, our stockholders overwhelmingly approved the proposal, with approximately 98% of the votes cast voting in favor of the proposal. This year we are again asking our stockholders to vote “FOR” the compensation of our named executive officers as disclosed in this proxy statement in accordance with the SEC’s rules.
As described in detail under the heading “Compensation of Executive Officers—Compensation Discussion and Analysis,” our executive compensation programs are designed to retain and incentivize the high quality executives whose efforts are key to our long-term success. Under these programs, our named executive officers are rewarded on the basis of individual and corporate performance measured against pre-established corporate and strategic goals. Please read theOfficers” section of this proxy statement understatement. While this vote isnon-binding, we value the heading “Compensationopinions of Executive Officers—our shareholders and will consider the outcome of the vote when making future compensation decisions. As described in the Compensation Discussion and Analysis” for additional details aboutAnalysis below, we believe that we have made significant improvements in our executive compensation programs, including information aboutprogram to further align pay with company performance and the 2018 compensationinterests of our named executive officers.
The Compensation Committee ofshareholders and to enhance our Board of Directors continually reviews the compensation programs for our named executive officers to ensure they achieve the desired goals of aligning our executive compensation structure with our stockholders’ interests and current marketgovernance practices.

We are asking our stockholdersshareholders to indicate their support for our Named Executive Officernamed executive officer compensation as described in this proxy statement. This proposal gives our stockholdersshareholders the opportunity to express their views on our named executive officers’ compensation. This vote is not intended to address any specific item of compensation, but rather the overall compensation of our named executive officers and the philosophy, policies and practices described in this proxy statement. Accordingly, we are asking our stockholdersshareholders to cast anon-binding advisory vote “FOR” the following resolution at the Annual Meeting:

“RESOLVED, that the compensation paid to the named executive officers, as disclosed in the Company’s Proxy Statementproxy statement for the 20192020 Annual Meeting of StockholdersShareholders pursuant to Item 402 of RegulationS-K, including the Compensation Discussion and Analysis, compensation tables and narrative discussion is hereby APPROVED.”

The say-on-pay vote is advisory, and therefore not binding on Seattle Genetics, the Compensation Committee or our Board of Directors. Nevertheless, our Board of Directors and our Compensation Committee value the opinions of our stockholders, whether expressed through this vote or otherwise and, accordingly, the Board and Compensation Committee intend to consider the results of this vote in making determinations in the future regarding executive compensation arrangements.

Unless our Board of Directors modifies its policy on the frequency of future advisory votes on the compensation of our named executive officers, the next advisory vote on the compensation of our named executive officers will be held at the 20202021 Annual Meeting of Stockholders.Shareholders. In addition, our stockholdersshareholders will be able to indicate by advisory vote at our 2023 Annual Meeting of StockholdersShareholders their preference as to the frequency of future advisory votes.

Stockholder

Shareholder approval of this Proposal No. 42 will require the affirmative vote of a majority of the votes cast in person or by proxy at the Annual Meeting.

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The Board recommends a voteFOR this Proposal No. 2.

2020 PROXY STATEMENT29


COMPENSATION OF EXECUTIVE OFFICERS

THE BOARD RECOMMENDS A VOTE FOR THIS PROPOSAL NO. 4


COMPENSATION OF EXECUTIVE OFFICERS

A MESSAGE FROM THE COMPENSATION COMMITTEE

We are committed to ensuring that our compensation programs help support and drive the Company’s focus to discover, develop and commercialize transformative medicines targeting cancer to make a meaningful difference in people’s lives.

2019 was a tremendous year for Seattle Genetics and we believe the Company’s future is bright. In determining compensation, we wanted to make sure that the compensation of the executive team reflected their solid performance and the need to retain them for the long term to deliver on our key, strategic objectives over the next several years.

Additionally, we received an approval of 73% on thesay-on-pay vote at our 2019 Annual Meeting of Shareholders, a significant decrease from the nearly 99% support level we received in 2018. We took the message conveyed by that vote very seriously. In response, we conducted a comprehensive review of our advisors, programs, and processes to ensure alignment of our programs to our business strategy and industry best practices.

During this review, we met with shareholders and different compensation consulting firms. Our Compensation Discussion and Analysis describes the feedback we received and specific program design changes made in 2019 based on this feedback, as well as the individual compensation decisions for our 2019 named executive officers and the reasons for them. We remain committed to listening to shareholder feedback as we continue to evaluate and refine the Company’s compensation programs.

Sincerely,

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COMPENSATION DISCUSSION AND ANALYSIS

This compensation discussionCompensation Discussion and analysisAnalysis describes how the Compensation Committee of our Board of Directors determined the total compensation for the following executive officers during the year ended December 31, 2018,2019, whom we refer to as our named executive officers:

Clay B. Siegall, Ph.D., our President and Chief Executive Officer, or CEO;

Todd Simpson, our Chief Financial Officer;

Roger Dansey, M.D., our Chief Medical Officer;

Vaughn Himes, Ph.D., our Chief Technical Officer;

Jean I. Liu, General Counsel and

Darren Cline, our former Executive Vice President, Legal Affairs; and

Robin G. Taylor, Ph.D., former Chief Commercial Officer who served until February 2019.2020.

This compensation discussionCompensation Discussion and analysisAnalysis also describes our overall executive compensation philosophy, objectives and practices, as well as the Compensation Committee’s decisions and determinations regarding executive compensation for 2018.2019.

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Executive Summary
2018 Business Highlights
The financial

COMPENSATION DISCUSSION AND ANALYSIS

SHAREHOLDER ENGAGEMENT

In 2019, we conducted a proactive shareholder outreach program to solicit feedback and better understand investor perspectives on operational, highlightsgovernance and executive compensation matters. We held discussions with a number of our company performance for 2018 were as follows:

With regard to ADCETRIS® (brentuximab vedotin):
We continued execution of our sales strategy for ADCETRISshareholders in the United Statesspring before the Annual Meeting and Canada. Net sales of ADCETRIS were $476.9 milliononce again in 2018, representing an increase of 55% over net sales of $307.6 millionlate fall. Our cross-functional team that participated in 2017.
these discussions to address investors’ specific focus areas included executives from our Investor Relations, Human Resources and Legal departments as well as our Chief Financial Officer. In March 2018, the U.S. Food and Drug Administration, or FDA, approved ADCETRIS in combination with doxorubicin, vinblastine, and dacarbazine, for patients with newly diagnosed, previously untreated Stage III/IV classical Hodgkin lymphoma.
In November 2018, the FDA approved ADCETRIS in combination with cyclophosphamide, doxorubicin, and prednisone for patients with previously untreated systemic anaplastic large cell lymphoma or other CD30- expressing peripheral T-cell lymphoma, or PTCL, including angioimmunoblastic T-cell lymphoma and PTCL not otherwise specified, based on the positive resultsaddition, Dr. Baker, our Lead Independent Director, who also serves as Chair of the ECHELON-2 phase 3 clinical trial.
With regardCompensation Committee, participated in some of these discussions. Feedback from these engagement activities was shared with management and our Board of Directors to our clinical pipeline:
We continued to advance pivotal trials of enfortumab vedotin, or EV, and tisotumab vedotin, or TV, in collaboration with our respective collaborators, Astellas Pharma, Inc., or Astellas, and Genmab A/S, or Genmab.
In March 2018, we obtained global rights to tucatinib, an oral tyrosine kinase inhibitor targeting HER2, a growth factor receptor overexpressed in many cancers, through the acquisition of Cascadian Therapeutics, Inc., or Cascadian, and are conducting a pivotal trial of tucatinib in combination with capecitabine and trastuzumab for patients with HER2-positive metastatic breast cancer.
We also continued to advance our earlier stage clinical pipeline and pre-clinical technologies.
With regard to business and operations:
we completed a significant transaction through the acquisition of Cascadian, and continued to scale our business and expand our operations internationally as we continue to move towardinform our goal of becoming a multi-product oncology company.
2018 Executive Compensation Highlights
The following key compensation actions were taken with respect to our named executive officers for 2018:
Annual Cash Incentive Awards – We performed above target with respect to our 2018 corporate performance goals, and the annual cash incentive awards earned by our named executive officers under our Senior Executive Annual Bonus Plan, or the Executive Bonus Plan, ranged from 110% to 138% of the named executive officer’s target annual cash bonus opportunities, including an annual cash incentive award to our CEO equal to 130% of his target annual cash bonus opportunity, in line with achievement of 130% of our annual corporate performance goals and the fact that our CEO’s annual cash incentive award is entirely dependent on corporate performance.

Annual Long-Term Incentive Compensation – Our named executive officers were granted long-term incentive compensation opportunities in the form of options to purchase shares of our common stock, or options, and restricted stock unit awards, or RSUs, which vest in installments over four years to better align our grant practicesaligning Company interests with those of our peer group. Our prior practice wasshareholders. Investor feedback is important to us, and we are committed to continuing to engage with our shareholders in the future to understand and consider their views.

2019 SHAREHOLDER ENGAGEMENT EFFORT

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SHAREHOLDER FEEDBACK

In 2019, these discussions covered a wide range of topics, including:

executive compensation

our voting standard for RSUs to cliff vest in three years.director elections

director overboarding
the role of our lead independent director

enhanced proxy statement disclosure

diversity of our Board of Directors

Special Long-Term Performance-Based Compensation AwardsOUTCOMES OF ENGAGEMENT

The feedback from the – They are eligiblesay-on-pay vote and discussions with shareholders led to receive certain equity awards under the Long-Term Incentive Plan for Tucatinib, or the Tucatinib LTIP, a special program intendedchanges in 2019 to incentivize the achievement of FDA approval of tucatinib, which is anticipated to require performance over a multiple year period to attain. While the grant date fair value of these awards is reflected as 2018 compensation in the “Summary Compensation Table,” these awards will not be earned if the performance goal is not achieved.

Further Alignment of Executive Compensation to Peer Group Practices – The Compensation Committee also took steps to further align our executive compensation with that of our peer group of mid-sized commercial biotech companies. Changes include:
program and corporate governance practices, as described below.

  Executive

  Compensation

  Incorporated performance-based equity awards into our CEO’s long-term incentive program

  Adopted a clawback policy for executives

  Enhanced our scrutiny ofpay-for-performance alignment in making compensation decisions

  Corporate

  Governance

Revisions to

  Adopted majority vote standard in uncontested director elections

  Revised our policy on outside board commitments

  Enhanced the severance benefit provisions set forthauthority and responsibilities of our lead independent director

  Increased our disclosure on diversity at the Company

  Enhanced the information provided in our executive employment agreements to increase the cash and COBRA premium severance benefits payable in connection with certain qualifying terminations.proxy statement

The elimination of single trigger equity vesting acceleration provisions previously contained in our CEO’s employment agreement in favor of a double trigger vesting acceleration provision.
Use of value-based equity awards as opposed to fixed share awards.2020 PROXY STATEMENT31
All of these actions are discussed in further detail in the sections that follow.
Executive Compensation Policies and Practices
We endeavor to maintain sound executive compensation policies and practices, including compensation-related corporate governance standards, consistent with our executive compensation philosophy. During 2018, we maintained the following executive compensation policies and practices to drive performance and to minimize behaviors that we believe do not serve our stockholders’ long-term interests:
Independent Compensation Committee. The Compensation Committee is comprised solely of independent directors.


COMPENSATION DISCUSSION AND ANALYSIS

KEY COMPENSATION CHANGES AND HIGHLIGHTS FOR 2019

Implemented a new performance-based RSU, or PSU, program for our CEO’s equity award

In response to investor feedback and the results of the“say-on-pay” vote at our 2019 Annual Meeting of Shareholders, we granted approximately 33% of our CEO’s annual equity award in the form of PSU awards to align our equity program with market practices and shareholder expectations. The performance goals for the PSU awards are based on 2022 adjusted revenues and relative TSR over a three-year period.
Implemented a clawback policy for executives, including our CEO and other named executive officersThis new policy is an important step to address shareholder feedback. It provides for the recoupment of certain cash and equity incentive compensation paid to any of our executives if we are required to prepare an accounting restatement due to material noncompliance with any financial reporting requirement under securities laws and it is determined that the executive’s misconduct contributed to that noncompliance.
Revised our Executive Bonus Plan to ensure only strongly performing executives receive the upside of the corporate performance componentStarting in 2019, if an executive’s individual performance is determined to be less than 100%, then when calculating the bonus payout, the executive’s corporate performance percentage will be capped at such individual performance percentage, regardless of actual corporate performance. This change enhances properpay-for-performance alignment and covers not only executive officers, but also all employees at the vice president level and above within the Company.
New independent advisor for the Compensation Committee

In July 2019, the Compensation Committee engaged Radford as its new independent compensation consultant to obtain a different voice and perspective as we evolved from a single-product to a multiple-product company and from a U.S.-focused to a globally-focused, commercial biotechnology company. Radford is a leading compensation consulting firm with extensive expertise in biotechnology and has broad client relationships with many of our commercial biotechnology peers.

Independent Compensation Committee AdvisorCOMPENSATION PHILOSOPHY AND OBJECTIVES. The Compensation Committee engaged its own compensation consultant to assist with making the 2018 compensation decisions.

Executive Compensation Review. The Compensation Committee conducted a review and approval of our compensation strategy, and reviewed and determined our compensation peer groups used for comparative purposes.
Additional Policies and Practices. Our compensation philosophy and related corporate governance policies and practices are complemented by several specific compensation practices that are designed to align our executive compensation with long-term stockholder interests, including the following:
Compensation At-Risk. Our executive compensation program is designed so that a significant portion of compensation is “at risk” based on our performance, including short-term cash incentives and long-term cash and equity incentives to align the interests of our executive officers and stockholders.
Special Performance-Based Awards. We maintain three special long-term incentive programs. Two of the special long-term incentive programs relate to our late stage product candidates, EV, tucatinib, and TV, and offer certain cash and equity awards that become payable, or subject to grant or vesting, as applicable, only if we achieve designated performance goals relating to certain regulatory approvals of these product candidates. The equity awards under these programs are generally subject to further vesting contingent on continued service over a multi-year period following the achievement of such performance goals. We also maintain an additional special long-term incentive program relating to the FDA approval of ADCETRIS in frontline Hodgkin lymphoma based on the phase 3 ECHELON-1 trial. The options that were granted to our executive officers under this program commenced vesting upon the achievement of the plan's desired performance objective in March 2018 and vest over a multi-year period, and a cash award was also paid to our executive officers in March 2018 upon goal achievement.
No Special Health or Welfare Benefits. Our executive officers participate in broad-based company-sponsored health and welfare benefits programs on the same basis as our other full-time, salaried employees.
No Post-Employment Tax Reimbursements. We do not provide any post-employment tax reimbursement payments (including “gross-ups”) on any severance or change-in-control payments or benefits.

Stock Ownership Policy. We maintain a policy that requires minimum ownership of shares of our common stock by our CEO and our other executive officers.
Multi-Year Vesting Requirements. The equity awards granted to our executive officers generally vest over multi-year periods, consistent with current market practice and our retention objectives.
Hedging and Pledging Prohibited. Pursuant to our insider trading policy, we prohibit our executive officers from engaging in short-term speculative transactions and further prohibit them from hedging or pledging our securities as collateral.
No Stock Option Repricings. Our equity plan does not permit repricing underwater stock options without stockholder approval.
Results of Most Recent Stockholder Advisory Vote on Executive Compensation
Approximately 98% of the votes cast in the “say-on-pay” stockholder advisory vote on the compensation of our named executive officers in 2018 approved our executive compensation as described in our 2018 definitive proxy statement. The Compensation Committee considered the result of the stockholder advisory vote as an endorsement of its compensation policies, practices and philosophy for our named executive officers, and did not make any significant changes as a result of the vote. In addition, in part based on the support shown by the vote, the Compensation Committee has maintained a consistent approach in making compensation decisions.
The Compensation Committee considers the results of the say-on-pay vote on our executive compensation program as part of its annual executive compensation review. Our Board of Directors values the opinions of our stockholders, and the Compensation Committee will continue to consider the outcome of future say-on-pay votes, as well as any feedback received throughout the year, when making compensation decisions for the named executive officers.
Compensation Philosophy and Objectives

Our compensation philosophy is to provide overall compensation that is competitive with biotechnology peers to attract and retain the highest caliber executive officers. In particular, we believe that, when targeted levels of performance are achieved, the resulting compensation should approximate the 50th percentile of pay practices of a peer group of companies selected by the Compensation Committee, and that additional performance should be rewarded by adjusting compensation upwards towards the 75th percentile of our peer group if an individual’s and our corporate performance exceeds expectations. The Compensation Committee believes that this approach is reasonable and appropriate to achieve the objectives of our compensation program and applies its experience and judgment when interpreting competitive market data and making compensation decisions for our executive officers. Other keytalent. Key objectives of our executive compensation program include include:

supporting our business strategy,

aligning pay with company performance driving the achievement of key business goals that increase stockholder value over theand shareholder interests,

ensuring competitiveness when compared to companies with whom we compete for talent,

rewarding success in building both short- and long-term and growth,

weighting pay deliberately toward “at risk” performance-based compensation.compensation,

ensuring that our pay practices are executed consistently and fairly for all executives, regardless of ethnicity or gender, and

motivating performance that aligns with our corporate values of integrity, scientific excellence, teamwork, innovation and mutual respect.

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COMPENSATION DISCUSSION AND ANALYSIS

OUR EXECUTIVE COMPENSATION PRACTICES

We endeavor to maintain sound executive compensation policies and practices consistent with our executive compensation philosophy. The following table highlights some of our executive compensation policies and practices, which are structured to drive performance and align our executives’ interests with our shareholders’ long-term interests:

WHAT WE DO
LOGOPay for Performance. We design our executive compensation program to align pay with company performance.
LOGOSignificant Portion of Compensation is at Risk. Under our executive compensation program, a significant portion of compensation is “at risk” based on our performance, including short-term cash incentives and long-term cash and equity incentives, to align the interests of our executive officers and shareholders.
LOGODouble-Trigger Vesting. We use double-trigger accelerated vesting of equity awards in the event of a change in control. Cash amounts payable upon a change in control are also subject to a double trigger.
LOGOIndependent Compensation Committee. The Compensation Committee is comprised solely of independent directors.
LOGOIndependent Compensation Advisor Reports Directly to the Compensation Committee. The Compensation Committee engages its own compensation consultant to assist with making compensation decisions.
LOGOAnnual Market Review of Executive Compensation. The Compensation Committee and its compensation consultant annually assess competitiveness and market alignment of our compensation plans and practices.
LOGOStock Ownership Guidelines for Directors and Executive Officers. We maintain a policy that requires minimum ownership of shares of our common stock by our CEO and other executive officers.
LOGOMulti-Year Vesting Requirements. The equity awards granted to our executive officers generally vest over multi-year periods, consistent with current market practice and our retention objectives.
LOGOAnnualSay-on-Pay Vote. We hold an annualsay-on-pay advisory vote for shareholders.
LOGOActive Shareholder Engagement Program. We proactively engage with our shareholders throughout the year.
LOGOClawback Policy. In December 2019, we adopted a policy that provides for the recoupment of certain incentive compensation paid to any of our executives if we are required to prepare an accounting restatement due to material noncompliance with any financial reporting requirement under securities laws and it is determined that such noncompliance was due in whole or in part to such executive’s misconduct.
LOGOCap on Annual Cash Bonuses. Each executive officer’s annual bonus is capped at 200% of the target award amount.
LOGOMinimize Inappropriate Risk Taking. Our compensation program is weighted toward long-term incentive compensation to discourage short-term risk taking, and it includes goals that are quantifiable with objective criteria, multiple performance measures and caps on short-term incentive compensation.
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Competitive Peer Group. Our Compensation Committee selects our peers from biotechnology and pharmaceutical companies that are similar to us with respect to market capitalization, revenue, headcount and commercialization stage, while also taking into account a number of qualitative criteria.

2020 PROXY STATEMENT33


Compensation-Setting Process

COMPENSATION DISCUSSION AND ANALYSIS

WHAT WE DON’T DO
LOGONo Special Health or Welfare Benefits for Executives. Our executive officers participate in broad-based, company-sponsored health and welfare benefits programs on the same basis as our other full-time, salaried employees. Executives do not have access to special benefits programs.
LOGONo Post-Employment TaxGross-Ups. We do not provide any post-employment tax reimbursement payments (including“gross-ups”) on any severance orchange-in-control payments or benefits.
LOGOProhibition on Hedging and Pledging. Our insider trading policy prohibits our employees (including executive officers) and directors from engaging in hedging or short-term speculative transactions involving our securities. In addition, none of these persons may hold Seattle Genetics securities in a margin account or otherwise pledge Seattle Genetics securities as collateral for a loan.
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No Stock Option Repricing. Our equity plan does not permit repricing underwater stock options without shareholder approval.

COMPANY OVERVIEW

Seattle Genetics is a global, multi-product biotechnology company that discovers, develops and commercializes transformative medicines targeting cancer to make a meaningful difference in people’s lives. We are commercializing ADCETRIS for the treatment of several types of CD30-expressing lymphomas and PADCEV for the treatment of certain metastatic urothelial cancers. In addition, we have submitted marketing applications for tucatinib, our small molecule tyrosine kinase inhibitor, for patients with metastatic HER2-positive breast cancer. We are also advancing a pipeline of novel therapies for solid tumors and blood-related cancers designed to address unmet medical needs and improve treatment outcomes for patients. Many of our programs, including ADCETRIS and PADCEV, are based on our proprietary ADC technology that utilizes the targeting ability of monoclonal antibodies to deliver cell-killing agents directly to cancer cells.

BUSINESS HIGHLIGHTS

2019 was a transformational year during which Seattle Genetics achieved record revenues driven by continued growth of ADCETRIS product sales, increasing royalty revenues and significant progress by our collaborators that triggered several milestone payments. ADCETRIS product sales in the U.S. and Canada were $628 million in 2019, an increase of 32% over 2018, and more than double net sales in 2017. In 2020, we expect continued product sales growth of ADCETRIS, and are continuing to invest in clinical trials to further expand this important global brand.

We also realized our goal of becoming a multi-product company. In December 2019, approximately three months before the target action date, we and our partner Astellas received FDA accelerated approval of PADCEV for the treatment of previously treated metastatic urothelial cancer. Prior to approval, these patients had limited treatment options. We are also conducting additional trials to potentially expand PADCEV’s use to first-line metastatic disease and to earlier stages of bladder cancer as well as outside of bladder cancer in a range of other solid tumors. PADCEV received BTD from the FDA for previously treated metastatic urothelial cancer prior to its approval and more recently received BTD for its use in combination with Merck’s Keytruda® in the first-line setting.

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Role

COMPENSATION DISCUSSION AND ANALYSIS

Additionally, in late 2019 and early 2020, we submitted marketing applications for tucatinib in the United States, Europe and other countries for the treatment of patients with metastatic HER2-positive breast cancer based on positive results from theHER2CLIMB-01 trial. The results demonstrated that the tucatinib-containing regimen improved PFS, overall survival and PFS in patients with brain metastases, along with a manageable safety profile in patients with previously treated locally advanced or metastatic HER2-positive breast cancer. TheHER2CLIMB-01 data supported BTD from the FDA and the PDUFA target action date is August 20, 2020. This positions tucatinib to be our third commercial product, if approved. We are also conducting a broad tucatinib development program, including the phase 3HER2CLIMB-02 trial for first- or second-line metastatic HER2-positive breast cancer and a potentially pivotal phase 2 trial in metastatic HER2-positive colorectal cancer.

We also continue to advance our pipeline, and in 2019 we and our partner Genmab completed enrollment in a pivotal trial of tisotumab vedotin for patients with metastatic cervical cancer. We expect to report topline data in the first half of 2020 that, if positive, could support an accelerated approval pathway with the FDA.

We continue to invest in the development of our earlier-stage pipeline with ongoing clinical trials and advancement of several new product candidates into clinical development in 2019. We have also licensed our ADC technology to other companies, which generates milestone payments and royalties to us. In 2019 and early 2020, Genentech/Roche received approval in the U.S. and the European Union for their product Polivy, an ADC using our technology, in the U.S. and the European Union for which we receive royalties on global sales.

As we enter 2020, we are well-positioned to continue our progress. And, while the global impact of theCOVID-19 pandemic is evolving, we remain committed to delivering innovative medicines that improve outcomes for people living with cancer.

ALIGNMENT OF CEO PAY TO TOTAL SHAREHOLDER RETURN

We design our executive compensation program to align pay with company performance, and as highlighted in the charts below, there is strong alignment between the two. The charts below compare our CEO’s total compensation and our annual TSR over theone-year and three-year periods ended December 31, 2019 to the CEO total compensation and annual TSR of our compensation peer group over theone-year and three-year periods ended December 31, 2018, which are the most recent periods for which data was available to the Compensation Committee

The Compensation Committee’s basic responsibility is to review the performance of when making pay decisions in August 2019. For more information on our management in achieving corporate goalspay elements and objectives and to ensure that our management is compensated effectively in a manner consistent with our compensation philosophy, competitive practicedecision making process, including our compensation peer group, please see “Principal Elements of Pay” and “Compensation-Setting Process” below.

LOGOLOGO

2020 PROXY STATEMENT35


COMPENSATION DISCUSSION AND ANALYSIS

PRINCIPAL ELEMENTS OF PAY

Our 2019 executive compensation program generally consisted of three principal components, as further described below. We also provide other forms of compensation, including discretionary and other cash bonuses and equity awards and long-term incentive plans or awards. In addition, we provide retirement and benefits plans to executives on the requirementssame basis as our other employees and we provide certain other limited remuneration to them. For additional information, please see “Compensation-Setting Process” and “Summary Compensation Table” below.

Percentage of 2019 Target Compensation(1)
President and CEO

Average of Other Named

Executive Officers

Description and Purpose

Base Salary

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Competitive fixed cash compensation used to attract and retain talented executives.

Annual Cash Incentive Awards

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Cash incentives designed to reward executive officers for successful corporate performance against Board approved annual bonus targets and individual performance toward achieving corporate goals.

Annual Long-Term Equity Awards

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Stock option, RSU and PSU awards subject to time-based and/or performance-based vesting designed to align each executive officer’s incentives with shareholder value creation.

(1)

For purposes of the appropriate regulatory bodies. Toward that end, the charts in this table, target compensation consists of base salary and target annual incentive awards as set by the Compensation Committee in February 2019 and target annual equity awards determined based on market data. It does not include other forms of compensation the executive officers received. Target compensation for Dr. Taylor, who joined the Company in May 2019, consists of annualized amounts to represent a full year of compensation for his position.

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COMPENSATION DISCUSSION AND ANALYSIS

COMPENSATION-SETTING PROCESS

The Compensation Committee oversees, reviews, and approves our executive compensation program.

For 2018, The calendar below summarizes the key compensation-setting decisions made by our Compensation Committee reviewedthroughout the base salaries, annual cash incentive compensation, and the long-term incentive compensation of our named executive officers and compared them to our compensation peer group as described below in “Competitive Positioning primarily to ensure that our named executive officer target total direct compensation opportunities as a whole were market competitive and to determine whether any adjustments were necessary. Generally, the year:

Compensation Committee seeks to establish a mix between cash compensation and long-term equity incentives similar to the mix used by the companies in our compensation peer group. For example, generally, and for 2018, the Compensation Committee set a significant portion of compensation to be “at risk” based on our performance, in the form of both cash and equity, with heavier weight towards equity incentives that directly align the interests of our executives with our stockholders. Calendar

February – MarchJuly – AugustDecember

  Assess Company and individual performance in the prior year and determine corporate payout factor for corporate performance

  Approve annual bonus awards for the prior year and base salary adjustments based on prior year’s performance and market data on compensation for the executive’s position

  Finalize corporate and strategic goals for the upcoming year

  Set annual bonus award targets for the upcoming year

  Review director compensation against the market

  Review Compensation Committee charter

  Conduct compensation risk assessment

  Review director and executive officer share ownership against corporate ownership guidelines

  Review and approve Compensation Discussion and Analysis

  Update compensation peer group

  Conduct market assessment of base salaries, annual bonuses and long-term equity incentive compensation using new peer group

  Approve long-term RSU, stock option and PSU equity awards

  Prepare performance-based equity plans and metrics for annual equity grants

  Make market-based adjustments to base salaries and annual bonus award opportunities when appropriate

  Review feedback from investor outreach

  Assess compensation governance practices

  Prepare for incentive plans for the following year

  Prepare for annual compensation decisions

The Compensation Committee also believes that it is important to align compensation levels and the mix and levels of compensation we offer to thatthose offered by our peers in order to retain and incentivize the talented executive officers whose efforts are key to our long-term success.


At As an executive’s ability to impact operational performance increases, so does the time it makes its executiveproportion ofat-risk compensation. Target long-term incentive compensation decisions, the Compensation Committee also reviews individual performance andgrows proportionately as job responsibilities increase, which encourages our executives to focus on the Company’s performance against pre-established company corporatelong-term success and strategic goals, as well as the Company’s performance generally. In this regard, decisions with respect to the principal, ongoing elements of compensation for our executive officers are based, in combinationaligns with the competitive market analysis described above, upon the Compensation Committee’s assessment of:
each individual’s performance as assessed by our CEO (other than his own performance) in consultation with the Compensation Committee and our Executive Vice President, Human Resources; and
overall company performance measured against corporate and strategic goals as defined by our Board of Directors.
Generally, determinations of individual performance at the executive officer level are based on a holistic evaluation of the executive’s performance taking into account department and functional goals which are aligned with the broader corporate and strategic goals of the company. The Compensation Committee believes that successful execution against these goals is an essential way to enhance long-term stockholder value. The executive officer’s job criticality, role and responsibilities, and personal integrity and commitment to ethical business conduct are also considered.
The Compensation Committee generally relies upon its judgment and not upon rigid guidelines or formulas in determining the amount and mix of compensation elements for each executive officer, particularly with respect to base salary determinations and overall levels of long-term incentive compensation. However, as set forth below, bonus awards under our Executive Bonus Plan are formulaic in that the target and maximum bonus opportunities are established, as is the extent to which bonuses are awarded based on the achievement of pre-established company goals and, in the case of our named executive officers other than our CEO, on individual performance. In addition, since 2011 for reasons described further below in “Principal Elements of CompensationLong Term Equity Awards,” the Compensation Committee has delivered annual stock awards in a combination of options and RSU awards, with options representing approximately 50% of the overall value of the equity awards granted and with RSU awards comprising the other approximately 50%. Specifically, an equity grant value is determined for each executive officer role after the Compensation Committee reviews peer group data and the performance of the executive. This total value is then divided in half, and approximately 50% of the value allocated in the form of options and approximately 50% of the value is allocated to be granted in the form of RSUs. The number of shares underlying each option grant will be based on an approximation of 50% of grant date fair value, using the Black Scholes methodology for stock options. The number of shares underlying each RSU grant will be calculated by dividing 50% of the value by the average stock price over the 30 calendar days leading up to the date of grant. This 50/50 mix is based on the goal of attracting and retaining top performers and reflects a balanced approach between options, a more leveraged equity instrument that we believe to be highly performance based and to help drive stockholder value, and RSU awards, that serve as an effective retention vehicle even in periods of volatility.
The Compensation Committee continues to believe that this mix, and the continued granting of options in particular, as opposed to performance-based RSUs, is appropriate for our current stage of development and effective in aligning the interests of our executives with thoseshareholders. The charts below show the mix of the target compensation of our stockholders.
RoleCEO and the average target compensation of Executive Officersour other named executive officers.

2020 PROXY STATEMENT37


COMPENSATION DISCUSSION AND ANALYSIS

2019 TARGET COMPENSATION AT RISK(1)

LOGO

(1)

For purposes of these charts, target compensation consists of base salary and target annual incentive awards as set by the Compensation Committee in February 2019 and target annual equity awards determined based on market data. It does not include other forms of compensation the executive officers received. Target compensation for Dr. Taylor, who joined the Company in May 2019, consists of annualized amounts to represent a full year of compensation for his position.

ROLE OF EXECUTIVE OFFICERS

Our CEO makes recommendations to the Compensation Committee with respect to base salary levels, annual cash incentive awards, individual performance assessments, and the amount of long-term equity awards to be granted to our executive officers (other than with respect to his own compensation) in consultation with CompensiaRadford and our Executive Vice President, Human Resources. In addition, our Executive Vice President, Human Resources supports the Compensation Committee in its work, including preparation of historical and prospective executive compensation data, review of peer group data and biotechnology market practices, and research in response to technical Compensation Committee inquiries. Other than as described above, neither the CEO nor any other executive officers take part in the Compensation Committee’s decisions regarding executive officer compensation.

Role of Compensation Consultant
Under its charter,

ROLE OF COMPENSATION CONSULTANT

In early 2019, the Compensation Committee has the authority, in its sole discretion, to retain (or obtain the advice of) any compensation consultant, legal counsel or other adviser to assist it in the performance of its duties and responsibilities. Pursuant to this authority, the Compensation Committee has engaged Compensia, Inc., a national compensation consulting firm, for support on matters related to the compensation of our executive officers.

In 2018,June 2019, the Compensation Committee engaged a new compensation consulting firm, Radford, to support the Compensation Committee in reviewing pay against the market, provide independent and expert advice relative to our pay programs, and ensure the Compensation Committee stays abreast of trends in practices and legislative updates and is equipped to properly make decisions regarding the Company’s compensation programs. In 2019, the Compensation Committee analyzed whether the work of Compensia and Radford as a compensation consultant hasconsultants raised any conflict of interest, taking into consideration the following factors: (i)factors set forth in the provision of other services to our company by Compensia; (ii) the amount of fees from our company paid to Compensia as a percentage of the firm’s total revenue; (iii) Compensia’s policiesSEC and procedures that are designed to preventNasdaq rules regarding compensation advisor conflicts of interest; (iv) any business or personal relationship of Compensia or the individual compensation advisors employed by the firm with an executive officer of our company; (v) any business or personal relationship of the individual compensation advisors with any member of the

Compensation Committee;interest and (vi) any stock of the Company owned by the individual compensation advisors employed by the firm.independence. The Compensation Committee determined that, based on its analysis of the abovethose factors, that the work of Compensia and the individual compensation advisors employed by Compensia as compensation consultants to our company has not created any conflictRadford are each independent and free from conflicts of interest.

38

LOGO


Base salary and annual target bonus decisions made in January 2018 were made after considering the compensation provided by our peer group and Compensia’s previously provided competitive market analysis with respect to our August 2017 peer group. Compensia was again retained by the Compensation Committee in July 2018 to provide an updated competitive market analysis of the base salary, annual cash incentive awards, and long-term incentive compensation of our executive officers compared against our compensation peer group and to review other market practices and trends. This market analysis was reviewed with the Compensation Committee and was used to guide decisions regarding the August 2018 grants of long term equity awards in the form of options and RSUs, and in determining the August 2018 increase to Mr. Simpson's base salary. These data were also used to determine salary and cash incentive targets in February 2019.
Competitive Positioning

COMPENSATION DISCUSSION AND ANALYSIS

COMPETITIVE POSITIONING

The Compensation Committee reviews our peer group periodicallyannually to reflect changes in market capitalization and other factors, including acquisitions, and revises the companies included in the peer group accordingly. The compensation peer group used by the Compensation Committee to review compensation in August 2019 and February 2020 was approved by the Compensation Committee, with input provided by senior management and Radford, in July 2019. The criteria used to select this peer group are described below:

CORE CRITERIA

  Market Capitalization

25%-300% of our market cap as of April 30, 2019($3B-$36B) to capture a wide array of commercially successful or very promising emerging biotechnology companies

  Commercial

As a company that has been commercial for seven years, a peer company should also be commercial. Breakthrough companies on the cusp of becoming commercial may also be considered

  Revenue

25%-500% of last four quarters’ reported revenue (~$200M-$3B) to capture companies becoming like us and directionally where we are heading

  Global Headcount

25%-300% of our current headcount (~300 to 4,000) to capture our market segment

OTHER QUALITATIVE CRITERIA

  Cutting Edge Research

  and Development

Innovative, research based research and development companies with cutting edge science and a preference for oncology focus

  Headquarters Location

Primarily focused on U.S. based headquartered companies

  Past Peer

Preference would be given to a past peer company in order to ensure year-over-year stability

  Recruiting

Based on initial quantitative screen, where the Company loses talent to and recruits from will be considered to help narrow the list

  Cross-Pollination

Peers of peers will also be considered, including those companies that consider us a peer company

2020 PROXY STATEMENT39


COMPENSATION DISCUSSION AND ANALYSIS

Based on this analysis, the Compensation Committee arrived at the following peer group in July 2019:

Peer Group Companies

ACADIA Pharmaceuticals Inc.

Alexion Pharmaceuticals, Inc.

Alkermes plc

Alnylam Pharmaceuticals, Inc.

BeiGene Ltd.

BioMarin Pharmaceutical Inc.

bluebird bio, Inc.

Exelixis, Inc.

Incyte Corporation

Ionis Pharmaceuticals, Inc.

Jazz Pharmaceuticals Public Limited Company

Nektar Therapeutics

Neurocrine Biosciences, Inc.

Sarepta Therapeutics Corporation

United Therapeutics, Inc.

Vertex Pharmaceuticals Incorporated

LOGO

(1) Based on data used by the Compensation Committee in July 2019 when selecting the peer group.

(2) Market capitalization of the peer group is as of June 21, 2019.

(3) Revenue for the peer group reflects the trailing twelve months ended March 31, 2019.

(4) Global headcount for the peer group is as of December 31, 2018.

Changes from Prior Peer Group

Added:   ACADIA Pharmaceuticals Inc.
BeiGene Ltd.

Deleted:   Agios Pharmaceuticals, Inc.
Clovis Oncology, Inc.

The peer group used by the Compensation Committee when making salary bonus and bonus target compensation decisions in January 2018 was our peer group that resulted from Compensia’s analysis in August 2017 that2019 was approved by the Compensation Committee, with input provided by senior management and Compensia, at that time. As ofin August 2018. The criteria used to select this peer group were similar to the date this analysis was performed, these twentycriteria used to select the new peer companies had a mediangroup in July 2019, as described above, except as follows:

The criterion for market capitalization was25%-500%of approximately $6.8 billion, as compared to our market capitalization as of approximately $9 billion, median 12-month revenue through June 30, 2017May 31, 2018; and

The criterion for global headcount was25%-500% of approximately $89 million, as compared to our 12-month revenue through June 30, 2017 of approximately $429 million, and a median of 456 employees, as compared to our 890 employees. This peer group consisted of:then-current headcount.

ACADIA Pharmaceuticals, Inc. Clovis Oncology, Inc.40 Kite Pharma, Inc.
Agios Pharmaceuticals, Inc.

LOGO

  Exelixis, Inc.Puma Biotechnology, Inc.
Alexion Pharmaceuticals, Inc.Incyte CorporationTesaro, Inc.
Alkermes plcIntercept Pharmaceuticals, IncUltragenyx Pharmaceutical Inc.
Alnylam Pharmaceuticals, Inc.Ionis Pharmaceuticals, Inc.United Therapeutics, Inc.
BioMarin Pharmaceutical, Inc.Jazz Pharmaceuticals, plcVertex Pharmaceuticals Incorporated
bluebird bio, Inc.Juno Therapeutics, Inc.                     


The compensation peer group used by

COMPENSATION DISCUSSION AND ANALYSIS

As of the Compensation Committee to review compensationdate the analysis was performed in August 2018, was approved by the Compensation Committee, with input provided by senior management and Compensia, and included biotechnology and pharmaceutical companies that were similar to the Company with respect to revenue, market capitalization, headcount, development and commercialization stage and number of employees. In each case, as of the date this analysis was performed, these prior peer group companies had a median market capitalization of approximately $8 billion, as compared to our market capitalization of approximately $9.5 billion, median12-month revenue of approximately $452 million, as compared to our12-month revenue of approximately $482 million, and a median of 715 employees, as compared to our 1,100 employees. This peer group consisted of:

Agios Pharmaceuticals, Inc.Clovis Oncology, Inc.Neurocrine Biosciences, Inc.
Alexion Pharmaceuticals, Inc.Exelixis, Inc.Sarepta Therapeutics, Inc.
Alkermes plcIncyte CorporationTesaro, Inc.
BioMarin Pharmaceutical, Inc.Jazz Pharmaceuticals, plcUnited Therapeutics, Inc.
bluebird bio, Inc.Nektar TherapeuticsVertex Pharmaceuticals Incorporated
2018 Compensation Decisions for

BASE SALARY

In considering the Named Executive Officers

We believe that 2018 was a productive year for us due in part to FDA approvalappropriate level of two new indications for ADCETRIS, progress on pivotal trials of EV, tucatinib and TV, and the acquisition and integration of Cascadian, as described above under the heading “Executive Summary.” Our 2018 executive compensation program consisted of four principal components: base salary annual cash incentive awards, long-term equity awards in the form of stock options and RSU awards subject to time-based vesting, and performance-based incentive awards.

Base Salary
We use base salaries to attract and retain talented executives by providing them with a baseline level of competitive pay. Typically, annual base salary adjustments are effective February 1 of each year.
The following table sets forth the 2018 base salaries for each of our named executive officers that were approved byfor 2019, the Compensation Committee in Januaryreferenced market data on compensation for the executive’s position and August of 2018 and the percentages by which their base salaries were increased from their 2017 base salary levels.
Named Executive Officer 2017 Base Salary 2018 Base Salary Approved in January 2018 Revised 2018 Base Salary Approved in August 2018 Total Percentage Increase
Dr. Siegall $890,000 $921,150 No adjustment 3.50%
Mr. Simpson $493,600 $510,900 $540,900 9.58%
Dr. Dansey (1)
   No adjustment 
Dr. Himes $478,400 $507,500 No adjustment 6.10%
Mr. Cline $454,300 $482,500 No adjustment 6.20%
________________
(1) Dr. Dansey commenced employment with us in May 2018.
In determining 2018 base salary increases for each of the executive officers, the Compensation Committee first referenced the 50th percentile of the peer group data for similar positions and then adjusted for theconsidered aspects of individual performance and additional factors further described below.performance. In making such determination, the Compensation Committee also considered any changes in the executive’s job duties and responsibilities due to growth and scale of the organization or other changes, base compensation relative to our other executive officers budget considerations, and the scope and criticality of the executive’s role.
In January 2018, the Compensation Committee approved a merit increase of 3.5% to our CEO’s base salary in recognition of his role in leading the achievement of our strong corporate performance and following its analysis of competitive market data based on the peer group salary levels.
With respect to Mr. Simpson, the Compensation Committee focused on his leadership in our finance, investor relations and real estate and facilities functions including in our January 2018 financing. In January 2018, the Compensation Committee approved a merit increase of 3.5% to Mr. Simpson’s base salary and in August 2018, the Compensation Committee further increased Mr. Simpson’s base salary to $540,900 based on a review of the July 2018 peer group median.
Dr. Dansey commenced employment with us in May 2018, and the Compensation Committee set his initial base salary at $650,000. Thislevel of base salary was consistent with the higher range of the peer group for his position. The Compensation Committee determined that setting Dr. Dansey’s salarydid not apply a formula, but rather employed a holistic analysis of these factors using its professional judgment and experience. We compare executive base salaries to similar roles at this level was appropriateour peer companies and review them annually to recruit an executiveensure competitiveness and internal equity for the value of Dr. Dansey’s skill and experience in late-stage drug development efforts.
In January 2018, theour unique roles. The Compensation Committee approveddoes not target a merit increase and a market adjustmentspecific percentile within our peer group to Dr. Himes'sdetermine base salary that together equaled 6.1% based on his leadershiplevels for the named executive officers. Instead, we review the practices of our peer group and the general biotechnology market as merely a reference point to assist us in technical operationsdeveloping programs designed to attract and manufacturingretain exceptional talent and information technology, including in our efforts to become a multi-product, global oncologydrive company as well as a merit increase and market adjustment to Mr. Cline's base salary that together equaled 6.2% based on his leadership ofperformance.

Named Executive Officer

  2019 Base Salary
Approved in
February 2019
  Percentage 
Increase 

Dr. Siegall

   $967,208     5.0% 

Mr. Simpson

   $575,200     6.34% 

Dr. Dansey

   $672,800     3.51% 

Ms. Liu

   $522,200     4.5% 

Dr. Taylor(1)

          

(1)

Dr. Taylor began employment with us in May 2019.

ANNUAL CASH INCENTIVE AWARDS

We maintain an annual cash incentive bonus plan, or the commercial organization.

Annual Cash Incentive Awards
We have adopted an Executive Bonus Plan, which annual provides annual cash incentives designed to reward each executive officer for our corporate performance and such officer’s individual contributions and performance toward achieving key corporate goals.
The Executive Bonus Plan Target Awards
The target annual cash incentive award opportunities for our named executive officers for 2018 are set forth in the table below ashas a percentage of base salary. These targets were set in January 2018 basedstrong link to performance, focusing both on market data from our August 2017 peer group for similar positions after referencing the bonus targets for similarly positioned executives in our peer group. There were no changes from 2017 targets (as a percentage of base salary) because the Compensation Committee determined that such target percentages continued to be appropriate.

Named Executive Officer 
Target Annual Cash Incentive
Award Opportunity
(percentage of base salary)
 
Target Annual Cash Incentive
Award Opportunity
Dr. Siegall 100% $921,150
Mr. Simpson 50% $270,450
Dr Dansey 50% 
  $200,330(1)
Dr. Himes 50% $253,750
Mr. Cline 45% $217,125
________________
(1) Dr. Dansey’s 2018 bonus target was prorated due to commencement of employment in May 2018.
Performance Weighting and Bonus Award Payout Formula
The weighting between theteam-based corporate performance percentage and individual-based functional and department performance under the individual performance percentage used for determiningexecutive’s remit. In the annual cash incentive awards is determined for each named executive officer based on his or her position. Consistent with prior years, the Compensation Committee determined that greater weightingcase of the corporate goals should apply to our CEO, than our other named executive officers because100% of his position and responsibilities give him more opportunity to significantly impact overall corporate performance. With respect to Dr. Siegall, the corporate performance percentage is 100% and the individual performance percentage is 0%, and with respect to each of Mr. Simpson, Dr. Dansey, Dr. Himes and Mr. Cline, the corporate performance percentage is 60% and the individual performance percentage is 40%. The corporate performance percentage and individual performance percentage are multiplied by the target annual cash incentive award opportunity for each executive officer to determine the actual amount of the bonus award.
Corporate and individual performance goal achievement is targeted at 100%. The achieved corporate performance percentage and/or the achieved individual performance percentage may exceed 100% in the event we and/or the executive officer exceed expected goals, provided that under the Executive Bonus Plan effective in 2018 neither percentage could exceed 150%. Accordingly, each executive officer’s target annual cash incentive award opportunity under the Executive Bonus Plan in 2018 was capped at 150% of the target bonus amount. In addition, each executive officer must achieve at least a 50% individual performance percentage to receive a bonus award under our Executive Bonus Plan in 2018 (other than our CEO whose annual cash incentive award is based solely onlinked to the achievementperformance of the Company against Board-approved corporate goals. In the case of our corporate goals).
Corporate Performance Goals
The corporate goals for our Executive Bonus Plan are generally approved by the Compensation Committee near the beginningother executives, 60% of each year, but the Compensation Committee reserves the rightexecutive’s annual cash incentive award is tied to modify these goalscorporate performance and 40% is tied to reflect changing business circumstances and to consider any significant additional achievements that were not contemplated at the beginning of the year and our overallindividual performance in determining actual awards.toward achieving corporate goals.

2020 PROXY STATEMENT41


COMPENSATION DISCUSSION AND ANALYSIS

CORPORATE PERFORMANCE GOALS

The corporate performance goals under the Executive Bonus Plan for 20182019 were approved in March 2018 and were not subsequently modified. The performance goals were primarily based on sales of ADCETRIS, the advancement of development and clinical activities related to ADCETRIS, advancement of EV, TV and tucatinib and additional product candidates with the goal of becoming a multi-product company, goals related to antibody-drug conjugate, or ADC, leadership goals relating to scaling our operations, and business and operations goals related to expense management, hiring and retention and stock performance, all of whichby the Compensation Committee believes strongly relate to the creation of stockholder value.in February 2019. The weighting of these goals as approved in March 2018 is set forth in the chart below:

2018 Corporate Performance Goal

Weighting

ADCETRIS Sales and Development40%
Development of EV, TV, Tucatinib and Additional Product Candidates30%
ADC Leadership7.5%
Scaling Operations7.5%
Business Goals

7.5%
Operations Goals7.5%
The 20182019 performance goals were aggressive and set at challenging levels such that the attainment of executive target annual cash incentive award opportunities was not assured at the time they were set and would require a high level of effort and execution on the part of the executive officers and others in order to achieve the goals. OurThe Compensation Committee believes that each of these goals is strongly aligned to the creation of shareholder value.

The specific target performance goals, and their relative weightings, established


for 2018, and our actual performance as measured against those goals,2019 are set forth in the chart below:

2018 Corporate Performance Goal2018 Performance

ADCETRIS Sales and Development

Met or exceeded all goals including:
Goals(30%)

obtaining FDA approval based on the ECHELON-1 trial in the first half of 2018 and successfully launching ADCETRIS for the treatment of patients with newly diagnosed, previously untreated Stage III/IV classical Hodgkin lymphoma

• preparing for FDA approval and launch in frontline PTCL, including topline release and preparing for supplemental Biologics License Application, or sBLA, submission as soon as possible thereafter. In November 2018, the FDA approved ADCETRIS in combination with cyclophosphamide, doxorubicin, and prednisone for patients with previously untreated systemic anaplastic large-cell lymphoma or other CD30-expressing peripheral T-cell lymphoma, or PTCL, including angioimmunoblastic T-cell lymphoma and PTCL not otherwise specified
• achieving   Achieve sales goalsgoal established by the Board of Directors in the United States and Canada; net sales of ADCETRIS were $476.9 million in 2018, representing an increase of 55% over net sales of $307.6 million in 2017
Canada

meeting commercial manufacturing supply chain goals   Determine development paths and certain other goals relatingfinalize protocols for potential label expansions

PADCEV Development Goals(20%)

   Submit a Biologics License Application to the development and commercializationFDA by the end of ADCETRISthe third quarter for approval

   Achieve commercial launch readiness by year end

   Initiate at least one study for potential label expansion

Tucatinib Development of EV, TV, TucatinibGoals(20%)

   Submit a New Drug Application to the FDA and Additional Product Candidatesa Marketing Authorization Application to the European Medicines Agency for approval

   Prepare for first quarter 2020 commercial launch readiness

   Initiate at least one study for potential label expansion

Met or exceeded most

Hiring and Business Infrastructure Goals(12.5%)

   Achieve hiring and business infrastructure goals including:

• meeting enrollment targets in pivotal trials of EV, tucatinib and TV obtaining Breakthrough Therapy Designation for EV for patients with locally advanced or metastatic urothelial cancer who were previously treated with a checkpoint inhibitor
• assisting collaborative partners with regulatory-related manufacturing and supply chain deliverables that supportto enable multiple product launches for EV and TV programs
• performing specified tasks to prepare for the potential commercial launch of EV, tucatinib and TV
• collaborating with Astellas and Genmab to advance additional clinical development activities with respect to EV and TV
• completing the acquisition of Cascadian, adding a clinical-stage product to our pipeline
• advancing the clinical development of tucatinib including the HER2CLIMB study
• completing additional actions with regard to our earlier stage pipeline
Certain goals with respect to Breakthrough Therapy Designation and certain clinical development actions relating to EV and TV were only partially achieved, and one clinical development goal relating to TV was not achieved.
in expanding territories

ADC Leadership
Met all

Tisotumab Vedotin and Ladiratuzumab Vedotin Development Goals(7.5%)

   Complete enrollment in tisotumab vedotin pivotal study

   Determine at least one additional solid tumor registration opportunity

   Determine a potential regulatory approval path for ladiratuzumab vedotin

Pipeline Development Goals(5%)

   Achieve goals including:

• conducting multiple combinationto generate data to informgo/no-go decisions for Phase 1 programs, start two phase 1 trials and presenting and publishing preclinical and clinical data relatingadd two new development-stage programs

Stock Performance Goals(5%)

   Stock performance relative to ADCs in immuno-oncology combination regimens

• licensing a multi-program platform opportunity
• further developing and vetting certain ADC and immuno-oncology strategies
• advancing two programs to development stage
appropriate biotech indices


2018 Corporate Performance Goal2018 Performance
Scaling Operations42

LOGO


Met almost all goals including:
• enhancing organizational capacity to enable concurrent pivotal trials and regulatory submissions
• completing commercial stage agreement with Astellas
• completing certain steps with respect to commercial plans in our territories
• advancing certain global framework and governance goals
• enhancing alliance management function
• completed successful integration of Cascadian
One goal relating to a collaboration was not achieved.
Business and Operations Goals

COMPENSATION DISCUSSION AND ANALYSIS

Met all goals including:
• hiring key employees to plan and minimizing employee attrition
• managing expenses to budget
• achieving stock performance relative to appropriate biotechnology indices

Determined Performance Levels and Determined Awards

CORPORATE PERFORMANCE LEVELS

The Compensation Committee considered 2019 to be an exceptional year for our Company. In making its assessment regarding the extentaddition to which the corporatemeeting or exceeding most of our 2019 performance objectives for 2018 were achieved,goals, the Compensation Committee consideredbelieved that the Company had outstanding overall performance on the PADCEV and tucatinib development goals, hiring and infrastructure goals, pipeline development goals and stock performance goals. To determine our corporate performance percentage for 2019, the Compensation Committee employed a holistic analysis that took into account both the extent to which the objectivesperformance goals had been achieved or exceeded as well as the relative difficulty of each objective that was achieved compared to any objectivesachieving the goals that were not achieved.met and that were only partially met. In light of our strong performance in meeting or exceeding most of our corporate performance goals and the challenging nature of the goals, the Compensation Committee, in its discretion, determined our corporate performance percentage to be 130%160% of the target performance level for 2018.2019. The table below provides additional details about the Compensation Committee’s assessment of our actual performance against our 2019 corporate performance goals:

2019 Corporate

Performance Goal

Relative
Weighting
Highlights2019 Performance

ADCETRIS Sales and Development Goals

30%

  Developed an updated ADCETRIS label expansion strategy

  Determined development paths and study concepts for multiple potential indications

  Obtained approval of the majority of protocols for label expansion trials

  Began enrollment in multiple potentially registration-enabling trials

  Obtained label expansion in Canada for use as frontline therapy for patients with CD30-expressing peripheralT-cell lymphoma based on theECHELON-2 trial results

  Achieved an annual net sales increase of 32% in the U.S. and Canada, resulting in record annual sales and partially achieving an aggressive sales goal.

Met or exceeded
most goals

PADCEV Development Goals

20%

  Achieved positive results from the first cohort of theEV-201 trial, providing the basis for a Biologics License Application to the FDA

  Received FDA accelerated approval of our second product, PADCEV, with Astellas, three months prior to the PDUFA target action date based on the results from the first cohort of theEV-201 trial, transforming us from a single-product, into a multi-product, oncology company

  Established cross-functional commercial launch readiness and achieved the first sale of PADCEV

  Achieved encouraging initial results from the phase 1/2EV-103 trial as a frontline treatment in combination with pembrolizumab for patients with advanced urothelial cancer and presented these initial results at the 2019 European Society for Medical Oncology conference

  Expanded theEV-103 trial, and submitted protocols to the FDA for two additional trials, to inform potential label expansion, including in frontline indications

Outstanding overall performance; met or exceeded all goals

2020 PROXY STATEMENT43


COMPENSATION DISCUSSION AND ANALYSIS

2019 Corporate

Performance Goal

Relative
Weighting
Highlights2019 Performance

Tucatinib Development Goals

20%

  Achieved positive results in theHER2CLIMB-01 trial

  Expedited the submission of a New Drug Application to the FDA

  Obtained Breakthrough Therapy Designation for tucatinib from the FDA and participated in the FDA Oncology Center of Excellence’s, or OCE’s, Real Time Oncology Review pilot program, which allows the FDA to review much of the data earlier, before the application is formally submitted, so that by the time of submission, the agency’s review team is in a better position to conduct a more efficient review

  Participated in the FDA OCE’s Project Orbis initiative which provides a framework for concurrent submission and review of oncology products among Australia, Canada, Singapore, Switzerland and the U.S.

  Prepared a Marketing Authorization Application for submission to the European Medicines Agency. Although the submission occurred in January 2020, the Compensation Committee determined that this goal was exceeded as no submission date was available in December.

  Engaged in preparations for launch readiness

  Finalized plans to expand the therapeutic potential of tucatinib

  Began enrollment in the phase 3HER2CLIMB-02 trial, which could potentially provide the basis for the use of tucatinib in an earlier line of therapy for metastatic HER2-positive breast cancer

  Expanded the phase 2 MOUNTAINEER trial of tucatinib to support potential accelerated approval of tucatinib in HER2-positive colorectal cancer

Outstanding overall performance; met or exceeded all goals

Hiring and Business Infrastructure Goals

12.5%

  Hired 454 new employees, including 7 key executives, increasing the size of the work force by 23%

  Maintained a turnover rate of approximately 10% compared to a benchmark of approximately 16% among life sciences companies

  Expanded our footprint in the U.S. and European Union

  Undertook infrastructure build plans to enable tucatinib submissions in other geographies, including Project Orbis countries

  Expanded product supply and quality functions to scale up commercial manufacturing and potential distribution of tucatinib in Europe

Outstanding overall performance; exceeded all goals

Tisotumab Vedotin and Ladiratuzumab Vedotin Development Goals

7.5%

  Completed enrollment in the innovaTV 204 trial

  Certain goals relating to clinical development actions for tisotumab vedotin and ladiratuzumab vedotin were only partially achieved.

Met or partially met all goals

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COMPENSATION DISCUSSION AND ANALYSIS

2019 Corporate

Performance Goal

Relative
Weighting
Highlights2019 Performance

Pipeline Development Goals

5%

  Began enrollment of new product candidates in phase 1 trials

  Added new development-stage programs

  Filed three Investigational New Drug, or IND, applications with the FDA and assumed an additional IND application

Outstanding overall performance; met or exceeded all goals

Stock Performance Goals

5%

  In addition to achieving TSR of 102% in 2019, the Company exceeded goals related to stock performance relative to appropriate biotechnology indices.

Outstanding overall performance; exceeded all goals

INDIVIDUAL PERFORMANCE LEVELS

Our CEO assessed the other executive officers’ contributions to the 20182019 corporate goals and made a recommendation to the Compensation Committee with respect to the individual performance percentagepercentages for the other executive officers for 2018.2019. The factors considered by the CEO in making this determination included a holistic,non-formulaic evaluation of individual officer’s performance the criticality of the executive officer’s role in achieving corporate deliverables,and the executive officer’s contribution to achieving corporate goals and the achievement of individual or departmental goals. The Compensation Committee reviewed the CEO’s recommendations on individual performance factors for each executive officer for 20182019 and then made a final determination of the 20182019 individual performance percentage for each executive officer as follows: 140% for Dr. Himes, 130% for Mr. Simpson, 150% for Dr. Dansey and 80% for Mr. Cline. Noofficer. The factors considered by the Compensation Committee in determining the individual performance factor was determinedpercentage of each executive officer are described below under “2019 Key Compensation Decisions for Named Executive Officers.” The individual performance percentages for each of our executive officers are set forth in under “Annual Cash Incentive Payout Formula” below.

ANNUAL CASH INCENTIVE PAYOUT FORMULA

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Named Executive Officer

 Target Cash Incentive
Award for 2019
  Corporate
Performance
Weighting
   Corporate
Performance
Percentage
          Annual
Cash
Incentive
Award
for 2019
 
 

Percentage

of Base
Salary

   Dollar
Amount
  Individual
Performance
Weighting
   Individual
Performance
Percentage
 

Dr. Siegall

  100%   $967,208   100%    160%   0%       $1,547,500 

Mr. Simpson

  50%   $287,600   60%    160%   40%    130%   $425,700 

Dr. Dansey

  50%   $336,400   60%    160%   40%    175%   $558,400 

Ms. Liu

  50%   $261,100   60%    160%   40%    130%   $386,500 

Dr. Taylor

  50%   $154,800(1)   60%    80%(2)   40%    80%   $123,800 
(1)

Dr. Taylor’s bonus reflects a pro rata amount of his $250,000 annual bonus target to reflect his hiring date in May 2019.

(2)

Dr. Taylor’s corporate performance percentage was capped at his individual performance percentage, because his individual performance percentage was less than 100%.

With the exception of Ms. Liu, the target cash incentive awards of our executive officers as a percentage of base salary remained unchanged from 2018. For 2019, Ms. Liu’s target cash incentive award changed from 45% to 50% of base salary to more closely align with similarly situated peers.

Each executive officer’s annual cash incentive award is targeted at 100%, and capped at 200%, of the target award amount. Each executive officer (other than our CEO since hiswhose annual cash incentive award is based entirelysolely on the achievement of corporate performance factor discussed above.

Based on the 2018 attained performance levels, the Compensation Committee determined thatDr. Siegall’s overall annual cash incentive award percentage was 130%, equalinggoals) must achieve at least a 2018 annual cash incentive award of $1,197,495, Mr. Simpson’s overall annual cash incentive award percentage was 130%, equaling a 2018 annual cash incentive award of $351,550, Dr. Dansey’s overall annual cash incentive award percentage was 138%, equaling a prorated 2018 annual cash incentive award of $276,455, Dr. Himes’ overall annual cash incentive award percentage was 134%, equaling a 2018 annual cash incentive award of $340,025, and Mr. Cline’s overall annual cash incentive award percentage was 110%, equaling a 2018 annual cash incentive award of $238,838.
2019 Executive Bonus Plan Design Changes
To reflect market practice among peer companies and further align pay with performance, in February 2019, our Compensation Committee amended the Executive Bonus Plan to: (i) increase the maximum Company and individual performance percentages from 150% to 200% in the event that the Company or the individual exceeds expected goals or performance for any Plan year and (ii) provide that if a participant’s50% individual performance percentage for any Plan yearto receive a bonus award under our Executive Bonus Plan. If the executive officer’s individual performance percentage is less than 100%,

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COMPENSATION DISCUSSION AND ANALYSIS

then regardless ofwhen calculating the actual Company performance percentage, in calculating such participant’s final bonus payout, the Companyexecutive officer’s corporate performance percentage will be capped at the participant’ssuch individual performance percentage.  These changes are effective aspercentage, regardless of February 2019 and will apply toactual corporate performance.

DISCRETIONARY AND OTHER CASH BONUS AWARDS

Historically, the determination of executiveCompensation Committee has approvedsign-on bonuses for new executives as an inducement to joining Seattle Genetics and to compensate the executive for forgone compensation with a previous employer. In 2019, which willDr. Taylor was paid a $360,000sign-on bonus in connection with the commencement of his employment with us. The Compensation Committee viewed thissign-on bonus as appropriate as part of a package to recruit Dr. Taylor in light of the importance of Dr. Taylor’s skill and experience to our commercialization efforts and the competitiveness of the market for top talent. In addition, in 2019, Dr. Dansey received the portion of hissign-on bonus payable after 18 months of employment in the amount of $150,000. The Compensation Committee viewed thissign-on bonus as appropriate as part of a package to recruit and retain Dr. Dansey in May 2018, particularly in light of the importance of his skills and experience in late stage drug development to our efforts to become a multi-product oncology company. Discretionary bonuses may also be madeawarded for an anniversary with Seattle Genetics. In 2019, Ms. Liu was awarded a five-year work anniversary bonus in early 2020.


Long-Term Equity Awards
the amount of $500.

ANNUAL LONG-TERM EQUITY AWARDS

We offer long-term incentive compensation in the form of equity awards to our executive officers to align their incentives with stockholder value creation.officers. Generally, a significant equity award is granted aton the timedate an executive officer commences employment, with the grant date occurring on the fifteenth day of the month following the month he or she commences employment (or the first business day thereafter).employment. Thereafter, equity awards may be granted at varying times and in varying amounts in the discretion of the Compensation Committee, but are generally granted once a year at the Compensation Committee’s regularly scheduled meeting held in August unless such executive officer is promoted, provided with a retention grant, recognized for outstanding performance or granted a performance-based incentive award. We do not have any program, plan or practice to time stock awards to our executive officers or other employees in coordination with the release of material,non-public information.

Since 2011 the Compensation Committee has delivered annual long-term awards in a combination of options and RSU awards, with options representing approximately 50% of the overall value of the

Annual equity awards are granted and RSU awards comprising the other approximately 50%. Specifically, anunder our 2007 Equity Plan, using mix of different equity grant value is determined for each executive officer role after the Compensation Committee reviews peer group data and the performance of the executive. This total value is then divided in half, and approximately 50% of the value is allocatedinstruments to be granted in the form of options and approximately 50% of the value is allocated to be granted in the form of RSUs.  The number of shares underlying each option grant will be based on an approximation of 50% of grant date fair value, using the Black Scholes methodology for stock options. The number of shares underlying each RSU grant will be calculated by dividing 50% of the value by the average stock price over the 30 calendar days leading up to the date of grant. This 50/50 mix is based on thefurther its goal of attracting and retaining top performers and reflects a balanced approach that includes both options and RSUs. to balance the relative advantages of different instruments.

Stock options are grantedan important vehicle for tying executive pay to performance, because they deliver future value only if the value of our common stock increases above the exercise price and therebyprice. As a result, they provide strong incentives for our executive officers to increase the value of our common stock over the long term. The Compensation Committee grants term, and they tightly align the interests of our executives with those of our shareholders.

RSU awards are granted because they are less dilutive to our stockholders,shareholders, as fewer shares of our common stock are granted to achieve an equivalent value relative to stock options, and because relative to options, RSUsRSU awards are an effective retention tool that maintain value even in a case in which our tradingcases where the share price is low as compared with option exercise prices. Thetrading lower than the initial grant price.

In 2019, our Compensation Committee continuesalso granted PSU awards, including to believe that this mix is appropriate for our current stage of development and is effective in aligningCEO to further align the interestscompensation of our executivesCEO with those of our stockholders.

Generally, each RSU award granted prior to August 2018 cliff vests in full on the third-anniversary of the date of grant, subject to continued service. To better align with the practices of our peer group, each RSU award granted in or after August 2018 vests in four equal installments on the anniversary of the grant vesting commencement date. These vesting provisions are consistent with the intention that these awards servecompany performance, as a long-term retention incentive.further described below.

2018 Long-Term Equity Awards
In line with our typical practice, the equity awards granted to our executive officers in 2018 included a 50/50 combination of stock options and RSU awards that may be settled for shares of our common stock.

In August 2018,ALLOCATION OF ANNUAL EQUITY AWARDS

Generally, the Compensation Committee considered and approveddetermines the grantvalue of each executive officer’s annual equity awards to our executive officers after reviewinggrant using a holistic evaluation that takes into account a competitive market analysis prepared by Compensia and referencing the 50th percentileour independent compensation consultant with market data for each role, the recommendations of our CEO based on his evaluation of their individual performance (except with respect to the CEO'sCEO’s performance), the executive officer’s prior grant levels and the extent to which the executive officer is currently vested in his or her stock awards, scope and criticality of the executive’s role and parity in targets among executives in roles of a given level. In cases of outstanding performance, theThe Compensation Committee will approvedoes not target a specific percentile within our peer group to determine annual equity awards targetingfor the 75th percentile. Based on Dr. Siegall's crucial leadershipnamed executive officers. Instead, we review the practices of our peer group and outstanding performance,the general biotechnology market as merely a reference point to assist us in 2018,developing programs designed to attract and retain exceptional talent and drive company performance.

In August 2019, the Compensation Committee approved anthe annual equity awards for our named executive officers (other than our CEO) in a combination of options and RSU awards with approximately 50% of the value allocated in the form of options and approximately 50% of the value allocated in the form of RSU awards.

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COMPENSATION DISCUSSION AND ANALYSIS

In the case of the annual equity awards granted to our CEO, based on investor feedback and to further align equity compensation of our CEO with company performance and market practice among peer companies, we granted approximatelyone-third of the overall value of our CEO’s 2019 equity grant at approximatelyin the 75th percentileform of PSU awards,one-third in the form of RSUs andone-third in the form of stock options.

2019 TARGET ANNUAL LONG-TERM EQUITY AWARDS

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The number of shares underlying each stock option grant was calculated by dividing the target value of the option award by the product of the average stock price for the 30 calendar days prior to Dr. Siegall.

the effective date of the grant and the Company’s then-current Black-Scholes factor. The table below shows the number of shares underlying each RSU grant and the target number of shares underlying each PSU grant were calculated by dividing the target value of the grant by the average stock price over the 30 calendar days leading up to the date of grant.

Each RSU award granted as part of the annual equity awards in 2019 vests in four equal installments on the anniversary of the grant vesting commencement date. Each option award granted as part of the annual equity awards in 2019 have a ten year term and vest as to 1/4th of the shares subject to the stock options and RSU awards granted to our named executive officers in the 2018 annual equity grant (other than pursuant to the special performance-based incentive awards described separately above and below), as well as the total grant date fair value of these awards on the applicable date of grant.

Named Executive Officer 
Options to Purchase
Shares of our Common
Stock
 
RSU Awards for Shares of
our Common Stock
 
Aggregate Grant Date
Fair Value (1)
Dr. Siegall 227,984 95,981 $14,916,892
Mr. Simpson 49,205 20,715 $3,219,442
Dr. Dansey (2)
 17,199 7,241 $1,131,657
Dr. Himes 42,644 17,953 $2,790,176
Mr. Cline 44,285 18,644 $2,897,553


_______________ 
(1)The amounts in this column represent the aggregate full grant date fair value of stock options and RSUs granted in the 2018 annual grants in accordance with FASB ASC Topic 718 with no estimate for future forfeitures. For information regarding the assumptions used in calculating these amounts with respect to stock options, see Note 16 of the Notes to the Consolidated Financial Statements included in our Annual Report on Form 10-K for theone year ended December 31, 2018.
Dr. Dansey's annual equity grant was prorated in light of his partial year of service with us as of the date of grant. The table above reflects only annual equity grants and does not include the performance-based RSU grant to Dr. Dansey or his new hire grants discussed below. A portion of Dr. Dansey's annual equity award was granted in September 2018 in order to fix a proration error with respect to his August 2018 annual equity award.
(2)Dr. Dansey also received a new hire option grant for 50,000 shares and a new hire RSU award for 70,000 shares in connection with and as an inducement to his commencement of employment with us. Vesting of 50,000 shares underlying the new hire RSU grant will occur in full on the third anniversary of the grant date. Vesting of 20,000 shares underlying the new hire RSU grant will occur 50% on the first anniversary of the grant date and 50% on the second anniversary of the grant date.
The annual grant options to purchase shares of our common stock granted to our named executive officers in 2018 in the annual equity grant described above vest as to 25% of the shares subject to the option upon the first anniversary of the grant date and as to 1/36th of the remaining shares each month thereafter until such grantoption is fully vested on the fourthfour year anniversary of the grant date. Such optionsThese vesting provisions are also subject to vesting acceleration as described under “—Post-Employment Compensation” below.
The exercise pricecontinued employment of the options granted to our executive officers in 2018 equaled the fair market value of our common stock, the closing price of our common stock on the Nasdaq Global Select Market, onapplicable vesting date and are subject to accelerated vesting under the dateterms of grant.
each executive’s employment agreement with us and pursuant to the 2007 Equity Plan. These vesting provisions are consistent with the intention that these awards serve as a long-term retention incentive.

RSUCEO PSU AWARDS

The PSU awards granted to our CEO were allocated among two separate awards and are not earned unless certainpre-specified long-term performance goals are achieved, as shown in the table below.

Percentage of Total CEO

PSU Grant, by Target

Number of Shares

Type of Target

Factors Considered to Establish Rigorous

Targets

Performance

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Adjusted Revenue—designed to only include revenues tied to products, program candidates or research programs that we owned at the time of grant, to incentivize organic revenue growth in our core business rather than revenue from acquisitions

Target value is based on an internal benchmark for revenue growth and long-range goals that incorporate optimistic assumptions regarding contributions from the commercialization of PADCEV and the potential commercialization of one or more of our product candidates. In order to achieve the target, the Company must achieve significant revenue growth.

Fiscal Year

2022

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Relative TSR—designed to measure our relative TSR performance compared to a group of other public biotechnology companies, or the PSU Index Companies(1)

Based on relative performance as compared to other public biotechnology companies.Three years,

beginning

September 1,

2019

(1)

The other public biotechnology companies are ACADIA Pharmaceuticals Inc.; Agios Pharmaceuticals, Inc.; Alexion Pharmaceuticals, Inc.; Alkermes plc; Alnylam Pharmaceuticals, Inc.; Amgen Inc.;Bio-Techne Corporation; Biogen Inc.; BioMarin Pharmaceutical Inc.; bluebird bio, Inc.; Charles River Laboratories International,

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COMPENSATION DISCUSSION AND ANALYSIS

Inc.; Exact Sciences Corporation; Exelixis, Inc.; FibroGen Inc.; Gilead Sciences, Inc.; Grifols SA ADR; Illumina, Inc.; Incyte Corporation; Intercept Pharmaceuticals Inc.; Ionis Pharmaceuticals, Inc.; IQVIA Holdings Inc.; Nektar Therapeutics; Neurocrine Biosciences, Inc.; QIAGEN N.V.; Regeneron Pharmaceuticals, Inc.; Sarepta Therapeutics, Inc.; Ultragenyx Pharmaceuticals Inc.; United Therapeutics Corporation; and Vertex Pharmaceuticals Incorporated. The list of companies is subject to adjustment in certain circumstances such as a bankruptcy, acquisition of the reference company or going private transaction.

Each PSU award granted in 2019 will vest upon the Compensation Committee’s certification as to the level of achievement of the performance target. Depending on the adjusted revenue and relative TSR results actually achieved, the payout on each of these PSU awards may vary from 0% to 200% of target. In addition, for each PSU award, a threshold level of performance must be achieved or no stock units will be earned.

At the time the Compensation Committee set the 2022 Adjusted Revenue target, the Company was a single-product oncology company, with only ADCETRIS approved for marketing. Nevertheless, the target was set at a level that the Compensation Committee believed would only be achievable if the Company expanded into a multi-product oncology company. The Compensation Committee set the target at a level that it believed challenging and that presented significant risk of not being achieved in light of the competitive nature of our industry, pricing pressures, the stage of our pipeline candidates and the degree of execution required to expand into a multi-product oncology company on the scale necessary to meet the target. In addition, for a single product company to adequately forecast its revenues three years in the future for multiple products involves a significant amount of challenge, uncertainty and risk of loss.

The PSU award based on Relative TSR, or the Relative TSR PSU award, vests based on the Company’s TSR performance relative to the PSU Index Companies over a three-year performance period. To calculate the Company’s relative TSR performance, the cumulative three-year TSR performance for the Company and each of the PSU Index Companies is calculated and then the Company’s discrete percentile rank is calculated. The potential payouts for the TSR PSU are set forth below.

Company’s Relative TSR Ranking

Percentage of
Target Shares

90th percentile or above

200%

75th percentile

150%

50th percentile

100%

25th percentile

25%

Below 25th percentile

0%

Vesting of the PSU awards granted as part of the annual equity awards in 2019 will cease upon termination of service as an employee for any reason other than death or disability. The PSU awards provide for acceleration of vesting in the event of certain specified change in control events involving us or the termination of our CEO’s employment due to death or disability. Vesting of the PSU awards granted in 2019 will cease upon termination of service as an employee for any reason other than death or disability. The PSU awards provide for acceleration of vesting in the event of certain specified change in control events wherein the PSU awards are assumed by the surviving entity, the PSU awards will convert to time-based vesting and cliff vest on the last day of the applicable performance period, subject to our CEO’s continued service through the applicable vesting date; provided, however, that if our CEO is involuntarily terminated immediately prior to or within 12 months after any such change in control event, the PSU awards will vest effective as of the date of such involuntary termination.

PARTIALLY EARNED EV/TV LTIP AWARDS

In September 2017, the Compensation Committee approved a long-term incentive plan, or the EV/TV LTIP, for the purpose of incentivizing the Company’s employees to achieve regulatory approval of PADCEV and potentially achieve regulatory approval of tisotumab vedotin, or TV, a product candidate currentlybeing co-developed by the Company and Genmab A/S, or Genmab, under the Company’s collaboration and license agreement with Genmab. The EV/TV LTIP provides that each eligible employee, including each named executive officer, is eligible to receive a cash award and, depending on the participant’s position with the Company, may also be eligible for an RSU award, subject to the participant’s (i) continued employment with the Company and (ii) good standing as of each applicable payment and grant date. A portion of each cash award was payable and a portion of each RSU award was to be granted upon certification by the Compensation Committee that the FDA approved PADCEV. PADCEV received FDA accelerated approval on December 18, 2019. As a result, the Compensation Committee approved cash awards and the grant of RSU awards to eligible employees, including our named executive officers, under the EV/TV LTIP in December 2019. The EV/TV LTIP RSU awards that were granted will vest on the second anniversary of the date of FDA approval, subject to continuous service with the Company through the vesting date. A portion of the award remains earnable based on performance against goals related to TV.

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PSU AWARDS DEEMED ELIGIBLE TO VEST

In August 2018, (other thanthe Compensation Committee also approved a PSU grant to Dr. Dansey with a target and maximum number of shares equal to 17,263. The PSU awards vest in tranches contingent on the FDA’s approval of PADCEV, tucatinib and TV but will not vest prior to December 31, 2021, subject to Dr. Dansey’s new hire RSU award andcontinued employment on the awards granted undervesting date. Upon the Tucatinib LTIP, as described below)Compensation Committee’s certification that PADCEV received FDA accelerated approval, the EV portion of the PSU was deemed eligible to vest. The EV portion will vest 25% per year over a four year period,on December 31, 2021, subject to Dr. Dansey’s continued employment on the vesting acceleration as described under “—Post-Employment Compensation” below.date.

EV FRONTLINE PSU AWARDS

Performance-Based Incentive Awards

From time to time we grant long-term cash or equity incentive opportunities intended to drive attainment of key performance goals over a multi-year period.


Tucatinib LTIP
On October 24, 2018, Effective as of December 31, 2019, the Compensation Committee approved the Tucatinib LTIP forgrant of PSU awards, or the purposeEV Frontline PSU awards, to eligible employees, including our named executive officers, as part of incentivizing the Company’sa company-wide long-term incentive grant to incentivize our employees to potentially achieve the FDA approval of tucatinib.
UnderPADCEV in combination with pembrolizumab with or without platinum chemotherapy in previously untreated urothelial cancer patients, or the Tucatinib LTIP, our executive officers are eligible to receive grants of RSU awards relating to our common stock, which consist of a “First Tranche” and a “Second Tranche” as set forth in the Tucatinib LTIP, each of which is granted as a separate RSU award on the applicable date of grant. Any RSU awards provided under the Tucatinib LTIP are granted under, and subject to the terms of, our Amended and Restated 2007 Equity Incentive Plan, or our 2007 Equity Plan, and our standard forms of Stock Unit Grant Notice and Stock Unit Agreement for United States employees and non-United States employees.
frontline urothelial cancer indication.

The target number of stock units in the First Tranche granted on November 1, 2018 equaled 50% of the target award value applicable tovalues for each executive officer divided by the average closing price of our common stock for the 30 calendar day period ending on October 31, 2018. The First Tranche will only vest upon certification by the Compensation Committee of the first approval by the FDA for the commercial sale and marketing of tucatinib in the United States by us or any of our partners for any indication, based on the clinical trial data from the pivotal HER2CLIMB trial (such achievement, the Tucatinib Milestone, and the date on which the Compensation Committee certifies achievement, the Certification Date), provided that the executive officer is still employed by us as of the date of vesting. If the First Tranche vests due to achievement of the Tucatinib Milestone, the number of shares that vest will be determined by multiplying the target number of RSUs subject to each RSU award by the applicable earn out percentage. An earn out percentage, on a sliding scale from 0% to 144%, will be determined based on the date of achievement of the Tucatinib Milestone and the breadth of the indication or indications, as the case may be, for which tucatinib is approved by the FDA for commercial sale and marketing in the United States on the date that the Tucatinib Milestone occurs.

The Second Tranche will be granted upon certification by the Compensation Committee of achievement of the Tucatinib Milestone provided that the executive officer is still employed by us as of the date of grant. The number of RSUs granted, if any, with respect to the Second Tranche will be equal to 50% of the target award value applicable to each executive officer multiplied by the applicable earn out percentage determined by the Compensation Committee on the Certification Date, with

the product of these numbers then divided by the average closing sales price of our common stock for the 30 calendar day period ending on the calendar day prior to the date of grant of the Second Tranche. If the Second Tranche is granted due to achievement of the Tucatinib Milestone, it will vest on the second anniversary of the Certification Date, provided that the executive officer’s continuous service with us has not terminated prior to the vesting date.
The vesting of each outstanding RSU is subject to partial or full acceleration in the event of a termination of service (without cause or due to constructive termination) immediately prior to, or within twelve months after, a change of control of Seattle Genetics, or in the event an acquirer in a change of control of Seattle Genetics fails to assume the stock unit awards.
If the Tucatinib Milestone is not achieved by a specified date, then the First Tranche will not vest, the Second Tranche will not be granted and the Tucatinib LTIP will automatically terminate. In addition, in the event that we cease to have rights to tucatinib, the Tucatinib LTIP shall automatically terminate.
The target values for these Tucatinib LTIPEV Frontline PSU awards approximate full year bonus target applicable for each individual executive’sthe executive officer’s grade level. The Compensation Committee selected this approach to setting target value because the Compensation Committee previously used the same approach with respect to long-term incentive plans it previously approved in 2010 and 2016, and continues to see this approach as an effective means to reach its incentive and retention goals for this plan.
The target award values for our named executive officers underthese PSU awards.

None of the Tucatinib LTIP are as follows:

Named Executive OfficerTarget Award Value
Dr. Siegall$920,000
Mr. Simpson$280,000
Dr. Dansey$280,000
Dr. Himes$280,000
Mr. Cline (1)
$200,000
 _________________
(1)Mr. Cline is not eligible to earn any awards under the Tucatinib LTIP because his last day of employment was March 21, 2019 and no performance milestones under the Tucatinib LTIP had been achieved as of that date.
Dr. Dansey Performance RSU and EV/TV LTIP Participation
In August 2018,EV Frontline PSU awards will vest unless the Compensation Committee also approvedcertifies that a performance-based RSU grantmilestone has been met under the EV Frontline PSU awards. Upon certification that the FDA has granted accelerated approval of PADCEV in the frontline urothelial cancer indication, or the Accelerated Approval Milestone, 25% of the target number of stock units will vest, provided that the applicable executive officer is still employed by us as of the date of vesting. Upon certification that the FDA has granted regular approval of PADCEV in the frontline urothelial cancer indication, or the Regular Approval Milestone, 75% of the target number of stock units will vest, provided that the applicable executive officer is still employed by us as of the date of vesting.

Each of the Accelerated Approval Milestone and the Regular Approval Milestone has a deadline by which it must be achieved. If it is not achieved by its deadline, then the associated number of stock units will be forfeited. Neither the Accelerated Approval Milestone nor the Regular Approval Milestone can be achieved within one year of the date of grant.

DISCRETIONARY AND OTHER EQUITY AWARDS

Discretionary equity awards may be granted for special recognition of achievement and to provide an additional long-term retention and other incentives to top performing employees. In February 2019, Dr. Dansey received a special-recognition RSU award valued at $412,297 in recognition of his leadership in connection with a target and maximumthe FDA accelerated approval of ADCETRIS for the treatment of peripheralT-cell lymphoma patients based on the results of theECHELON-2 trial. The number of shares equalsubject to 17,263 and a grant date fairthis RSU award was determined by dividing the target value of $1,337,019. The RSU will vest in tranches contingent on FDA approval of EV, FDA approval of tucatinib and FDA approval of TV, subjectthe award by the average stock price for the thirty days prior to Dr. Dansey’s continued employment on the vesting date. The performance-based RSU was granted to Dr. Dansey in order to enhance retention and further incentivize his efforts in support of key late stage drug development programs. The vesting of Dr. Dansey’s performance-basedan including January 31, 2019. This RSU award is subject to partial accelerationvesting in the event an acquirer in a change of control of the Company fails to assume the RSU award or Dr. Dansey is terminated in certain circumstances following a change in control.

In addition, upon his hiring, Dr. Dansey became eligible to participate in the Long-Term Incentive Plan for EV and TV, or the EV/TV LTIP, which the Compensation Committee adopted in 2017. Dr. Dansey will be eligible to receive a potential cash award and potential RSUs upon the achievement of applicable milestones.
The Compensation Committee approved the EV/TV LTIP in 2017 for the purpose of incentivizing the Company’s employees to potentially achieve regulatory approvals of (i) enfortumab vedotin, a product candidate currently being co-developed by the Company and Astellas under the Company’s collaboration and license agreement with Astellas (the “EV Collaboration Agreement”), and (ii) tisotumab vedotin, a product candidate currently being co-developed by the Company and Genmab under the Company’s collaboration and license agreement with Genmab (the “TV Collaboration Agreement”).
The Compensation Committee designed the EV/TV LTIP to include an award that is 50% cash and 50% RSUs basedfour equal tranches on the long term nature of the goal and the additional retentive value that can be provided by RSU awards.
A portion of each cash award will become payable, and a portion of each RSU award will be granted, only upon certification by the Compensation Committee that the FDA has approved enfortumab vedotin (such approval, the “EV Approval Milestone”), and the remaining portion of each cash award will become payable, and the remaining portion of each RSU award will be granted, only upon certification by the Compensation Committee that the FDA has approved tisotumab vedotin (such achievement, the “TV Approval Milestone” and together with the EV Approval Milestone, the “Milestones”), provided in each case that Dr. Dansey is still actively employed by the Company. The Compensation Committee selected these milestones because of their importance to our long-term business strategy and have the potential, if achieved, to drive increases in stockholder value. Any RSU awards granted to Dr. Dansey due to achievement of a Milestone will vest on the second anniversary of the occurrence of such Milestone, provided that Dr. Dansey’s continuous service with the Company or any of its

subsidiaries has not terminated prior to the vesting date. The vesting of any granted RSU awards iscommencement date until vested in full, subject to full acceleration in the event of a termination of Dr. Dansey’s service (without cause or due to constructive termination) immediately prior to, or within twelve months after, a change of control of the Company, or in the event an acquirer in a change of control of the Company fails to assume the RSU awards. If a Milestone is not achieved by a specified date, then no cash or RSU awards will be paid or granted with respect to such Milestone. In addition, in the event that the Company exercises its right to terminate its co-funding obligations with respect to enfortumab vedotin under the EV Collaboration Agreement (an “EV Opt-Out”) prior to the achievement of the EV Approval Milestone, or with respect to tisotumab vedotin under the TV Collaboration Agreement (a “TV Opt-Out”) prior to the achievement of the TV Approval Milestone, then no cash or RSU awards will be paid or granted with respect to such Milestone. If both an EV Opt-Out and a TV Opt-Out occur, then the EV/TV LTIP will automatically terminatecontinued employment on the later to occur of the date of the EV Opt-Out and the date of the TV Opt-Out. Likewise, the EV/TV LTIP will automatically terminate if neither Milestone is achieved by a specifiedapplicable vesting date. Any RSU awards provided to Dr. Dansey pursuant to the EV/TV LTIP will be granted under, and subject to the terms of, the 2007 Equity Plan.
The target cash award value for Dr. Dansey was $94,000 and the target RSU award value (expressed in dollars) for Dr. Dansey was $94,000 and such target values were determined based on the target value approved by the Committee for C-level officers under the EV/TV LTIP (which was prorated to reflect the extent of Dr. Dansey's service during the total performance period under the EV/TV LTIP). The Compensation Committee selected this approach to setting Dr. Dansey’s target values because we previously set the target award values for our other executives based on their 2017 bonus targets when the EV/TV LTIP was adopted. Actual cash and RSU award values, on a sliding scale from 0% to 120% of the target award value, are calculated based on the dates of achievement of each Milestone.
The amount of cash paid, if any, with respect to the EV Approval Milestone for Dr. Dansey will be equal to 50% of the target cash award value, multiplied by a specified percentage with respect to such Milestone, multiplied by the applicable earn out percentage from the sliding scale. The amount of cash paid, if any, with respect to the TV Approval Milestone will be equal to 50% of Dr. Dansey’s target cash award value, multiplied by a specified percentage with respect to such Milestone, multiplied by the applicable earn out percentage from the sliding scale. The number of restricted stock units granted, if any, with respect to the EV Approval Milestone to Dr. Dansey will be equal to 50% of Dr. Dansey’s target RSU award value, multiplied by a specified percentage with respect to such Milestone, multiplied by the applicable earn out percentage from the sliding scale, with the product of these numbers then divided by the closing price of the Company’s common stock on the date of grant. The number of restricted stock units granted, if any, with respect to the TV Approval Milestone to Dr. Dansey will be equal to 50% of Dr. Dansey’s target RSU award value, multiplied by a specified percentage with respect to such Milestone, multiplied by the applicable earn out percentage from the sliding scale, with the product of these numbers then divided by the closing price of the Company’s common stock on the date of grant. The specified percentages with respect to the Milestones together equal 100%.
ECHELON-1 LTIP Earned Awards
In May 2016, the Compensation Committee approved the ECHELON-1 LTIP, a performance-based long-term incentive plan to incentivize our executive officers and other employees to achieve FDA regulatory approval of a label expansion of ADCETRIS based on the phase 3 ECHELON-1 trial. Under the ECHELON-1 LTIP, each participant was eligible to receive a cash award and an option to purchase shares of our common stock. We received FDA approval of the ADCETRIS label expansion in March 2018. As a result, the Compensation Committee approved the following cash awards under the ECHELON-1 LTIP to our named executive officers, which were paid in March 2018, and the following stock options previously granted in 2016 will be eligible to vest in four equal annual installments on the first four anniversaries of the date of the FDAapproval:
Named Executive Officer Earned Cash Award 
Options for Shares of
our Common Stock
Dr. Siegall $212,500  37,280 
Mr. Simpson 60,000  10,526 
Dr. Dansey(1)
 

  

 
Dr. Himes 47,500  8,333 
Mr. Cline 47,500  8,333 
_______________ 
(1) Dr. Dansey did not receive any award under the ECHELON-1 LTIP because he commenced employment with us in May 2018.
Discretionary and Other Bonus Awards.
Discretionary bonuses may be awarded for special recognition of achievement or for an anniversary with Seattle Genetics.

Historically, the Compensation Committee has also approvedsign-on bonuses equity grants for new executives as an inducement to joining Seattle Genetics, and to compensate the executive for forgone compensation with a previous employer.employer and to provide long-term retention incentive. In 2018,2019, Dr.


Dansey Taylor was paid a $300,000 awardedsign-on bonus equity grants consisting of stock options valued at $1,515,200 and RSUs valued at $1,821,825 in connection with the commencement of his employment with us. The stock options were subject to vesting as to 1/4th of the shares subject to the options on the one year anniversary of the grant date and 1/36th of the remaining shares each month thereafter until such options are fully vested on the four year anniversary of the grant date, subject to continued employment on the applicable vesting date. A portion of the RSUs valued at $305,225 was subject to vesting in full one year from the grant date and was intended to compensate Dr. Taylor for forgone compensation with his previous employer. The remaining RSUs valued at $1,516,600 were subject to vesting in four equal tranches on the anniversary of the vesting commencement date until vested in full, subject to continued employment on the applicable vesting date. The amount and vesting timing of thesesign-on equity grants were negotiated with Dr. Taylor prior to the commencement of his employment.

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COMPENSATION DISCUSSION AND ANALYSIS

The Compensation Committee viewed this sign on bonusthesesign-on equity grants as appropriate as part of a package to recruit Dr. DanseyTaylor in light of the importance of Dr. Dansey'sTaylor’s skill and experience to our late stage drug development efforts. In addition, Dr. Siegall was paid a twenty year employee anniversary bonus of $2,000commercialization efforts and Mr. Simpson received a $13,300 CEO award, which included a $3,300 gross up for taxes, that the Compensation Committee and Dr. Siegall awarded as partcompetitiveness of the Company’s CEO award program to recognize Mr. Simpson's outstanding performance in connection with our acquisition of Cascadian and follow-on equity financing in the first quarter of 2018.

Health and Welfare Benefits
market for top talent.

HEALTH AND WELFARE AND RETIREMENT BENEFITS

All of our named executive officers are eligible to receive our standard employee benefits, such as our 401(k) plan, medical, dental and vision coverage, short-term disability, long-term disability, group life insurance, cafeteriaand employee stock purchase plan, and the ESPP, in each case on the same basis as our other employees, including the matching contributions provided under our Section 401(k) plan. For 2018,2019, we made a matching contribution equal to 75%100% of each employee’s salary deferral contribution up to 6%5% of the employee’s compensation, subject to the applicable statutory limit. For 2019,2020, the match has changed to 100% of each employee'semployee’s deferral up to 5%5.5% of eligible compensation. The matched contribution is not subject to a vesting period.

Other Benefits
We provide

OTHER BENEFITS

In 2019, Dr. Dansey withreceived reimbursement of the cost of hisfor commuting expenses incurred in connection with his travel from his California residence to our headquarters in Bothell, Washington, including airfare and the cost of a corporate apartment. The Compensation Committee approved this benefit toapartment, grossed up for related payroll taxes. These commuting benefits were negotiated with Dr. Dansey in orderat the time of his initial employment and were deemed a reasonable expense and necessary inducement to induce his commencement of employment with us, particularly in light of the importance of his skills and experience in late stage drug development to our efforts to become a multi-product oncology company. In addition, Dr. Taylor received reimbursement for relocation costs in connection with the commencement of his employment with us, grossed up for related payroll taxes. This benefit was deemed a reasonable expense and necessary inducement to his commencement of employment with us.

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Post-Employment

COMPENSATION DISCUSSION AND ANALYSIS

2019 KEY COMPENSATION DECISIONS FOR NAMED EXECUTIVE OFFICERS

The table below highlights performance factors and key compensation decisions for our named executive officers for 2019. It includes decisions regarding base salary, annual cash incentive awards and annual equity awards. It does not include other forms of compensation the executive officers received, including EV Frontline PSU awards, earned awards under the EV/TV LTIP, discretionary or other cash or equity awards, retirement and benefits plans or other remuneration. For additional information, please see “Compensation-Setting Process” above and “Summary Compensation Table” below.

Named Executive Officer Performance2019 Key Compensation Decisions

Dr. Siegall

2019 was an exceptional year for the Company and the patients we serve. We became a multi-product company with the FDA accelerated approval of PADCEV, filed our New Drug Application for tucatinib, and served more patients than ever before with ADCETRIS. Specifically:

FINANCIAL PERFORMANCE

  Under Dr. Siegall’s leadership in 2019, revenue grew by more than 40% in 2019 to over $916M. ADCETRIS net sales in the U.S. and Canada were strong, growing by more than 32% when compared to 2018.

 Additionally, the Company’s one-year TSR was at the 88th percentile when compared to our peers for 2019.

PRODUCTS

  During 2019, under Dr. Siegall’s leadership, the Company transformed into a multi-product company with PADCEV’s accelerated approval for patients suffering with metastatic urothelial cancer.

 Additionally, the Company submitted marketing applications to the FDA and EMA for tucatinib in HER2+ breast cancer. This product candidate met all primary and secondary endpoints and would, if approved, expand our commercial reach from just the U.S. & Canada to other countries around the globe.

 In addition, the Company filed three IND applications with the FDA, and assumed an additional IND application, to bring new potential therapies into the clinic.

PEOPLE

  During 2019, Dr. Siegall oversaw the continued evolution of the Company into a global, multi-product oncology company and the integration of hundreds of new employees to deliver on the vision of serving more patients.

  He oversaw the hiring and onboarding of seven new key executive leaders.

  He was heavily engaged in discussions around our global commercial strategy and the footprint the Company should have as it prepares to commercialize tucatinib.

  He remains very involved in overseeing the work to drive cultural changes that support the creation of an environment where each employee can thrive, do their best work and support the Company’s mission.

  He also continues to be involved in work promoting diversity, inclusion and pay equity.

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Base Salary: Effective February 1, 2019 Dr. Siegall’s base salary increased by 5.0% to $967,208 due to performance and to maintain competitive positioning in the market.

Annual Cash Incentive Award: Dr. Siegall’s annual bonus was 160% of target and reflected the corporate performance percentage. To ensure absolute alignment between the CEO’s bonus and corporate performance, Dr. Siegall’s bonus percentage is equal to the corporate performance percentage.

Annual Equity Awards: Dr. Siegall’s annual equity awards granted August 30, 2019 had a grant date fair value of $10,675,042, which consisted of approximately 1/3 options, 1/3 RSU awards and 1/3 PSU awards. Of the PSU awards, 20% of the target number of shares were based on TSR relative to the PSU Index Companies, and 80% were based on 2022 Adjusted Revenue, or the Adjusted Revenue PSU award.

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COMPENSATION DISCUSSION AND ANALYSIS

Named Executive Officer Performance2019 Key Compensation Decisions

Mr. Simpson

FINANCIAL PERFORMANCE

  Mr. Simpson provided leadership in multiple transactions, including raising approximately $550M in new capital and multiple licensing and collaboration arrangements. The Company ended 2019 with over $2B in assets and no debt.

PRODUCTS

  Under Mr. Simpson’s leadership, the Company invested over $719M into research and development, and made investments to prepare for the commercialization of the Company’s second and potentially third products in 2020.

PEOPLE

  During 2019, Mr. Simpson oversaw the scaling of the finance team, and the hiring and onboarding of a new head of global real estate and facilities, to support multiple products and our expanding global operations.

  Mr. Simpson also assumed the leadership and oversight of our European expansion.

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Base Salary: Effective February 1, 2019, Mr. Simpson’s salary increased by 6.34% to $575,200 due to performance, an expanding role, and to align with the market.

Annual Cash Incentive Award: Mr. Simpson’s annual bonus was 148% of target and reflected an individual performance factor of 130%.

Annual Equity Awards: Mr. Simpson’s annual equity awards granted August 30, 2019 had a grant date fair value of $3,098,483, which consisted of approximately 50% options and 50% RSU awards.

Dr. Dansey

PRODUCTS

  With the support of Dr. Dansey’s leadership, the Company completed two pivotal studies and released positive results for both PADCEV and tucatinib paving the way for the Company to become a multi-product, global oncology company.

  Under Dr. Dansey’s leadership in 2019, the Company obtained FDA accelerated approval for PADCEV and submitted a New Drug Application for tucatinib to the FDA under the Real Time Oncology Review program in less than three months following topline results from theHER2CLIMB-01 trial.

  Dr. Dansey also oversaw a large expansion of the scope of development efforts for ADCETRIS, PADCEV and tucatinib to potentially expand the labels for these drugs and bring these drugs to more patients in need.

  Under Dr. Dansey’s leadership in 2019, the Company filed three IND applications with the FDA, and assumed an additional IND application, to bring new potential therapies into the clinic.

PEOPLE

  During 2019, Dr. Dansey oversaw the continued solidification of his leadership team.

 In addition, he added a new head of Global Medical Affairs and oversaw the growth of his global development team, as we prepare to expand into multiple products and geographies.

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Base Salary: Effective February 1, 2019, Dr. Dansey’s salary increased by 3.51% to $672,800 due to performance and to maintain competitive positioning in the market.

Annual Cash Incentive Award: Dr. Dansey’s annual bonus was 166% of target and reflected an individual performance factor of 175%.

Annual Equity Awards: Dr. Dansey’s annual equity award granted August 30, 2019 had a grant date fair value of $4,290,155, which consisted of approximately 50% options and 50% RSU awards.

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COMPENSATION DISCUSSION AND ANALYSIS

Named Executive Officer Performance2019 Key Compensation Decisions

Ms. Liu

FINANCIAL PERFORMANCE

  With the support of Ms. Liu’s leadership, the Company executed multiple transactions, including raising over $700M in new capital and thein-licensing of new technology such as the partnership with BeiGene to develop an advanced preclinical product for the treatment of cancer.

PRODUCTS

  With the support of Ms. Liu’s leadership, we believe that the Company is positioned to support multiple products globally.

  In addition, Ms. Liu was instrumental in the Company’s efforts to protect and maximize its intellectual property assets and in managing the Company’s litigation matters.

PEOPLE

  During 2019, Ms. Liu oversaw the expansion of her legal team and its capabilities in transactional law, securities law, compliance and the Company’s European expansion.

LOGO

Base Salary: Effective February 1, 2019, Ms. Liu’s salary increased by 4.5% to $522,200 due to performance and to maintain competitive positioning in the market.

Annual Cash Incentive Award: Ms. Liu’s annual bonus was 148% of target and reflected an individual performance factor of 130%.

Annual Equity Award: Ms. Liu’s annual equity award granted August 30, 2019 had a grant date fair value of $2,764,754, which consisted of approximately 50% options and 50% RSU awards.

Dr. Taylor

FINANCIAL PERFORMANCE

  The Compensation Committee considered the level of ADCETRIS net sales in the U.S. and Canada in reviewing Dr. Taylor’s performance.

PRODUCTS

  During 2019, Dr. Taylor oversaw the meetings and discussions to determine our global commercial strategy and the product launches for PADCEV and tucatinib (if approved) while also leading our ADCETRIS sales organization.

PEOPLE

  After joining the Company in May of 2019, Dr. Taylor supported the build out and launch readiness for two potential new products: enfortumab vedotin (PADCEV, which has since been approved) and tucatinib.

LOGO

Base Salary: Dr. Taylor joined the Company in May 2019 with a base salary of $500,000.

Annual Cash Incentive Award(1): Dr. Taylor’s annual bonus was 80% of target and reflected an individual performance factor of 80%.

Annual Equity Award(1): Dr. Taylor’s annual equity award granted August 30, 2019 had a grant date fair value of $679,140, which consisted of approximately 50% options and 50% RSU awards.

(1) The chart above reflects annualized amounts to represent full-year awards for Dr. Taylor’s position.

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COMPENSATION DISCUSSION AND ANALYSIS

POST-EMPLOYMENT COMPENSATION

We provide severance benefit protection to our named executive officers through our individual employment agreements with each such individual. The Compensation Committee reviewed the employment agreements against our updated peer group in August 2018, and approved the following revisions to the severance benefit terms of the employment agreements to more closely conform our severance benefit practices to those of our peer group. These revised employment agreement terms became effective in October 2018.

The following changes were made to Dr. Siegall’s employment agreement:
In the event that his employment is constructively terminated or terminated by us without cause and not in connection with a change of control, he will be entitled to receive cash severance in the form of his monthly base salary for 18 months instead of 12 months as was provided under his prior agreement, the COBRA premium benefit period was also increased to 18 months, and he will receive a new additional payment equal to his annual target bonus multiplied by one and one-half.
If such termination occurs immediately prior to or within 12 months after a change of control, Dr. Siegall will be entitled to receive an additional payment equal to his annual target bonus multiplied by two plus an amount equal to a pro-rated portion of his annual target bonus based on the percentage of time during the applicable year he was employed by us (and his prior 24 month base salary cash severance and COBRA premium benefit period remains unchanged). We also replaced the single-trigger change of control equity vesting acceleration provision in Dr. Siegall’s previous agreement with a double-trigger providing for vesting acceleration of all of Dr. Siegall’s outstanding and unvested equity awards if his employment is constructively terminated or terminated by us without cause immediately prior to or within 12 months after a change of control.
The following changes were made to each of Mr. Simpson, Dr. Dansey, Dr. Himes and Mr. Cline’s employment agreements:
In the event that the applicable executive officer’s employment is constructively terminated or terminated by us without cause and such termination is not immediately prior to or within 12 months after a change of control, the executive officer will be entitled to receive an additional severance payment equal to his or her annual target bonus (the 12 months’ base salary cash severance, COBRA premium and equity vesting benefit in the employment agreements that we previously entered into with these executive officers was not unchanged).
In the event that the applicable executive officer’s employment is constructively terminated or terminated by us without cause immediately prior to or within 12 months after a change of control, then such executive officer will be entitled to receive payment of COBRA health insurance premiums and cash severance in an amount equal to his or her monthly base salary for a period of 18 months (instead of 12 months as provided under the prior agreements), plus an additional amount equal to his or her annual target bonus multiplied by one and one-half. The double-trigger change of

control vesting acceleration provisions in the employment agreements that we had previously entered into with these executive officers remain unchanged.

The Compensation Committee believes these severance payments and benefits are important from a retention perspective to provide some level of protection to our executive officers from having their employment terminated without cause or constructively terminated prior to or after a change in control of the Company, or from experiencing a life-changing disability, and that the amounts are reasonable when compared with similar arrangements adopted by other biotechnology companies. In addition, the Compensation Committee believes that these severance payments and benefits align our executive officer and stockholdershareholder interests by enabling them to consider corporate objectives and possible transactions that are in the best interests of the stockholdersshareholders and other constituents of the Company without undue concern over whether such objectives or transactions may jeopardize their own employment.

With these arrangements, the Compensation Committee sought uniformity of terms among our executive officers based on their positions at the Company. In addition, the Compensation Committee believes that the payment-triggering event outside of the death or disability context, namely, being terminated without cause or constructively terminated, and then only when there is no misconduct by the executive officer, is a fair hurdle for the corresponding compensation.

More information regarding these arrangements is provided under the heading “Potential Payments Upon Termination orChange-in-Control—Employment Agreements.”

CLAWBACK POLICY

Tax

In December 2019, we adopted a policy that provides for the recoupment of certain cash and Accounting Considerations

Deduction Limitation
equity incentive compensation paid to any of our executives if we are required to prepare an accounting restatement due to material noncompliance with any financial reporting requirement under the securities laws and it is determined that such noncompliance was due in whole or in part to such executive’s misconduct.

TAX AND ACCOUNTING CONSIDERATIONS

DEDUCTION LIMITATION

Under Section 162(m) of the Internal Revenue Code, or Section 162(m),the Code, compensation paid to any publicly held corporation’s “covered employees” that exceeds $1 million per taxable year for any covered employee is generallynon-deductible.

Prior to the enactment of the Tax Cuts and Jobs Act, Section 162(m) of the Code provided a performance-based compensation exception, pursuant to which the deduction limit under Section 162(m) of the Code did not apply to any compensation that qualified as “performance-based compensation” under Section 162(m). of the Code. Pursuant to the Tax Cuts and Jobs Act, the performance-based compensation exception under Section 162(m) of the Code was repealed with respect to taxable years beginning after December 31, 2017, except that certain transition relief is provided for compensation paid pursuant to a written binding contract which was in effect on November 2, 2017 and which is not modified in any material respect on or after such date.

As a result, compensation

Compensation paid to anyeach of the Company’s “covered employees” in excess of $1 million per taxable year generally will not be deductible unless it qualifies for the performance-based compensation exception under Section 162(m) of the Code pursuant to the transition relief provided by the Tax Cuts and Jobs Act.described above. Because of certain ambiguities and uncertainties as to the application and interpretation of Section 162(m), of the Code, as well as other factors beyond the control of the Compensation Committee, no assurance can be given that any compensation paid by the Company will be eligible for such transition relief and qualify forbe deductible by the performance-based compensation exception under Section 162(m).Company in the future. Although the Compensation Committee will continue to monitor the applicability of Section 162(m) to the Company’s ongoingconsider tax implications as one factor in determining executive compensation, arrangements, the Compensation Committee also intends to continuelooks at other factors in making its decisions and retains flexibility to provide compensation for the Company’s named executive officers in a manner consistent with the goals of the Company’s executive compensation program and the best interests of the Company and its stockholdersshareholders (which may include providing for compensation that is non-deductiblenot deductible by the Company due to the deduction limit under Section 162(m)) of the Code). The Compensation Committee also retains the flexibility to modify compensation that was initially intended to be exempt from the deduction limit under Section 162(m) of the Code if it determines that such modifications are consistent with the Company’s business needs.

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Accounting Considerations

COMPENSATION DISCUSSION AND ANALYSIS

ACCOUNTING CONSIDERATIONS

We follow Financial Accounting Standards Board ASC Topic 718 for our stock-based compensation awards. In accordance with ASC Topic 718, stock-based compensation cost is measured at the grant date, or with respect to performance-based awards, the service inception date, based on the estimated fair value of the awards using a variety of assumptions. This calculation is performed for accounting purposes and, as applicable, reported in the compensation tables, even though recipients may never realize any value from their awards. We expect to record this expense on an ongoing basis over the requisite employee service period. For performance-based stock options, we expect to record compensation expense over the estimated service period once the achievement of the performance-based milestone is considered probable. At each reporting date, we assess whether achievement of a milestone is considered probable, and if so, record compensation expense based on the portion of the service period elapsed to date with respect to that milestone, with a cumulative catch-up, net of estimated forfeitures. We will recognize remaining compensation expense with respect to a milestone, if any, over the remaining estimated service period. Accounting rules also require us to record cash compensation as an expense at the time the obligation is incurred.

Stock Ownership Guidelines

STOCK OWNERSHIP GUIDELINES

On the recommendation of the Nominating and CorporateGovernance Committee, or the Governance Committee, our Board has adopted the following stock ownership guidelines for our named executive officers:


Role

Stock Ownership Guidelines

CEO

5x base salary

Executive Officers

1.5x base salary

Our executives are required to be in compliance with the stock ownership requirement by December 31st of the fifth year following the year during which such individual becomes subject to these ownership guidelines. As of December 31, 2018,2019, our CEO was in compliance with this stock ownership requirement. With the exception of Dr. Dansey, our currently serving executive officers first became subject to thesethe guidelines duringin 2017, when we first adopted stock ownership guidelines for executive officers other than our CEO, and will be required to be in compliance by December 31, 2022. Dr. Dansey first became subject to these guidelines on the datein 2018 when he commenced employment with us and will be required to be in compliance with the guidelines by December 31, 2023.

Prohibitions on Hedging and Pledging
Pursuant to

PROHIBITIONS ON HEDGING, PLEDGING AND SHORT-TERM SPECULATIVE TRANSACTIONS

Under the terms of our insider trading policy, we prohibit ourno employees (including executive officers and theofficers) of Seattle Genetics or its subsidiaries, members of our Board or consultants who know or have access to material information regarding Seattle Genetics that has not been fully disclosed to the public may engage in any hedging or monetization transactions relating to Seattle Genetics or its securities, including through the use of Directors from engagingfinancial instruments such as prepaid variable forwards, equity swaps, collars and exchange funds, nor may any of these persons engage in short-term speculative transactions involving Seattle Genetics securities (or derivatives of Seattle Genetics securities), including short sales and further prohibit them from hedgingthe buying and selling of put or pledging ourcall options. In addition, none of these persons may hold Seattle Genetics securities in a margin account or otherwise pledge Seattle Genetics securities as collateral.

Compensation Recovery Policy
Currently, we do not havecollateral for a policy to recover incentive compensation paid to our executive officers in the event of a financial restatement. We will comply with the requirements of the Dodd-Frank Act and will adopt a compensation recovery policy in accordance with such requirements once the SEC adopts final regulations on the subject.
As a public company subject to the provisions of Section 304 of the Sarbanes-Oxley Act of 2002, if we are required as a result of misconduct to restate our financial results due to our material noncompliance with any financial reporting requirements under the federal securities laws, our Chief Executive Officer and Chief Financial Officer may be legally required to reimburse us for any bonus or other incentive-based or equity-based compensation they receive.
Compensation and Risk
loan.

COMPENSATION AND RISK

We believe that the risks arising from our compensation policies and practices are not reasonably likely to have a material adverse effect on the Company. In addition, the Compensation Committee believes that the mix and design of the elements of executive compensation do not encourage our employees to assume excessive risks.

The Compensation Committee periodically reviews the elements of executive compensation to determine whether any portion of executive compensation encourages excessive risk taking. The Compensation Committee most recently conducted this review in March 20192020 and concluded that it does not. Among the factors that the Compensation Committee considered were:

significant weighting towards long-term incentive compensation discourages short-term risk taking;

goals are appropriately set to provide meaningful target levels that enhance stockholdershareholder value but that are quantifiable using objective criteria and include multiple performance measures; and

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COMPENSATION DISCUSSION AND ANALYSIS

short-term incentive awards are capped by the Compensation Committee.Committee; and

sales incentive plans and associated award programs for the Company’s sales team are aligned with market practice and support performance towards appropriate business objectives.

COMPENSATION COMMITTEE REPORT(1)

The Compensation Committee has reviewed and discussed the foregoing Compensation Discussion and Analysis required by Item 402(b) of RegulationS-K with management and, based on such review and discussions, the Compensation Committee has recommended to our Board of Directors that the Compensation Discussion and Analysis be included in this Proxy Statementproxy statement and incorporated into our Annual Report onForm 10-K for the fiscal year ended December 31, 2018.

2019.

Submitted by the members of the Compensation Committee:

Felix Baker, Ph.D. (chair)
John Orwin
Daniel Welch
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(1)

The material in this report is not “soliciting material,” is not deemed “filed” with the SEC and is not to be incorporated by reference in any filing of Seattle Genetics under the Securities Act or the Exchange Act, other than in Seattle Genetics’ Annual Report on Form10-K where it shall be deemed to be furnished, whether made before or after the date hereof and irrespective of any general incorporation language in any such filing.



COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

During 2018,2019, the Compensation Committee consisted of Felix J. Baker (chair), John A. Orwin and Daniel G. Welch, none of whom is a current or former officer or employee of Seattle Genetics. Please refer to the section of this proxy statement entitled “Certain Relationships and Related Party Transactions” for information concerning certain transactions involving entities affiliated with Dr. Baker.

During 2018,2019, no member of the Compensation Committee or executive officer of Seattle Genetics has or had a relationship that would constitute an interlocking relationship with executive officers or directors of another entity.

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COMPENSATION DISCUSSION AND ANALYSIS


SUMMARY COMPENSATION TABLE

The following table sets forth all of the compensation awarded to, or earned by, our named executive officers.

Name and Principal Position Year Salary Bonus (1) 
Stock
Awards
(2) (3)
 
Option
Awards
(2) (4)
 
Non-Equity
Incentive Plan
Compensation
(5)
 
All Other
Compensation
(6)
 Total
Clay B. Siegall, Ph.D. 2018 $918,554
 $2,000
 $8,217,394
(7)$7,539,792
 $1,409,995
(9)$19,302
 $18,107,037
President and CEO 2017 $887,146
 $
 $3,561,064
 $3,217,921
 $934,500
 $15,713
 $8,616,344
  2016 $852,354
 $
 $3,686,600
 $4,015,160
 $985,000
 $20,283
 $9,559,397
                 
Todd E. Simpson 2018 $519,458
 $13,300
 $1,847,912
(7)$1,627,287
 $411,550
(10)$12,855
 $4,432,362
Chief Financial Officer 2017 $492,208
 $
 $1,191,510
 $1,101,374
 $264,076
 $12,630
 $3,061,798
  2016 $475,371
 $
 $935,400
 $1,026,148
 $269,500
 $12,405
 $2,718,824
                 
Roger D. Dansey, M.D. 2018 $399,479
 $300,000
 $6,804,499
(7)(8)$1,970,275
 $276,455
 $176,312
 $9,927,020
Chief Medical Officer                
                 
Vaughn B. Himes, Ph.D. 2018 $505,075
 $
 $1,635,625
(7)$1,410,308
 $387,525
(11)$12,855
 $3,951,388
Chief Technical Officer 2017 $476,867
 $
 $1,052,400
 $957,716
 $260,728
 $12,630
 $2,760,341
  2016 $441,138
 $
 $1,292,780
 $939,330
 $246,900
 $12,405
 $2,932,553
                 
Darren Cline 2018 $480,150
 $
 $1,615,653
(7)$1,464,575
 $286,338
(12)$18,500
 $3,865,216
Former Executive Vice President, Commercial 2017 $453,108
 $
 $888,290
 $814,060
 $222,834
 $16,709
 $2,395,001
  2016 $436,667
 $200,000
 $1,088,180
 $893,161
 $221,700
 $20,211
 $2,859,919
________________ 

Name and Principal Position

  Year   

Salary

($)

   

Bonus(1)

($)

   

Stock

Awards(2)

($)

  

Option

Awards(3)

($)

   

Non-Equity

Incentive Plan

Compensation(4)

($)

  

All Other

Compensation(5)

($)

   

Total

($)

 

Clay B. Siegall, Ph.D.

   2019    963,369        8,137,179(6)(7)   3,502,217    1,903,500(8)   15,230    14,521,495 

President and CEO

   2018    918,554    2,000    8,217,394   7,539,792    1,409,995   19,302    18,107,037 
    2017    887,146        3,561,064   3,217,921    934,500   15,713    8,616,344 

Todd E. Simpson

   2019    572,342        1,824,697(7)   1,552,123    525,700(9)   15,230    4,490,092 

Chief Financial Officer

   2018    519,458    13,300    1,847,912   1,627,287    411,550   12,855    4,432,362 
    2017    492,208        1,191,510   1,101,374    264,076   12,630    3,061,798 

Roger D. Dansey, M.D.

   2019    670,900    150,000    2,831,698(7)   2,149,091    622,675(10)   294,460    6,718,824 

Chief Medical Officer

   2018    399,479    300,000    6,804,499   1,970,275    276,455   176,312    9,927,020 

Jean I. Liu

   2019    520,325    500    1,578,609(7)   1,384,957    466,500(11)   15,230    3,966,121 

General Counsel and Executive Vice President, Legal Affairs

   2018    485,017    13,300    1,536,026   1,383,188    330,802   12,855    3,761,188 
    2017    461,788        888,290   814,060    223,175   12,630    2,399,943 

Robin G. Taylor, Ph.D.(13)

   2019    309,028    360,000    2,439,100(7)   1,855,402    130,762(12)   144,205    5,238,497 

Former Chief Commercial Officer

                                      

(1)

For 2018,2019, the amounts in this column consist of the portion of Dr. Dansey’ssign-onbonus for the Dr. Siegall’s twenty year anniversary with Seattle Genetics, a discretionary bonus for special recognitionpayable after 18 months of achievement for Mr. Simpson and a sign-on bonus for Dr. Dansey whichemployment that was awarded as an inducement to joining Seattle Genetics.Genetics, asign-on bonus for Dr. Taylor that was awarded as an inducement to joining Seattle Genetics, and a bonus for Ms. Liu for a five year work anniversary bonus.

(2)

The amounts in the “Stock Awards” and “Option Awards” columnsthis column do not represent amounts the named executive officers received or are entitled to receive. Rather, the reported amounts represent the aggregate fair value of awards computed in accordance with FASB ASC Topic 718, as required to be disclosed under SEC rules. The reported amounts for 2018 do not reflect the risks that potential RSUs to be granted under the Tucatinib LTIP or the EV/TV LTIP, with respect to Dr. Dansey, upon the satisfaction of performance conditions may not be granted because the applicable performance conditions are not met. See footnotes (7) and (8) below.

(3)The amounts in this column include the aggregate grant date fair value ofnon-performance based RSUs granted during the relevant year in accordance with FASB ASC Topic 718 with no estimate for future forfeitures, which value, fornon-performance based RSUs, is based on the closing price of our common stock on the date of grant. Please see “Compensation“—Compensation Discussion and Analysis” above and “Grants of Plan-Based Awards” below for more information regarding the RSUs we granted to the named executive officers in 2018.officers. For 2018,2019, the amounts in this column also include the fair value of potentialthe EV Frontline PSU awards, and with respect to Dr. Siegall, his other performance-based RSUs, to be granted undereach in accordance with FASB ASC Topic 718 based upon the Tucatinib LTIP orprobable outcome of the performance conditions. See footnotes (6) and (7) for additional information on these performance-based RSUs. For 2019, the amounts in this column do not include the fair value of the EV/TV LTIP withRSUs that were granted in 2019, as the fair value of such RSUs were reported in 2017 or 2018 (with respect to Dr. Dansey. See footnotes (7) and (8) below.Dansey) as the fair value on the service inception date (i.e., the date the Compensation Committee approved the EV/TV LTIP), based on the then-probable outcome of the performance conditions.

(3)
(4)

The amounts in this column represent the aggregate grant date fair value of stock options granted during the relevant year in accordance with FASB ASC Topic 718 with no estimate for future forfeitures. For information regarding the assumptions used in calculating these amounts, see Note 16 of the Notes to the Consolidated Financial Statements included in our Annual Report on Form10-K for the year ended December 31, 2018.2019.

(4)
(5)

The amounts in this column reflect the cash bonus awards to the named executive officers under our Executive Bonus Plans, as well as cash payments earned under the ECHELON-1EV/TV LTIP. See “Compensation“—Compensation Discussion and Analysis” above and footnotes (9)(8) through (12) below for more information on these cash payments.

(5)
(6)

The amounts in this column consist of life insurance premiums and company matching contributions to our 401(k) plan for all named executive officers and, with respect to Dr. Siegall and Mr. Cline, the full cost of companion travel for a sales-award trip with the top ADCETRIS sales performers, grossed up for related payroll taxes.officers. In addition, the amounts in this column with respect to Dr. Dansey include relocation costs,$279,230 for corporate housing in Washington and travel to and from his residence in California, grossed up for related payroll taxes and corporate housing in Washington of $163,657,to Dr. Taylor include $133,436 for relocation costs, grossed up for related payroll taxes.

(6)
(7)For 2018, the reported amount

Amount includes the fair value of First Tranche RSUsDr. Siegall’s Adjusted Revenue PSU and Relative TSR PSU awards granted in 2018 and the fair value of the potential Second Tranche RSUs to be granted under the Tucatinib LTIP, each as computed in accordance with FASB ASC Topic 718 with no estimate for future forfeitures. Under FASB ASC Topic 718, the grant date for the Second Tranche RSUs will not be determined until the settlement date for the awards after performance has been completed.


As a result, the amounts reported for 2018 for these Second Tranche RSU awards, which have not yet been granted, represent the fair value on the service inception date (i.e., the date the Compensation Committee approved the Tucatinib LTIP), based upon the then-probable outcome of the performance conditions. For these purposes, the fair value of these potential Second Tranche RSUs was computed based on the target award value for these awards, which was $460,000 for Dr. Siegall, $140,000 for each of Mr. Simpson, Dr. Dansey and Dr. Himes, and $100,000 for Mr. Cline. The fair value at the service inception date for these awards, assuming the maximum level of performance, would be $662,400 for Dr. Siegall, $201,600 for each of Mr. Simpson, Dr. Dansey and Dr. Himes, and $144,000 for Mr. Cline. The reported amounts do not reflect the risks that the RSUs granted under the Tucatinib LTIP First Tranche may not vest, or that potential RSUs to be granted under the Tucatinib LTIP Second Tranche may not be granted, because the applicable performance conditions are not met. Please see “Compensation Discussion and Analysis—2018 Compensation Decisions for named executive officers—Performance-Based Incentive Awards above and “Grants of Plan-Based Awards” below for more information about the Tucatinib LTIP.
(8)For 2018, the reported amount includes the fair value of a potential RSU award to be granted under the EV/TV LTIP as computed in accordance with FASB ASC Topic 718 with no estimate for future forfeitures. Under FASB ASC Topic 718, the grant date will not be determined for this potential RSU award until the settlement date for the award after performance has been completed. As a result, the amount reported for 2018 for this award, which has not yet been granted, represents the fair value on the service inception date, based upon the then-probable outcome of the performance conditions and prorated based on Dr. Dansey’s hire date.August 30, 2019. For these purposes, the fair value of this potential RSU awardthese awards was computed based on achieving the target award valuelevel. Assuming the highest level of $94,000. Theachievement of the performance conditions under each of these performance-based RSUs, the fair value at the service inception date for this award, assuming the maximum level of performance,these awards would be $104,000.$6,978,379. Please see “—Compensation Discussion and Analysis” above and “Grants of Plan-Based Awards” below for more information regarding the RSUs we granted to Dr. Siegall.

(7)

Amount includes the fair value of the EV Frontline PSU awards. Please see “—Compensation Discussion and Analysis” above and “Grants of Plan-Based Awards” below for more information regarding the RSUs we granted to the named executive officers.

(9)(8)

Amount includes Dr. Siegall’s 20182019 annual bonus of $1,197,495$1,547,500 pursuant to the Executive Bonus Plan and a cash payment earned under the ECHELON-1EV/TV LTIP in the amount of $212,500.$356,000.

(9)
(10)

Amount includes Mr. Simpson’s 20182019 annual bonus of $351,550$425,700 pursuant to the Executive Bonus Plan and a cash payment earned under the ECHELON-1EV/TV LTIP in the amount of $60,000.$100,000.

(10)
(11)

Amount includes Dr. Himes 2018Dansey’s 2019 annual bonus of $340,025$558,400 pursuant to the Executive Bonus Plan and a cash payment earned under the ECHELON-1EV/TV LTIP in the amount of $47,500.$64,275.

(11)
(12)Amount includes Mr. Cline’s 2018

Ms. Liu’s 2019 annual bonus of $238,838$386,500 pursuant to the Executive Bonus Plan and a cash payment earned under the ECHELON-1EV/TV LTIP in the amount of $47,500.$80,000.

(12)

Amount includes Dr. Taylor’s 2019 pro rata portion of his annual bonus of $123,800 pursuant to the Executive Bonus Plan and a cash payment earned under the EV/TV LTIP in the amount of $6,962.

(13)

Dr. Taylor was appointed Chief Commercial Officer in May 2019 and left the Company in February 2020.


2020 PROXY STATEMENT57



COMPENSATION DISCUSSION AND ANALYSIS


GRANTS OF PLAN-BASED AWARDS

The following table sets forth each equity andnon-equity award granted to our named executive officers during 2018.

  
Grant
Date
(1)
 
Estimated Future
Payouts Under 
Non-Equity
Incentive Plan Awards
 
 
Estimated Future
Payouts Under Equity
Incentive Plan Awards
 
All Other
Stock 
Awards:
Number of
Shares of
Stock or
Units
 
All Other
Option
Awards:
Number of
Securities
Underlying
Options
 
Exercise or
Base Price
of Option
Awards
(per share)
 
Grant Date
Fair Value of
Stock 
Options
and Awards
(2)
Name  Target Maximum Target Maximum 
Clay B. Siegall, Ph.D.                  
Executive Bonus Plan (3) N/A $921,150
 $1,381,725
 
 
 
 
 
 
Discretionary Stock Option Award (4) 8/30/2018 
 
 
 
 
 227,984
 $76.86
 $7,539,792
Discretionary RSU Award (5) 8/30/2018 
 
 
 
 95,981
 
 
 $7,377,100
Tucatinib LTIP First Tranche RSU Award (6) 11/1/2018 
 
 6,541
 9,419
 
 
 
 $380,294
Tucatinib LTIP Second Tranche RSU Target (7) 11/1/2018 
 
 $460,000
 $662,400
 
 
 
 $460,000
Todd E. Simpson                  
Executive Bonus Plan (3) N/A $270,450
 $405,675
 
 
 
 
 
 
Discretionary Stock Option Award (4) 8/30/2018 
 
 
 
 
 49,205
 $76.86
 $1,627,287
Discretionary RSU Award (5) 8/30/2018 
 
 
 
 20,715
 
 
 $1,592,155
Tucatinib LTIP First Tranche RSU Award (6) 11/1/2018 
 
 1,991
 2,867
 
 
 
 $115,757
Tucatinib LTIP Second Tranche RSU Target (7) 11/1/2018 
 
 $140,000
 $201,600
 
 
 
 $140,000
Roger D. Dansey, M.D.                  
Executive Bonus Plan (3) N/A $325,000
 $487,500
 
 
 
 
 
 
New Hire Stock Option Award (8) 6/15/2018 
 
 
 
 
 50,000
 $65.11
 $1,398,640
New Hire RSU Award (9) 6/15/2018 
 
 
 
 70,000
 
 
 $4,557,700
Discretionary Stock Option Award (4) 8/30/2018 
 
 
 
 
 17,199
 $76.86
 $571,635
Discretionary RSU Award (5) 8/30/2018 
 
 
 
 7,241
 
 
 $560,023
Performance-Based RSU Award (10) 9/7/2018 
 
 
 
 17,263
 
 
 $1,337,019
EV/TV LTIP - Cash Award (11) N/A $94,000
 $104,000
 
 
 
 
 
 
EV/TV LTIP - RSU Award (12) 5/21/2018 
 
 $94,000
 $104,000
 
 
 
 $94,000
Tucatinib LTIP First Tranche RSU Award (6) 11/1/2018 
 
 1,991
 2,867
 
 
 
 $115,757
Tucatinib LTIP Second Tranche RSU Target (7) 11/1/2018 
 
 $140,000
 $201,600
 
 
 
 $140,000
Vaughn B. Himes, Ph.D.                  
Executive Bonus Plan (3) N/A $253,750
 $380,625
 
 
 
 
 
 
Discretionary Stock Option Award (4) 8/30/2018 
 
 
 
 
 42,644
 $76.86
 $1,410,308
Discretionary RSU Award (5) 8/30/2018 
 
 
 
 17,953
 
 
 $1,379,868
Tucatinib LTIP First Tranche RSU Award (6) 11/1/2018 
 
 1,991
 2,867
 
 
 
 $115,757
Tucatinib LTIP Second Tranche RSU Target (7) 11/1/2018 
 
 $140,000
 $201,600
 
 
 
 $140,000
Darren Cline                  
Executive Bonus Plan (3) N/A $217,125
 $325,688
 
 
 
 
 
 
Discretionary Stock Option Award (4) 8/30/2018 
 
 
 
 
 44,285
 $76.86
 $1,464,575
Discretionary RSU Award (5) 8/30/2018 
 
 
 
 18,644
 
 
 $1,432,978
Tucatinib LTIP First Tranche RSU Award (6) 11/1/2018 
 
 1,422
 2,047
 
 
 
 $82,675
Tucatinib LTIP Second Tranche RSU Target (7) 11/1/2018 
 
 $100,000
 $144,000
 
 
 
 $100,000
_____________________
2019.

     Estimated Future
Payouts under
Non-Equity Incentive
Plan Awards(1)
     Estimated Future
Payouts under
Equity Incentive
Plan Awards
             
                           

Name

 Grant
Date
  Target  

Maximum

($)

      Target  Maximum  

All Other Stock
Awards: Number
of Shares of
Stock or Units

($)

  

All Other Option
Awards: Number
of Securities
Underlying Options

($)

  

Exercise or Base
price of Option
Awards (per
share)

($)

  

Grant
Date Fair
Value of
Stock
Options
and
Awards

($)(2)

 

Clay B. Siegall, Ph.D.

                                        

Executive Bonus Plan

  N/A   967,208   1,934,416                       

Discretionary Stock Option Award(3)

  8/30/2019                      114,095   72.64   3,502,217 

Discretionary RSU Award(4)

  8/30/2019                   48,034         3,489,190 

Adjusted Revenue PSU Award(5)

  8/30/2019             38,427   76,854            2,791,337 

Relative TSR PSU Award(6)

  8/30/2019             9,607   19,214            892,298 

EV Frontline PSU Award(7)

  12/31/2019          8,440   8,440            964,354 

Todd E. Simpson

                                        

Executive Bonus Plan

  N/A   287,600   575,200                       

Discretionary Stock Option Award(3)

  8/30/2019                      50,565   72.64   1,552,123 

Discretionary RSU Award(4)

  8/30/2019                   21,288         1,546,360 

EV Frontline PSU Award(7)

  12/31/2019          2,436   2,436            278,337 

Roger D. Dansey, M.D.

                                        

Executive Bonus Plan

  N/A   336,400   672,800                       

Discretionary RSU Award(4)

  2/15/2019                   5,768         412,297 

Discretionary Stock Option Award(3)

  8/30/2019                      70,013   72.64   2,149,091 

Discretionary RSU Award(4)

  8/30/2019                   29,475         2,141,064 

EV Frontline PSU Award(7)

  12/31/2019          2,436   2,436            278,337 

Jean I. Liu

                                        

Executive Bonus Plan

  N/A   261,100   522,200                       

Discretionary Stock Option Award(3)

  8/30/2019                      45,119   72.64   1,384,957 

Discretionary RSU Award(4)

  8/30/2019                   18,995         1,379,797 

EV Frontline PSU Award(7)

  12/31/2019          1,740   1,740            198,812 

Robin G. Taylor, Ph.D.

                                        

Executive Bonus Plan

  N/A   154,800   309,600                       

Discretionary Stock Option Award(3)

  5/20/2019                       54,491   64.38   1,515,200 

Discretionary Stock Option Award(3)

  8/30/2019                      11,083   72.64   340,202 

Discretionary RSU Award(4)

  5/20/2019                   23,557         1,516,600 

Discretionary RSU Award(8)

  5/20/2019                   4,741         305,225 

Discretionary RSU Award(4)

  8/30/2019                   4,666         338,938 

EV Frontline PSU Award(7)

  12/31/2019             2,436   2,436            278,337 

(1)For purposes of this column, “grant date,” with respect to the potential Second Tranche RSUs to be granted under the Tucatinib LTIP, is the service inception date as determined under FASB ASC Topic 718.
(2)The amounts in this column do not represent amounts the named executive officers received or are entitled to receive. Rather, the reported amounts represent the fair value of each award as computed in accordance with FASB ASC Topic

718 on the applicable grant date or, if earlier, the service inception date, as required to be disclosed under SEC rules. The reported amounts do not reflect the risks that the RSUs granted under the Tucatinib LTIP First Tranche may not vest, or that potential RSUs to be granted under the Tucatinib LTIP Second Tranche or the EV/TV LTIP, with respect to Dr. Dansey, may not be granted because the applicable performance conditions are not met. See also “Summary Compensation Table” – footnotes (7) and (8) for more information regarding the service inception date fair value for the potential RSUs to be granted under the Tucatinib LTIP and the EV/TV LTIP, with respect to Dr. Dansey.
(3)

The dollar amounts represent the target and maximum amounts of each named executive officer’s potential annual cash bonus award for the year ended December 31, 2018,2019, pursuant to our Executive Bonus Plan. The amount shown as target reflects the target payment level under the Executive Bonus Plan if Seattle Genetics and each individual had achieved 100% of the specific performance objectives and goals previously approved by the Compensation Committee in 2018.2019. An individual must have attained an individual performance percentage of 50% or more to receive any compensation under the Executive Bonus Plan. The amount shown as maximum reflects the payment level under the Executive Bonus Plan if Seattle Genetics and each individual had achieved 150%200% performance percentages based on the corporate goals approved by the Compensation Committee in 2018.2019. A percentage of 150%200% is the maximum percentage allowed for both Seattle Genetics and individual performance percentages. Actual payouts made under the Executive Bonus Plan differed based on the actual performance objectives and goals achieved. The actual cash bonus award earned for the year ended December 31, 20182019 under our Executive Bonus Plan for each named executive officer is set forth in the Summary“Summary Compensation TableTable” above. As such, the amounts set forth in these columns do not represent additional compensation earned by the named executive officers for the year ended December 31, 2018.2019. The Executive Bonus Plan is discussed in greater detail under the heading “Compensation“—Compensation Discussion and Analysis” above.

(2)

The amounts in this column do not represent amounts the named executive officers received or are entitled to receive. Rather, the reported amounts represent the fair value of each award as computed in accordance with FASB ASC Topic 718 on the applicable grant date, as required to be disclosed under SEC rules.

(4)
58

LOGO


COMPENSATION DISCUSSION AND ANALYSIS

(3)

Discretionary stock options were granted under our 2007 Equity Plan. Vesting of all of these discretionary options occurs 1/4th4th on the one yearone-year anniversary of the grant date and 1/36th36th of the remaining shares thereafter on a monthly basis until the grant is fully vested on the fourth anniversary of the grant date.

(4)
(5)

Discretionary RSUs were granted under our 2007 Equity Plan. Vesting of all of these discretionary RSUs vests 25% per year over a four yearfour-year period.

(5)

A performance-based RSU was approved by the Compensation Committee and granted to Dr. Siegall on August 30, 2019, the vesting of such is based on Adjusted Revenue in fiscal year 2022 as described under the heading “Compensation Discussion and Analysis—CEO PSU Awards”. The share amounts reported represent the target and maximum number of shares to be issued upon the vesting of this performance-based RSU. The payout of this award may vary from 0% to 200% of the target number of shares.

(6)

A performance-based RSU was approved by the Compensation Committee and granted to Dr. Siegall on August 30, 2019, the vesting of such is based on Relative TSR for the 3 years beginning September 1, 2019 as described under the heading “Compensation Discussion and Analysis—CEO PSU Awards”. The First Trancheshare amounts reported represent the target and maximum number of shares to be issued upon the vesting of this performance-based RSU. The payout of this award may vary from 0% to 200% of the RSUs under the Tucatinib LTIPtarget number of shares.

(7)

EV Frontline PSU awards were granted on November 1, 2018December 31, 2019 and will vest upon certification by the Compensation Committee of certain milestones as further described under the heading “-Compensation“Compensation Discussion and Analysis—2018 Compensation Decisions for the Named Executive Officers—Performance-Based Incentive Awards.”EV Frontline PSU Awards”.

(7)The Second Tranche of RSUs under the Tucatinib LTIP will be granted upon certification by the Compensation Committee of achievement of certain milestones and will vest on the second anniversary of such certification date, as further described under the heading “—Compensation Discussion and Analysis—2018 Compensation Decisions for the named executive officers—Performance-Based Incentive Awards.”
(8)
The new hire stock option grant

Discretionary RSU was granted under our 2007 Equity Plan. Vesting of this stock option occurs 1/4thdiscretionary RSU vests 100% on the one year anniversary of the grant date and 1/36th of the remaining shares thereafter on a monthly basis until the grant is fully vested on the fourth anniversary of the grant date.

(9)The new hire RSU award was granted under our 2007 Equity Plan. Vesting of 50,000 of the RSUs occurs in full on the third anniversary of the grant date. Vesting of 20,000 of the RSUs occurs 50% on the first anniversary of the grant date and 50% on the second anniversary of the grant date.
(10)A performance-based RSU was approved by the Compensation Committee in August 2018 and granted to Dr. Dansey on September 7, 2018, the vesting of which described under the heading “—Compensation Discussion and Analysis— 2018 Compensation Decisions for the Named Executive Officers—Performance-Based Incentive Awards.”
(11)The dollar amounts represent the target and maximum amounts potential cash award under the EV/TV LTIP as of the plan’s inception date. The amounts shown as target are based on the target award value established for Dr. Dansey under the EV/TV LTIP, and actual payment amounts will be based on a sliding scale from 0% to 120% of the amount shown as target, as calculated based on the dates of achievement of the applicable milestone. Accordingly, the amount shown as maximum reflects potential payment at the 120% level. The target and maximum amounts are prorated based on Dr. Dansey's hire date.
(12)The amounts reported represent the dollar values of the target and maximum amounts of the potential RSUs to be granted under the EV/TV LTIP as of the service inception date, and do not represent the actual number of shares that will be subject to these awards when granted. The grant of a portion of these RSU awards is contingent upon FDA approval of each of EV and TV. The amounts shown as target are based on the target award value established under the EV/TV LTIP, and actual payouts will be based on a sliding scale from 0% to 120% of the amount shown as target, as calculated based on the dates of achievement of the applicable milestone. Accordingly, the amount shown as maximum reflects potential payout at the 120% level. The actual number of shares subject to the RSUs, if granted, will be based on the resulting dollar value divided by the closing market price of our common stock on the date of grant. The target and maximum amounts are prorated based on Dr. Dansey's hire date.


EMPLOYMENT AGREEMENTS AND ARRANGEMENTS
Employment Agreements.

EMPLOYMENT AGREEMENTS

Each of our named executive officers has entered into a written employment agreement with Seattle Genetics. For a description of these employment agreements, please see the section of this proxy statement under the heading “Potential“—Potential Payments Upon Termination orChange-In-Control—Employment Agreements” below.

Annual Cash Bonus Awards.

ANNUAL CASH BONUS AWARDS

We have adopted our Executive Bonus Plan that provides for annual bonus awards to reward executive officers based on our achievement of specific corporate goals and their achievementa holistic evaluation of individualseveral factors, including the executive’s performance and contribution toward achieving corporate goals. For more information regarding our Executive Bonus Plan, please see the section of this proxy statement under the heading “—Compensation Discussion and Analysis—Principal Elements of Compensation—Annual Compensation-Setting Process—Cash Incentive Awards” and footnote (3)(1) to the Grants“Grants of Plan-Based AwardsAwards” table above.

TIME-BASED STOCK AWARDS

Discretionary andnew-hire

Stock Awards. Discretionary options that we granted in 20182019 under the 2007 Equity Plan have a ten year term and vest as to 1/4th4th of the shares subject to the options on the one year anniversary of the grant date and 1/36th36th of the remaining shares each month thereafter until such option is fully vested on the four year anniversary of the grant date, subject to the accelerated vesting of such options under the terms of each executive’s employment agreement with us and pursuant to the 2007 Equity Plan. Performance-based stock options that we granted in 2016 vest in accordance with the terms set forth in the ECHELON-1 LTIP (as defined below) and were also granted under the 2007 Equity Plan. Options granted under the 2007 Equity Plan carry an exercise price equal to the fair market value on the date of grant (the closing price of our common stock on the grant date on the Nasdaq Global Select Market),Market, and the 2007 Equity Plan permits the exercise price of stock options to be paid by cash, check, wire transfer, other shares of our common stock (with some restrictions), broker assistedsame-day sales, cancellation of debt, cashless “net exercise” arrangements, and any other form of consideration permitted by applicable law. If an executive’s service with us terminates for any reason other than cause, death, disability or, with respect to options granted on or after August 30, 2018, retirement, then options held by the executive under the 2007 Equity Plan generally will be exercisable to the extent they are vested on the termination date for a period of three months after the termination (if an executive’s service with us terminates for cause, then the Board or the Compensation Committee has the authority to terminate all options held by the executive under the 2007 Equity Plan immediately), however, an executive terminated under the involuntary termination provision of the employment agreements will be eligible for one year of acceleration of such executive'sexecutive’s equity awards as further described in the section below. Generally, if an executive’s service with us terminates as a result of the executive’s death or in the event of the executive’s death within 30 days following the executive’s termination of service, all outstanding options that were vested and exercisable as of the date of the executive’s death or termination of service, if earlier, may be exercised for six months following the executive'sexecutive’s death for options granted on or prior to May 18, 2018 and may be exercised for twelve months following the executive'sexecutive’s death for options granted after May 18, 2018, but in no event after the expiration date of such option. Generally, if an executive'sexecutive’s service with us terminates as a result of the executive’s disability or, with respect to options granted on or after August 30, 2018, retirement, then all options to the extent they are vested and exercisable on the termination date may be exercised for one year following the termination date but in no event after the expiration date of such option. Each RSU represents a right to receive one share of our common stock (subject to adjustment for certain specified changes in our capital structure). In the event that RSUsRSU awards vest, we will deliver one share of our common stock for each RSU

2020 PROXY STATEMENT59


COMPENSATION DISCUSSION AND ANALYSIS

that has vested. Discretionary RSUsandnew-hire RSU awards that we granted in or after August 20182019 generally vest in four equal tranches on the anniversary of the vesting commencement date until vested in full, provided that vesting will cease if an executive’s service with us terminates for any reason. A portion of the RSUs that Dr. Taylor received as part of hissign-on

equity award were subject to vesting in full one year from the grant date.

Under the 2007 Equity Plan, in the event of (i) an acquisition of Seattle Genetics by means of any reorganization, merger or consolidation but excluding any merger effected exclusively for the purpose of changing the domicile of the company,Company, (ii) any sale of all or substantially all of our assets or (iii) any other event specified by the plan administrator, so long as in either (i) or (ii), our stockholdersshareholders of record immediately prior to the transaction hold less than 50% of the voting power of the surviving entity and, so long as in (iii) that no change in control shall be deemed to occur upon announcement or commencement of a tender offer or upon a “potential” takeover or upon stockholdershareholder approval of a merger or other transaction, in each case without a requirement that the change in control actually occur, then the Board or the compensation committeeCompensation Committee may, in its discretion: (i) provide for the assumption or substitution of, or adjustment (including to the number and type of shares and exercise price applicable) to, each outstanding equity award; (ii) accelerate the vesting of equity awards; and/or (iii) provide for termination of awards as a result of the change in control on such terms and conditions as it deems appropriate, including providing for the cancellation of awards for a cash or other payment to the executive.

Additionally, (i) if the successor corporation does not assume or substitute equivalent awards for all outstanding equity awards granted pursuant to the 2007 Equity Plan, then as of the date of completion of the acquisition or merger, the vesting of such equity awards will be accelerated in full; and (ii) if outstanding equity awards are assumed or equivalent awards are substituted by the successor corporation and if at the time of, immediately prior to or within twelve months after the effective time of the change ofin control, an equity awardee’s service as an employee or consultant is terminated without cause or due to constructive termination, then the vesting of such substituted equity award will be accelerated in full.


For more information regarding grants of equity awards to our named executive officers, please see the section of this proxy statement under the headings “Compensation Discussion and Analysis—Principal Elements of Compensation—Long-Term Equity Awards” and “Compensation Discussion and Analysis—Post-Employment Compensation” above.
Long-Term Incentive Plans.

LONG-TERM INCENTIVE PLANS AND PSU AWARDS

In May 2016, the Compensation Committee approved theECHELON-1 LTIP. LTIP, a performance-based long-term incentive plan, or LTIP, to incentivize our executive officers and other employees to achieve FDA regulatory approval of a label expansion of ADCETRIS based on the phase 3ECHELON-1 trial. Under theECHELON-1 LTIP, each eligible employee, including each named executive officer other than Dr. Dansey and Dr. Taylor, was eligible to receive a cash award and an option to purchase shares of our common stock, with the amount of each cash and option award based on the participant’s position with the Company. The cash awards were paid to participants in theECHELON-1 LTIP following the Compensation Committee’s certification of the achievement of the FDA approval milestone in March 2018. TheECHELON-1 LTIP options, which were granted to our named executive officer participants inECHELON-1 LTIP on May 9, 2016 with an exercise price of $34.20 per share (the fair market value of our common stock on the date of grant), commenced vesting upon the Compensation Committee’s certification of the achievement of the FDA approval milestone, and vest in four equal annual installments on the first four anniversaries of the date the FDA approval milestone was achieved, subject to continuous service with the Company as of each vesting date.

In September 2017, the Compensation Committee approved the EV/TV LTIP. Under theThe EV/TV LTIP provides that each eligible employee, including each named executive officer, is eligible to receive a cash award and, and depending on the participant’s position with the company,Company, may also be eligible for an RSU award.award, subject to the participant’s (i) continued employment with the Company and (ii) good standing as of each applicable payment and grant date. A portion of each cash award will becomewas payable and a portion of each RSU award willwas to be granted only upon certification by the Compensation Committee that the FDA has approved EV,PADCEV. PADCEV received FDA accelerated approval on December 18, 2019. As a result, the Compensation Committee approved cash awards and the grant of RSU awards to eligible employees, including our named executive officers, under the EV/TV LTIP in December 2019. The remaining portion of each cash award will become payable, and the remaining portion of each RSU award will be granted only upon certification by the Compensation Committee that the FDA has approved TV, provided thatsubject to the participant is still actively employed byparticipant’s (i) continued employment with the Company and is in(ii) good standing as of eachthe applicable payment and grant date. The portion of the EV/TV LTIP RSU awards that were granted will vest on the second anniversary of the date of FDA approval of PADCEV, subject to continuous service with the Company through the vesting date. Any additional RSU awardawards that may by granted due to achievement of athe TV milestone, will vest on the second anniversary of the occurrence of suchthe TV milestone, subject to continuous service with the Company through the vesting date. If a particularthe TV milestone is not achieved by a specified date, with respect to such milestone, then no cash award will be made nor will an RSU award be granted with respect to suchthat milestone.

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In October 2018, the Compensation Committee approved the Tucatinib LTIP for the purpose of incentivizing the Company’s employees to potentially achieve the FDA approval of tucatinib. Under the Tucatinib LTIP, our named executive officers, other than Dr. Taylor, are eligible to receive grants of equity awards relating to our common stock, which consist of a “First Tranche” and a “Second Tranche” as set forth in the Tucatinib LTIP, each of which is granted as a separate stock unit award on the applicable date of grant. Any stock unit awards provided under the Tucatinib LTIP are granted under, and subject to the terms of, our 2007 Equity Plan and our standard forms of Stock Unit Grant Notice and Stock Unit Agreement for United States employees andnon-United States employees. The target number of stock units granted in the First Tranche granted on November 1, 2018 equaled 50% of the target award value applicable to each executive officer divided by the average closing sales price of our common stock for the 30 calendar day period ending on October 31, 2018. The First Tranche will only vest upon certification by the Compensation Committee of the first approval by the FDA for the commercial sale and marketing of tucatinib in the United States by us or any of our partners for any indication, which such approval is based on the clinical trial data from the pivotal HER2CLIMBHER2CLIMB-01 trial (such achievement, the Tucatinib Milestone, and the date on which the Compensation Committee certifies achievement, the Certification Date), provided that the executive officer is still employed by us as of the date of vesting. If the First Tranche vests due to achievement of the Tucatinib Milestone, the number of shares that vest will be determined by multiplying the target number of stock units subject to each stock unit award by the applicable earn out percentage. An earn out percentage, on a sliding scale from 0% to 144%, will be determined based on the date of achievement of the Tucatinib Milestone and the breadth of the indication or indications, as the case may be, for which tucatinib is approved by the FDA for commercial sale and marketing in the United States on the date that the Tucatinib Milestone occurs. The Second Tranche will be granted upon certification by the Compensation Committee of achievement of the Tucatinib Milestone provided that the executive officer is still employed by us as of the date of grant. The number of stock units granted, if any, with respect to the Second Tranche will be equal to 50% of the target award value applicable to each executive officer multiplied by the applicable earn out percentage determined by the Compensation Committee on the Certification Date, with the product of these numbers then divided by the average closing sales price of our common stock for the 30 calendar day period ending on the calendar day prior to the date of grant of the Second Tranche. If the Second Tranche is granted due to achievement of the Tucatinib Milestone, it will vest on the second anniversary of the Certification Date, provided that the executive officer’s continuous service with us has not terminated prior to the vesting date. The vesting of each outstanding stock unit award is subject to partial or full acceleration in the event of a termination of service (without cause or due to constructive termination) immediately prior to, or within twelve months after, a change of control of Seattle Genetics, or in the event an acquirer in a change of control of Seattle Genetics fails to assume the stock unit awards. If the Tucatinib Milestone is not achieved by a specified date, then the First Tranche will not vest, the Second Tranche will not be granted and the Tucatinib LTIP will automatically terminate. In addition, in the event that we cease to have rights to tucatinib, the Tucatinib LTIP shall automatically terminate.


In August 2018, the Compensation Committee also approved a performance-based RSUPSU grant to Dr. Dansey with a target and maximum number of shares equal to 17,263. The RSU willPSU awards vest in tranches contingent on the achievement of regulatory milestones, the FDA'sFDA’s approval of EV,PADCEV, tucatinib and TV but will not vest prior to December 31, 2021, subject to Dr. Dansey'sDansey’s continued employment on the vesting date. Upon the Compensation Committee’s certification that PADCEV received FDA accelerated approval, the EV portion of the PSU was deemed eligible to vest. The EV portion will vest on December 31, 2021, subject to Dr. Dansey’s continued employment on the vesting date.

In August 2019, the Compensation Committee approved two PSU grants to Dr. Siegall:

A grant with vesting contingent on the achievement of certainpre-specified 2022 adjusted revenue goals, subject to Dr. Siegall’s continued employment on the vesting date, which has a target number of shares equal to 38,427 and a maximum number of shares equal to 76,854; and

A grant with vesting contingent on the achievement of certainpre-specified three-year TSR goals, subject to Dr. Siegall’s continued employment on the vesting date, which has a target number of shares equal to 9,607 and a maximum number of shares equal to 19,214.

In December 2019, the Compensation Committee approved the issuance of EV Frontline PSU awards to eligible employees, including each of our named executive officers, as part of a company-wide long-term incentive grant. The EV Frontline PSU awards were granted under, and are subject to the terms of, our 2007 Equity Plan and our standard forms of performance-based Stock Unit Grant Notice and Stock Unit Agreement. The target number of stock units for each executive officer was calculated by dividing a target award value by the average closing price of our common stock during the month of December 2019. None of the EV Frontline PSU awards will vest unless the Compensation Committee certifies that a milestone has been met under the EV Frontline PSU awards. Upon certification of the Accelerated Approval Milestone, 25% of the target number of stock units will vest, provided that the applicable executive officer is still employed by us as of the date of vesting. Upon certification of the Regular Approval Milestone, 75% of the target number of stock units will vest, provided that the applicable executive officer is still employed by us

2020 PROXY STATEMENT61


COMPENSATION DISCUSSION AND ANALYSIS

as of the date of vesting. Each of the Accelerated Approval Milestone and the Regular Approval Milestone has a deadline by which it must be achieved. If it is not achieved by its deadline, then the associated number of stock units will be forfeited. Neither the Accelerated Approval Milestone nor the Regular Approval Milestone can be achieved within one year of the date of grant. The vesting of outstanding EV

For more information regarding these performance-based incentive plans,grants of equity awards to our executive officers, please see the sections of this proxy statement under the headings “—Compensation Discussion and Analysis—Compensation-Setting Process—Long-Term Equity Awards” and the “Grants of Plan-Based Awards” table above. For more information regarding the acceleration of equity awards held by our executive officers, please see the section of this proxy statement under the “Compensation Discussion and Analysis—Principal Elements of Compensation—Long-Term Equity Awards” and the Grants of Plan-Based Awards table above.

heading “—Potential Payments Upon Termination orOther Compensatory Arrangements.Change-In-Control.”

OTHER COMPENSATORY ARRANGEMENTS

Seattle Genetics pays the life insurance premium for all of its employees, including the executive officers. In addition, in 20182019 Seattle Genetics matched 75%100% of the first 6%5% of salary contributed to Seattle Genetics’ 401(k) plan by employees, including the executive officers. For 2019,2020, the match has changed to 100% of each employee's deferral up to 5%the first 5.5% of eligible compensation.salary contributed. The matched contribution is not subject to a vesting period. From time to time, individual executives negotiate other compensatory arrangements in connection with their initial hire.

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COMPENSATION DISCUSSION AND ANALYSIS


OUTSTANDING EQUITY AWARDS AT FISCALYEAR-END

The following table sets forth certain information regarding equity awards granted to the named executive officers that were outstanding as of December 31, 2018.

2019.

  Option Awards  Stock Awards(1)     Equity Incentive
Plan Awards(1)
 
                

Name

 

Number of

Securities

Underlying

Unexercised

Options

Exercisable

  

Number of

Securities

Underlying

Unexercised

Options

Unexercisable(2)

  

Option
Exercise
Price

($)

  

Vesting

Start

Date

  

Expiration

Date

      

Number
of

Shares
or Units

of Stock
That

Have Not
Vested

  

Market
Value of

Shares or
Units of
Stock That

Have Not

Vested(3)

($)

      Number of
Unearned
Shares,
Units or
Other
Rights That
Have Not
Vested
  

Market or
payout value
of unearned
shares, units
or other
rights that
have not
vested(3)

($)

 

Clay B. Siegall, Ph.D.

  227,779      12.00   8/27/2010   8/27/2020                         
   300,000      15.46   8/24/2011   8/24/2021                         
   185,625      26.10   8/20/2012   8/20/2022                         
   137,500      41.04   8/19/2013   8/19/2023                         
   150,000      44.09   8/26/2014   8/26/2024                         
   160,000      39.15   8/25/2015   8/25/2025                         
   150,000   30,000   45.30   8/27/2016   8/27/2026                         
   98,000   70,000   46.37   8/17/2017   8/17/2027                         
   75,994   151,990   76.86   8/30/2018   8/30/2028                         
   9,320   27,960   34.20   3/20/2018   5/9/2026                         
      114,095   72.64   8/30/2019   8/30/2029                         
                           67,200(4)   7,678,272             
                           71,985(5)   8,225,006             
                                       6,541(6)   747,375 
                           48,034(7)   5,488,365             
                                       38,427(8)   4,390,669 
                                       9,607(9)   1,097,696 
                           3,100(10)   354,206             
                                       8,440(11)   964,354 

Total

  1,494,218   394,045                   190,319   21,745,849       63,015   7,200,094 

Todd E. Simpson

  14,167      12.00   8/27/2010   8/27/2020                         
   26,867      15.46   8/24/2011   8/24/2021                         
   37,500      26.10   8/20/2012   8/20/2022                         
   36,000      41.04   8/19/2013   8/19/2023                         
   42,500      44.09   8/26/2014   8/26/2024                         
   42,500      39.15   8/25/2015   8/25/2025                         
   37,500   7,500   45.30   8/27/2016   8/27/2026                         
   33,541   23,959   46.37   8/17/2017   8/17/2027                         
   16,402   32,803   76.86   8/30/2018   8/30/2028                         
   2,632   7,894   34.20   3/20/2018   5/9/2026                         
      50,565   72.64   8/30/2019   8/30/2029                         
                           23,000(4)   2,627,980             
                           15,536(5)   1,775,143             
                                       1,991(6)   227,492 
                           21,288(7)   2,432,367             
                           871(10)   99,520             
                                       2,436(11)   278,337 

Total

  289,609   122,721                   60,695   6,935,010       4,427   505,829 

  Option Awards Stock Awards (1)
Name 
Number of
Securities
Underlying
Unexercised
Options
Exercisable
 
Number of
Securities
Underlying
Unexercised
Options
Unexercisable
(2)
 
Option
Exercise
Price 
 
Vesting
Start
Date
 
Expiration
Date
 
Number of 
Shares or Units
of Stock That
Have Not Vested
 
Market Value of
Shares or Units of Stock That
Have Not
Vested
(3)
Clay B. Siegall, Ph.D. 169,408
 
 $12.16
 8/25/2009 8/25/2019    
  350,000
 
 $12.00
 8/27/2010 8/27/2020    
  300,000
 
 $15.46
 8/24/2011 8/24/2021    
  185,625
 
 $26.10
 8/20/2012 8/20/2022    
  137,500
 
 $41.04
 8/19/2013 8/19/2023    
  150,000
 
 $44.09
 8/26/2014 8/26/2024    
  133,333
 26,667
 $39.15
 8/25/2015 8/25/2025    
  105,000
 75,000
 $45.30
 8/27/2016 8/27/2026    
  56,000
 112,000
 $46.37
 8/17/2017 8/17/2027  �� 
  
 227,984
 $76.86
 8/30/2018 8/30/2028    
  
 37,280
 $34.20
 3/20/2018 5/9/2026    
            72,000
(4) 
$4,079,520
            67,200
(5) 
3,807,552
            95,981
(6) 
5,438,283
            6,541
(7) 
370,613
Total 1,586,866
 478,931
       241,722
 $13,695,968
Todd E. Simpson 14,167
 
 $12.00
 8/27/2010 8/27/2020    
  26,867
 
 $15.46
 8/24/2011 8/24/2021    
  37,500
 
 $26.10
 8/20/2012 8/20/2022    
  36,000
 
 $41.04
 8/19/2013 8/19/2023    
  42,500
 
 $44.09
 8/26/2014 8/26/2024    
  35,416
 7,084
 $39.15
 8/25/2015 8/25/2025    
  26,250
 18,750
 $45.30
 8/27/2016 8/27/2026    
  19,166
 38,334
 $46.37
 8/17/2017 8/17/2027    
  
 49,205
 $76.86
 8/30/2018 8/30/2028    
  
 10,526
 $34.20
 3/20/2018 5/9/2026    
            

 

            18,000
(4) 
$1,019,880
            23,000
(5) 
1,303,180
            20,715
(6) 
1,173,712
            1,991
(7) 
112,810
Total 237,866
 123,899
       63,706
 $3,609,582

  Option Awards Stock Awards (1)
Name 
Number of
Securities
Underlying
Unexercised
Options
Exercisable
 
Number of
Securities
Underlying
Unexercised
Options
Unexercisable
(2)
 
Option
Exercise
Price 
 
Vesting
Start
Date
 
Expiration
Date
 
Number of 
Shares or Units
of Stock That
Have Not Vested
 
Market Value of
Shares or Units of Stock That
Have Not
Vested
(3)
Roger D. Dansey, M.D. 
 50,000
 $65.11
 6/15/2018 6/15/2028    
  
 17,199
(8) 
$76.86
 8/30/2018 8/30/2028    
            50,000
(9) 
$2,833,000
            20,000
(10) 
1,133,200
            7,241
(6), (11) 
410,275
            17,263
(12) 
978,122
            1,991
(7) 
112,810
Total 
 67,199
       96,495
 $5,467,407
Vaughn B. Himes, Ph.D. 36,498
 
 $12.00
 8/27/2010 8/27/2020    
  50,199
 
 $15.46
 8/24/2011 8/24/2021    
  36,169
 
 $26.10
 8/20/2012 8/20/2022    
  36,000
 
 $41.04
 8/19/2013 8/19/2023    
  37,500
 
 $44.09
 8/26/2014 8/26/2024    
  31,250
 6,250
 $39.15
 8/25/2015 8/25/2025    
  24,791
 17,709
 $45.30
 8/27/2016 8/27/2026    
  16,666
 33,334
 $46.37
 8/17/2017 8/17/2027    
  
 42,644
 $76.86
 8/30/2018 8/30/2028    
  
 8,333
 $34.20
 3/20/2018 5/9/2026    
            17,000
(4) 
$963,220
            9,600
(13) 
543,936
            20,000
(5) 
1,133,200
            17,953
(6) 
1,017,217
            1,991
(7) 
112,810
Total 269,073
 108,270
       66,544
 $3,770,383
Darren Cline 3,241
 
 $26.10
 8/20/2012 8/20/2022    
  16,000
 
 $41.04
 8/19/2013 8/19/2023    
  16,125
 
 $44.09
 8/26/2014 8/26/2024    
  1,583
 417
 $31.37
 2/3/2015 2/3/2025    
  25,000
 5,000
 $39.15
 8/25/2015 8/25/2025    
  23,333
 16,667
 $45.30
 8/27/2016 8/27/2026    
  14,166
 28,334
 $46.37
 8/17/2017 8/17/2027    
  
 44,285
 $76.86
 8/30/2018 8/30/2028    
  
 8,333
 $34.20
 3/20/2018 5/9/2026    
            8,400
(14) 
$475,944
            16,000
(4) 
906,560
            17,000
(5) 
963,220
            18,644
(6) 
1,056,369
            1,422
(7) 
80,571
Total 99,448
 103,036
       61,466
 $3,482,664
Total 2,193,253
 881,335
          
_________________ 
2020 PROXY STATEMENT63


COMPENSATION DISCUSSION AND ANALYSIS

  Option Awards  Stock Awards(1)     Equity Incentive
Plan Awards(1)
 
                

Name

 

Number of

Securities

Underlying

Unexercised

Options

Exercisable

  

Number of

Securities

Underlying

Unexercised

Options

Unexercisable(2)

  

Option
Exercise
Price

($)

  

Vesting

Start

Date

  

Expiration

Date

      

Number
of

Shares
or Units

of Stock
That

Have Not
Vested

  

Market
Value of

Shares or
Units of
Stock That

Have Not

Vested(3)

($)

      Number of
Unearned
Shares,
Units or
Other
Rights That
Have Not
Vested
  

Market or
payout value
of unearned
shares, units
or other
rights that
have not
vested(3)

($)

 

Roger D. Dansey, M.D.

  9,791   30,209   65.11   6/15/2018   6/15/2028                         
   1,063   2,126   76.86   8/30/2018   8/30/2028                         
   4,670   9,340   77.45   9/7/2018   9/7/2028                         
      70,013   72.64   8/30/2019   8/30/2029                         
                           50,000(12)   5,713,000             
                           10,000(13)   1,142,600             
                           1,007(5)   115,060             
                           4,423(5)   505,372             
                           6,905(14)   788,965       10,358(15)   1,183,505 
                                       1,991(6)   227,492 
                           5,768(16)   659,052             
                           29,475(7)   3,367,814             
                           560(10)   63,986             
                                       2,436(11)   278,337 

Total

  15,524   111,688                   108,138   12,355,849       14,785   1,689,334 

Jean I. Liu

  56,000      35.95   12/01/2014   12/1/2024                         
   35,000      39.15   8/25/2015   8/25/2025                         
   31,250   6,250   45.30   8/27/2016   8/27/2026                         
   24,791   17,709   46.37   8/17/2017   8/17/2027                         
   13,941   27,883   76.86   8/30/2018   8/30/2028                         
   2,084   6,249   34.20   3/20/2018   5/9/2026                         
      45,119   72.64   8/30/2019   8/30/2029                         
                           17,000(4)   1,942,420             
                           13,206(5)   1,508,918             
                                       1,422(6)   162,478 
                           18,995(7)   2,170,369             
                           697(10)   79,639             
                                       1,740(11)   198,812 

Total

  163,066   103,210                   49,898   5,701,346       3,162   361,290 

Robin G. Taylor, Ph.D.

     54,491   64.38   5/20/2019   5/20/2029                         
      11,083   72.64   8/30/2019   8/30/2029                         
                           23,557(17)   2,691,623             
                           4,741(18)   541,707             
                           4,666(7)   533,137             
                           61(10)   6,970             
                                       2,436(11)   278,337 

Total

     65,574                   33,025   3,773,437       2,436   278,337 

Total

  1,962,417   797,238                   442,075   50,511,491       87,825   10,034,884 

(1)

The number of shares or units that have not vested and the market value of shares or units that have not vested does not include the potential RSUs to be granted under the Tucatinib LTIP or the EV/TV LTIP, with respect to Dr. Dansey as the RSU award opportunities are denominated in dollars, and the payout, if any, earned will be made in RSUs based on the closing stock price of our common stock on the date of grant following the achievement of performance milestones. Please see the “Grants of Plan-Based Awards Table” above for more information regarding these awards.LTIP.

(2)

All of the unexercisable options set forth in this column (other than the options with a vesting start date of March 20, 2018) vest at a rate of 1/4th4th upon the one year anniversary of the vesting commencement date of such award, which vesting commencement date for each award is based on the date of hire of such person for their initial grant and thereafter on the grant date of such award. 1/36th36th of the remaining unvested shares vest on an equal monthly basis

thereafter until the award is fully vested on the fourth anniversary of the vesting commencement date. The options with a vesting start date of March 20, 2018 vest in four equal annual installments on the first four anniversaries of March 20, 2018.


thereafter until the award is fully vested on the fourth anniversary of the vesting commencement date. The options with a vesting start date of March 20, 2018 vest in four equal annual installments on the first four anniversaries of March 20, 2018.
(3)

The market value of the RSU awards is based on the closing stock price of $56.66$114.26 per share for our common stock as reported on the Nasdaq Global Select Market on December 31, 2018.2019.

(4)

RSU awards vest in full on August 27, 2019.17, 2020.

(5) RSU awards vest in full on August 17, 2020.
(6) RSU awards vests 25% per year until fully vested on August 30, 2022.
(7) The First Tranche of the RSUs under the Tucatinib LTIP were granted on November 1, 2018 and will vest upon certification by the Compensation Committee of certain milestones, as further described under the heading “Compensation Discussion and Analysis—2018 Compensation Decisions for the named executive officers-Performance-Based Incentive Awards.” The First Tranche may vest for up to 144% of the amount set forth in the table above, based on the date of achievement of the Tucatinib Milestone and the breadth of the indication or indications, as the case may be, for which tucatinib is approved by the FDA for commercial sale and marketing in the United States on the date that the Tucatinib Milestone occurs.
(5)

RSU awards vests 25% per year until fully vested on August 30, 2022.

(8)
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Includes discretionary stock options that were granted under our 2007 Equity Plan. 14,010

COMPENSATION DISCUSSION AND ANALYSIS

(6)

The First Tranche of the 17,199 stock optionsRSUs under the Tucatinib LTIP were granted on September 7,November 1, 2018 with an exercise priceand will vest upon certification by the Compensation Committee of $77.45certain milestones, as further described above under the heading “—Employment Agreements and have a vesting start date and expirationArrangements—Long-Term Incentive Plans.” The First Tranche may vest for up to 144% of the amount set forth in the table above, based on the date of August 30, 2018achievement of the Tucatinib Milestone and September 7, 2028, respectively. Vestingthe breadth of all of these discretionary options occurs 1/4ththe indication or indications, as the case may be, for which tucatinib is approved by the FDA for commercial sale and marketing in the United States on the onedate that the Tucatinib Milestone occurs.

(7)

RSU awards vests 25% per year anniversary of the grant date and 1/36th of the remaining shares thereafter on a monthly basis until the grant is fully vested on August 30, 2023.

(8)

The Adjusted Revenue PSU awards were granted on August 30, 2019 and will vest after December 31, 2022 upon certification by the fourth anniversaryCompensation Committee of achievement of the grant date.2022 revenue-based performance metric, as further described above under the heading “Employment Agreements and Arrangements—Stock Awards.” Number of unearned shares and market value represent achievement of the performance metric at target. Maximum number of shares under the Adjusted Revenue PSU awards is 76,854.

(9) RSU awards vest in full on June 15, 2021.
(10) RSU awards vest 50% per year until fully vested on June 15, 2020.
(11) Dr. Dansey was awarded 1,343 and 5,898 RSUs on August 30, 2018 and September 7, 2018, respectively as part his annual discretionary award.
(12) RSU awards will vest in tranches contingent on the FDA approval of EV, FDA approval of tucatinib and FDA approval of TV, subject to Dr. Dansey’s continued employment on the vesting date, as further described under the heading “- Compensation Discussion and Analysis - 2018 Compensation Decisions for the named executive officers -Performance-Based Incentive Awards.
(13) RSU awards vest in full on August 31, 2019.
(14) RSU awards vest in full on March 1, 2019.



(9)

The Relative TSR PSU awards were granted on August 30, 2019 and will vest after August 31, 2022 upon certification by the Compensation Committee of the market-based performance metric, as further described above under the heading “Employment Agreements and Arrangements—Stock Awards.” Number of unearned shares and market value represent achievement of the performance metric at target. Maximum number of shares under the Relative TSR PSU awards is 19,214.

(10)

Upon the Compensation Committee’s certification that PADCEV received FDA approval, the EV portion of the RSU award was deemed eligible to vest and will vest on December 18, 2021, subject to the named executive officer’s continued employment on the vesting date, as further described under the heading “Employment Agreements and Arrangements—Long Term Incentive Plans and PSU Awards.”

(11)

The EV Frontline PSU awards were granted on December 31, 2019 and will vest upon certification by the Compensation Committee of certain milestones, as further described above under the heading “Employment Agreements and Arrangements—Long-Term Incentive Plans and Programs.”

(12)

RSU awards vest in full on June 15, 2021.

(13)

RSU awards vest 50% per year until fully vested on June 15, 2020.

(14)

Upon the Compensation Committee’s certification that PADCEV received FDA approval, the EV portion of Dr. Dansey’s PSU award was deemed eligible to vest and will vest on December 31, 2021, subject to Dr. Dansey’s continued employment on the vesting date, as further described under the heading “Employment Agreements and Arrangements—Long Term Incentive Plans and PSU Awards.”

(15)

The remaining portion of Dr. Dansey’s PSU awards will vest in tranches contingent on the FDA approval of tucatinib and FDA approval of TV, subject to Dr. Dansey’s continued employment on the vesting date, as further described under the heading “Employment Agreements and Arrangements—Long Term Incentive Plans and PSU Awards.”

(16)

RSU awards vests 25% per year until fully vested on February 1, 2023.

(17)

RSU awards vests 25% per year until fully vested on May 20, 2023.

(18)

RSU awards vest in full on May 20, 2020.


OPTION EXERCISES AND STOCK VESTED

The following table sets forth information regarding exercises of stock options and vesting of RSU awards by our named executive officers for the year ended December 31, 2018.

  Option Awards Stock Awards
Name 
Number
of Shares
Acquired
on Exercise
 
Value Realized
on Exercise (1)
 
Number
of Shares
Acquired
on Vesting
 
Value Realized
on Vesting (2)
Clay B. Siegall, Ph.D. 231,247
 $11,741,863
 64,000
 $4,773,760
Todd E. Simpson 
 $
 17,000
 $1,268,030
Roger D. Dansey, M.D. 
 $
 
 $
Vaughn B. Himes, Ph.D. 20,000
 $1,051,000
 15,000
 $1,118,850
Darren Cline 19,086
 $757,852
 17,400
 $1,196,940
_____________________
2019.

   Option Awards      Stock Awards 
              

Name

  

Number

of Shares

Acquired

on Exercise

   

Value Realized

on Exercise(1)

$

       

Number

of Shares

Acquired

on Vesting

   

Value Realized

on Vesting(2)

$

 

Clay B. Siegall, Ph.D.

   291,629         19,575,954        95,996         7,127,229 

Todd E. Simpson

                    23,179         1,722,243 

Roger D. Dansey, M.D.

   10,000         535,650        11,811         816,551 

Jean I. Liu

                    19,402         1,441,461 

Robin G. Taylor, Ph.D.

                              

(1)

The value realized on exercise is calculated based on the difference between the exercise price of each option exercised and the closing price of our common stock on the date of exercise multiplied by the number of shares underlying each option exercised, and does not represent actual amounts received by the named executive officers as a result of the option exercises.

(2)

The value realized on vesting is calculated based on the closing price of our common stock on the date of vest multiplied by the number of shares underlying each award vested.

CEO PAY RATIO

Under SEC regulations, we are required to calculate and disclose the total annual compensation paid to our median employee, as well as the ratio of the total compensation paid to the median employee as compared to the total compensation paid to our CEO, or the CEO Pay Ratio. Set forth below is a description of the methodology, including material assumptions, adjustments and estimates, we used to identify the median employee for purposes of calculating the CEO Pay Ratio:

We identified the median employee using our employee population as of October 31, 2018.2019. For this purpose, we identified all company employees on payroll and all individuals who would receive an IRS Form 1099 from the Company but who did not meet the following exclusion criteria: (i) receipt of annual payments from the Company that totaled less than twenty thousand dollars ($20,000); (ii) employment by another entity, such as employment as faculty of a university; (iii) 1099 recipient constituted a generally recognizable, bona fide third-party service provider such as a law firm or accounting firm; and (iv) 1099 recipient employed more than two or more employees and has two or more other bona fide clients.

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COMPENSATION DISCUSSION AND ANALYSIS

faculty of a university; (iii) 1099 recipient constituted a generally recognizable, bona fide third-party service provider such as a law firm or accounting firm; and (iv) 1099 recipient employed more than two or more employees and has two or more other bona fide clients.

In determining compensation for purposes of the median calculation, we used each employee’s annual base pay, target annual bonus and regular annual equity awards (at grant date fair value). For individuals receiving 1099s and not excluded based on the criteria above, the amount of compensation reflected in the individual’s Form 1099 was the annual compensation number utilized.

We annualized the base salary earned in 20182019 by permanent employees (full-time and part-time) hired after January 1, 2018.2019.

Using this approach, we selected the median of our employee population. Once the median employee was identified, we then calculated annual total compensation for this employee in accordance with the requirements of the Summary Compensation Table.

For 2018,2019, the median of the annual total compensation of our employees (other than our CEO) was $198,658$222,352 and the annual total compensation of our CEO was $18,107,037.$14,521,495. The ratio of the annual total compensation of our CEO to the median of the annual total compensation of all employees other than the CEO was 91:65:1.

The pay ratio above represents the Company’s reasonable estimate calculated in a manner consistent with the rule and applicable guidance. The rule and guidance provide significant flexibility in how companies identify the median employee, and each company may use a different methodology and make different assumptions particular to that company. As a result, as the SEC explained when it adopted the rule, in considering thepay-ratio disclosure, stockholdersshareholders should keep in mind that the rule was not designed to facilitate comparisons of pay ratios among different companies, even companies within the same industry, but rather to allow stockholdersshareholders to better understand and assess each particular company’s compensation practices andpay-ratio disclosures. Neither the Compensation Committee nor our management used our CEO Pay Ratio measure in making compensation decisions.

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POTENTIAL PAYMENTS UPON TERMINATION ORCHANGE-IN-CONTROL

The following table reflects the potential payments and benefits to which the named executive officers would be entitled under each individual’s employment agreement with Seattle Genetics and ourECHELON-1 LTIP, the EV/TV LTIP, the Tucatinib LTIP and any performance-based RSU granted to a named executive officer, in the event of termination orchange-in-control of the Company. The amounts shown in the table below assume that each termination or event was effective as of December 31, 20182019 and that all eligibility requirements under the respective agreement were satisfied.

  
Involuntary Termination (1)
   
Name and Principal Position 
Before or
more than 12
months after a
Change in
Control
 
Immediately before or within 12
months after a
Change in
Control
  
Termination
due to
Death or
Disability (2)
Clay B. Siegall, Ph.D.       
President and CEO       
Base salary continuation $1,381,725
 $1,842,300
  $
Lump sum bonus award payment 1,381,725
 2,763,450
  921,150
Health benefit continuation 23,411
 23,411
  
Vacation payout 85,173
 85,173
  85,173
Stock award acceleration (3)
 7,058,723
 17,004,696
  
Total $9,930,757
 $21,719,030
  $1,006,323
Todd E. Simpson       
Chief Financial Officer       
Base salary continuation $540,900
 $811,350
  $
Lump sum bonus award payment 270,450
 405,675
  270,450
Health benefit continuation 26,672
 40,009
  
Vacation payout 52,008
 52,008
  52,008
Stock award acceleration (3)
 1,772,139
 4,577,494
  
Total $2,662,169
 $5,886,536
  $322,458
Roger D. Dansey, M.D.       
Chief Medical Officer       
Base salary continuation $650,000
 $975,000
  $
Lump sum bonus award payment 325,000
 487,500
  325,000
Health benefit continuation 26,672
 40,009
  
Vacation payout 27,079
 27,079
  27,079
Stock award acceleration (3)
 102,498
 5,467,407
  
Total $1,131,249
 $6,996,995
  $352,079
Vaughn B. Himes, Ph.D.       
Chief Technical Officer       
Base salary continuation $507,500
 $761,250
  $
Lump sum bonus award payment 253,750
 380,625
  253,750
Health benefit continuation 26,672
 40,009
  
Vacation payout 46,926
 46,926
  46,926
Stock award acceleration (3)
 2,167,015
 4,498,351
  
Total $3,001,863
 $5,727,161
  $300,676
Darren Cline       
Former Executive Vice President, Commercial       
Base salary continuation $482,500
 $723,750
  $
Lump sum bonus award payment 217,125
 325,688
  217,125
Health benefit continuation 26,672
 40,009
  
Vacation payout 6,853
 6,853
  6,853
Stock award acceleration (3)
 2,014,430
 4,168,242
  
Total $2,747,580
 $5,264,542
  $223,978


_______________

   

Involuntary Termination(1)

     
          

Name and Principal Position

  

Before or

more than 12

months after a

Change in

Control

   

Immediately
before or
within 12

months after a

Change in

Control

   

Termination

due to

Death or

Disability(2)

 

Clay B. Siegall, Ph.D.

               

President and CEO

               

Base salary continuation

  $     1,450,812   $     1,934,416   $      

Lump sum bonus award payment

        1,450,812         2,901,624         967,208 

Health benefit continuation

        38,691         51,588          

Vacation payout

        83,697         83,697         83,697 

Stock award acceleration(3)

        21,172,872         48,438,581         8,398,533 

Total

  $     24,196,884   $     53,409,906   $     9,449,438 

Todd E. Simpson

               

Chief Financial Officer

               

Base salary continuation

  $     575,200   $     862,800   $      

Lump sum bonus award payment

        287,600         431,400         287,600 

Health benefit continuation

        18,615         27,922          

Vacation payout

        49,775         49,775         49,775 

Stock award acceleration(3)

        6,693,195         13,547,957         2,361,379 

Total

  $     7,624,385   $     14,919,854   $     2,698,754 

Roger D. Dansey, M.D.

               

Chief Medical Officer

               

Base salary continuation

  $     672,800   $     1,009,200   $      

Lump sum bonus award payment

        336,400         504,600         336,400 

Health benefit continuation

        25,794         38,691          

Vacation payout

        55,628         55,628         55,628 

Stock award acceleration(3)

        5,153,239         17,947,409         4,409,955 

Total

  $     6,243,861   $     19,555,528   $     4,801,983 

Jean I. Liu

               

General Counsel and Executive Vice President, Legal Affairs

               

Base salary continuation

  $     522,200   $     783,300   $      

Lump sum bonus award payment

        261,100         391,650         261,100 

Health benefit continuation

        25,794         38,691          

Vacation payout

        43,264         43,264         43,264 

Stock award acceleration(3)

        5,324,059         11,116,872         2,062,543 

Total

  $     6,176,417   $     12,373,777   $     2,366,907 

(1)

Each employment agreement with a named executive officer provides that in the case of involuntary termination occurring not in connection with a change in control, such individual is entitled to receive either alump-sum payment equal to 12 months of monthly base salary or payment of such amount in accordance with Seattle Genetics’ standard payroll schedule, at our discretion, such individual’s annual target bonus, 12 months of continued health benefits and 12 months of accelerated vesting of outstanding equity awards (i.e., stock options and RSUs)RSU awards), except that Dr. Siegall is entitled to 18 months of base salary and continued health benefits and his annual target bonus multiplied by 1.5. In the case of involuntary termination occurring immediately prior to or within 12 months after a change in control, each named executive officer is entitled to receive 18 months of monthly base salary, such individual’s annual bonus at target, multiplied by 1.5, 18 months of continued health benefits and 100% acceleration of vesting of outstanding equity awards, except that Dr. Siegall is entitled to 24 months of base salary and 24 months of continued health benefits, apro-rata portion of his annual bonus at target and his annual bonus at target multiplied by 2. Such severance benefits are conditioned upon the individual’s resignation from all positions held by the individual and execution of a full release and waiver of claims. See the description of each named executive officer’s employment agreement set forth below under the heading “Employment Agreements.”

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COMPENSATION DISCUSSION AND ANALYSIS

(2)

Upon termination due to death or disability, each employment agreement provides for payment of the portion of any annual bonus earned prior to the date of termination at target and any accrued but unused vacation.vacation, and 12 months accelerated vesting of outstanding equity awards granted after May 18, 2018. The PSUs awarded to Dr. Siegall in August 2019 and performance-based RSUs awarded Dr. Dansey in September 2018 provide for accelerated vesting due to termination of employment due to death or disability.

(3)

The value of equity award vesting acceleration is based on the closing stock price of $56.66$114.26 per share for our common stock as reported on the Nasdaq Global Select Market on December 31, 20182019 with respect to unvested RSUsRSU awards andin-the-money unvested stock option shares (and in the case of unvested stock option shares, minus the exercise price of the unvested option shares). The potential RSUsRSU awards to be granted under the Tucatinib LTIP and EV/TV LTIP as of December 31, 2019 are not included as those awards were not outstanding as of December 31, 20182019 and the payout of those awards are not subject to acceleration upon change in control or termination.

Employment Agreements

EMPLOYMENT AGREEMENTS

We are a party to an amended and restated employment agreement with Dr. Siegall entered into in October 2018. This agreement provides that he receive an annual base salary, which is currently set at $967,208$1,050,600 effective February 1, 2019,5, 2020, and he may receive an annual bonus based upon performance criteria and financial and operational results of Seattle Genetics as determined by the Compensation Committee of the Board of Directors under our Executive Bonus Plan. Dr. Siegall is also eligible to receive additional grants of stock options or other equity awards from time to time in the future as determined by the Compensation Committee of the Board of Directors. In the event Dr. Siegall’s employment is constructively terminated or terminated by Seattle Genetics without cause, he will be entitled to receive his monthly base salary and COBRA premium benefits for an additional 18 months (or 24 months if he is constructively terminated or terminated by Seattle Genetics without cause immediately prior to or within 12 months after a change in control of Seattle Genetics), payable in either alump-sum payment or in accordance with Seattle Genetics’ standard payroll schedule, at Seattle Genetics’ discretion, and to stock award vesting acceleration equal to an additional 12 months of vesting, as well as his annual bonus at target multiplied by 1.5. The employment agreement additionally provides that if Dr. Siegall’s employment is constructively terminated or terminated by Seattle Genetics without cause immediately prior to or within 12 months after a change in control of Seattle Genetics, all of Dr. Siegall’s stock awards will become fully vested and, in the case of stock options, exercisable, and he will be entitled to his pro rata bonus at target for the year in which the change in control occurs, and to his target bonus at target multiplied by two. Such severance benefits are conditioned upon Dr. Siegall’s resignation from all positions held by Dr. Siegall and execution of a full release and waiver of claims. Dr. Siegall’s employment is for no specified length of time, and either he or Seattle Genetics has the right to terminate his employment at any time with or without cause.

We are a party to an amended and restated employment agreement with Mr. Simpson entered into in October 2018. This agreement provides that he receive an annual base salary, which is currently set at $575,200$604,000 effective February 1, 2019,5, 2020, and is eligible to receive an annual bonus at a target percentage of his base salary as determined by the Compensation Committee. Mr. Simpson is also eligible to receive additional grants of stock options or other equity awards from time to time in the future as determined by the Compensation Committee of the Board of Directors.

We are a party to an amended and restated employment agreement with Dr. Dansey entered into in October 2018. This agreement provides that he receive an annual base salary, which is currently set at $672,800$706,400 effective February 1, 2019,5, 2020, and is eligible to receive an annual bonus at a target percentage of his base salary as determined by the Compensation Committee. Dr. Dansey is also eligible to receive additional grants of stock options or other equity awards from time to time in the future as determined by the Compensation Committee of the Board of Directors.

We are a party to an amended and restated employment agreement with Dr. HimesMs. Liu entered into in October 2018. This agreement provides that heshe receive an annual base salary, which is currently set at $530,300$548,300 effective February 1, 2019,5, 2020, and is eligible to receive an annual bonus at a target percentage of hisher base salary as determined by the Compensation Committee.


Dr. Himes Ms. Liu is also eligible to receive additional grants of stock options or other equity awards from time to time in the future as determined by the Compensation Committee of the Board of Directors.

We were a party to an amended and restated employment agreement, entered into in May 2019, with Mr. Cline,Dr. Taylor, our former Executive Vice President, Commercial.Chief Commercial Officer. This agreement provided that he would receive an annual base salary, which was set at $482,500$507,000 effective February 1, 2019,5, 2020, and was eligible to receive an annual bonus at a target percentage of his base salary as determined by the Compensation Committee. Under the agreement, Mr. ClineDr. Taylor was also eligible to receive additional grants of stock options or other equity awards from time to time in the future as determined by the Compensation Committee of the Board of Directors.

Each of Mr. Simpson,Simpson’s, Dr. DanseyDansey’s and Dr. Himes’Ms. Liu’s amended and restated employment agreements provide that if such executive'sexecutive’s employment is constructively terminated or terminated by us without cause, such executive will be entitled to 12 months of base salary, his or her annual bonus at target, COBRA premium benefits and equity award vesting acceleration equal to 12 months of vesting. Their employment agreements additionally provide that in the event such executive is involuntarily terminated immediately prior to or within 12 months after a change in control, all of such

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executive’s stock awards will become fully vested and, in the case of stock options, exercisable, and he or she will be entitled to 18 months of base salary and his or her annual bonus at target, multiplied by 1.5. Such severance benefits are conditioned upon such executive’s resignation from all positions held by such executive and execution of a full release and waiver of claims. Each such executive’s employment is for no specified length of time, and either such executive or we have the right to terminate such executive’s employment at any time with or without cause. Mr. Cline’s amended and restatedDr. Taylor’s employment agreement contained the same terms as those of Mr. Simpson, Dr. Dansey and Ms. Liu. When Dr. Himes.

Other Benefits on Termination or ChangeTaylor left the Company in Control
February 2020, he received severance payments equivalent to 12 months of base salary, 12 months’ bonus at target and 12 months of COBRA premiums and equity award vesting acceleration equal to 12 months of vesting from the date of his separation. His other unvested equity awards were cancelled.

OTHER BENEFITS ON TERMINATION OR CHANGE IN CONTROL

We do not provide any “gross-ups”“gross-ups” or other payments based on taxes attributable to any of the severance payments and benefits described above.

Upon a termination of employment due to death or disability, each employment agreement also provides for payment of the portion of any annual bonus earned prior to the date of termination and any accrued but unused vacation. In addition, the 2007 Equity Plan provides that all outstanding options to purchase shares of our common stock that are vested and exercisable as of the date of the executive officer’s death or, in the event of the executive officer’s death within 30 days following the termination of service or his or her disability, may be exercised for six months following his or her death or, in the event of termination of service due to the executive officer’s disability, one year following the termination date but in no event after the expiration date of such option.

Other Termination Benefits

OTHER TERMINATION BENEFITS

Other than as set forth in each named executive officer’s employment agreement and except as otherwise provided by applicable law, the named executive officers are generally not entitled to any additional benefits upon a termination or change in control of Seattle Genetics. However, under the 2007 Equity Plan, and our Amended and Restated 1998 Stock Option Plan, or 1998 Equity Plan, in the event of a change in control of Seattle Genetics, (i) if the successor corporation does not assume or substitute equivalent awards for all outstanding equity awards granted pursuant to the 2007 Equity Plan or the 1998 Equity Plan, then as of the date of completion of the acquisition or merger, the vesting of such equity awards shall be accelerated in full; and (ii) if outstanding equity awards are assumed or equivalent awards are substituted by the successor corporation and if at the time of, immediately prior to or within twelve months after the effective time of the change ofin control, an equity awardee’s service as an employee or consultant is terminated without cause or due to constructive termination, then the vesting of such substituted equity award shall be accelerated in full. The value of such stock option acceleration in full for each named executive officer, assuming such termination or event was effective as of December 31, 2018,2019, is set forth in the Potential“Potential Payments Upon Termination or Change-In-ControlChange-In-Control” table above under the column “Involuntary Termination—Within 12 months after a Change in Control.”

Under the 2007 Equity Plan, if a named executive officer’s service with us is terminated as a result of death or disability, the period of time in which options may be exercised following termination is extended as described in more detail under the heading “Employment Agreements and Arrangements—Stock Awards.” The terms of the 1998 Equity Plan are substantially similar to the 2007 Equity Plan with respect to the extension of the post-termination exercise period in the case of a termination due to death or disability.

Under theECHELON-1 LTIP, the payment of the cash awards payable to a named executive officer and the vesting of the stock options held by a named executive officer are subject to full acceleration in the event of a termination of service (without cause or due to constructive termination) immediately prior to or within 12 months after, a change ofin control of the Company, or in the event an acquirer in a change ofin control of the Company fails to assume the cash award or stock option. The value of such cash award and stock option acceleration in full for each named executive officer, assuming such termination or event was effective as of December 31, 2018,2019, is set forth in the Potential“Potential Payments Upon Termination or Change-In-ControlChange-In-Control” table above.


Under the EV/TV LTIP, the vesting of any RSU awards held by a named executive officer is subject to full acceleration in the event of a termination of service (without cause or due to constructive termination) immediately prior to or within 12 months after, a change ofin control of the Company, or in the event an acquirer in a change ofin control of the Company fails to assume the awards. The value of the acceleration of the portion of such RSU award that was granted upon approval of PADCEV is included in the “Potential Payments Upon Termination orChange-In-Control” table above. The value of the remaining portion of such RSU award acceleration is not included in the Potential“Potential Payments Upon Termination or Change-In-ControlChange-In-Control” table above, as those awards wereit was not outstanding as of December 31, 2018.2019.

2020 PROXY STATEMENT69


COMPENSATION DISCUSSION AND ANALYSIS

Under the Tucatinib LTIP, the vesting of any RSU awards held by a named executive officer is subject to partial or full acceleration in the event of a termination of service (without cause or due to constructive termination) immediately prior to, or within twelve months after, a change ofin control of the Company, or in the event an acquirer in a change ofin control of the Company fails to assume the stock unit awards. The value of such acceleration applicable to the First Tranche of stock unit awards in full for each named executive officer, assuming such termination or event was effective as of December 31, 2018,2019, is set forth in the Potential“Potential Payments Upon Termination or Change-In-ControlChange-In-Control” table above. The value of such acceleration applicable to the Second Tranche of stock unit awards is not included in the Potential“Potential Payments Upon Termination or Change-In-ControlChange-In-Control” table above, as those awards were not outstanding as of December 31, 2018.

2019.

Under the terms of the performance-based RSU award granted to Dr. Dansey in September 2018, the vesting of such award is subject to partial acceleration in the event an acquirer in a change ofin control of the Company fails to assume the RSU award. The portion of the RSU award eligible to vest upon such change ofin control will be determined based on the level of achievement of the relevant performance conditions and the applicable remaining period preceding the scheduled deadline for achieving any remaining performance conditions not yet satisfied, in each case as of the change ofin control. In addition, the event of a termination of service with the Company (or an acquirer, if such termination occurs within twelve months after the date of a change ofin control and the acquirer has continued or assumed the award) without cause, due to constructive termination or due to death or disability, the number of shares deemed eligible to vest, as determined pursuant to the terms of the RSU award, will vest on the later of the date of the termination and the date that the Compensation Committee certifies achievement of the relevant performance conditions, which shall be no later than 60 days following the termination. The value of such RSU award acceleration in full for Dr. Dansey, assuming such termination or event was effective as of December 31, 2018,2019, is set forth in the Potential“Potential Payments Upon Termination or Change-In-ControlChange-In-Control” table above.

Under the terms of the PSU awards granted to Dr. Siegall in August 2019, the vesting of such PSU awards will cease upon termination of service as an employee for any reason other than death or disability. The PSU awards provide for acceleration of vesting in the event of certain specified change in control events involving us or the termination of our CEO’s employment due to death or disability. In addition, following certain change in control events wherein the PSU awards are assumed by the surviving entity, the PSU awards convert to time-based vesting and cliff vest on the last day of the applicable performance period, subject to our CEO’s continued service through the applicable vesting date; provided, however, that if our CEO is involuntarily terminated immediately prior to or within 12 months after any such change in control event, the PSU awards will vest effective as of the date of such involuntary termination. The value of such PSU award acceleration is included in the “Potential Payments Upon Termination orChange-In-Control” table above.

Under the terms of the EV Frontline PSU awards held by our named executive officers, the vesting of such awards is subject to partial acceleration in the event of a termination of service (without cause or due to constructive termination) immediately prior to or within 12 months after, a change in control of the Company, or in the event an acquirer in a change in control of the Company fails to assume the awards. The value of such EV Frontline PSU award acceleration, assuming such termination or event was effective as of December 31, 2019, is included in the “Potential Payments Upon Termination orChange-In-Control” table above.

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CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS

CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS
Policies and Procedures for Review of Related Party Transactions

POLICIES AND PROCEDURES FOR REVIEW OF RELATED PARTY TRANSACTIONS

Pursuant to the Audit Committee Charter, the Audit Committee is responsible for the review, oversight and approval of any transaction with an executive officer, director, principal stockholdershareholder or any of such persons’ immediate family members or affiliates in which the amount involved exceeds $120,000 or is otherwise required to be disclosed by Seattle Genetics under applicable rules and regulations of the SEC. The Audit Committee will consider the relevant facts and circumstances available and deemed relevant, including, but not limited to, the risks, costs and benefits to Seattle Genetics, the terms of the transaction, and the availability of other sources for comparable services or products.

Certain Transactions With

CERTAIN TRANSACTIONS WITH OR INVOLVING RELATED PERSONS

Since January 1, 2019, we have not engaged in any transactions, nor are any such transactions currently proposed, in which we were a participant and the amount involved exceeded $120,000, and in which any related person had or Involving Related Persons

Participation in Public Offering andRegistrationwill have a direct or indirect material interest, except as follows:

BeiGene License Agreement. In November 2019, we entered into a license agreement with BeiGene, Ltd., or BeiGene, for the advancement of Shares. Entities affiliated with onea preclinical product candidate for treating cancer. One of our directors, Felix J. Baker, and entities affiliated with Dr. Baker, which together are our largest stockholders,shareholders, or the Baker Entities, purchased an aggregateowned 15.8% of 3,846,153BeiGene as of January 2, 2020, according to the shares of common stock offered in our public offering we completed in February 2018 at the public offering price of $52.00 per share, for an aggregate purchase price of approximately $200 million. In addition, in September 2015, we entered into a registration rights agreement with the Baker Entities. Under the registration rights agreement, we agreed that, if at any time and from time to time, the Baker Entities demand that we register their shares of our common stock for resale under the Securities Act, we would be obligated to effect such registration. Our registration obligations under this registration rights agreement cover all shares now held or hereafter acquiredSchedule13-D/A filed by the Baker Entities will continue in effect for up to ten years, and include our obligation to facilitate certain underwritten public offeringson January 7, 2020. In addition, two representatives of our common stock by the Baker Entities in the future.serve on BeiGene’s board of directors. Under the terms of the registrationagreement, Seattle Genetics retained rights agreement, we are obligated to pay all expenses incurred by us in effecting any registration pursuant to the registrationproduct candidate in the Americas (United States, Canada and Latin American countries), Europe and Japan. BeiGene was granted exclusive rights agreementto develop and commercialize the product candidate in Asia (except Japan) and the rest of the world. Seattle Genetics will lead global development, and BeiGene agreed to fund and operationalize the portion of global clinical trials attributable to its territories. BeiGene will also be responsible for all clinical development and regulatory submissions specific to its territories. Seattle Genetics received an upfront payment of $20 million and is eligible to receive progress-dependent milestones for total potential upfront and milestone payments of up to $160 million, as well as up to $50,000royalties for potential sales of reasonable legal expenses of one special counsel for Baker Entities per underwritten public offering effected pursuant to the registration rights agreement. On July 26, 2018, pursuant to the registration rights agreement, we registered for resale, from time to time, up to 50,977,960 shares of our common stock held by the Baker Entities.product candidate. The Audit Committee, in exercise of its review and oversight responsibilities, approved both the entry into the registration rightslicense agreement with the Baker Entities and the participation of related parties in our public offering.

Indemnification AgreementsBeiGene.

INDEMNIFICATION AGREEMENTS

Seattle Genetics has entered into indemnification agreements with its directors and certain officers for the indemnification of and advancement of expenses to these persons to the fullest extent permitted by law. Seattle Genetics also intends to enter into these agreements with our future directors and certain future officers.

2020 PROXY STATEMENT71


EQUITY COMPENSATION PLAN INFORMATION


EQUITY COMPENSATION PLAN INFORMATION

The following table provides information as of December 31, 20182019 with respect to the shares of our common stock that may be issued under our existing equity compensation plans: our 2007 Equity Plan, our 1998 Equity Plan, our 2000 Directors’ Stock Option Plan and our ESPP.

Plan Category 
Number of securities
to be issued upon 
exercise of 
outstanding 
options and rights
(a)
 
Weighted average
 exercise price of 
outstanding 
options and rights
(b)
 
Number of securities
remaining available
for future issuance under
equity compensation plans
(excluding securities
reflected in Column (a))
(c)
 
Equity compensation plans approved by stockholders:       
Amended and Restated 2007 Equity Incentive Plan (1)
 13,712,666
 $40.61
 6,775,642
(2) 
Amended and Restated 1998 Stock Option Plan 
 $
 
(3) 
2000 Directors’ Stock Option Plan 82,500
 $12.10
 
(4) 
Amended and Restated 2000 Employee Stock Purchase Plan 
 $
 382,789
(5) 
Equity compensation plans not approved by stockholders 
 $
 
 
Total 13,795,166
   7,158,431
 
_______________ 
Amended and Restated 2000 Employee Stock Purchase Plan.

Plan Category

  

Number of securities

to be issued upon

exercise of

outstanding

options and rights

(a)

     

Weighted average

exercise price of

outstanding

options and rights

(b)

   

Number of securities

remaining available

for future issuance under

equity compensation plans

(excluding securities

reflected in Column (a))

(c)

 

Equity compensation plans approved by shareholders:

                      

Amended and Restated 2007 Equity Incentive Plan(1)

 

   

 

13,133,711

 

 

 

    $

 

 

 

 

 

   

 

47.19

 

 

 

   

 

4,072,747(2)

 

 

 

2000 Directors’ Stock Option Plan

 

   

 

35,000

 

 

 

    $

 

 

 

 

 

   

 

12.76

 

 

 

   

 

(3)

 

 

 

Amended and Restated 2000 Employee Stock Purchase Plan

 

   

 

 

 

 

    $

 

 

 

 

 

   

 

 

 

 

   

 

1,194,180(4)

 

 

 

Equity compensation plans not approved by shareholders

        $         —   

Total

   13,168,711                5,266,927  

(1)

The number of securities to be issued upon exercise of outstanding options and rights (column (a)) includes shares subject to RSU awards granted under the 2007 Equity Plan, which RSU awards do not carry an exercise price. Accordingly, the weighted average exercise price of outstanding options and rights (column (b)) excludes the grant of RSU awards.

(2)

As of December 31, 2018, 6,775,6422019, 4,072,747 shares remained available for future issuance under our 2007 Equity Plan. As of March 1, 2019, 6,803,4112020, 4,138,239 shares remained available for future issuance under our 2007 Equity Plan.

(3)The Amended and Restated 1998 Stock Option Plan expired on December 23, 2007.
(4)

The 2000 Directors’ Stock Option Plan expired on March 7, 2011.

(4)
(5)

As of December 31, 2018, 382,7892019, 1,194,180 shares remained available for future issuance under our Amended and Restated 2000 Employee Stock Purchase Plan. As of March 1, 2019, 278,9012020, 1,061,282 shares remained available for purchase in the current purchase period under our Amended and Restated 2000 Employee Stock Purchase Plan.


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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The following table sets forth information as of March 1, 2020 (except as noted) regarding the beneficial ownership of our common stock by each director (including each nominee for director), by each person or group of affiliated persons known to us to beneficially own five percent or more of our outstanding common stock, by each named executive officer and by all executive officers and directors as a group. Unless otherwise indicated, the address of the individuals and entities below is c/o Seattle Genetics, Inc., 21823 – 30th Drive SE, Bothell, WA 98021.

Name and Address

  Total Common
Stock Equivalents(1)
   Percent of Common
Stock  Equivalents(2)
 

Felix J. Baker, Ph.D.(3)

Baker Bros. Advisors LP and Affiliates(3)

667 Madison Avenue, 21st Floor

New York, NY 10065

   50,595,325    29.3% 

Capital International Investors(4)

11100 Santa Monica Blvd., 16th Floor
Los Angeles, CA 90025

   20,996,099    12.2% 

PRIMECAP Management Company(5)

177 E. Colorado Blvd., 11th Floor

Pasadena, CA 91105

   10,951,717    6.4% 

The Vanguard Group(6)

100 Vanguard Blvd

Malvern, PA 19355

   10,916,170    6.3% 

Wellington Management Company(7)

280 Congress Street

Boston, MA 02210

   10,307,338    6.0% 

BlackRock, Inc.(8)

55 East 52nd Street

New York, NY 10055

   9,837,619    5.7% 

T. Rowe Price Associates, Inc.(9)

100 E. Pratt Street

Baltimore, MD 21202

   9,828,030    5.7% 

Clay B. Siegall, Ph.D.(10)

   2,063,058    1.2% 

Todd E. Simpson(11)

   402,626    * 

Roger D. Dansey, M.D.(12)

   28,992    * 

Vaughn Himes, Ph.D.(13)

   427,429    * 

Jean I. Liu(14)

   196,788    * 

Robin G. Taylor, Ph.D.(15)

   38,427    * 

Srinivas Akkaraju, M.D., Ph.D.(16)

   109,245    * 

David W. Gryska(17)

   132,090    * 

Marc E. Lippman, M.D.(18)

   200,390    * 

John A. Orwin(19)

   71,340    * 

Alpna H. Seth, Ph.D.(20)

   7,422    * 

Nancy A. Simonian, M.D.(21)

   101,340    * 

Daniel G. Welch(22)

   173,840    * 

All directors and executive officers as a group (12 persons)(23)

   54,509,885    31.1% 

*

Less than one percent

(1)

Beneficial ownership is determined in accordance with SEC rules. In computing the beneficial ownership, we have included shares for which the named person has sole or shared power over voting or investment decisions. The number of shares of common stock beneficially owned includes common stock which the named person has the right to acquire, through option exercise or otherwise, within 60 days after March 1, 2020.

(2)

Percentage of common stock equivalents is based on a total of 172,466,090 shares of common stock outstanding as of March 1, 2020. For each named person, the percentage ownership includes common stock that the person has the right to acquire within 60 days after March 1, 2020, as described in Footnote 1. However, such shares are not deemed outstanding with respect to the calculation of ownership percentage for any other person. In some cases, beneficial ownership calculations for five percent or greater shareholders are based solely on publicly-filed Schedules 13D or 13G, which five percent or greater shareholders are required to file with the SEC, and which generally set forth ownership interests as of December 31, 2019 unless otherwise provided.

(3)

The shares reported in the table as beneficially owned by the reporting persons includes 45,757,886 shares held by Baker Brothers Life Sciences, L.P. , or Life Sciences, 4,217,591 shares held by 667, L.P., or 667, 18,243 shares held by FBB2, LLC, or FBB2, 49,292 shares held by FBB3, LLC, or FBB3, 181,740 shares

2020 PROXY STATEMENT73


NOTE ABOUT FORWARD-LOOKING STATEMENTS

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

held by Felix J. Baker, 181,733 shares held by Julian C. Baker, 60,000 shares issued to Felix J. Baker as a result of the exercise of options and 21,800 shares issued to Felix J. Baker upon the vesting of restricted stock units. This number also includes 107,040 shares of common stock issuable upon exercise of options held by Felix J. Baker that are exercisable within 60 days of March 1, 2020 held by Felix J. Baker that vest within 60 days of March 1, 2020. According to a Schedule 13D/A filed with the SEC by the reporting persons on May 1, 2019 and a Form 4 filed with the SEC by the reporting persons on June 7, 2019, Baker Bros. Advisors LP, or the Adviser, serves as the Investment Adviser to Life Sciences and 667, or collectively the Baker Funds. Baker Bros. Advisors (GP) LLC, or the Adviser GP, is the Adviser’s sole general partner. Julian C. Baker and Felix J. Baker are principals of the Adviser GP. The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Baker Funds, and may be deemed to have the power to vote or direct the vote of and the power to dispose or direct the disposition of such securities. In addition, according to the Schedule 13D/A, the Adviser has voting and investment power over the options, RSU awards and common stock held by Felix J. Baker, and the Adviser GP, as well as Felix J. Baker and Julian C. Baker as principals of the Adviser GP, may be deemed to have the power to vote or direct the vote of and the power to dispose or direct the disposition of, the options, RSU awards and common stock held by Felix J. Baker. In addition, according to the Schedule 13D/A, Julian C. Baker and Felix J. Baker are also the sole managers of FBB2 and FBB3 and as such may be deemed to be beneficial owners of shares of common stock held by FBB2 and FBB3 and may be deemed to have the power to vote or direct the vote and dispose or direct the disposition of those shares.
(4)

The indicated ownership is based solely on a Schedule 13G/A filed with the SEC by the reporting person on February 14, 2020. According to the Schedule 13G/A, Capital International Investors has sole voting power over 20,081,588 shares of common stock and sole dispositive power over 20,996,099 shares of common stock. The Schedule 13G/A filed by the reporting person provides information as of December 31, 2019 and, consequently, the beneficial ownership of the reporting person may have changed between December 31, 2019 and March 1, 2020.

(5)

The indicated ownership is based solely on a Schedule 13G/A filed with the SEC by the reporting person on February 12, 2020. According to the Schedule 13G/A, PRIMECAP Management Company has sole voting power over 10,814,992 shares of common stock and sole dispositive power over 10,951,717 shares of common stock. The Schedule 13G/A filed by the reporting person provides information as of December 31, 2019 and, consequently, the beneficial ownership of the reporting person may have changed between December 31, 2019 and March 1, 2020.

(6)

The indicated ownership is based solely on a Schedule 13G/A filed with the SEC by the reporting person on February 12, 2020. According to the Schedule 13G/A, The Vanguard Group has sole voting power over 93,043 shares of common stock and sole dispositive power over 10,803,019 shares of common stock. The Schedule 13G/A filed by the reporting person provides information as of December 31, 2019 and, consequently, the beneficial ownership of the reporting person may have changed between December 31, 2019 and March 1, 2020.

(7)

The indicated ownership is based solely on a Schedule 13G filed with the SEC by the reporting person on January 27, 2020. Wellington Management Group LLP, Wellington Group Holdings LLP, Wellington Investment Advisors Holdings LLP and Wellington Management Company LLP, or collectively, Wellington, beneficially own 10,307,338 shares of our common stock that are owned of record by clients of one or more investment advisers directly or indirectly owned by Wellington Management Group LLP. The Schedule 13G filed by the reporting person provides information as of December 31, 2019 and, consequently, the beneficial ownership of the reporting person may have changed between December 31, 2019 and March 1, 2020.

(8)

The indicated ownership is based solely on a Schedule 13G filed with the SEC by the reporting person on February 7, 2020. According to the Schedule 13G, BlackRock Inc, has sole voting power over 9,186,748 shares of common stock and sole dispositive power over 9,837,619 shares of common stock. The Schedule 13G filed by the reporting person provides information as of December 31, 2019 and, consequently, the beneficial ownership of the reporting person may have changed between December 31, 2019 and March 1, 2020.

(9)

The indicated ownership is based solely on a Schedule 13G/A filed with the SEC by the reporting person on February 14, 2020. According to the Schedule 13G/A, T. Rowe Price Associates, Inc. has sole voting power over 2,627,959 shares of common stock and sole dispositive power over 9,828,030 shares of common stock. The Schedule 13G/A filed by the reporting person provides information as of December 31, 2019 and, consequently, the beneficial ownership of the reporting person may have changed between December 31, 2019 and March 1, 2020.

(10)

Includes 1,494,593 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2020.

(11)

Includes 304,883 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2020.

(12)

Includes 21,124 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2020.

(13)

Includes 291,388 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2020.

(14)

Includes 175,301 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2020.

(15)

Dr. Taylor, our former Chief Commercial Officer, left the Company in February 2020. He received 38,427 shares of equity award vesting acceleration equal to 12 months of vesting from the date of his separation.

(16)

Includes 72,040 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2020.

(17)

Includes 87,040 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2020.

(18)

Includes 72,040 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2020.

(19)

Includes 49,540 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2020.

(20)

Includes 7,422 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2020.

(21)

Includes 79,540 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2020.

(22)

Includes 86,540 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2020.

(23)

Includes 2,848,491 shares of common stock issuable upon exercise of options that are exercisable within 60 days of March 1, 2020. Dr. Taylor’s shares are not included in the total since he is no longer an executive officer.

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PROPOSAL NO. 3

APPROVAL OF THE AMENDMENT AND RESTATEMENT OF

THE SEATTLE GENETICS, INC.

AMENDED AND RESTATED 2007 EQUITY INCENTIVE PLAN

The Board approved an amendment and restatement of the 2007 Equity Plan in March 2020, subject to shareholder approval. Throughout this proxy statement, we refer to the 2007 Equity Plan, as amended and restated by the Board in March 2020, as the “Restated 2007 Equity Plan”.

In this Proposal No. 3, we are requesting shareholder approval of the Restated 2007 Equity Plan in order to:

increase the number of shares of common stock authorized for issuance under the Restated 2007 Equity Plan beyond those remaining available for future grant under the 2007 Equity Plan by an additional 6,000,000 shares, subject to adjustment for certain changes in our capitalization;

increase the limit on the number of shares that may be issued in settlement of incentive stock options granted under the Restated 2007 Equity Plan to 78,000,000 shares, subject to adjustment for certain changes in our capitalization; and

make certain additional changes under the Restated 2007 Equity Plan, as described below under the section entitled “Summary of Material Changes and Terms in the Restated 2007 Equity Plan.”

WHY WE RECOMMEND THAT YOU VOTE FOR THE RESTATED 2007 EQUITY PLAN

EQUITY AWARDS ARE AN IMPORTANT PART OF OUR COMPENSATION PHILOSOPHY

The Restated 2007 Equity Plan is critical to our ongoing effort to build shareholder value. As discussed in this proxy statement under the heading “Compensation of Executive Officers—Compensation Discussion and Analysis”, equity awards are central to our compensation program. Equity compensation represents a significant percentage ofthe at-risk, or variable, portion of our executive officers’ compensation arrangements. We believe that it is appropriate to align the interests of our executive officers with those of our shareholders to achieve and sustain long-term stock price growth. Additionally, equity awards represent a significant portion of the compensation we payto non-employee members of the Board, as well as employees below the executive officer level.

The Board believes we must continue to offer a competitive equity compensation program in order to attract, retain and motivate the extraordinarily talented employees necessary for our continued growth and success. The share reserve of the Restated 2007 Equity Plan is structured to ensure that we have a sufficient number of shares to continue to utilize a broad array of equity incentives in order to secure and retain the services of our and our affiliates’ employees and directors, and to provide incentives for such persons to exert maximum efforts toward our success.

In the event that our shareholders do not approve this Proposal No. 3, the Restated 2007 Equity Plan will not become effective and the 2007 Equity Plan will continue in its current form. However, without the Restated 2007 Equity Plan, we believe that the shares available for grant under the 2007 Equity Plan will be insufficient to meet our anticipated employee recruiting and retention needs.

WE MANAGE OUR EQUITY AWARD USE CAREFULLY AND DILUTION IS REASONABLE

We manage our long-term shareholder dilution by limiting the number of equity awards granted annually. The Board carefully monitors our annual burn rate, dilution, and equity expense to ensure that we maximize shareholders’ value by granting only the appropriate number of equity awards necessary to attract, reward, and retain employees.

2020 PROXY STATEMENT75


PROPOSAL NO. 3: APPROVAL OF THE AMENDMENT AND RESTATEMENT OF THE SEATTLE GENETICS, INC. AMENDED AND RESTATED 2007 EQUITY INCENTIVE PLAN

The following table shows our responsible burn rate history.

       Seattle Genetics 
    Peer group
FY19
   FY19   FY18   FY17 

Gross Burn Rate as a % of Outstanding(1)

   2.74%    2.04%    2.05%    2.13% 

Adjusted Burn Rate as a % of Outstanding(2)

        1.79%    1.74%    1.57% 

(1)

Gross Burn Rate is calculated as: (shares subject to options granted + shares subject to full value awards granted)/weighted average common shares outstanding.

(2)

Adjusted Burn Rate is calculated as: (shares subject to options granted + shares subject to full value awards granted—shares subject to options and full value awards that expired, terminated or were forfeited)/weighted average common shares outstanding.

As of March 1, 2020, there were 172,466,090 shares of our common stock outstanding. The closing price of our common stock as reported on the Nasdaq Global Select Market as of February 28, 2020, the last trading day prior to March 1, 2020, was $113.86 per share.

THE SIZE OF OUR SHARE RESERVE REQUEST IS REASONABLE

If our request to increase the share reserve of the 2007 Equity Plan is approved, we will add 6,000,000 shares to the 4,138,239 shares that were available for grant under the Restated 2007 Equity Plan as of March 1, 2020. Based on our current award targets and headcount as well as our hiring as we expand into multiple products and new countries, we anticipate this will provide a pool of shares adequate to cover the next two years. Our equity program encourages ownership, incentivizes long-term thinking aligned with the interests of our shareholders, and is based on performance and retention of top talent. In addition, we continually monitor our practices and policies to ensure the continued sustainability of our rate of share utilization as shown in our burn rate when compared to our peers.

THE RESTATED 2007 EQUITY PLAN COMBINES COMPENSATION AND GOVERNANCE BEST PRACTICES

The Restated 2007 Equity Plan includes provisions that are designed to protect our shareholders’ interests and to reflect corporate governance best practices including:

Repricing is not allowed. The Restated 2007 Equity Plan prohibits the repricing of outstanding stock options and stock appreciation rights and the cancellation of any outstanding stock options or stock appreciation rights that have an exercise or strike price greater than the then-current fair market value of our common stock in exchange for cash or other awards under the Restated 2007 Equity Plan without prior shareholder approval.

Shareholderapproval is required for additional shares. The Restated 2007 Equity Plan does not contain an annual “evergreen” provision. The Restated 2007 Equity Plan authorizes a fixed number of shares, so that shareholder approval is required to issue any additional shares, allowing our shareholders to have direct input on our equity compensation programs.

Responsible change in control provisions. The definition of change in control in the Restated 2007 Equity Plan requires the consummation of an actual transaction so that no vesting acceleration benefits may occur without an actual change in control transaction occurring. In addition, if awards are assumed or equivalent awards are substituted by the successor corporation, vesting acceleration benefits would only occur if the recipient’s service is involuntarily terminated.

Independent Compensation Committee. Our Compensation Committee consists entirely of independent directors. Our Board currently consists of eight independent directors and Dr. Siegall, our President and Chief Executive Officer.

SUMMARY OF MATERIAL CHANGES AND TERMS IN THE RESTATED 2007 EQUITY PLAN

The Restated 2007 Equity Plan contains the following material changes from the 2007 Equity Plan, each as further described below under “Summary of the Restated 2007 Equity Plan”:

increases the maximum aggregate number of shares of common stock authorized for issuance under the Restated 2007 Equity Plan to 39,000,000 shares, subject to adjustment for certain changes in our capitalization (the maximum aggregate number of shares of common stock authorized for issuance under the 2007 Equity Plan is 33,000,000 shares);

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PROPOSAL NO. 3: APPROVAL OF THE AMENDMENT AND RESTATEMENT OF THE SEATTLE GENETICS, INC. AMENDED AND RESTATED 2007 EQUITY INCENTIVE PLAN

increases the maximum aggregate number of shares that may be issued under the Restated 2007 Equity Plan through incentive stock options to 78,000,000 shares, subject to adjustment for certain changes in our capitalization (the maximum aggregate number of shares that may be issued under the 2007 Equity Plan through incentive stock options is 66,000,000 shares);

extends the term of the Restated 2007 Equity Plan through May 14, 2030 (the term of the 2007 Equity Plan ends on May 18, 2028);

provides the following additional performance objectives called “qualifying performance criteria” that may determine the grant, issuance, retention, vesting and/or settlement of awards under the Restated 2007 Equity Plan: implementation or completion of projects or processes (including, without limitation, clinical trial initiation, clinical trial enrollment and dates, clinical trial results, regulatory filing submissions, regulatory filing acceptances, regulatory or advisory committee interactions, regulatory approvals, presentation of studies and launch of commercial plans, compliance programs or education campaigns); and

provides that the aggregate value of all compensation granted or paid to any individual for service as anon-employee director with respect to any calendar year, including awards granted under the Restated 2007 Equity Plan and cash fees paid by us to suchnon-employee director, will not exceed (i) $1,000,000 in total value or (ii) in the event suchnon-employee director is first appointed or elected to the Board during such calendar year, $1,500,000 in total value, in each case calculating the value of any equity awards based on the grant date fair value of such equity awards for financial reporting purposes.

The other material terms of the Restated 2007 Equity Plan will remain the same as in the 2007 Equity Plan as follows:

the types of awards that may be granted are stock options (including incentive stock options and nonstatutory stock options), restricted stock, restricted stock units, stock appreciation rights and other similar types of awards;

shares subject to awards that are canceled, expired or are forfeited (including with respect to any shares that have been issued under an award) will be availablefor re-grant under the Restated 2007 Equity Plan;

if an awardee pays the exercise or purchase price of an award through the tendering of shares, the number of shares tendered will become availablefor re-grant under the Restated 2007 Equity Plan;

no awardee may be granted, in any calendar year under the Restated 2007 Equity Plan, awards covering more than 1,000,000 shares, subject to adjustment for certain changes in our capitalization;

in the event of any stock split, reverse stock split, stockdividend, spin-off, combination or reclassification of our common stock, or similar change to our capital structure (effected without receipt of consideration by us), the plan administrator will make proportionate adjustments to (1) the number and kind of shares covered by each outstanding award under the Restated 2007 Equity Plan, (2) the exercise or purchase (including repurchase) price per share subject to each outstanding award under the Restated 2007 Equity Plan and (3) each of the share limitations under the Restated 2007 Equity Plan; and

shareholder approval is required for certain types of amendments to the Restated 2007 Equity Plan.

SHAREHOLDER APPROVAL

The Restated 2007 Equity Plan will not become effective unless this Proposal No. 3 is approved by our shareholders. If this Proposal No. 3 is approved by our shareholders, the Restated 2007 Equity Plan will become effective upon the date of the 2020 Annual Meeting. In the event that our shareholders do not approve this Proposal No. 3, the Restated 2007 Equity Plan will not become effective and the 2007 Equity Plan will continue in its current form.

SUMMARY OF THE RESTATED 2007 EQUITY PLAN

GENERAL

A copy of the Restated 2007 Equity Plan is attached to this proxy statement as Appendix A. The following description of the Restated 2007 Equity Plan is a summary and so is qualified by reference to the complete text of the Restated 2007 Equity Plan. This Proxy Statement contains forward-looking statementssummary reflects the terms set forth above.

The purpose of the Restated 2007 Equity Plan is to enhance the long-term shareholder value of Seattle Genetics by offering opportunities to eligible individuals to participate in the growth in value of our equity. Stock options and stock

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awards, including restricted stock, restricted stock units, stock appreciation rights and similar types of awards, may be granted under the Restated 2007 Equity Plan. Options granted under the Restated 2007 Equity Plan may be either “incentive stock options,” as defined in Section 422 of the Code, or nonstatutory stock options.

ADMINISTRATION

The Restated 2007 Equity Plan may be administered by the Board, a committee of the Board, or one or more of our officers delegated by the Board or the Board committee in accordance with the terms of the Restated 2007 Equity Plan. We refer to the group or person that administers the Restated 2007 Equity Plan from time to time below as the plan administrator.

ELIGIBILITY

Awards may be granted under the Restated 2007 Equity Plan to our employees, directors and consultants and the employees, directors and consultants of our affiliates. Incentive stock options may be granted only to our employees or the employees of our subsidiaries. As of March 1, 2020, we (including our affiliates) had approximately 1,730 employees andeight non-employee directors. The plan administrator, with direction from the Compensation Committee as appropriate, selects the employees and directors to whom awards may be granted, the time or times at which such awards are granted, and the terms of such awards.

SHARE RESERVE

If this Proposal No. 3 is approved, the total number of shares of our common stock authorized for issuance under the Restated 2007 Equity Plan will be 39,000,000 shares, subject to adjustment for certain changes in our capitalization.

Shares subject to awards that are canceled, expired or are forfeited (including with respect to any shares that have been issued under an award) will be availablefor re-grant under the Restated 2007 Equity Plan. If an awardee pays the exercise or purchase price of an award through the tendering of shares, the number of shares tendered will become availablefor re-grant under the Restated 2007 Equity Plan.

SHARE LIMITS

If this Proposal No. 3 is approved, the total number of shares of our common stock that may be issued under the Restated 2007 Equity Plan pursuant to the exercise of incentive stock options will be 78,000,000 shares, subject to adjustment for certain changes in our capitalization.

Under the Restated 2007 Equity Plan, no awardee may be granted awards covering more than 1,000,000 shares in any calendar year, subject to adjustment for certain changes in our capitalization.

NON-EMPLOYEE DIRECTOR COMPENSATION LIMIT

The aggregate value of all compensation granted or paid to any individual for service as anon-employee director with respect to any calendar year, including awards granted under the Restated 2007 Equity Plan and cash fees paid by us to suchnon-employee director, will not exceed (i) $1,000,000 in total value or (ii) in the event suchnon-employee director is first appointed or elected to the Board during such calendar year, $1,500,000 in total value, in each case calculating the value of any equity awards based on the grant date fair value of such equity awards for financial reporting purposes.

SECTION 162(m) TRANSITION RELIEF FOR PERFORMANCE-BASED COMPENSATION

Under Section 162(m) of the Code, compensation paid to any publicly held corporation’s “covered employees” (as defined under Section 162(m) of the Code) that exceeds $1 million per taxable year for any covered employee is generallynon-deductible. Certain provisions in the Restated 2007 Equity Plan refer to the “performance-based compensation” exception to the $1 million deductibility limit under Section 162(m) of the Code. Pursuant to the Tax Cuts and Jobs Act, this exception was repealed with respect to taxable years beginning after December 31, 2017. However, an award may still be eligible for this exception if, among other requirements, it is intended to qualify, and is eligible to qualify, as “performance-based compensation” under Section 162(m) of the Code pursuant to the transition relief provided by the Tax Cuts and Jobs Act for remuneration provided pursuant to a written binding contract which

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was in effect on November 2, 2017 and which was not modified in any material respect on or after such date. For purposes of this Proposal No. 3, the term “Section 162(m) Transition Relief” refers to such transition relief. Accordingly, the provisions in the Restated 2007 Equity Plan which refer to the “performance-based compensation” exception under Section 162(m) of the Code will only apply to any award that is intended to qualify, and is eligible to qualify, as “performance-based compensation” under Section 162(m) of the Code pursuant to the Section 162(m) Transition Relief and, therefore, such provisions are not applicable to any other awards granted under the Restated 2007 Equity Plan. However, even if an award is intended to qualify as “performance-based compensation” under Section 162(m) of the Code, no assurance can be given that the award will in fact qualify for the Section 162(m) Transition Relief or the “performance-based compensation” exception under Section 162(m) of the Code.

TERMS AND CONDITIONS OF OPTIONS

Each option is evidenced by a stock option agreement between us and the optionee and is subject to the following additional terms and conditions.

Exercise Price. The plan administrator determines the exercise price of options at the time the options are granted. The exercise price of an incentive stock option or a nonstatutory stock option may not be less than 100% of the fair market value of our common stock on the date the option is granted, provided that the exercise price of an incentive stock option granted to an employee who holds more than 10% of the voting power of all classes of our stock may not be less than 110% of the fair market value of our common stock on the date the option is granted. However, we may grant options with exercise prices less than the fair market value of our common stock on the date of grant in connection with an acquisition by us of another company. The fair market value of our common stock is the closing price for the shares as reported on the Nasdaq Global Select Market as of the applicable date. As of February 28, 2020, the closing price of our common stock as reported on the Nasdaq Global Select Market was $113.86 per share.

Exercise of Option; Form of Consideration. The plan administrator determines when options vest and become exercisable and in its discretion may accelerate the vesting of any outstanding option;provided, however, that (i) each option must have a minimum vesting period of one year from the earlier of the date of grant or vesting commencement date, if any, and (ii) in the event of an optionee’s termination due to death or disability, the vesting and exercisability of each outstanding time-based option granted to the optionee under the Restated 2007 Equity Plan will be accelerated for an additional 12 months. The means of payment for shares issued upon exercise of an option are specified in each option agreement. The Restated 2007 Equity Plan permits payment to be made by cash, check, wire transfer, other shares of our common stock (with some restrictions), brokerassisted same-day sales, cashless “net exercise” arrangements, any other form of consideration permitted by applicable law and the plan administrator, or any combination thereof.

Term of Option. The term of an option may be no more than ten years from the date of grant, provided that the term of an incentive stock option granted to an employee who holds more than 10% of the voting power of all classes of our stock may be no more than five years from the date of grant. No option may be exercised after the expiration of its term.

Termination of Service. If an optionee’s service as an employee, director or consultant (referred to in this Proposal No. 3 as “service”) terminates for any reason other than cause, death or disability, then options held by the optionee under the Restated 2007 Equity Plan generally will be exercisable to the extent they are vested and exercisable on the termination date for a period (as specified by the plan administrator) after the termination date but not after the options’ expiration date. If an optionee’s service terminates for cause, then the plan administrator has the authority to terminate all options held by the optionee under the Restated 2007 Equity Plan immediately.

Generally, if an optionee’s service terminates as a result of the optionee’s death or in the event of an optionee’s death within 30 days following the optionee’s termination of service, all outstanding options that were vested and exercisable as of the date of the optionee’s death may be exercised for twelve months following the optionee’s death but in no event after the options’ expiration date. Generally, if an optionee’s service terminates as a result of the optionee’s disability, then all options to the extent they are vested and exercisable on the termination date may be exercised for twelve months following the termination date but in no event after the options’ expiration date. The plan administrator has the authority to extend the period of time for which an option is to remain exercisable following an optionee’s termination (taking into account limitations and consequences under the Code) but not beyond the expiration of the term of the option.

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PROPOSAL NO. 3: APPROVAL OF THE AMENDMENT AND RESTATEMENT OF THE SEATTLE GENETICS, INC. AMENDED AND RESTATED 2007 EQUITY INCENTIVE PLAN

TERMS AND CONDITIONS OF STOCK AWARDS

Stock awards may be restricted stock grants, restricted stock units, stock appreciation rights or other similar awards. Restricted stock grants are awards of a specific number of shares of our common stock. Restricted stock units represent a promise to deliver shares of our common stock, or an amount of cash or property equal to the value of the underlying shares, at a future date. Stock appreciation rights are rights to receive cash and/or shares of our common stock based on the amount by which the exercise date fair market value of a specific number of shares exceeds the grant date fair market value of the exercised portion of the stock appreciation right.

Each stock award agreement will contain provisions regarding (i) the number of shares subject to the stock award, (ii) the purchase price of the shares, if any, and the means of payment for the shares, (iii) the performance criteria (including qualifying performance criteria), if any, and level of achievement versus these criteria that will determine the number of shares granted, issued, retainable and vested, as applicable, (iv) such terms and conditions on the grant, issuance, vesting, settlement, and forfeiture of the shares, as applicable, as may be determined from time to time by the plan administrator, (v) restrictions on the transferability of the stock award, and (vi) such further terms and conditions, in each case not inconsistent with the Restated 2007 Equity Plan, as may be determined from time to time by the plan administrator; provided, however, that (i) each stock award must have a minimum vesting period of one year from the earlier of the date of grant or the vesting commencement date, if any, and (ii) in the event of an awardee’s termination due to death or disability, the vesting (and exercisability, if applicable) of each outstanding time-based stock award granted to the awardee under the Restated 2007 Equity Plan will be accelerated for an additional 12 months. The term of a stock appreciation right may be no more than ten years from the date of grant.

REPRICING; CANCELLATIONAND RE-GRANT OF AWARDS

No option or stock appreciation right may be repriced to reduce the exercise or strike price of such option or stock appreciation right without shareholder approval (except in connection with a change in our capitalization—see “Adjustments upon Changes in Capitalization, Change in Control or Dissolution” below). Additionally, the plan administrator will not have the authority to cancel any outstanding option or stock appreciation right that has an exercise or strike price greater than the then-current fair market value of our common stock in exchange for cash or other awards under the Restated 2007 Equity Plan, unless our shareholders have approved such an action within twelve months prior to such an event.

NONTRANSFERABILITY

Generally, awards granted under the Restated 2007 Equity Plan are not transferable other than by will or the laws of descent and distribution or to a designated beneficiary upon the awardee’s death. The plan administrator may in its discretion make an award transferable to an awardee’s family member or any other person or entity as it deems appropriate.

QUALIFYING PERFORMANCE CRITERIA

The Restated 2007 Equity Plan permits us to grant awards incorporating performance objectives called “qualifying performance criteria”. Qualifying performance criteria means any one or more of the performance criteria listed below, either individually, alternatively or in combination, applied to either Seattle Genetics as a whole or to a business unit, affiliate or business segment, either individually, alternatively or in any combination, and measured either annually or cumulatively over a period of years, on an absolute basis or relative toa pre-established target, to previous years’ results or to a designated comparison group, in each case as specified by the plan administrator in the award agreement: (i) cash flow; (ii) earnings (including gross margin, earnings before interest and taxes, earnings before taxes, and net earnings); (iii) earnings per share; (iv) growth in earnings or earnings per share; (v) stock price; (vi) return on equity or average shareholders’ equity; (vii) total shareholder return; (viii) return on capital; (ix) return on assets or net assets; (x) return on investment; (xi) revenue; (xii) income or net income; (xiii) operating income or net operating income, in aggregate or per share; (xiv) operating profit or net operating profit; (xv) operating margin; (xvi) return on operating revenue; (xvii) market share; (xviii) growth in shareholder value relative to the moving average of a peer group index; (xix) strategic plan development and implementation (including individual performance objectives that relate to achievement of the Company’s or any business unit’s strategic plan); (xx) improvement in workforce diversity; (xxi) growth of revenue, operating income or net income; (xxii) approval by the U.S. Food and Drug Administration or other regulatory body of a product candidate; and (xxiii) implementation or completion of projects or processes

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(including, without limitation, clinical trial initiation, clinical trial enrollment and dates, clinical trial results, regulatory filing submissions, regulatory filing acceptances, regulatory or advisory committee interactions, regulatory approvals, presentation of studies and launch of commercial plans, compliance programs or education campaigns) and (xxiv) any other similar criteria.

The Compensation Committee may appropriately adjust any evaluation of performance under a qualifying performance criteria to exclude any of the following events that occurs during a performance period: (A) asset write-downs; (B) litigation or claim judgments or settlements; (C) the effect of changes in tax law, accounting principles or other such laws or provisions affecting reported results; (D) accruals for reorganization and restructuring programs and/or other nonrecurring charges; and (E) any gains or losses that are “unusual” in nature or occur “infrequently” under generally accepted accounting principles or discontinued operations in our financial statements.

DEFERRAL OF AWARD BENEFITS

The plan administrator may permit awardees whom it selects to defer compensation payable pursuant to the terms of an award or defer compensation arising outside the terms of the Restated 2007 Equity Plan pursuant to a program that provides for deferred payment in satisfaction of other compensation amounts through the issuance of one or more awards under the Restated 2007 Equity Plan and in a manner that complies with Section 409A of the Code.

ADJUSTMENTS UPON CHANGES IN CAPITALIZATION, CHANGE IN CONTROL OR DISSOLUTION

In the event of any stock split, reverse stock split, combination or reclassification of common stock, stockdividend, spin-off, or similar change to our capital structure effected without receipt of consideration by us, the plan administrator will make proportionate adjustments to (i) the number and kind of shares covered by each outstanding award under the Restated 2007 Equity Plan, (ii) the exercise or purchase (including repurchase) price per share subject to each outstanding award under the Restated 2007 Equity Plan and (iii) each of the share limitations under the Restated 2007 Equity Plan.

In the event of (i) an acquisition of us by means of any transaction or series of related transactions, including any reorganization, merger or consolidation but excluding any merger effected exclusively for the purpose of changing our domicile, (ii) any sale of all or substantially all of our assets or (iii) any other event specified by the plan administrator, so long as in either (i) or (ii), our shareholders of record immediately prior to the transaction hold less than 50% of the voting power of the surviving entity and, so long as in (iii) that no change in control will be deemed to occur upon announcement or commencement of a tender offer or upon a “potential” takeover or upon shareholder approval of a merger or other transaction, in each case without a requirement that the change in control actually occur (each, a “change in control”), then:

if the successor corporation does not assume or substitute equivalent awards for an awardee’s outstanding equity awards granted pursuant to the Restated 2007 Equity Plan and the awardee’s service has not terminated as of, or has terminated without cause immediately prior to, the effective time of the change in control, then as of immediately prior to the effective time of the change in control, the vesting of such awards will be accelerated in full; and

if the awardee’s outstanding equity awards are assumed or equivalent awards are substituted by the successor corporation and if at the time of, immediately prior to or within twelve months after the effective time of the change in control, the awardee’s service is terminated without cause or due to constructive termination, then as of the date of such termination, the vesting of such awards will be accelerated in full.

In the event of a liquidation or dissolution, any options or stock awards that have not been exercised will terminate immediately prior to the transaction.

The plan administrator has the authority to accelerate vesting of outstanding awards under the Restated 2007 Equity Plan at any time in its sole discretion.

AMENDMENT AND TERMINATION OF THE RESTATED 2007 EQUITY PLAN

The plan administrator may amend, alter or discontinue the Restated 2007 Equity Plan at any time. However, we will obtain shareholder approval for any amendment to the Restated 2007 Equity Plan if shareholder approval is necessary or desirable to comply with any applicable law or listing requirements. In addition, we will obtain shareholder approval of any of the following: (i) an increase to the shares reserved for issuance under the Restated 2007 Equity Plan other

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than an increase in connection with a change in our capitalization as described in “Adjustments upon Changes in Capitalization, Change in Control or Dissolution” above; (ii) a change of the class of persons eligible to receive awards under the Restated 2007 Equity Plan; (iii) a reduction in the minimum exercise prices at which options or stock appreciation rights may be granted; or (iv) any amendment of outstanding options or stock appreciation rights that results in a repricing of such awards. No amendment of the Restated 2007 Equity Plan will impair the rights of an outstanding award without the consent of the awardee, except as otherwise provided in the Restated 2007 Equity Plan. If the Restated 2007 Equity Plan is approved by our shareholders, then unless sooner terminated, the Restated 2007 Equity Plan will automatically terminate on May 15, 2030, which is the date ten years from the date of shareholder approval of the Restated 2007 Equity Plan.

RESTATED 2007 NEW PLAN BENEFITS

RESTATED 2007 EQUITY PLAN

Name and Position

Dollar Value
of Awards

$

Number of Shares

Subject to Awards

Clay B. Siegall, Ph.D.(1)

**

President and Chief Executive Officer

Todd E. Simpson(1)

**

Chief Financial Officer

Roger Dansey, M.D.(1)

**

Chief Medical Officer

Jean I. Liu(1)

**

General Counsel and Executive Vice President, Legal Affairs

Robin G. Taylor, M.B.A., Ph.D.(1)

**

Former Chief Commercial Officer

All current executive officers as a group(1)

**

All current directors who are not executive officers as a group(2)


$3,200,000 per
calendar year

*

All employees, including all current officers who are not executive officers, as a group(1)

**

(1)

Awards granted under the Restated 2007 Equity Plan to our executive officers and other employees are discretionary and are not subject to set benefits or amounts under the terms of the Restated 2007 Equity Plan, and the Compensation Committee and Board have not granted any awards under the Restated 2007 Equity Plan subject to shareholder approval of this Proposal No. 3. Accordingly, the benefits or amounts that will be received by or allocated to our executive officers and other employees under the Restated 2007 Equity Plan, as well as the benefits or amounts which would have been received by or allocated to our executive officers and other employees for 2019 if the Restated 2007 Equity Plan had been in effect, are not determinable.

(2)

Awards granted under the Restated 2007 Equity Plan toour non-employee directors are discretionary and are not subject to set benefits or amounts under the terms of the Restated 2007 Equity Plan. However, ourcurrent non-employee director compensation policy establishes certain target values for initial and annual awards that automatically will be granted toour non-employee directors under the Restated 2007 Equity Plan if this Proposal No. 3 is approved by our shareholders. Pursuant to such policy, if this Proposal No. 3 is approved by our shareholders, then on the date of the 2020 Annual Meeting and each annual meeting of our shareholders thereafter, each of ourcurrent non-employee directors will be granted annual awards under the Restated 2007 Equity Plan consisting of an option and a restricted stock unit award, each with a target value of $200,000 (resulting in a total value of $400,000 for each of our currentnon-employee directors individually and an aggregate total value of $3,200,000 for all of ourcurrent non-employee directors as a group). The actual number of shares of our common stock subject to each such option is calculated based on an approximation of the target award value based on the average stock price during the 30 calendar days preceding the effective date of the grant and using the Black Scholes methodology for stock option valuation, and the actual number of shares of our common stock subject to each such restricted stock unit award is calculated by dividing the target value of such restricted stock unit award by the average stock price during the 30 calendar days preceding the effective date of the grant. Therefore, the actual number of shares of our common stock subject to such options and restricted stock unit awards is not determinable at this time. For additional information regarding ourcurrent non-employee director compensation policy, see “Director Compensation—Equity Compensation” above.

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2007 EQUITY PLAN BENEFITS

The following table sets forth, for each of the individuals and the various groups indicated, the total number of shares of our common stock subject to awards that have been granted (even if not currently outstanding) under the 2007 Equity Plan since its approval by our shareholders in 2007 through March 1, 2020.

2007 EQUITY PLAN

Name and Position

Number of Shares

Subject to Awards

Clay B. Siegall, Ph.D.

3,176,201

President and Chief Executive Officer

Todd E. Simpson

868,384

Chief Financial Officer

Roger Dansey, M.D.

271,946

Chief Medical Officer

Vaughn B. Himes, Ph.D.

841,504

Chief Technical Officer

Jean I. Liu

375,138

General Counsel and Executive Vice President, Legal Affairs

Robin G. Taylor, M.B.A., Ph.D.

101,035

Former Chief Commercial Officer

All current executive officers as a group

5,533,173

All current directors who are not executive officers as a group

1,119,888

Each nominee for election as a director:

David W. Gryska

178,841

John A. Orwin

79,341

Alpna H. Seth, Ph.D.

30,001

Each associate of any executive officers, current directors or director nominees

Each other person who received or is to receive 5% of awards

All employees, including all current officers who are not executive officers, as a group

13,876,255

EQUITY COMPENSATION PLAN INFORMATION

Please see the section of this proxy statement entitled “Equity Compensation Plan Information” for certain information with respect to compensation plans under which equity securities of Seattle Genetics are authorized for issuance.

FEDERAL INCOME TAX CONSEQUENCES

THE FOLLOWING IS A GENERAL SUMMARY OF THE FEDERAL INCOME TAX CONSEQUENCES OF THE ISSUANCE AND EXERCISE OF OPTIONS OR OTHER AWARDS UNDER THE RESTATED 2007 EQUITY PLAN. IT DOES NOT DESCRIBE STATE OR OTHER TAX CONSEQUENCES OF THE ISSUANCE AND EXERCISE OF OPTIONS OR OTHER AWARDS. THE INFORMATION SET FORTH BELOW IS A SUMMARY ONLY AND DOES NOT PURPORT TO BE COMPLETE. THE INFORMATION IS BASED UPON CURRENT FEDERAL INCOME TAX RULES AND THEREFORE IS SUBJECT TO CHANGE WHEN THOSE RULES CHANGE. THE RESTATED 2007 EQUITY PLAN IS NOT QUALIFIED UNDER THE PROVISIONS OF SECTION 401(A) OF THE CODE AND IS NOT SUBJECT TO ANY OF THE PROVISIONS OF THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974. OUR ABILITY TO REALIZE THE BENEFIT OF ANY TAX DEDUCTIONS DESCRIBED BELOW DEPENDS ON OUR GENERATION OF TAXABLE INCOME, AS WELL AS THE REQUIREMENT OF REASONABLENESS, THE PROVISIONS OF SECTION 162(M) OF THE CODE AND THE SATISFACTION OF OUR TAX REPORTING OBLIGATIONS.

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PROPOSAL NO. 3: APPROVAL OF THE AMENDMENT AND RESTATEMENT OF THE SEATTLE GENETICS, INC. AMENDED AND RESTATED 2007 EQUITY INCENTIVE PLAN

OPTIONS

The grant of an incentive stock option has no federal income tax effect on the optionee. Upon exercise the optionee does not recognize income for “regular” tax purposes. However, the excess of the fair market value of the stock subject to an option over the exercise price of such option (which is often referred to as the “option spread”) is included in the optionee’s “alternative minimum taxable income” for purposes of the alternative minimum tax. If the optionee does not dispose of the stock acquired upon exercise of an incentive stock option until more than two years after the option grant date and more than one year after exercise of the option, any gain (or loss) upon sale of the shares will be a long-term capital gain (or loss). If shares are sold or otherwise disposed of before these periods have expired, which is referred to as a disqualifying disposition, the option spread at the time of exercise of the option (but not more than the amount of the gain on the sale or other disposition) is ordinary income in the year of such sale or other disposition. If gain on a disqualifying disposition exceeds the amount treated as ordinary income, the excess is taxable as capital gain (which will be long-term capital gain if the shares have been held more than one year after the date of exercise of the option). We are not entitled to a federal income tax deduction in connection with incentive stock options, except to the extent that the optionee has taxable ordinary income on a disqualifying disposition (unless limited by Section 162(m)).

The grant of a nonstatutory stock option having an exercise price equal to the grant date fair market value of our common stock has no federal income tax effect on the optionee. Upon the exercise of a nonstatutory stock option, the optionee has taxable ordinary income (and unless limited by Section 162(m), we are entitled to a corresponding deduction) equal to the option spread on the date of exercise. Upon the disposition of stock acquired upon exercise of a nonstatutory stock option, the optionee recognizes either long-term or short-term capital gain or loss, depending on how long such stock was held, on any difference between the sale price and the exercise price, to the extent not recognized as taxable income on the date of exercise. We may allow nonstatutory stock options to be transferred subject to conditions and restrictions imposed by the plan administrator; special tax rules may apply on such a transfer. In the case of both incentive stock options and nonstatutory stock options, special federal income tax rules apply if our common stock is used to pay all or part of the option price, and different rules than those described above will apply if unvested shares are purchased on exercise of the option.

STOCK AWARDS

Stock Awards. Stock awards will generally be taxed in the same manner as nonstatutory stock options. Shares issued under a restricted stock award are subject to a “substantial risk of forfeiture” within the meaning of Section 27A83 of the Code to the extent the shares will be forfeited in the event that the participant ceases to provide services to us and are not transferable. As a result of this substantial risk of forfeiture, the participant will not recognize ordinary income at the time the award shares are issued. Instead, the participant will recognize ordinary income on the dates when the stock is no longer subject to a substantial risk of forfeiture, or when the stock becomes transferable, if earlier. The participant’s ordinary income is measured as the difference between the amount paid for the stock, if any, and the fair market value of the stock on the date the stock is no longer subject to forfeiture.

The participant may accelerate his or her recognition of ordinary income, if any, and begin his or her capital gains holding period by timely filing (i.e., within thirty days of the share issuance date) an election pursuant to Section 83(b) of the Code. In such event, the ordinary income recognized, if any, is measured as the difference between the amount paid for the stock, if any, and the fair market value of the stock on the date of such issuance, and the capital gain holding period commences on such date. The ordinary income recognized by an employee will be subject to tax withholding by us. We are entitled to a deduction in the same amount as and at the time the employee recognizes ordinary income.

Stock Appreciation Rights. We may grant under the Restated 2007 Equity Plan stock appreciation rights separate from any other award or in tandem with other awards under the Restated 2007 Equity Plan. Where the stock appreciation rights are granted with a strike price equal to the fair market value of the underlying stock on the grant date, the participant will recognize ordinary income equal to the fair market value of the stock or cash received upon such exercise. Subject to the requirement of reasonableness, the provisions of Section 162(m) of the Code, and the satisfaction of a tax reporting obligation, we will generally be entitled to a tax deduction equal to the taxable ordinary income realized by the participant in connection with the stock appreciation right.

Restricted Stock Units. Generally, the recipient of a stock unit structured to conform to the requirements of Section 409A of the Code or an exception to Section 409A of the Code will recognize ordinary income at the time the stock is delivered equal to the excess, if any, of the fair market value of the shares of our common stock received over any amount paid by the participant in exchange for the shares of our common stock. To conform to the requirements

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of Section 409A of the Code, the shares of our common stock subject to a stock unit award may generally only be delivered upon one of the following events: a fixed calendar date (or dates), separation from service, death, disability or a change in control. If delivery occurs on another date, unless the stock units otherwise comply with or qualify for an exception to the requirements of Section 409A of the Code, in addition to the tax treatment described above, the participant will owe an additional 20% federal tax and interest on any taxes owed.

The participant’s basis for the determination of gain or loss upon the subsequent disposition of shares acquired from stock units, will be the amount paid for such shares plus any ordinary income recognized when the stock is delivered.

Subject to the requirement of reasonableness, the provisions of Section 162(m) of the Code and the satisfaction of a tax reporting obligation, we will generally be entitled to a tax deduction equal to the taxable ordinary income realized by the participant.

SECTION 409A OF THE CODE

The American Jobs Creation Act of 2004 added Section 409A to the Code, generally effective January 1, 2005. Section 409A covers most programs that defer the receipt of compensation to a succeeding year. It provides rules for elections to defer, if any, and for timing of payouts. There are significant penalties placed on the individual participant for failure to comply with Section 409A. However, it does not impact our ability to deduct deferred compensation.

Section 409A does not apply to incentive stock options, nonstatutory stock options that have an exercise price that is at least equal to the grant date fair market value and restricted stock provided there is no deferral of income beyond the vesting date. Section 409A also does not cover stock appreciation rights if the exercise price is not less than the fair market value of the underlying stock on the date of grant, the rights are settled in such stock and no features defer the recognition of income beyond the exercise date.

SECTION 162(M) OF THE CODE

Under Section 162(m) of the Code, compensation paid to any publicly held corporation’s “covered employees” (as defined under Section 162(m) of the Code) that exceeds $1 million per taxable year for any covered employee is generallynon-deductible. Prior to the enactment of the Tax Cuts and Jobs Act, compensation that qualified as “performance-based compensation” under Section 162(m) of the Code was not subject to this deduction limitation. Pursuant to the Tax Cuts and Jobs Act, this exception for “performance-based compensation” under Section 162(m) of the Code was repealed with respect to taxable years beginning after December 31, 2017, except that certain transition relief is provided for remuneration provided pursuant to a written binding contract which was in effect on November 2, 2017 and which was not modified in any material respect on or after such date. As a result, compensation paid to any of our “covered employees” in excess of $1 million per taxable year generally will not be deductible unless, among other requirements, it is intended to qualify, and is eligible to qualify, as “performance-based compensation” under Section 162(m) of the Code pursuant to the transition relief described above. Because of certain ambiguities and uncertainties as to the application and interpretation of Section 162(m) of the Code, as well as other factors beyond the control of the Compensation Committee, no assurance can be given that any award granted under the Restated 2007 Equity Plan will be eligible for such transition relief and, therefore, eligible for the “performance-based compensation” exception under Section 162(m) of the Code.

ACCOUNTING TREATMENT

We will recognize compensation cost in connection with awards granted under the Restated 2007 Equity Plan as required under applicable accounting standards. We currently recognize compensation cost associated with equity awards over an award’s requisite service period and establish fair value of equity awards in accordance with applicable accounting standards.

VOTE REQUIRED

Shareholder approval of this Proposal No. 3 will require the affirmative vote of a majority of the votes cast in person or by proxy at the Annual Meeting.

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The Board recommends a voteFOR this Proposal No. 3.

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PROPOSAL NO. 4

RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Our Audit Committee has selected PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2020. PricewaterhouseCoopers LLP has served as our independent registered public accounting firm since June 1998. A representative of PricewaterhouseCoopers LLP is expected to be present at the Annual Meeting. This representative will have an opportunity to make a statement and will be available to respond to appropriate questions.

Shareholder ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm is not required by our bylaws or other governing documents. However, the Board is submitting the appointment of PricewaterhouseCoopers LLP to the shareholders for ratification as a matter of good corporate governance. While the Audit Committee is not bound by a vote either for or against the proposal, it will consider a vote against PricewaterhouseCoopers LLP by the shareholders in selecting our independent registered public accounting firm in the future. Even if the shareholders do ratify the appointment, the Audit Committee in its discretion may direct the appointment of a different independent registered public accounting firm at any time during the year if it believes that such a change would be in the best interests of Seattle Genetics and its shareholders.

Shareholder approval of this Proposal No. 4 will require the affirmative vote of a majority of the votes cast in person or by proxy at the Annual Meeting.

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On behalf of the audit committee, the Board recommends a voteFOR this Proposal No. 4.

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PROPOSAL NO. 4: RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FEES

PricewaterhouseCoopers LLP served as our independent registered public accounting firm for 2019 and 2018 and their aggregate fees for services rendered were as follows:

Type of Fees

  2019   2018 

Audit Fees

  $1,330,000   $1,543,000 

Audit-Related Fees

        

Tax Fees

        

All Other Fees

   2,790    2,700 

Total Fees

  $1,332,790   $1,545,700 

Audit Fees. Audit fees represent fees for professional services provided in connection with the audit of our financial statements and review of our quarterly financial statements and audit services provided in connection with other statutory or regulatory filings. In 2018, these fees included services to support the acquisition of Cascadian Therapeutics, Inc.

Audit-Related Fees. Audit-related fees consist of fees billed for assurance and related services that are reasonably related to the performance of the audit or review of our financial statements and are not reported under “— Audit Fees.” There were no audit-related fees billed to Seattle Genetics for services rendered during 2019 or 2018.

Tax Fees. Tax fees principally included tax compliance, tax advice and tax planning fees. There were no tax fees billed to Seattle Genetics for services rendered during 2019 or 2018.

All Other Fees. All other fees include any fees billed that are not audit, audit related, or tax fees. In 2019 and 2018, these fees related to accounting research software licenses.

PRE-APPROVAL POLICIES AND PROCEDURES

In October 2006, the Audit Committee adopted an Audit and Audit-Related ServicesPre-Approval Policy, or the Policy, which sets forth the procedures and the conditions pursuant to which services proposed to be performed by the independent registered public accounting firm may bepre-approved. Proposed services either may bepre-approved by the Audit Committee without consideration of specificcase-by-case services (i.e., generalpre-approval) or require the specificpre-approval of the Audit Committee (i.e., specificpre-approval). The Audit Committee believes that the combination of these two approaches has resulted in an effective and efficient procedure topre-approve services performed by the independent registered public accounting firm. As set forth in the Policy, unless a type of service has received generalpre-approval, it will require specificpre-approval by the Audit Committee if it is to be provided by the independent registered public accounting firm. Any proposed services exceedingpre-approved cost levels or budgeted amounts will also require specificpre-approval by the Audit Committee. In addition, the Audit Committee has delegated to the Chair of the Audit Committee the authority topre-approve services not prohibited by the Policy to be performed by our independent registered public accounting firm and associated fees up to $25,000, provided that the Chair is required to report any decision topre-approve such audit-related ornon-audit services and fees to the full Audit Committee for ratification at its next regular meeting. All audit-related andnon-audit related services performed by our independent registered public accounting firm in 2019 werepre-approved.

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AUDIT COMMITTEE REPORT

AUDIT COMMITTEE REPORT(1)

The Audit Committee of the Board of Directors is currently comprised of three independent directors and operates under a written charter originally adopted by the Board of Directors in March 2001, which charter is reviewed on an annual basis and amended as necessary by the Board of Directors upon recommendation by the Audit Committee.

The members of the Audit Committee are currently David W. Gryska (chairman), John A. Orwin and Alpna H. Seth. Each of the members of the Audit Committee is an “independent director” as currently defined in Rules 5605(c)(2)(A)(i) and (ii) of the Nasdaq listing standards and Rule10A-3 of the Exchange Act. The Board of Directors has also determined that David W. Gryska is an “audit committee financial expert” as described in applicable rules and regulations of the Securities Actand Exchange Commission, or the SEC.

The Audit Committee appoints an accounting firm as our independent registered public accounting firm. The independent registered public accounting firm is responsible for performing an independent audit of 1933our financial statements in accordance with the standards of the Public Company Accounting Oversight Board, or the PCAOB, and Section 21Eissuing a report thereon. Management is responsible for our internal controls and the financial reporting process. The Audit Committee is responsible for monitoring and overseeing these processes.

The Audit Committee held six meetings during 2019. The meetings were designed to provide information to the Audit Committee necessary for it to conduct its oversight function of the external financial reporting activities and audit process of Seattle Genetics, and to facilitate and encourage communication between the Audit Committee, management and our independent registered public accounting firm, PricewaterhouseCoopers LLP. Management represented to the Audit Committee that our financial statements were prepared in accordance with accounting principles generally accepted in the United States of America. The Audit Committee reviewed and discussed the audited financial statements for 2019 with management and the independent registered public accounting firm. The Audit Committee also instructed the independent registered public accounting firm that the Audit Committee expects to be advised if there are any subjects that require special attention.

The Audit Committee has received the written disclosures and the letter from the independent registered public accounting firm, PricewaterhouseCoopers LLP, required by applicable requirements of the PCAOB regarding the independent registered public accounting firm’s communications with the Audit Committee concerning independence, and has discussed with PricewaterhouseCoopers LLP that firm’s independence.

Based on its review of the audited financial statements and the various discussions noted above, the Audit Committee recommended to the Board of Directors that the audited financial statements be included in our Annual Report on Form10-K for the fiscal year ended December 31, 2019.

The Audit Committee of the Board of Directors of Seattle Genetics, Inc.:

    LOGOLOGO       LOGO         

David W. Gryska

(chair)

John A. OrwinAlpna H. Seth

(1)

The material in this report is not “soliciting material,” is not deemed “filed” with the SEC and is not to be incorporated by reference in any filing of Seattle Genetics under the Securities Act of 1933, as amended, or the Securities Act, or the Exchange Act, whether made before or after the date hereof and irrespective of any general incorporation language in any such filing.

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FREQUENTLY ASKED QUESTIONS AND OTHER INFORMATION

2020 MEETING INFORMATION

Meeting Date:Friday, May 15, 2020Meeting Place:

Seattle Genetics, Inc.

21823 – 30th Drive SE, Building 3

Bothell, WA 98021

Meeting Time:11:00 a.m. (Pacific)
Record Date:

March 19, 2020

VOTING MATTERS

Management Proposals

Board Vote
Recommendation
See Page Number
for More Detail

PROPOSAL NO. 1

Election of Class I directors

FOR EACH

NOMINEE

Page 8

PROPOSAL NO. 2

Advisory vote on the compensation of our named executive officers

FOR

Page 29

PROPOSAL NO. 3

Amendment and restatement of the 2007 Equity Plan to, among other things, increase the aggregate number of shares of common stock authorized for issuance thereunder by 6,000,000 shares

FOR

Page 75

PROPOSAL NO. 4

Ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm for the fiscal year ending December 31, 2020

FOR

Page 86

WHY DID I RECEIVE THIS PROXY STATEMENT?

Our Board of Directors is soliciting your proxy to vote at the Annual Meeting, including at any adjournments or postponements of the Annual Meeting. This proxy statement describes the proposals on which we would like you, as a shareholder, to vote. It also gives you information on these proposals so that you can make an informed decision, information you may find useful in determining how to vote and information regarding voting procedures.

WHY DID I RECEIVE A NOTICE ABOUT INTERNET AVAILABILITY OF PROXY MATERIALS, INSTEAD OF PAPER COPIES OF THE PROXY MATERIALS?

This proxy statement and our 2019 annual report are available on the Internet at http://www.edocumentview.com/SGEN. In accordance with the rules of the SEC, we are using the Internet as our primary means of furnishing proxy materials to shareholders. Consequently, most shareholders will not receive paper copies of our proxy materials. We will instead send these shareholders a Notice of Internet Availability of Proxy Materials, or the Notice of Internet Availability, with instructions for accessing the proxy materials, including our proxy statement and 2019 annual report, and voting via the Internet. The Notice of Internet Availability also provides information on how shareholders may obtain paper copies of our proxy materials if they so choose. This makes the proxy distribution process more efficient and less costly, and it helps conserve natural resources.

WHEN AND WHERE WILL THE ANNUAL MEETING BE HELD?

The Annual Meeting is being held on Friday, May 15, 2020, at 11:00 a.m. local time at our principal offices located in Building 3 at 21823 – 30th Drive SE, Bothell, Washington 98021. Directions to our principal offices may be found at www.seattlegenetics.com. We are monitoring the emerging public health impact of the coronavirus outbreak (COVID-19). The health and well-being of our employees and shareholders are paramount. If public health developments warrant, we may need to change the location of the Annual Meeting or switch to a virtual meeting format. Any such change will be announced via press release and the filing of additional soliciting materials with the SEC. Please retain the control number from your proxy card or voting instruction form so that you can access the Annual Meeting if it is converted to a virtual meeting format.

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FREQUENTLY ASKED QUESTIONS AND OTHER INFORMATION

CAN I VOTE AT THE ANNUAL MEETING?

All shareholders of record who owned shares of our stock as of March 19, 2020, the record date, may attend and vote on the proposals considered at the Annual Meeting.

WHAT IS THE DIFFERENCE BETWEEN A SHAREHOLDER OF RECORD AND A BENEFICIAL OWNER?

Shareholders whose shares are registered with our transfer agent, Computershare, Inc., in their own name are record holders, also known as shareholders of record. Shareholders whose shares are not registered in their own name with Computershare, Inc. are beneficial holders of shares held in street name. Such shares may be held in an account at a bank or at a brokerage firm (your record holder). If you are a beneficial holder, you have the right to direct your record holder on how to vote your shares, and you will receive instructions from your record holder that must be followed in order for your record holder to vote your shares per your instructions.

HOW CAN I VOTE?

For the election of directors (Proposal No. 1), you may vote “FOR” or “AGAINST” each nominee, or you may abstain from voting for all or any of the nominees. For each of the other three proposals, you may vote “FOR” or “AGAINST” or abstain from voting.

If you are a shareholder of record, as of the record date, you may vote via any of the following methods:

LOGOLOGOLOGO
Via the Internet:Call Toll-Free:Mail Signed Proxy Card:
www.envisionreports.com/SGEN1-800-652-VOTE (8683)

Using the Provided

Postage-Paid Envelope

In addition, if you are a shareholder of record, you may vote in person at the Annual Meeting. Whether or not you plan to attend the Annual Meeting, we urge you to vote by proxy to ensure your vote is counted. You may still attend the Annual Meeting and vote in person even if you have already voted by proxy. If your shares are held in street name, your shares may be voted by you in person at the Annual Meeting only if you obtain a legal proxy from your record holder giving you the right to vote such shares in person at the Annual Meeting.

If you are a beneficial holder, you have the right to direct your record holder on how to vote your shares, and you will receive instructions from your record holder that must be followed in order for your record holder to vote your shares per your instructions. Many banks and brokerage firms have a process for their beneficial holders to provide instructions via the Internet or by telephone. If Internet or telephone voting is unavailable from your record holder, please complete and return the voting instruction form in the addressed, postage paid envelope provided. If your shares are held beneficially in street name and you have not given your record holder voting instructions, your record holder will not be able to vote your shares with respect to any matter other than ratification of the appointment of Seattle Genetics’ independent registered public accounting firm as explained in more detail below.

For those shareholders who receive a Notice of Internet Availability, the Notice of Internet Availability provides information on how to access your proxy materials on the Internet, which contains instructions on how to vote via the Internet or by telephone. If you received a Notice of Internet Availability, you can request a printed copy of your proxy materials by following the instructions contained in the Notice of Internet Availability.

IF I AM A BENEFICIAL HOLDER, HOW CAN I VOTE?

If you are the record holder of your shares, you must vote by proxy or attend the Annual Meeting in person in order to vote on the proposals. If the shares you own are held in “street name” by a brokerage firm, your brokerage firm, as the record holder of your shares, is required to vote your shares according to your instructions. In order to vote your shares, you will need to follow the directions your brokerage firm provides you. Many brokers also offer the option of voting via the Internet or over the telephone, instructions for which would be provided by your brokerage firm on your voting instruction form. Under the current rules that govern brokers, if you do not give instructions to your brokerage firm, it will still be able to vote your shares, but only with respect to proposals for which it has discretionary voting authority. A “brokernon-vote” occurs when a broker or other holder of record holding shares for a beneficial owner

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submits a proxy for the Annual Meeting but does not vote on a particular proposal because that holder does not have discretionary voting power with respect to that proposal and has not received instructions from the beneficial owner.

The election of directors (Proposal No. 1), the advisory vote on the compensation of our named executive officers (Proposal No. 2) and amendment and restatement of the 2007 Equity Plan (Proposal No. 3) are proposals for which brokers do not have discretionary voting authority. If you do not instruct your broker how to vote with respect to these proposals, your broker may not vote with respect to these proposals and thosenon-votes will be counted as “brokernon-votes.” The ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm (Proposal No. 4) is considered to be discretionary and your brokerage firm will be able to vote on Proposal No. 4 even if it does not receive instructions from you, so long as it holds your shares in its name.

If you are a beneficial owner of shares held in street name, in order to ensure your shares are voted in the way you would prefer, you must provide voting instructions to your broker, bank or other agent by the deadline provided in the materials you receive from your broker, bank or other agent.

CAN I CHANGE MY VOTE OR REVOKE MY PROXY?

You may revoke or change a previously delivered proxy at any time before the final vote at the Annual Meeting. If you are the shareholder of record for your shares, you may revoke your proxy in any one of the following ways:

You may submit another properly completed proxy card with a later date.

You may grant a subsequent proxy over the telephone or via the Internet.

You may send a timely written notice that you are revoking your proxy to our Corporate Secretary at 21823 – 30th Drive SE, Bothell, Washington 98021.

You may attend the Annual Meeting and vote in person. Simply attending the Annual Meeting will not, by itself, revoke your proxy.

Your most recent proxy card or telephone or Internet proxy is the one that is counted.

If you are a beneficial owner whose shares are held by your broker, bank or other agent as a nominee or agent, you should follow the instructions provided by your broker, bank or other agent.

WHAT IF I RECEIVED MORE THAN ONE SET OF PROXY MATERIALS?

If you receive more than one set of proxy materials, or more than one Notice of Internet Availability or a combination thereof, your shares may be registered in more than one name or are registered in different accounts. Please follow the voting instructions on each set of proxy materials or Notices of Internet Availability to ensure that all of your shares are voted.

WHAT CONSTITUTES A QUORUM TO CONDUCT BUSINESS AT THE ANNUAL MEETING?

There were 172,601,285 shares of common stock issued and outstanding on the record date, March 19, 2020. Each share of common stock is entitled to one vote. The holders of a majority of our issued and outstanding shares of common stock entitled to vote as of the record date must be present at the Annual Meeting (either in person or by proxy) in order to hold the Annual Meeting and conduct business. This is called a “quorum.” Your shares will be counted towards the quorum only if you submit a valid proxy (or if one is submitted on your behalf by your broker, bank or other agent) or if you vote in person at the Annual Meeting. Abstentions and brokernon-votes will be treated as shares present for the purpose of determining the presence of a quorum for the transaction of business at the Annual Meeting.

WHAT VOTE IS REQUIRED TO APPROVE EACH PROPOSAL?

Assuming that a quorum is present at the Annual Meeting, the following votes will be required:

With respect to the election of Class I directors (Proposal No. 1), directors in an uncontested election, such as this one, are elected by a majority of the votes cast. Accordingly, each of the three Class I director nominees must receive the affirmative vote of a majority of the votes cast on his or her election in order to be elected (i.e., the number of shares voted ‘FOR” such nominee must exceed the number of shares voted “AGAINST” such nominee).

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FREQUENTLY ASKED QUESTIONS AND OTHER INFORMATION

With respect to the advisory vote on the compensation of our named executive officers as disclosed in this proxy statement (Proposal No. 2), approval will require the affirmative vote of a majority of the votes cast in person or by proxy at the Annual Meeting.

With respect to the vote on the amendment and restatement of the 2007 Equity Plan to, among other things, increase the aggregate number of shares of common stock authorized for issuance thereunder by 6,000,000 shares (Proposal No. 3), approval will require the affirmative vote of a majority of the votes cast in person or by proxy at the Annual Meeting.

With respect to the ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm (Proposal No. 4), approval will require the affirmative vote of a majority of the votes cast in person or by proxy at the Annual Meeting.

We believe that the procedures to be used by the Inspector of Election to count the votes are consistent with Delaware law concerning voting of shares and determination of a quorum.

Abstentions and brokernon-votes will not be considered votes cast at the Annual Meeting. Because the approval of all of the proposals is based on the votes cast at the Annual Meeting, abstentions and, as applicable, brokernon-votes will not have any effect on the outcome of voting on the proposals.

WHO SOLICITS PROXIES AND WHO BEARS THE COST OF SOLICITATION?

The Board of Directors of Seattle Genetics is soliciting your proxy to vote your shares at the Annual Meeting. We will bear the entire cost of this solicitation of proxies, including the preparation, assembly, printing, and mailing of the Notice of Internet Availability, this proxy statement, the proxy card and any additional solicitation material that we may provide to our shareholders. In addition to these proxy materials, our directors, officers and other employees may contact you by telephone, via the Internet, in person or otherwise to obtain your proxy. Our directors, officers and other employees will not receive any additional compensation for assisting in the solicitation. We have also engaged Morrow Sodali LLC to assist in the solicitation of proxies for a fee of approximately $15,000, plus reasonableout-of-pocket expenses. We will also request brokerage firms, nominees, custodians and fiduciaries to forward proxy materials to the beneficial owners. We will reimburse these entities and our transfer agent for their reasonableout-of-pocket expenses in forwarding proxy materials.

WHO WILL COUNT THE VOTES AND DETERMINE IF A QUORUM IS PRESENT?

Votes cast by proxy or in person at the Annual Meeting will be tabulated by a representative of Computershare, Inc., our transfer agent, who will act as the Inspector of Election. The Inspector of Election will also determine whether a quorum is present at the Annual Meeting.

IF I RETURN A PROXY BUT DO NOT PROVIDE VOTING INSTRUCTIONS, HOW WILL MY SHARES BE VOTED?

Shares properly voted by proxy will be voted at the Annual Meeting. If you specify a choice with respect to any matter to be acted on, the shares will be voted in accordance with that specified choice. If you are the record holder of your shares and you do not specify your vote on each proposal individually when voting via the Internet or over telephone, or if you sign and return a proxy card without giving specific voting instructions, then your shares will be voted as follows:

FOR all of the director nominees named herein (Proposal No. 1);

FOR the approval of the compensation of our named executive officers as disclosed in this proxy statement (Proposal No. 2);

FOR the approval of the amendment and restatement of the 2007 Equity Plan to, among other things, increase the aggregate number of shares of common stock authorized for issuance thereunder by 6,000,000 shares (Proposal No. 3); and

FOR the ratification of the appointment of PricewaterhouseCoopers LLP as our independent registered public accounting firm (Proposal No. 4).

If any other matter is properly presented at the Annual Meeting, it is the intention of the persons named in the accompanying proxy, referred to in this proxy statement as the “proxy holders,” to vote on those matters in accordance with their best judgment.

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FREQUENTLY ASKED QUESTIONS AND OTHER INFORMATION

Please note that if you are a beneficial owner of shares held in “street name” and you do not instruct your brokerage firm on how to vote your shares, your brokerage firm may still be able to vote your shares in its discretion. Please see “If I am a Beneficial Holder, How Can I Vote?” above or more information.

IF OTHER BUSINESS IS BROUGHT BEFORE THE ANNUAL MEETING, HOW WILL MY SHARES BE VOTED?

The Board of Directors knows of no other business that will be presented to the Annual Meeting. If any other business is properly brought before the Annual Meeting, or with respect to any adjournment or postponement thereof, it is the intention of the proxy holders to vote on such matters in accordance with their best judgment.

HOW CAN I FIND OUT THE RESULTS OF THE ANNUAL MEETING?

We will announce preliminary voting results at the Annual Meeting. We will publish the final results in a current report onForm 8-K, which we expect to file with the SEC within four business days of the Annual Meeting. If final voting results are not available to us in time to file a Form8-K within four business days after the meeting, we intend to file a Form8-K to publish preliminary results and, within four business days after the final results are known to us, file an additional Form8-K to publish the final results. You can obtain a copy of any of these filings on our website at www.seattlegenetics.com or by contacting our Investor Relations Department at(425) 527-4000.

WHEN ARE PROPOSALS AND NOMINATIONS DUE FOR THE 2021 ANNUAL MEETING?

To have your proposal included in our proxy statement for the 2021 Annual Meeting, you must submit your proposal in writing by December 3, 2020 to Jean I. Liu, Corporate Secretary, Seattle Genetics, 21823 – 30th Drive SE, Bothell, Washington 98021, and you must comply with all applicable requirements ofRule 14a-8 promulgated under the Securities Exchange Act of 1934. Forward-looking statements1934, as amended, or the Exchange Act. However, if the 2021 Annual Meeting is not held between April 15, 2021 and June 14, 2021, then the deadline will be a reasonable time prior to the time we begin to print and send our proxy materials.

Shareholders wishing to submit proposals or director nominations for our 2021 Annual Meeting that are based onnot to be included in our management’s beliefs and assumptions and on information currently availableproxy statement must give timely written notice to our management. All statements otherCorporate Secretary in accordance with our bylaws. To be “timely,” written notice must be received by our Corporate Secretary at the above address no earlier than statementsJanuary 15, 2021 and no later than February 14, 2021; provided, however, that in the event the date of historical facts are “forward-looking statements”the 2021 Annual Meeting is not scheduled to be held between April 15, 2021 and June 14, 2021, then such notice must be received by the later of the 90th day prior to the date of the 2021 Annual Meeting or the 10th day following the date on which public announcement or disclosure of the date of the 2021 Annual Meeting is first made. However, in the event that the number of directors to be elected to the Board of Directors is increased and either all of the nominees for purposesdirector or the size of these provisions, including those relatingthe increased Board of Directors is not publicly announced or disclosed by Seattle Genetics on or prior to future events orFebruary 4, 2021, a shareholder’s notice to our future financial performance and financial guidance. In some cases, you can identify forward-looking statementsCorporate Secretary will also be considered timely, but only with respect to nominees for any new positions created by terminology such as “may,” “might,” “will,” “should,” “expect,” “plan,” “anticipate,” “project,” “believe,” “estimate,” “predict,” “potential,” “intend” or “continue,”increase, if the negativeshareholder’s notice is delivered to our Corporate Secretary at the above address not later than the close of terms like these or other comparable terminology, and other words or terms of similar meaning in connection with any discussion of future operating or financial performance. These statements are only predictions. All forward-looking statements included in this Proxy Statement are based on information available to usbusiness on the 10th day following the first date hereof,all of such nominees or the size of the increased Board of Directors has been publicly announced or disclosed by Seattle Genetics. We also advise you to review our bylaws, which contain additional requirements about advance notice of shareholder proposals and we assume no obligationdirector nominations, including attendance requirements. A shareholder’s notice to update any such forward-looking statements, except asour Corporate Secretary must set forth the information required by law. Anyour bylaws with respect to each nominee or allmatter the shareholder proposes to bring before the 2021 Annual Meeting, and must be updated not later than ten days after the record date for the determination of shareholders entitled to vote at 2021 Annual Meeting to provide any material changes in the foregoing information. The person presiding at the 2021 Annual Meeting may determine, if the facts warrant, that a nominee or matter has not been properly brought before the meeting and, therefore, may not be considered at the meeting. In addition, the proxy solicited by the Board of Directors for the 2021 Annual Meeting will confer discretionary voting authority with respect to (i) any proposal presented by a shareholder at that meeting for which Seattle Genetics has not been provided with timely notice and (ii) any proposal made in accordance with our forward-looking statements in this document may turn outbylaws, if the 2021 proxy statement briefly describes the matter and how management proxy holders intend to be incorrect. Actual events or results may differ materially. Our forward-looking statements can be affected by inaccurate assumptions we might make or by known or unknown risks, uncertainties and other factors. We caution investors that our business and financial performance are subject to substantial risks and uncertainties.vote on it, if the shareholder does not comply with the requirements of Rule14a-4(c)(2) promulgated under the Exchange Act.

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STOCKHOLDERS

FREQUENTLY ASKED QUESTIONS AND OTHER INFORMATION

SHAREHOLDERS SHARING THE SAME ADDRESS

The SEC has adopted rules that permit companies and intermediaries (such as brokers) to implement a delivery procedure called “householding.” Under this procedure, multiple stockholdersshareholders who reside at the same address may receive a single copy of our annual report and proxy materials, including the Notice of Internet Availability, unless the affected stockholdershareholder has provided contrary instructions. This procedure reduces printing costs and postage fees. Once you have received notice from your broker that it will be “householding” communications to your address, “householding” will continue until you are notified otherwise or until you revoke your consent. If, at any time, you no longer wish to participate in “householding” and would prefer to receive a separate copy of the Notice of Internet Availability and, if applicable, a separate copy of the annual report and other proxy materials, you may


request a separate copy by contacting the bank, broker or other holder of record, by contacting our Investor Relations Department at(425) 527-4000 or by sending a written request to: Jean I. Liu, Corporate Secretary, Seattle Genetics, 21823 – 30th Drive SE, Bothell, Washington 98021. The voting instructions sent to a street name stockholdershareholder should provide information on how to request (1) householding of future Seattle Genetics proxy materials, including Notices of Internet Availability, or (2) separate materials if only one set of documents is being sent to a household. If it does not, a stockholdershareholder who would like to make one of these requests should contact Seattle Genetics as described above.
OTHER MATTERS
The Board of Directors knows of no other business that will be presented to the Annual Meeting. If any other business is properly brought before the Annual Meeting, or with respect to any adjournment or postponement thereof, it is the intention

NOTE ABOUT FORWARD-LOOKING STATEMENTS

Certain of the proxy holdersstatements made in this Proxy Statement are forward looking, such as those, among others, relating to voteour potential to achieve the noted development and regulatory milestones; our potential to bring a third product to market and effectively commercialize the Company’s products; the potential for our clinical trials to support further development, regulatory submissions and potential marketing approvals; the opportunities for, and the therapeutic and commercial potential of, ADCETRIS, PADCEV, tucatinib and our other product candidates; our ability to meet financial projections and guidance; our beliefs regarding the benefits and effects of our compensation policies and our expectations to attract and retain executive talent; statements related to our corporate responsibility and sustainability efforts; statements about our prospects for the future generally, as well as other statements that are not historical facts. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include risks and uncertainties associated with maintaining or increasing sales of ADCETRIS and PADCEV due to competition, unexpected adverse events, regulatory action, reimbursement, market adoption by physicians, the impacts of the COVID-19 pandemic or other factors. We may also be delayed or unsuccessful in planned clinical trial initiations, enrollment in and conduct of our clinical trials, obtaining data from clinical trials, planned regulatory submissions, regulatory approvals and launch in each case for a variety of reasons including the difficulty and uncertainty of pharmaceutical product development, the impacts of the COVID-19 pandemic, negative or disappointing clinical trial results, unexpected adverse events or regulatory discussions or actions and the inherent uncertainty associated with the regulatory approval process and the pricing and reimbursement process when applicable. We may not be successful in retaining or attracting executive talent or in achieving the goals of our compensation policies or corporate responsibility and sustainability efforts due to market competition, the actions of third parties with which we do business or other factors. More information about the risks and uncertainties we face is contained under the caption “Risk Factors” included in our Annual Report on such matters in accordance with their best judgment.

It is important that your shares are represented atForm10-K for the Annual Meeting.year ended December 31, 2019. We urge youdisclaim any intention or obligation to vote your shares via the Internet, over the telephoneupdate or if you receivedrevise any forward-looking statements, whether as a paper proxy cardresult of new information, future events or voting instruction formotherwise except as required by mail, by marking, dating and signing the proxy card or voting instruction form and mailing it promptly in the return envelope provided.
applicable law.

By Order of the Board of Directors,

proxysignature2a01.jpg
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Jean I. Liu

Corporate Secretary
Bothell, Washington

CORPORATE SECRETARY

April 5, 2019

2, 2020

A copy of the Company’s Annual Report to the Securities and Exchange CommissionSEC on Form10-K for the fiscal year ended December 31, 20182019 is available without charge upon written request to: Jean I. Liu, Corporate Secretary, Seattle Genetics, 21823 – 30th Drive SE, Bothell, Washington 98021.


APPENDIX A

SEATTLE GENETICS, INC.
AMENDED AND RESTATED 2000 EMPLOYEE STOCK PURCHASE PLAN
Adopted by the Board of Directors: November 16, 2000
Approved by the Stockholders: February 14, 2001
Amended and Restated by the Board of Directors: February 1, 2011
Amended and Restated by the Board of Directors: February 11, 2011
Approved by the Stockholders: May 20, 2011
Amended and Restated by the Board of Directors: February 9, 2015
Approved by the Stockholders: May 15, 2015
Amended and Restated by the Board of Directors: November 11, 2016
Amended and Restated by the Board of Directors: March 21, 2019
Approved by the Stockholders: May 20, 2019

The following constitute the provisions of the Amended and Restated 2000 Employee Stock Purchase Plan of Seattle Genetics, Inc.
1.     Purpose. The purpose of the Plan is to provide eligible employees of the Company and its Designated Corporations with an opportunity to purchase Common Stock of the Company. The Company intends for the Plan to have two components: a component intended to qualify as an employee stock purchase plan within the meaning of Section 423 of the Code (the “423 Component”) and a component that is not intended to qualify as an employee stock purchase plan under Section 423 of the Code (the “Non-423 Component”). The provisions of the 423 Component will be interpreted so as to extend and limit Plan participation in a uniform and nondiscriminatory basis consistent with the requirements of Section 423 of the Code. The provisions of the Non-423 Component shall be subject to rules, procedures, or sub-plans adopted by the Administrator from time to time for compliance with local tax, securities, exchange control, privacy and other laws that apply to Offerings under the Plan by Designated Corporations domiciled outside of the United States. Except as specifically set forth in the Plan or provided by action of the Administrator, the Non-423 Component will operate and be administered in the same manner as the 423 Component.
2.     Definitions.
(a)
Administrator” means the Board or its Committee.
(b)
Affiliate” means any entity, whether now or hereafter existing, that is directly or indirectly controlled by the Company which does not meet the definition of a Subsidiary below, as determined by the Administrator, and which may participate only in an Offering under the Non-423 Component of the Plan.
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(c)
Applicable Laws” means the requirements relating to the administration of equity-based awards and the related issuance of Shares under state corporate laws, United States federal and state securities laws, the Code, any stock exchange or quotation system on which the Shares are listed or quoted and the applicable laws of any foreign country or jurisdiction where options are, or will be, granted under the Plan.
(d)
Board” means the Board of Directors of the Company.
(e)
Code” means the United States Internal Revenue Code of 1986, as amended. Reference to a specific section of the Code or United States Treasury Regulation thereunder will include such section or regulation, any valid regulation or other official applicable guidance promulgated under such section, and any comparable provision of any future legislation or regulation amending, supplementing or superseding such section or regulation.
(f)
Common Stock” means the Common Stock of the Company.
(g)
Company” means

APPENDIX A

SEATTLE GENETICS, INC.

AMENDED AND RESTATED 2007 EQUITY INCENTIVE PLAN

(amended and restated by the Board August 5, 2009)

(amended and restated by the Board March 11, 2010)

(approved by the Company’s stockholders May 21, 2010)

(amended and restated by the Board February 16, 2012)

(approved by the Company’s stockholders May 18, 2012)

(amended and restated by the Board February 28, 2014)

(approved by the Company’s stockholders May 16, 2014)

(amended and restated by the Board March 4, 2016)

(approved by the Company’s stockholders May 20, 2016)

(amended and restated by the Board March 14, 2018)

(approved by the Company’s stockholders May 18, 2018)

(amended and restated by the Board March 18, 2020)

(approved by the Company’s stockholders May 15, 2020)

1. General.

(a)Purpose of the Plan.    The purpose of this Plan is to encourage ownership in Seattle Genetics, Inc., a Delaware corporation.

(h)
Committee” means a committee of one (1) or more members of the Board to whom authority has been delegated by the Board in accordance with Section 14(c).
(i)
Compensation” means total cash compensation received by an Employee from the Company or a Designated Corporation. By way of illustration, but not limitation, Compensation includes regular compensation such as salary, wages, overtime, shift differentials, bonuses (other than bonuses offered in connection with, and as an inducement for, the commencement of employment), commissions and incentive compensation, but excludes relocation payments or reimbursements, expense reimbursements, tuition or other reimbursements, automobile allowances, housing allowances, cash payments in lieu of sick or vacation time benefits and income realized as

a resultDelaware corporation (the “Company”), by key personnel whose long-term employment or other service relationship with the Company is considered essential to the Company’s continued progress and, thereby, encourage recipients to act in the stockholders’ interest and share in the Company’s success.

(b)Section 162(m) Transition Relief.    Notwithstanding anything in the Plan to the contrary, any provision in the Plan that refers to “performance-based compensation” under Section 162(m) of participationthe Code will only apply to any Award that is intended to qualify, and is eligible to qualify, as “performance-based compensation” under Section 162(m) of the Code pursuant to the transition relief provided by the Tax Cuts and Jobs Act (the “TCJA”) for remuneration provided pursuant to a written binding contract which was in effect on November 2, 2017 and which was not modified in any stock option, stock purchase,material respect on or similar plan of the Company or any Designated Corporation. The Administrator shall have discretion to determine the application of this definition to Employees outside the United States.

(j)
Continuous Statusafter such date, as an Employee” means the absence of any interruption or termination of service as an Employee. Continuous Status as an Employee shall not be considered interrupted in the case of (i) sick leave; (ii) military leave; (iii) any other leave of absence approved by the Administrator, provided that such leave is for a period of not more than 90 days, unless reemployment upon the expiration of such leave is guaranteed by contract or statute, or unless provided otherwise pursuant to Company policy adopted from time to time or required under Applicable Laws; or (iv) in the case of transfers between locations of the Company or between the Company and Designated Corporations.
(k)
Contributions” means the amount contributed by a Participant through payroll deductions or other means as may be permitted or required by the Administrator, and other additional payments that the Administrator may permit a Participant to make to fund the exercise of options granted pursuant to the Plan.
(l)
Corporate Transaction” means any of the following, unless the Board provides otherwise: (i) an acquisition of the Company by another entity by means of any transaction or series of related transactions (including, without limitation, any reorganization, merger or consolidation but excluding any merger effected exclusively for the purpose of changing the domicile of the Company), (ii) a sale of all or substantially all of the assets of the Company, so long as in either (i) or (ii) above, the Company’s stockholders of record immediately prior to such transaction will, immediately after such transaction, hold less than fifty percent (50%) of the voting power of the surviving or acquiring entity or (iii) any other event specified by the Board; provided, however, that no Corporate Transaction (or any analogous term) shall be deemed to occur upon announcement or commencement of a tender offer or upon a “potential” takeover or upon shareholder approval of a merger or other transaction, in each case without a requirement that the Corporate Transaction actually occur.
(m)
Designated Corporation” means the Company and any present or future Subsidiary or Affiliate that is designated by the Administrator, from time to time in its sole discretion, as eligible to participate in the Plan. For purposes of the 423 Component, only the Company and its Subsidiaries may be Designated Corporations, provided, however, that at any given time, a Subsidiary that is a Designated Corporation under the 423 Component will not be a Designated Corporation under the Non-423 Component. Unless otherwise determined by the Administrator, the term “Designated Corporation” shall include any corporation into which a Designated Corporation may be merged or consolidated or to which all or substantially all of its assets may be transferred.
(n)
Director” means a member of the Board.
(o)
Employee” means each Employee (within the meaning of Section 423(b)(1) of the Code) of a Designated Corporation. For purposes of clarity, the term “Employee” shall not include the following, regardless of any subsequent reclassification as an employee by the Company or a Designated Corporation, any governmental agency, or any court: (i) any independent contractor; (ii) any consultant; (iii) any individual performing services for the Company or a Designated Corporation who has entered into an independent contractor or consultant agreement with the Company or a Designated Corporation; (iv) any individual performing services for the Company or a Designated Corporation under an independent contractor or consultant agreement, a purchase order, a supplier agreement or any other agreement that the Company or a Designated Corporation enters into for services; (v) any individual classified by the Company or a Designated Corporation as contract labor (such as contractors, contract employees, job shoppers), regardless of length of service; (vi) any individual whose base wage or salary is not processed for payment by the payroll department(s) or payroll provider(s) of the Company or a Designated Corporation; and (vii) any leased employee. Further, service solely as a Director, or payment of a fee for such services, shall not cause a Director to be considered an “Employee” for purposes of the Plan. The Administrator shall have exclusive discretion to determine whether an individual is an Employee for purposes of the Plan.
(p)
Exchange Act” means the United States Securities Exchange Act of 1934, as amended.
(q)
Offering” means an offer under the Plan of an option that may be exercised during an Offering Period as further described in Section 4. Unless otherwise specified by the Administrator, each Offering under the Plan to the Employees of the Company or a Designated Corporation shall be deemed a separate Offering, even if the dates of the applicable Offering Periods of each such Offering are identical, and the provisions of the Plan will separately apply to each Offering. To the extent permitted by U.S. Treasury Regulation Section 1.423-2(a)(1), the terms of each Offering need not be identical provided that the terms of the Plan and an Offering together satisfy U.S. Treasury Regulation Section 1.423-2(a)(2) and (a)(3).
(r)
Offering Date” means the first business day of each Offering Period of the Plan.

(s)
Offering Period” means a period of approximately six (6) months commencing on or about February 1 and August 1 of each year (or at such other time or times as may be determined by the Board of Directors) pursuant to Section 4 below.
(t)
Officer” means a person who is an officer of the Company within the meaning of Section 16 of the Exchange Act and the rules and regulations promulgated thereunder.
(u)
Participant” means an Employee who enrolls in the Plan.
(v)
Plan” means this Amended and Restated 2000 Employee Stock Purchase Plan.
(w)
Purchase Date” means the last day of each Offering Period of the Plan.
(x)
Purchase Price” means with respect to an Offering Period an amount equal to 85% of the Fair Market Value (as defined in Section 7(b) below) of a Share of Common Stock on the Offering Date or on the Purchase Date, whichever is lower.
(y)
Securities Act” means the United States Securities Act of 1933, as amended.
(z)
Share” means a share of Common Stock, as adjusted in accordance with Section 19 of the Plan.
(aa)
Subsidiary” means a corporation, domestic or foreign, as such term is defined in Section 424(f) of the Code, whether or not such corporation now exists or is hereafter organized or acquired by the Company or a Subsidiary.
(bb)    “Tax-Related Items” Any income tax, social insurance, payroll tax, payment on account or other tax-related items arising in relation to the Participant’s participation in the Plan.
(cc) “Trading Day” means any day on which the exchange(s) or market(s) on which shares of Common Stock are listed, including the Nasdaq Global Select Market, the Nasdaq Global Market, or the Nasdaq Capital Market, is open for trading.
3.     Eligibility
(a)    Any person who has been an Employee for a continuous period of at least thirty (30) days ending on the Offering Date of a given Offering Period (or such other period of time as may be determined by the Administrator, in its discretion)sole discretion, in accordance with the TCJA and any applicable guidance, rulings or regulations issued by the U.S. Department of the Treasury, the Internal Revenue Service or any other governmental authority.

2. Definitions.

As used herein, the following definitions shall apply:

(a) “Administrator” means the Board, any Committees or such delegates as shall be eligible to participateadministering the Plan in such Offering Period, subject to any limitations underaccordance with Section 4234 of the CodePlan.

(b) “Affiliate” means any entity that is directly or adoptedindirectly controlled by the Administrator pursuantCompany or any entity in which the Company has a significant ownership interest as determined by the Administrator.

(c) “Applicable Laws” means the requirements relating to subsections (b) through (d) hereof. Separate Offerings applythe administration of stock option and stock award plans under U.S. federal and state laws, the Code, any stock exchange or quotation system on which the Company has listed or submitted for quotation the Common Stock to each Designated Corporation and an Employee is only eligible to participate in the Offering made available to Employeesextent provided under the terms of the Designated Corporation which is the employer ofCompany’s agreement with such Employee.

(b)    An Employee who works for a Designated Corporationexchange or quotation system and, is a citizen or resident of a jurisdiction other than the United States (without regardwith respect to whether such individual also is a citizen or resident of the United States or is a resident alien within the meaning of Section 7701(b)(1)(A) of the Code) may be excluded from participation in the Plan or an Offering if the participation of such Employee is prohibited underAwards subject to the laws of any foreign jurisdiction where Awards are, or will be, granted under the applicable jurisdiction or if complying withPlan, the laws of such jurisdiction.

(d) “Award” means a Stock Award or Option granted in accordance with the applicable jurisdiction would cause the Plan or an Offering under the Section 423 Componentterms of the Plan to violate Section 423 of the Code. In the case of an Offering under the Non-423 Component of the Plan,Plan.

(e) “Awardee” means an Employee, (or group of Employees) may be excluded from participation in the PlanConsultant or an Offering if the Administrator has determined, in its sole discretion, that participation of such Employee(s) is not advisable or practicable for any reason.

(c)    The Administrator, in its discretion, from time to time may, prior to an Offering Period for all options to be granted in an Offering, determine on a uniform and nondiscriminatory basis that the definition of Employee will or will not include an individual if he or she: (a) has not completed at least two (2) years of service since his or her last hire date (or such lesser period of time as may be determined by the Administrator in its discretion), (b) customarily works not more than twenty (20) hours per week (or such lesser period of time as may be determined by the Administrator in its discretion), (c) customarily works not more than five (5) months per calendar year (or such lesser period of time as may be determined by the Administrator in its discretion), (d) is a highly compensated employee within the meaning of Section 414(q) of the Code, or (e) is a highly compensated employee within the meaning of Section 414(q) of the Code with compensation above a certain level or is an officer or subject to the disclosure requirements of Section 16(a) of the Exchange Act, provided the exclusion is applied with respect to each Offering in an identical manner to all highly compensated individuals of the Designated Corporation whose employees are participating in that Offering.
(d)    Any provisions of the Plan to the contrary notwithstanding, no Employee shall be granted an option under the Plan (i) if, immediately after the grant, such Employee (or any other person whose stock would be attributed to such Employee pursuant to Section 424(d) of the Code) would own capital stock of the Company and/or hold outstanding options to purchase stock possessing five percent (5%) or more of the total combined voting power or value of all classes of stockDirector of the Company or any Affiliate who has been granted an Award under the Plan.

(f) “Award Agreement” means a Stock Award Agreement and/or Option Agreement, which may be in written or electronic format, in such form and with such terms and conditions as may be specified by the Administrator, evidencing the terms and conditions of an individual Award. Each Award Agreement is subject to the terms and conditions of the Plan.

2020 PROXY STATEMENTA-1


APPENDIX A

(g) “Board” means the Board of Directors of the Company.

(h) “Cause” means (i) an action or omission of Awardee which constitutes a willful and intentional material breach of any subsidiarywritten agreement or covenant with the Company, including without limitation, Awardee’s theft or other misappropriation of the Company’s proprietary information; (ii) Awardee’s commitment of fraud, embezzlement, misappropriation of funds or breach of trust in connection with Awardee’s employment; or (iii) Awardee’s conviction of any crime which involves dishonesty or a breach of trust, or gross negligence in connection with the performance of the Awardee’s duties. The determination as to whether an Awardee is being terminated for Cause shall be made in good faith by the Company and shall be final and binding on the Awardee. The foregoing definition does not in any way limit the Company’s ability to terminate an Awardee’s employment or consulting relationship at any time as provided in Section 16 below, and the term “Company” will be interpreted to include any Affiliate or successor thereto, if appropriate.

(i) “Change in Control” means any of the following, unless the Administrator provides otherwise:

i. an acquisition of the Company by another entity by means of any transaction or series of related transactions (including, without limitation, any reorganization, merger or consolidation but excluding any merger effected exclusively for the purpose of changing the domicile of the Company);

ii. a sale of all or substantially all of the assets of the Company,

so long as in either i. or ii. above, the Company’s stockholders of record immediately prior to such transaction will, immediately after such transaction, hold less than fifty percent (50%) of the voting power of the surviving or acquiring entity; or

iii. any other event specified by the Board or a Committee, regardless of whether at the time an Award is granted or thereafter;provided, however, that no Change in Control (or any analogous term) shall be deemed to occur upon announcement or commencement of a tender offer or upon a “potential” takeover or upon shareholder approval of a merger or other transaction, in each case without a requirement that the Change in Control actually occur.

(j) “Code” means the United States Internal Revenue Code of 1986, as amended.

(k) “Committee” means the compensation committee of the Board or a committee of Directors appointed by the Board in accordance with Section 4 of the Plan.

(l) “Common Stock” means the common stock of the Company.

(m) “Company” means Seattle Genetics, Inc., a Delaware corporation, or its successor.

(n) “Constructive Termination” means (i) there is a material reduction or change in job duties, responsibilities and requirements inconsistent with Awardee’s position with the Company and prior duties, responsibilities and requirements, provided that neither a mere change in title alone nor reassignment to a position that is substantially similar to the position held prior to the change in terms of job duties, responsibilities or requirements shall constitute a material reduction in job responsibilities; (ii) there is a reduction in Awardee’s then-current base salary by at least twenty percent (20%), provided that anacross-the-board reduction in the salary level of all other employees by the same percentage amount as part of a general salary level reduction shall not constitute such a salary reduction; or (iii) Awardee refuses to relocate to a facility or location more than fifty (50) miles from the Company’s current location.

(o) “Consultant” means any person engaged by the Company or any Affiliate to render services to such entity as an advisor or consultant.

(p) “Conversion Award” has the meaning set forth in Section 4(b)(xiii) of the Plan.

(q) “Director” means a member of the Board.

(r) “Disability” means any physical or mental disability for which an Awardee becomes eligible to receive long-term disability benefits under the Company’s or an Affiliate’s, as applicable, long-term disability plan or policy.

(s) “Employee” means a regular, active employee of the Company or (ii) if such option would permit his any Affiliate, including an Officer and/or her rights to purchase stock under all


employee stock purchase plans (described in Section 423Inside Director. Within the limitations of Applicable Law, the Code) of the Company and its Subsidiaries to accrue at a rate which exceeds Twenty-Five Thousand Dollars ($25,000) of the Fair Market Value (as defined in Section 7(b) below) of such stock (determined on the Offering Date of such option) for each calendar year in which such option is outstanding at any time. 
4.     Offering Periods.
(a)    Offering Periods. The Plan shall be implemented by a series of Offering Periods of approximately six (6) months duration, with new Offering Periods commencing on or about February 1 and August 1 of each year (or at such other time or times as may be determined by the Board ). The Plan shall continue until terminated in accordance with Section 21 hereof. The BoardAdministrator shall have the powerdiscretion to establish additional or alternative sequential or overlapping Offering Periods, a different duration for one or more Offering Periods or different commencement or ending dates for such Offering Periods with respect to future Offerings without shareholder approval, provided, however, that no Offering Period may have a duration exceeding twenty-seven (27) months. Notwithstanding determine

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APPENDIX A

the foregoing, if any Offering Date falls on a day that is not a Trading Day, then such Offering Date shall instead fall on the next subsequent Trading Day.

(b)    Purchase Dates. The Purchase Date ofeffect upon an Offering Period commencing on February 1 shall be the next July 31Award and the Purchase Date ofupon an Offering Period commencing on August 1 shall be the next January 31. The Board shall have the power to change the frequency of Purchase Dates with respect to future purchases without stockholder approval. Notwithstanding the foregoing, if any Purchase Date falls on a day that is not a Trading Day, then such Purchase Date shall instead fall on the immediately preceding Trading Day.
5.     Participation.
(a)    An eligibleindividual’s status as an Employee may become a Participant in the Plan by completing the electronic enrollment process designated by the Company (or other such enrollment process as the Company may designated) during the open enrollment period prescribed by the Company. The enrollment process shall require the Participant to specify the whole percentagecase of the Participant’s Compensation (subject to Section 6 below) to be paid as Contributions pursuant to the Plan. Once an Employee affirmatively enrolls in an Offering Period and authorizes payroll deductions (if contributing via payroll deductions), the Employee automatically shall be enrolled for all subsequent Offering Periods until he or she elects to withdraw from an Offering Period pursuant to Section 11 or terminates his or her participation in the Plan.
(b)    Payroll deductions, if applicable, shall commence on the first payroll paid following the Offering Date and shall end on the last payroll paid on or prior to the Purchase Date to which the election(i) any individual who is applicable, unless sooner terminated by the Participant as provided in Section 11.
6.     Method of Payment For Purchase of Shares.
(a)    This Plan shall be operated as a payroll deduction plan, except to the extent the Administrator determines that Contributions may be made in another form (including payment by check at the end of an Offering Period or, due to local law requirements, in another form with respect to categories of Participants outside the United States).
(b)    A Participant shall elect to have payroll deductions made on each payday during an Offering Period (or such other date as the Administrator may establish from time to time before an Offering Date) in an amount not less than one percent (1%) and not more than twenty percent (20%) (or such other maximum whole percentage as the Administrator may establish from time to time before an Offering Date) of such Participant’s Compensation on each payday during the Offering Period. All payroll deductions made by a Participant shall be credited to his or her account under the Plan. Once a Participant is participating in the Plan on a payroll deduction basis, he or she may not make any additional payments into such account.
Notwithstanding the foregoing or anything to the contrary herein, due to certain payroll deductions and withholdings, a Participant’s Contributions on any payday during an Offering Period may be less than the percentage of Compensation that the Participant elected to have contributed to the Plan on such payday. On each payday during an Offering Period, a Participant’s Contributions shall be deducted from the Participant’s Compensation after deducting any (i) amounts elected to be deferred by the Participant under any qualified cash or deferred arrangement described in Section 401(k) of the Code or other deferred compensation program or arrangement establishedclassified by the Company or its Affiliate as leased from or otherwise employed by a Designated Corporation,third party or as intermittent or temporary, even if any such classification is changed retroactively as a result of an audit, litigation or otherwise, (ii) payments for coverage under any Company or Designated Corporation health insurance plan or other employee benefit plan, (iii) contributions to any Company or Designated Corporation flexible spending account plan, (iv) other pre-tax deductions, (v) other deductions designatedleave of absence approved by the Company or a Designated Corporation, and (vi) applicable tax withholding. As a result, a Participant may not be able to make Contributions onan Affiliate, (iii) any payday during an Offering Period at the percentagetransfer between locations of Compensation that the Participant elected to have contributed to the Plan on such payday, and in such event, neitheremployment with the Company nor any Designated Corporation shall have the obligation to make up for any differenceor an Affiliate or between the Participant’s actual Contributions on such paydayCompany and the percentage of Compensation that the Participant elected to have contributed to the Plan on such payday.
(c)        A Participant may discontinue hisany Affiliate or her participation in the Plan as provided in Section 11 or, on one occasion only during an Offering Period may decrease the rate of his or her Contributions with respect to the Offering Period to

a rate not lower than one percent (1%), by authorizing abetween any Affiliates, (iv) any change in the rateAwardee’s status from an Employee to a Consultant or Director, and (v) at the request of Contributionsthe Company or an Affiliate, an Employee becomes employed by any partnership, joint venture or corporation not meeting the requirements of an Affiliate in which the Company or an Affiliate is a party.

(t) “Exchange Act” means the Securities Exchange Act of 1934, as amended.

(u) “Fair Market Value” of a Share on any given date means, unless otherwise required by Applicable Law, the fair market value of such Share as determined in good faith by the Administrator either through application of any reasonable valuation method or, in the manner designatedabsence of any method established under law, in the Company’s electronic ESPP interface (or such other enrollment process as the Company may designate from timepractice or otherwise to time). Any change in the rate of Contributionsbe reasonable, then pursuant to this Section 6(c) shall be effective as soon as administratively possible, but in no event later than thirty (30) days after the date the changeAdministrator’s good faith conclusion that its valuation determination is authorized. A Participant may not increase the rate of his or her Contributions with respect to the Offering Period during an Offering Period.

(d)    Notwithstanding the foregoing,reasonable; provided that, to the extent necessary to complypossible, such value shall be determined with Section 423(b)(8) of the Code and Section 3(d), a Participant’s rate of Contributions may be decreased by the Company to 0% at any time during an Offering Period. Contributions shall re-commence at the rate provided in such Participant’s election at the beginning of the first Offering Period, which is scheduled to end in the following calendar year, unless terminated by the Participant as provided in Section 11. In addition, a Participant’s rate of Contributions may be decreased by the Company to 0% at any time during an Offering Period in order to avoid unnecessary Contributions as a result of application of the maximum share limit set forth in Section 7(a), or as a result of the limitations set forth in Section 3(d), in which case Contributions shall re-commence at the rate provided in such Participant’s election at the beginning of the next Offering Period, unless terminated by the Participant as provided in Section 11.
7.      Grant of Option.
(a)    Subjectreference to the final sentence of this Section 7(a), on the Offering Date of each Offering Period, each eligible Employee participating in such Offering Period shall be granted an option to purchase on each Purchase Date a number of Sharesclosing price of the Company’s Common Stock determined by dividing such Employee’s Contributions accumulated prior to such Purchase Date and retained in the Participant’s account as of the Purchase Date by the applicable Purchase Price. Notwithstanding the above, the maximum number of Shares an Employee may purchase during each Offering Period shall be 2,000 Shares (subject to any adjustment pursuant to Section 19 below), and provided further that such purchase shall be subject to the limitations set forth in Sections 3(d) and 13.
(b)    If the Common Stock is listed on any established stock exchange or traded on any established market, the fair market value of the Company’s Common Stock on a given date (the “Fair Market Value”) shall be the closing price of the Common Stock as quoted on such exchangethe applicable date on Nasdaq or market (or the exchange or market with the greatest volume of trading in the Common Stock)Stock as of the applicable date, or if the Shares were not trading on such date, then the closing bid on the applicable date. The Administrator may make a good faith determination that it is reasonable to use one valuation method with respect one type of transaction arising under the Plan and a different valuation method with respect to another type of Plan transaction, provided that in each case the Administrator concludes that application of the particular method results in the most accurate measure of fair market value with respect thereto.

(v) “Grant Date” means, for all purposes, the date on which the Administrator makes the determination granting an Award, or such other date as is determined by the Administrator, provided that in the case of any Incentive Stock Option, the grant date shall be the later of the date on which the Administrator makes the determination granting such Incentive Stock Option or the date of determination,commencement of the Awardee’s employment relationship with the Company.

(w) “Incentive Stock Option” means an Option intended to qualify as reportedan incentive stock option within the meaning of Section 422 of the Code and the regulations promulgated thereunder.

(x) “Inside Director” means a Director who is an Employee.

(y) “Nasdaq” means the Nasdaq Global Market or its successor.

(z) “Nonstatutory Stock Option” means an Option not intended to qualify as an Incentive Stock Option.

(aa) “Officer” means a person who is an officer of the Company within the meaning of Section 16 of the Exchange Act and the rules and regulations promulgated thereunder.

(bb) “Option” means a right granted under Section 8 to purchase a number of Shares at such exercise price, at such times, and on such other terms and conditions as are specified in such sourcethe agreement or other documents evidencing the Option (the “Option Agreement”). Both Options intended to qualify as Incentive Stock Options and Nonstatutory Stock Options may be granted under the Board deems reliable. Unless otherwise provided byPlan.

(cc) “Outside Director” means a Director who is not an Employee.

(dd) “Participant” means the Board, if there is no closing sales price forAwardee or any person (including any estate) to whom an Award has been assigned or transferred as permitted hereunder.

(ee) “Plan” means this Seattle Genetics, Inc. Amended and Restated 2007 Equity Incentive Plan.

(ff) “Qualifying Performance Criteria” shall have the meaning set forth in Section 12(b) of the Plan.

(gg) “Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.

(hh) “Share” means a share of the Common Stock, as adjusted in accordance with Section 13 of the Plan.

(ii) “Stock Appreciation Right” means a right to receive cash and/or shares of Common Stock based on the date of determination, thena change in the Fair Market Value shall beof a specific number of shares of Common Stock between the closing selling price (or closing bid if no sales were reported) onGrant Date and the last precedingexercise date forgranted under Section 11.

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(jj) “Stock Award” means an award or issuance of Shares, Stock Units, Stock Appreciation Rights or other similar awards made under Section 11 of the Plan, the grant, issuance, retention, vesting, settlement and/or transferability of which is subject during specified periods of time to such quotation exists. Inconditions (including continued employment or performance conditions) and terms as are expressed in the absence of such markets foragreement or other documents evidencing the Common Award (the “Stock Award Agreement”).

(kk) “Stock Unit” means a bookkeeping entry representing an amount equivalent to the Fair Market Value of one Share (or a fraction or multiple of such value), payable in cash, property or Shares. Stock Units represent an unfunded and unsecured obligation of the Company, except as otherwise provided for by the Administrator.

(ll) “Subsidiary” means any company (other than the Company) in an unbroken chain of companies beginning with the Company, provided each company in the unbroken chain (other than the Company) owns, at the time of determination, stock possessing 50% or more of the total combined voting power of all classes of stock in one of the other companies in such chain.

(mm) “Termination of Employment” shall mean ceasing to be an Employee, Consultant or Director, as determined in the sole discretion of the Administrator. However, for Incentive Stock Option purposes, Termination of Employment will occur when the Awardee ceases to be an employee (as determined in accordance with Section 3401(c) of the Code and the regulations promulgated thereunder) of the Company or one of its Subsidiaries. The Administrator shall determine whether any corporate transaction, such as a sale orspin-off of a division or business unit, or a joint venture, shall be determined bydeemed to result in a Termination of Employment.

3. Stock Subject to the Board in good faith.

8.     ExercisePlan.

(a) Aggregate Limits.Subject to the provisions of Option. Unless a Participant withdraws fromSection 13 of the Plan, as provided in Section 11, his or her option for the purchasemaximum aggregate number of Shares willthat may be exercised automatically on each Purchase Datesold or issued pursuant to Awards granted under the Plan is 39,000,000 Shares. Shares subject to Awards granted under the Plan that are cancelled, expire or are forfeited (including without limitation, any such Shares having been issued under the Award to the Participant) shall be available forre-grant under the Plan. If an Awardee pays the exercise or purchase price of an Offering Period, andAward granted under the maximumPlan through the tender of Shares, the number of fullShares so tendered shall become available forre-issuance thereafter under the Plan. The Shares subject to the option willPlan may be purchased ateither Shares reacquired by the applicable Purchase Price with the accumulated Contributions in his or her account. No fractional Shares shall be issued. TheCompany, including Shares purchased upon exercise of an option hereunder shall be deemed to be transferredin the open market, or authorized but unissued Shares.

(b) Individual Share Limits.    Subject to the Participant on the Purchase Date. During his or her lifetime, a Participant’s option to purchase Shares hereunder is exercisable only by him or her.

9.    Taxes. At the time a Participant’s option is exercised, in whole or in part, or at the time a Participant disposesprovisions of some or allSection 13 of the Shares acquired under the Plan, the Participant shall make adequate provision for any Tax-Related Items, to the extent applicable. In their sole discretion, the Company or the Designated Corporation employing the Participant may satisfy their obligations to withhold Tax-Related Items by (i) withholding from the Participant’s wages or other compensation, (ii) withholding a sufficient wholeaggregate number of Shares otherwise issuable following purchase having an aggregate fair market value sufficientsubject to pay the Tax-Related Items requiredAwards granted under this Plan during any calendar year to be withheld with respectany one Awardee shall not exceed 1,000,000. Notwithstanding anything to the Shares, as determinedcontrary in accordance with generally accepted accounting principles, or (iii) withholding from proceeds from the sale of Shares issued upon purchase, either through a voluntary sale or a mandatory sale arranged byPlan, the Company.
10.     Delivery. As promptly as practicable after each Purchase Date of each Offering Period, the Companylimitation set forth in this Section 3(b) shall arrange the deliverybe subject to each Participant, as appropriate,adjustment under Section 13(a) of the Shares purchased upon exercise of his or her option. No fractional Shares shall be purchased; any payroll deductions accumulated in a Participant’s account which are not sufficient to purchase a full Share shall be retained in the Participant’s account for the subsequent Offering Period, subject to earlier withdrawal by the Participant as provided in Section 11 below. Any other amounts left over in a Participant’s account after a Purchase Date shall be returned to the Participant.
11.    Voluntary Withdrawal; Termination of Employment.
(a)    A Participant may withdraw all but not less than all the Contributions credited to his or her account under the Plan at any time prior to each Purchase Date by giving notice to the Company through the Company’s electronic ESPP interface (or such other method as the Company may specify) at least ten days prior to the Purchase Date (other by such other date as the Company may specify). All of the Participant’s Contributions credited to his or her account will be paid to him or her

promptly after receipt of his or her notice of withdrawal and his or her option for the current period will be automatically terminated, and no further Contributions for the purchase of Shares will be made during the Offering Period.
(b)    Upon termination of the Participant’s Continuous Status as an Employee prior to the Purchase Date of an Offering Period for any reason, including retirement or death, the Contributions credited to his or her account will be returned to him or her or, in the case of his or her death, to the person or persons entitled thereto under Section 15, and his or her option will be automatically terminated.
(c)    If a Participant transfers from an Offering under the 423 Component of the Plan to an Offering under the Non-423 Component due to a transfer of the Participant’s employment between Designated Corporations, the exercise of the option will be qualified under the 423 Component only to the extent that such exercise complies withadjustment will not affect the status of any Award intended to qualify as “performance based compensation” under Code Section 423162(m).

(c) Incentive Stock Option Limit.Subject to the provisions of the Code. If a Participant transfers from an Offering under the Non-423 ComponentSections 3(a) and 13 of the Plan, to an Offering under the 423 Component,maximum aggregate number of Shares that may be issued pursuant to the exercise of Incentive Stock Options is 78,000,000 Shares.

(d)Outside Director Compensation Limit.    The aggregate value of all compensation granted or paid, as applicable, to any individual for service as an Outside Director with respect to any calendar year, including Awards granted and cash fees paid by the rightCompany to such Outside Director, will remain non-qualifiednot exceed (i) $1,000,000 in total value or (ii) in the event such Outside Director is first appointed or elected to the Board during such calendar year, $1,500,000 in total value, in each case calculating the value of any equity awards based on the grant date fair value of such equity awards for financial reporting purposes.

4. Administration of the Plan.

(a) Procedure.

i. Multiple Administrative Bodies.    The Plan shall be administered by the Board, a Committee and/or their delegates.

ii. Rule 16b-3.    To the extent desirable to qualify transactions hereunder as exempt underRule 16b-3 promulgated under the Non-423 Component.

(d)    A Participant’s withdrawal from an Offering will not have any effect upon his or her eligibilityExchange Act (“Rule 16b-3”), Awards to participate in a succeeding Offering or in any similar plan which may hereafterOfficers and Directors shall be adoptedmade by the Company.
entire Board or a Committee of two or more12.    “non-employeeInterest. No interest shall accrue on directors” within the Contributionsmeaning ofRule 16b-3.

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iii. Other Administration.    The Board or a Participant inCommittee may delegate to an authorized officer or officers of the Company the power to approve Awards to persons eligible to receive Awards under the Plan (exceptwho are not (A) subject to Section 16 of the Exchange Act or (B) any other executive officer.

iv. Delegation of Authority for theDay-to-Day Administration of the Plan.    Except to the extent required underprohibited by Applicable Laws)Law, the Administrator may delegate to one or more individuals theday-to-day administration of the Plan and any of the functions assigned to it in this Plan. Such delegation may be revoked at any time.

v.Nasdaq.

13.     Stock.
(a)    The Plan will be administered in a manner that complies with any applicable Nasdaq or stock exchange listing requirements.

(b) Powers of the Administrator.    Subject to adjustment as provided in Section 19, the maximum numberprovisions of Shares which shall be made available for sale under the Plan and, in the case of a Committee or delegates acting as the Administrator, subject to the specific duties delegated to such Committee or delegates, the Administrator shall be 2,896,190 Shares. If any option granted underhave the Plan shall for any reason terminate without having been exercised,authority, in its discretion:

i. to select the sharesEmployees, Consultants and Directors of Common Stock not purchased under such option shall again become available for issuance under the Plan. If the Board determines that, on a given Purchase Date, the number of shares with respectCompany or its Affiliates to which optionswhom Awards are to be exercised may exceed (i)granted hereunder;

ii. to determine the number of shares of Common Stock that were availableor amount of cash to be covered by each Award granted hereunder;

iii. to determine the type of Award to be granted to the selected Employees, Consultants and Directors;

iv. to approve forms of Award Agreements for saleuse under the Plan onPlan;

v. to determine the Offering Dateterms and conditions, not inconsistent with the terms of the applicable Offering Period, Plan, of any Award granted hereunder. Such terms and conditions include, but are not limited to, the exercise and/or (ii)purchase price (if applicable), the numbertime or times when an Award may be exercised (which may or may not be based on performance criteria), the vesting schedule, any vesting and/or exercisability acceleration or waiver of shares available for sale underforfeiture restrictions, the Planacceptable forms of consideration, the term, and any restriction or limitation regarding any Award or the Shares relating thereto, based in each case on such Purchase Date,factors as the Board mayAdministrator, in its sole discretion, provide (x) thatshall determine and may be established at the Company shall make a pro rata allocation of the Sharestime an Award is granted or thereafter;

vi. to determine whether and under what circumstances an Option may be settled in cash under Section 8(h) instead of Common Stock available for purchase on such Offering Date or Purchase Date, as applicable, in as uniform a manner as shall be practicable and as it shall determine in its sole discretionStock;

vii. to be equitable among all Participants exercising optionscorrect administrative errors;

viii. to purchase Common Stock on such Purchase Date, and continue all Offering Periods then in effect, or (y) that the Company shall make a pro rata allocation of the shares available for purchase on such Offering Date or Purchase Date, as applicable, in as uniform a manner as shall be practicable and as it shall determine in its sole discretion to be equitable among all Participants exercising options to purchase Common Stock on such Purchase Date, and terminate any or all Offering Periods then in effect pursuant to Section 21 below. The Company may make pro rata allocation of the Shares available on the Offering Date of any applicable Offering Period pursuant to the preceding sentence, notwithstanding any authorization of additional Shares for issuance under the Plan by the Company’s stockholders subsequent to such Offering Date.


(b) The Participant shall have no interest or voting right in Shares covered by his or her option until such option has been exercised.

(c) Shares to be delivered to a Participant under the Plan will be registered in the name of the Participant.
14.    Administration.
(a)    The Board shall administer the Plan unless and until the Board delegates administration of the Plan to a Committee or Committees, as provided in Section 14(c).
(b)    The Board shall have the power, subject to, and within the limitations of, the express provisions of the Plan:
(i)To determine how and when options to purchase Shares shall be granted and the provisions of each Offering Period (which need not be identical).
(ii)To designate from time to time which Subsidiaries and Affiliates of the Company shall be eligible to participate in the Plan.
(iii)To construe and interpret the Plan and options, and to establish, amend and revoke rules and regulations for its administration. The Board, in the exercise of this power, may correct any defect, omission or inconsistency in the Plan, in a manner and to the extent it shall deem necessary or expedient to make the Plan fully effective.
(iv)To settle all controversies regarding the Plan and options granted under it, including whether Employees shall be granted an option and participate in the 423 Component or the Non-423 Componentterms of the Plan (includingsub-plansand which entities shall be Designated Corporations for participation in the 423 Component or the Non-423 Component of the Plan.

(v)To amend, suspend or terminate the Plan at any time as provided in Section 21.
(vi)Generally, to exercise such powersaddenda) and to perform such acts as it deems necessary or expedient to promote the best interests of the Company and its Subsidiaries and Affiliates and to carry out the intent that the Plan be treated as an Employee Stock Purchase Plan.
(vii)Notwithstanding any provisionAwards granted pursuant to the contrary in this Plan, the Board mayPlan;

ix. to adopt rules orand procedures relating to the operation and administration of the Plan to accommodate the specific requirements of local laws and procedures for jurisdictions outside of the United States.procedures. Without limiting the generality of the foregoing, the BoardAdministrator is specifically is authorized (A) to adopt the rules and procedures and sub-plans, which, for purposes ofregarding the Non-423 Component, may be outside of the scope of Section 423 of the Code, regarding, without limitation, eligibility to participate, the definition of Compensation, the dates and duration of Offering Periods or other periods during which Participants may make Contributions toward the purchase of Shares, the method of determining the Purchase Price and the discount from Fair Market Value at which Shares may be purchased, any minimum or maximum amount of Contributions a Participant may make in an Offering Period or other specified period under the applicable sub-plan or policy, the treatment of options upon a change in control or a change in capitalization of the Company, the handling of Contributions, the making of Contributions to the Plan (including, without limitation, in forms other than payroll deductions), establishment of bank or trust accounts to hold Contributions, payment of interest, conversion of local currency, obligations to pay payroll tax, determination of beneficiary designation requirements, withholding procedures and handling of Share issuances and stock certificates thatwhich vary with applicable local requirement.requirements and (B) to adoptsub-plans

(c)    The Board, and Plan addenda as the Administrator deems desirable, to accommodate foreign laws, regulations and practice;

x. to prescribe, amend and rescind rules and regulations relating to the extentPlan, including rules and regulations relating tosub-plans and Plan addenda;

xi. to modify or amend each Award, including, but not prohibited by Applicable Laws, may delegate some limited to, the acceleration of vesting and/or all of the administrationexercisability,provided, however, that any such amendment is subject to Section 14 of the Plan and except as set forth in that Section, may not impair any outstanding Award unless agreed to a Committee or Committees. If administration is delegated to a Committee, the Committee shall have, in connection with the administration of the Plan, the powers theretofore possessedwriting by the BoardParticipant;provided further, however, that have been delegated tonotwithstanding the Committee, includingforegoing or anything in the power to delegate to a subcommittee any of the administrative powers the Committee is authorized to exercise (and references in this Plan to the Board shall thereaftercontrary, the Administrator may amend any outstanding Award or the Plan, or may suspend or terminate the Plan, without the affected Participant’s consent, (A) to maintain the qualified status of the Award as an Incentive Stock Option under Section 422 of the Code or (B) to change the terms of an Incentive Stock Option, if such change results in impairment of the Award solely because it impairs the qualified status of the Award as an Incentive Stock Option under Section 422 of the Code;

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xii. to allow Participants to satisfy withholding tax amounts by electing to have the Company withhold from the Shares to be issued upon exercise of an Option or vesting of a Stock Award that number of Shares having a Fair Market Value equal to the Committeeamount required to be withheld. The Fair Market Value of the Shares to be withheld shall be determined in such manner and on such date that the Administrator shall determine or, subcommittee)in the absence of provision otherwise, on the date that the amount of tax to be withheld is to be determined. All elections by a Participant to have Shares withheld for this purpose shall be made in such form and under such conditions as the Administrator may provide;

xiii. to authorize conversion or substitution under the Plan of any or all stock options, stock appreciation rights or other stock awards held by service providers of an entity acquired by the Company (the “Conversion Awards”). Any conversion or substitution shall be effective as of the close of the merger, acquisition or other transaction. The Conversion Awards may be Nonstatutory Stock Options or Incentive Stock Options, as determined by the Administrator, with respect to options granted by the acquired entity;provided, however, subject, however,that with respect to the conversion of stock appreciation rights in the acquired entity, the Conversion Awards shall be Nonstatutory Stock Options. Unless otherwise determined by the Administrator at the time of conversion or substitution, all Conversion Awards shall have the same terms and conditions as Awards generally granted by the Company under the Plan;

xiv. to authorize any person to execute on behalf of the Company any instrument required to effect the grant of an Award previously granted by the Administrator;

xv. to impose such resolutions, not inconsistentrestrictions, conditions or limitations as it determines appropriate as to the timing and manner of any resales by a Participant or other subsequent transfers by the Participant of any Shares issued as a result of or under an Award, including without limitation, (A) restrictions under an insider trading policy or under any other Company policy relating to Company stock and stock ownership and (B) restrictions as to the use of a specified brokerage firm for such resales or other transfers;

xvi. to provide, either at the time an Award is granted or by subsequent action, that an Award shall contain as a term thereof, a right, either in tandem with the provisionsother rights under the Award or as an alternative thereto, of the Participant to receive, without payment to the Company, a number of Shares, cash or a combination thereof, the amount of which is determined by reference to the value of the Award; and

xvii. to make all other determinations deemed necessary or advisable for administering the Plan and any Award granted hereunder.

(c) Effect of Administrator’s Decision.    All decisions, determinations and interpretations by the Administrator regarding the Plan, any rules and regulations under the Plan and the terms and conditions of any Award granted hereunder, shall be final and binding on all Participants and on all other persons. The Administrator shall consider such factors as it deems relevant, in its sole and absolute discretion, to making such decisions, determinations and interpretations including, without limitation, the recommendations or advice of any officer or other employee of the Company and such attorneys, consultants and accountants as it may select.

5. Eligibility.

Awards may be granted to Employees, Consultants and Directors of the Company or any of its Affiliates; provided that Incentive Stock Options may be granted only to Employees of the Company or of a Subsidiary of the Company.

6. Term of Plan.

The Plan originally became effective on December 23, 2007. It shall continue in effect for a term of ten (10) years from the latest date that the stockholders of the Company approve any amendment to add shares to the Plan, unless terminated earlier under Section 14 of the Plan.

7. Term of Award.

The term of each Award shall be determined by the Administrator and stated in the Award Agreement. In the case of an Option or Stock Appreciation Right, the term shall be ten (10) years from the Grant Date or such shorter term as may be adoptedprovided in the Award Agreement;provided, however, that an Incentive Stock Option granted to an Employee who on the Grant Date owns stock representing more than ten percent (10%) of the voting power of all classes of stock of the Company or any Subsidiary shall have a term of no more than five (5) years from the Grant Date.

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8. Options.

The Administrator may grant an Option or provide for the grant of an Option, either from time to time in the discretion of the Administrator or automatically upon the occurrence of specified events, including, without limitation, the achievement of performance goals, the satisfaction of an event or condition within the control of the Awardee or within the control of others.

(a) Option Agreement.    Each Option Agreement shall contain provisions regarding (i) the number of Shares that may be issued upon exercise of the Option, (ii) the type of Option, (iii) the exercise price of the Shares and the means of payment for the Shares, (iv) the term of the Option, (v) such terms and conditions on the vesting and/or exercisability of an Option as may be determined from time to time by the Board. The Board may retainAdministrator, (vi) restrictions on the authority to concurrently administer the Plan with the Committee and may, at any time, revest in the Board some or alltransfer of the powers previously delegated. WhetherOption or not the Board has delegated administrationShares issued upon exercise of the Option and forfeiture provisions on either and (vii) such further terms and conditions, in each case not inconsistent with this Plan as may be determined from time to time by the Administrator;provided, however, that (x) each Option must have a Committee,minimum vesting period of one (1) year from the Board shall have the final power to determine all questions of policy and expediency that may arise in the administrationearlier of the Plan.

(d)    All determinations, interpretations and constructions made byGrant Date or the Board in good faith shall not be subject to review by any person and shall be final, binding and conclusive on all interested persons.
15.    Designation of Beneficiary.
(a)    A Participant may file a written designation of a beneficiary who is to receive any Shares and cash,vesting commencement date, if any, fromand (y) notwithstanding the Participant’s account under the Planforegoing, in the event of an Awardee’s Termination of Employment as a result of the Awardee’s death or Disability, the vesting and exercisability of all outstanding Options granted to the Awardee (where such vesting and exercisability is based on the Awardee’s continued service with the Company or any Affiliate and the passage of time) shall accelerate such that such Options shall become vested and exercisable as to an additional twelve (12) months, effective as of the date of such Termination of Employment.

(b) Exercise Price.    The per share exercise price for the Shares to be issued pursuant to exercise of an Option shall be determined by the Administrator, subject to the following:

i. In the case of an Incentive Stock Option, the per Share exercise price shall be no less than one hundred percent (100%) of the Fair Market Value per Share on the Grant Date; provided however, that in the case of an Incentive Stock Option granted to an Employee who on the Grant Date owns stock representing more than ten percent (10%) of the voting power of all classes of stock of the Company or any Subsidiary, the per Share exercise price shall be no less than one hundred ten percent (110%) of the Fair Market Value per Share on the Grant Date.

ii. In the case of a Nonstatutory Stock Option, the per Share exercise price shall be no less than one hundred percent (100%) of the Fair Market Value per Share on the Grant Date.

iii. Notwithstanding the foregoing, at the Administrator’s discretion, Conversion Awards may be granted in substitution and/or conversion of options of an acquired entity, with a per Share exercise price of less than 100% of the Fair Market Value per Share on the date of such substitution and/or conversion.

(c)No Option Repricings.    Other than in connection with a change in the Company’s capitalization (as described in Section 13(a) of the Plan), the exercise or strike price of an Option or Stock Appreciation Right may not be reduced without stockholder approval. Additionally, the Administrator will not have the authority to cancel any outstanding Option or Stock Appreciation Right that has an exercise price or strike price greater than the current Fair Market Value of the Common Stock in exchange for cash or other Awards under the Plan, unless the stockholders of the Company have approved such an action within twelve months prior to such an event.

(d) Vesting Period and Exercise Dates.    Subject to Section 8(a), Options granted under this Plan shall vest and/or be exercisable at such time and in such installments during the period prior to the expiration of the Option’s term as determined by the Administrator. The Administrator shall have the right to make the timing of the ability to exercise any Option granted under this Plan subject to continued employment, the passage of time and/or such performance requirements as deemed appropriate by the Administrator. At any time after the grant of an Option, the Administrator may reduce or eliminate any restrictions surrounding any Participant’s death subsequentright to exercise all or part of the Option.

(e) Form of Consideration.    The Participant may pay the exercise price of an Option using any of the following forms of consideration, unless the Administrator determines not to permit such form of consideration at any time including at the time of exercise:

i. cash;

ii. check or wire transfer (denominated in U.S. Dollars);

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iii. subject to the Company’s discretion to refuse for any reason and at any time to accept such consideration and subject to any conditions or limitations established by the Administrator, other Shares held by the Participant which have a Fair Market Value on the date of surrender equal to the aggregate exercise price of the Shares as to which said Option shall be exercised;

iv. consideration received by the Company under a broker-assisted sale and remittance program acceptable to the Administrator;

v. cashless “net exercise” arrangement pursuant to which the Company will reduce the number of Shares issued upon exercise by the largest whole number of Shares having an aggregate Fair Market Value that does not exceed the aggregate exercise price; provided that the Company shall accept a cash or other payment from the Participant to the extent of any remaining balance of the exercise price not satisfied by such reduction in the number of whole Shares to be issued; and also provided that Shares will no longer be outstanding under an Option and will not be exercisable thereafter to the extent that (A) Shares are withheld to pay the exercise price pursuant to a “net exercise,” and (B) the remaining number of whole Shares are delivered to the Participant as a result of such exercise;

vi. such other consideration and method of payment for the issuance of Shares to the extent permitted by Applicable Laws; or

vii. any combination of the foregoing methods of payment.

(f)Effect of Termination on Options

i.Generally.    Unless otherwise provided for by the Administrator, upon an Awardee’s Termination of Employment other than as a result of circumstances described in Sections 8(f)(ii) and (iii) below, any outstanding Option granted to such Awardee, whether vested or unvested, to the extent not theretofore exercised, shall terminate immediately upon the Awardee’s Termination of Employment;provided, however, that the Administrator may in the Option Agreement specify a period of time (but not beyond the expiration date of the Option) following Termination of Employment during which the Awardee may exercise the Option as to Shares that were vested and exercisable as of the date of Termination of Employment. To the extent such a period following Termination of Employment is specified, the Option shall automatically terminate at the end of an Offering Period but priorsuch period to delivery to him or herthe extent the Awardee has not exercised it within such period;provided, however, that (A) if during any part of such period, the Option is not exercisable because the issuance of the Shares and cash. In addition, a Participant may file a written designation of a beneficiary who is to receive any cash fromwould violate the Participant’s accountregistration requirements under the Plan inSecurities Act, the eventOption shall not expire until the Option shall have been exercisable for an aggregate of such Participant’s death priorperiod after the date of Termination of Employment (but in no event may the Option be exercised more than one year after the date of Termination of Employment), and (B) if on the date of such Termination of Employment, the Shares issued upon exercise of the Option may not be sold because the Awardee has material nonpublic information regarding the Company or is otherwise subject to a trading blackout period under the Purchase DateCompany’s Insider Trading Policy, the Option shall not expire until the five month period following the date of such Termination of Employment has elapsed.

ii. Disability of Awardee.    Unless otherwise provided for by the Administrator, upon an Offering Period. IfAwardee’s Termination of Employment as a Participant is marriedresult of the Awardee’s Disability, all outstanding Options granted to such Awardee that were vested and exercisable as of the designated beneficiary is notdate of the spouse, spousal consent shall be required for such designation to be effective.

(b)    Such designationAwardee’s Termination of beneficiaryEmployment may be changedexercised by the Awardee until (A) twelve (12) months following the Awardee’s Termination of Employment as a result of the Awardee’s Disability or (B) the expiration of the term of such Option. If the Participant (and hisdoes not exercise such Option within the time specified, the Option (to the extent not exercised) shall automatically terminate.

iii. Death of Awardee.    Unless otherwise provided for by the Administrator, upon an Awardee’s Termination of Employment as a result of the Awardee’s death or her spouse, if any) at any time by written notice. Inin the event of the death of a Participantan Awardee within thirty (30) days following an Awardee’s Termination of Employment, all outstanding Options granted to such Awardee that were vested and inexercisable as of the absencedate of a beneficiary validly designated under the Plan who is living atAwardee’s death may be exercised until the timeearlier of (A) twelve (12) months following the Awardee’s death or (B) the expiration of the term of such Participant’s death,Option. If an Option is held by the Company shall deliverAwardee when he or she dies, such Shares and/or cashOption may be exercised, to the extent the Option is vested and exercisable, by the beneficiary designated by the Awardee (as provided in Section 15 of the Plan), the executor or administrator of the Awardee’s estate of the Participant, or, if nonone, by the person(s)

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entitled to exercise the Option under the Awardee’s will or the laws of descent or distribution; provided that the Company need not accept exercise of an Option by such beneficiary, executor or administrator unless the Company has been appointedsatisfactory evidence of such person’s authority to act as such. If the Option is not so exercised within the time specified, such Option (to the knowledgeextent not exercised) shall automatically terminate.

iv. Termination for Cause.    The Administrator has the authority to cause all outstanding Options held by an Awardee to terminate immediately in their entirety upon first notification to the Awardee of the Company),Awardee’s Termination of Employment for Cause. If an Awardee’s employment or consulting relationship with the Company is suspended pending an investigation of whether the Awardee shall be terminated for Cause, the Administrator has the authority to cause all the Awardee’s rights under all outstanding Options to be suspended during the investigation period in itswhich event the Awardee shall have no right to exercise any outstanding Options.

v.Other Terminations of Employment.    The Administrator may provide in the applicable Option Agreement for different treatment of Options upon Termination of Employment of the Awardee than that specified above.

vi.Extension of Exercise Period.    The Administrator shall have full power and authority to extend the period of time for which an Option is to remain exercisable following an Awardee’s Termination of Employment from the periods set forth in Sections 8(f)(ii) and (iii) above or in the Option Agreement to such greater time as the Board shall deem appropriate, provided that in no event shall such Option be exercisable later than the date of expiration of the term of such Option as set forth in the Option Agreement.

(g)Leave of Absence.    The Administrator shall have the discretion may deliverto determine whether and to what extent the vesting of Options shall be tolled during any unpaid leave of absence;provided, however, that in the absence of such Shares and/or cashdetermination, vesting of Options shall be tolled during any leave that is not a leave required to be provided to the spouseAwardee under Applicable Law. In the event of military leave, vesting shall toll during any unpaid portion of such leave, provided that, upon an Awardee’s returning from military leave (under conditions that would entitle him or her to any oneprotection upon such return under the Uniform Services Employment and Reemployment Rights Act), he or more dependents or relatives ofshe shall be given vesting credit with respect to Options to the Participant, or if no spouse, dependent or relative is knownsame extent as would have applied had the Awardee continued to provide services to the Company thenthroughout the leave on the same terms as he or she was providing services immediately prior to such other personleave.

(h)Buyout Provisions.    The Administrator may at any time offer to buy out for a payment in cash or Shares, an Option previously granted, based on such terms and conditions as the Company may designate.

16.    Transferability. Neither Contributions credited to a Participant’s account nor any rights with regardAdministrator shall establish and communicate to the exerciseAwardee at the time that such offer is made.

9. Incentive Stock Option Limitations/Terms.

(a) Eligibility.    Only employees (as determined in accordance with Section 3401(c) of an optionthe Code and the regulations promulgated thereunder) of the Company or to receive Shares under the Planany of its Subsidiaries may be granted Incentive Stock Options.

(b) $100,000 Limitation.    Notwithstanding the designation “Incentive Stock Option” in an Option Agreement, if and to the extent that the aggregate Fair Market Value of the Shares with respect to which Incentive Stock Options are exercisable for the first time by the Awardee during any calendar year (under all plans of the Company and any of its Subsidiaries) exceeds U.S. $100,000, such Options shall be treated as Nonstatutory Stock Options. For purposes of this Section 9(b), Incentive Stock Options shall be taken into account in the order in which they were granted. The Fair Market Value of the Shares shall be determined as of the Grant Date.

(c) Transferability.    An Incentive Stock Option may not be sold, pledged, assigned, hypothecated, transferred pledged or otherwise disposed of in any way (othermanner by the Awardee otherwise than by will or the laws of descent and distribution, or as provided in Section 15)and, during the lifetime of such Awardee, may only be exercised by the Participant. Any such attempt at assignment, transfer, pledge or other dispositionAwardee. If the terms of an Incentive Stock Option are amended to permit transferability, the Option will be treated for tax purposes as a Nonstatutory Stock Option. The designation of a beneficiary by an Awardee will not constitute a transfer.

(d) Exercise Price.    The per Share exercise price of an Incentive Stock Option shall be without effect, except thatdetermined by the Company may treat such act as an election to withdraw fundsAdministrator in accordance with Section 11.

17.    Use8(b)(i) of Funds. All Contributions received or held by the Company under the PlanPlan.

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(e) Other Terms.    Option Agreements evidencing Incentive Stock Options shall contain such other terms and conditions as may be used by the Company for any corporate purpose (exceptnecessary to qualify, to the extent necessarydetermined desirable by the Administrator, with the applicable provisions of Section 422 of the Code.

10. Exercise of Option.

(a)Procedure for Exercise.

i. Any Option granted hereunder shall be exercisable according to complythe terms of the Plan and at such times and under such conditions as determined by the Administrator and set forth in the respective Option Agreement.

ii. An Option shall be deemed exercised when the Company receives (A) written or electronic notice of exercise (in accordance with Applicable Laws)the Option Agreement) from the person entitled to exercise the Option; (B) full payment for the Shares with respect to which the related Option is exercised; and (C) payment of all applicable withholding taxes.

iii. An Option may not be exercised for a fraction of a Share.

(b)Rights as a Stockholder.    The Company shall issue (or cause to be issued) such Shares as administratively practicable after the Option is exercised. Shares issued upon exercise of an Option shall be issued in the name of the Participant or, if requested by the Participant, in the name of the Participant and his or her spouse. Unless provided otherwise by the Administrator or pursuant to this Plan, until the Shares are issued (as evidenced by the appropriate entry on the books of the Company or of a duly authorized transfer agent of the Company), no right to vote or receive dividends or any other rights as a stockholder shall exist with respect to the Shares subject to an Option, notwithstanding the exercise of the Option.

11. Stock Awards.

(a) Stock Award Agreement.    Each Stock Award Agreement shall contain provisions regarding (i) the number of Shares subject to such Stock Award or a formula for determining such number, (ii) the purchase price of the Shares, if any, and the means of payment for the Shares, (iii) the performance criteria (including Qualifying Performance Criteria), if any, and level of achievement versus these criteria that shall determine the number of Shares granted, issued, retainable and/or vested, (iv) such terms and conditions on the grant, issuance, vesting, settlement and/or forfeiture of the Shares as may be determined from time to time by the Administrator, (v) restrictions on the transferability of the Stock Award and (vi) such further terms and conditions in each case not inconsistent with this Plan as may be determined from time to time by the Administrator;provided, however, that (x) each Stock Award must have a minimum vesting period of one (1) year from the earlier of the Grant Date or the vesting commencement date, if any, and (y) notwithstanding the foregoing, in the event of an Awardee’s Termination of Employment as a result of the Awardee’s death or Disability, the vesting (and exercisability, if applicable) of all outstanding Stock Awards granted to the Awardee (where such vesting and exercisability is based on the Awardee’s continued service with the Company or any Affiliate and the passage of time) shall accelerate such that such Stock Awards shall become vested (and exercisable, if applicable) as to an additional twelve (12) months, effective as of the date of such Termination of Employment.

(b) Restrictions and Performance Criteria.    The grant, issuance, retention, vesting and/or settlement of each Stock Award or the Shares subject thereto may be subject to such performance criteria (including Qualifying Performance Criteria) and level of achievement versus these criteria as the Administrator shall determine, which criteria may be based on financial performance, stock price performance, strategic plan development and implementation with respect to development, commercialization or other Company objectives, approval by the U.S. Food and Drug Administration or other regulatory body of a product candidate, implementation or completion of projects, processes or milestones (including, without limitation, clinical trial initiation, clinical trial enrollment and dates, clinical trial results, regulatory filing submissions, regulatory filing acceptances, regulatory or advisory committee interactions, regulatory approvals, presentation of studies and launch of commercial plans, compliance programs or education campaigns), achievement of business development objectives, personal performance evaluations, such other performance criteria as the Administrator shall determine appropriate, and/or completion of service by the Awardee. If applicable, the Committee shall establish the Qualifying Performance Criteria applicable to, and the formula for calculating the amount payable under, the Award no later than the

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earlier of (a) the date ninety (90) days after the commencement of the applicable performance period, or (b) the date on which 25% of the performance period has elapsed, and in any event at a time when the achievement of the applicable Qualifying Performance Criteria remains substantially uncertain.

(c) Forfeiture.    Unless otherwise provided for by the Administrator, upon the Awardee’s Termination of Employment, the Stock Award and the Shares subject thereto shall be forfeited, provided that to the extent that the Participant purchased or earned any Shares, the Company shall have a right to repurchase the unvested Shares at such price and on such terms and conditions as the Administrator determines.

(d) Rights as a Stockholder.    Unless otherwise provided by the Administrator in the Award Agreement, the Participant shall have the rights equivalent to those of a stockholder and shall be a stockholder only after Shares are issued (as evidenced by the appropriate entry on the books of the Company or of a duly authorized transfer agent of the Company) to the Participant. Unless otherwise provided by the Administrator, a Participant holding Stock Units shall not be obligatedentitled to segregatereceive dividend payments or any credit therefore as if he or she was an actual stockholder.

(e)Stock Appreciation Rights.

i.General.    Stock Appreciation Rights may be granted either alone, in addition to, or in tandem with other Awards granted under the Plan. The Board may grant Stock Appreciation Rights to eligible Participants subject to terms and conditions not inconsistent with this Plan and determined by the Board. The specific terms and conditions applicable to the Participant shall be provided for in the Stock Award Agreement. Stock Appreciation Rights shall be exercisable, in whole or in part, at such Contributions (excepttimes as the Board shall specify in the Stock Award Agreement.

ii.Exercise of Stock Appreciation Right.    Upon the exercise of a Stock Appreciation Right, in whole or in part, the Participant shall be entitled to a payment in an amount equal to the excess of the Fair Market Value on the date of exercise of a fixed number of Shares covered by the exercised portion of the Stock Appreciation Right, over the Fair Market Value on the Grant Date of the Shares covered by the exercised portion of the Stock Appreciation Right (or such other amount calculated with respect to Shares subject to the Award as the Board may determine). The amount due to the Participant upon the exercise of a Stock Appreciation Right shall be paid in such form of consideration as determined by the Board and may be in cash, Shares or a combination thereof, over the period or periods specified in the Stock Award Agreement. A Stock Award Agreement may place limits on the amount that may be paid over any specified period or periods upon the exercise of a Stock Appreciation Right, on an aggregate basis or as to any Participant. A Stock Appreciation Right shall be considered exercised when the Company receives written notice of exercise in accordance with the terms of the Stock Award Agreement from the person entitled to exercise the Stock Appreciation Right.

iii.Nonassignability of Stock Appreciation Rights.    Except as determined by the Administrator, no Stock Appreciation Right shall be assignable or otherwise transferable by the Participant except by will or by the laws of descent and distribution.

12. Other Provisions Applicable to Awards.

(a) Non-Transferability of Awards.    Unless determined otherwise by the Administrator, an Award may not be sold, pledged, assigned, hypothecated, transferred, or disposed of in any manner other than by beneficiary designation, will or by the laws of descent or distribution. Subject to Section 9(c), the Administrator may in its discretion make an Award transferable to an Awardee’s family member or any other person or entity as it deems appropriate. If the Administrator makes an Award transferable, either at the time of grant or thereafter, such Award shall contain such additional terms and conditions as the Administrator deems appropriate, and any transferee shall be deemed to be bound by such terms upon acceptance of such transfer.

(b) Qualifying Performance Criteria.    For purposes of this Plan, the term “Qualifying Performance Criteria” shall mean any one or more of the following performance criteria, either individually, alternatively or in any combination, applied to either the Company as a whole or to a business unit, Affiliate or business segment, either individually, alternatively or in any combination, and measured either annually or cumulatively over a period of years, on an absolute basis or relative to apre-established target, to previous years’ results or to a designated comparison group, in each case as specified by the Administrator in the Award: (i) cash flow; (ii) earnings (including

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gross margin, earnings before interest and taxes, earnings before taxes, and net earnings); (iii) earnings per share; (iv) growth in earnings or earnings per share; (v) stock price; (vi) return on equity or average stockholders’ equity; (vii) total stockholder return; (viii) return on capital; (ix) return on assets or net assets; (x) return on investment; (xi) revenue; (xii) income or net income; (xiii) operating income or net operating income, in aggregate or per share; (xiv) operating profit or net operating profit; (xv) operating margin; (xvi) return on operating revenue; (xvii) market share; (xviii) growth in stockholder value relative to the moving average of a peer group index; (xix) strategic plan development and implementation (including individual performance objectives that relate to achievement of the Company’s or any business unit’s strategic plan); (xx) improvement in workforce diversity; (xxi) growth of revenue, operating income or net income; (xxii) approval by the U.S. Food and Drug Administration or other regulatory body of a product candidate; (xxiii) implementation or completion of projects or processes (including, without limitation, clinical trial initiation, clinical trial enrollment and dates, clinical trial results, regulatory filing submissions, regulatory filing acceptances, regulatory or advisory committee interactions, regulatory approvals, presentation of studies and launch of commercial plans, compliance programs or education campaigns) and (xxiv) any other similar criteria. The Committee may appropriately adjust any evaluation of performance under a Qualifying Performance Criteria to exclude any of the following events that occurs during a performance period: (A) asset write-downs; (B) litigation or claim judgments or settlements; (C) the effect of changes in tax law, accounting principles or other such laws or provisions affecting reported results; (D) accruals for reorganization and restructuring programs and/or other nonrecurring charges; and (E) any gains or losses that are “unusual” in nature or occur “infrequently” under generally accepted accounting principles or discontinued operations in the Company’s financial statements.

(c) Certification.    Prior to the payment of any compensation under an Award intended to qualify as “performance-based compensation” under Section 162(m) of the Code, the Committee shall certify the extent to which any Qualifying Performance Criteria and any other material terms under such Award have been satisfied (other than in cases where such relate solely to the increase in the value of the Common Stock).

(d) Compliance with Section 409A.Notwithstanding anything to the contrary contained herein, to the extent necessary to comply with Applicable Laws). Proceeds fromthat the sale of shares of Common Stock pursuant to optionsAdministrator determines that any Award granted under the Plan is subject to Code Section 409A and unless otherwise specified in the applicable Award Agreement, the Award Agreement evidencing such Award shall constitute general fundsincorporate the terms and conditions necessary for such Award to avoid the consequences described in Code Section 409A(a)(1), and to the maximum extent permitted under Applicable Law (and unless otherwise stated in the applicable Award Agreement), the Plan and the Award Agreements shall be interpreted in a manner that results in their conforming to the requirements of Code Section 409A(a)(2), (3) and (4) and any Department of Treasury or Internal Revenue Service regulations or other interpretive guidance issued under Section 409A (whenever issued, the “Guidance”). Notwithstanding anything to the contrary in this Plan (and unless the Award Agreement provides otherwise, with specific reference to this sentence), to the extent that a Participant holding an Award that constitutes “deferred compensation” under Section 409A and the Guidance is a “specified employee” (also as defined thereunder), no distribution or payment of any amount shall be made before a date that is six (6) months following the date of such Participant’s “separation from service” (as defined in Section 409A and the Guidance) or, if earlier, the date of the Company.

18.    Reports. Individual accounts willParticipant’s death.

(e) Deferral of Award Benefits.The Administrator may in its discretion and upon such terms and conditions as it determines appropriate permit one or more Participants whom it selects to (a) defer compensation payable pursuant to the terms of an Award, or (b) defer compensation arising outside the terms of this Plan pursuant to a program that provides for deferred payment in satisfaction of such other compensation amounts through the issuance of one or more Awards. Any such deferral arrangement shall be maintained for each Participantevidenced by an Award Agreement in such form as the Plan. StatementsAdministrator shall from time to time establish, and no such deferral arrangement shall be a valid and binding obligation unless evidenced by a fully executed Award Agreement, the form of account willwhich the Administrator has approved, including through the Administrator’s establishing a written program (the “Program”) under this Plan to govern the form of Award Agreements participating in such Program. Any such Award Agreement or Program shall specify the treatment of dividends or dividend equivalent rights (if any) that apply to Awards governed thereby, and shall further provide that any elections governing payment of amounts pursuant to such Program shall be givenin writing, shall be delivered to participating Employees at least annually, which statements will set forth the amounts of Contributions, the per Share Purchase Price, the number of Shares purchasedCompany or its agent in a form and manner that complies with Code Section 409A and the remaining cash balance, if any.Guidance, and shall specify the amount to be distributed in settlement of the deferral arrangement, as well as the time and form of such distribution in a manner that complies with Code Section 409A and the Guidance.

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APPENDIX A

13. Adjustments Uponupon Changes in Capitalization; Corporate Transactions.

Capitalization, Dissolution, Merger or Asset Sale.

(a)Adjustment. Changes in Capitalization.    Subject to any required action by the stockholders of the Company, (i) the number and kind of Shares covered by each option underoutstanding Award, (ii) the Plan which has not yet been exercisedexercise or purchase (including repurchase) price per Share subject to each such outstanding Award and (iii) each of the number of Shares which have been authorized for issuance under the Plan but have not yet been placed under option (collectively, the “Reserves”), as well as the maximum number of shares of Common Stock which may be purchased by a Participant in an Offering Period, the number of shares of Common StockShare limitations set forth in Section 13(a) above, and3 of the price per Share of Common Stock covered by each option under the Plan, which has not yet been exercised, shall be proportionately adjusted for any increase or decrease in the number or kind of issued Sharesshares resulting from a stock split, reverse stock split, stock dividend, dividend in property other than cash, liquidating dividend,spin-off, combination exchange or reclassification of the Common Stock, (including any such change in the number of Shares of Common Stock effected in connection with a change in domicile of the Company), or any other similar increase or decrease in the number of Sharesissued shares of Common Stock effected without receipt of consideration by the Company (through merger, consolidation, reorganization, recapitalization, change in corporate structure or other similar transaction); Company;provided, however, that conversion of any convertible securities of the Company shall not be deemed to have been “effected without receipt of consideration.” Such adjustment shall be made by the Board,Administrator, whose determination in that respect shall be final, binding and conclusive. Except as expressly provided herein, no issueissuance by the Company of shares of stock of any class, or securities convertible into shares of stock of any class, shall affect, and no adjustment by reason thereof shall be made with respect to, the number or price of Sharesshares of Common Stock subject to an option.

Award.

(b)Corporate Transactions Dissolution or Liquidation.In the event of athe proposed dissolution or liquidation of the Company, any Offering Period then in progressthe Administrator shall notify each Participant as soon as practicable prior to the effective date of such proposed transaction. To the extent an Award has not been previously exercised or the Shares subject thereto issued to the Awardee and unless otherwise determined by the Administrator, an Award will terminate immediately prior to the consummation of the transaction. In addition, the Administrator may provide that any Company repurchase option or forfeiture applicable to any Shares purchased upon exercise of an Option or covered by a Stock Award shall lapse as to all such action, unless otherwiseShares, provided by the Board.proposed liquidation or dissolution takes place at the time and in the matter contemplated.

(c) Change in Control.    In the event there is a Change in Control of a Corporate Transaction, each option outstanding under the Plan shall be assumed or an equivalent option shall be substitutedCompany, as determined by the successor corporationBoard or a parentCommittee, the Board or subsidiaryCommittee may, in its discretion, (i) provide for the assumption or substitution of, such successor corporation. Inor adjustment (including to the event thatnumber and type of Shares and exercise or purchase price applicable) to, each outstanding Award; (ii) accelerate the successor corporation refuses to assume vesting of Options and terminate any restrictions on Stock Awards and/or substitute(iii) provide for outstanding options, the Offering Period then in progress shall be shortened andtermination of Awards as a new Purchase Date shall be set (the “New Purchase Date”), as of which date the Offering Period then in progress will terminate. The New Purchase Date shall be on or before the date of consummationresult of the transactionChange in Control on such terms and conditions as it deems appropriate, including providing for the Board shall notify each Participant in writing, at least ten (10) days priorcancellation of Awards for a cash or other payment to the New Purchase Date, that the Purchase Date for his or her option has been changed to the New Purchase Date and that his or her option will be exercised automatically on the New Purchase Date, unless prior to such date he or she has withdrawn from the Offering Period as provided in Section 11. Participant.

For purposes of this Section 19,13(c), an option granted under the PlanAward shall be deemed to beconsidered assumed, without limitation, if, at the time of issuance of the stock or other consideration upon a Corporate Transaction,Change in Control, as the case may be, each holder of an option under the PlanAward would be entitled to receive upon exercise of the optionAward the same number and kind of shares of stock or the same amount of property, cash or securities as such holder would have been entitled to receive upon the occurrence of the transaction if the holder had been, immediately prior to thesuch transaction, the holder of the number of Shares of Common Stock covered by the optionAward at such time (after giving effect to any adjustments in the number of Shares covered by the optionAward as provided for in this Section 19)13(a)); provided however that if thesuch consideration received in the transaction is not solely common stock of the successor corporation, or its parent (as defined in Section 424(e) of the Code), the BoardAdministrator may, with the consent of the successor corporation, provide for the consideration to be received upon exercise of the optionAward to be solely common stock of the successor corporation or its parent equal into the Fair Market Value toof the per Share consideration received by holders of Common Stock in the transaction.

The Board may, if it so determines in the exercise of its sole discretion, also make provision for adjusting the Reserves, as well as the price per Share of Common Stock covered by each outstanding option, in the event that the Company effects one or more reorganizations, recapitalizations, rights offerings or other increases or reductions of Shares of its outstanding Common Stock, and in

In the event of a Change in Control, and if an Awardee’s Awards are not assumed by the Company’s being consolidatedsuccessor corporation or its parent or subsidiary and such successor does not substitute equivalent options or awards for those outstanding under the Plan and the Awardee has not experienced a Termination of Employment without Cause as of, or has experienced a Termination of Employment without Cause immediately prior to, the effective time of the Change in Control, then such Awards shall become fully vested and exercisable and/or payable as applicable, and all forfeiture or repurchase restrictions on such Awards shall lapse immediately prior to the effective time of the Change in Control. Upon, or in anticipation of, such Change in Control, the Administrator may cause any and all Awards outstanding under the Plan to terminate at a specific time in the future and shall give each Awardee the right to exercise such Awards during a period of time as the Administrator, in its sole and absolute discretion, shall determine. The Administrator shall have sole discretion to determine whether an Award has been assumed by the successor corporation or its parent or subsidiary or whether such successor has substituted equivalent awards for those outstanding under the Plan in connection with a Change in Control subject to the preceding paragraph.

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APPENDIX A

In the event of a Change in Control, if outstanding Awards are assumed or merged intoequivalent awards are substituted by the successor corporation or a parent or subsidiary of such successor corporation, and if at the time of, immediately prior to or within twelve (12) months after, the effective time of such Change in Control, an Awardee experiences a Termination of Employment without Cause or as a result of a Constructive Termination, then, as of the date of Awardee’s Termination of Employment, the vesting and exercisability of any other corporation.

20.    Tax Qualification.Althoughassumed Option, or any option substituted for an Option by the successor corporation or a parent or subsidiary of such successor corporation, held by Awardee at the time of termination, and the lapse of any forfeiture or repurchase restrictions with respect to any assumed Stock Award, or any stock award substituted for a Stock Award by the successor corporation or a parent or subsidiary of such successor corporation, held by Awardee at the time of termination, shall be accelerated in full.

14. Amendment and Termination of the Plan.

(a) Amendment and Termination.    The Administrator may amend, alter or discontinue the Plan or any Award Agreement, but any such amendment shall be subject to approval of the stockholders of the Company in the manner and to the extent required by Applicable Law. In addition, without limiting the foregoing, unless approved by the stockholders of the Company, no such amendment shall be made that would:

i. increase the maximum number of Shares for which Awards may endeavor to (i) qualify an option for favorable tax treatmentbe granted under the lawsPlan, other than an increase pursuant to Section 13 of the United States or jurisdictions outside ofPlan;

ii. reduce the United States or (ii) avoid adverse tax treatment (e.g., under Section 409A of the Code), the Company makes no representation to that effect and expressly disavows any covenant to maintain favorable or avoid unfavorable tax treatment, notwithstanding anything to the contrary in this Plan. The Company shallminimum exercise prices at which Options may be unconstrained in its corporate activities without regard to any potential negative tax impact on Participantsgranted under the Plan (as set forth in Section 8(b));

iii. result in a repricing of Options or Stock Appreciation Rights; or

iv. change the class of persons eligible to receive Awards under the Plan.

21.    

(b) Effect of Amendment or Termination.

(a)    The Board may at any time and for any reason terminateTermination.    No amendment, suspension or amend the Plan. Except as provided in Section 19, no such termination of the Plan may affect options previously granted, provided that the Plan or an Offering Period may be terminated by the Board on a Purchase Date or by the Board’s setting a new Purchase Date with respect to an Offering Period then in progress if the Board determines that termination of the Plan and/or the Offering Period is in the best interests of the Company and the stockholders. Except as provided in Section 19 and in this Section 21, no amendment to the Plan shall make any change in any option previously granted which adversely affectsimpair the rights of any Participant. In addition,Award, unless mutually agreed otherwise between the Participant and the Administrator, which agreement must be in writing and signed by the Participant and the Company; provided further that the Administrator may amend an outstanding Award in order to conform it to the extent necessaryAdministrator’s intent (in its sole discretion) that such Award not be subject to comply with Rule 16b-3 under the Exchange Act, or underCode Section 423409A(a)(1). Termination of the CodePlan shall not affect the Administrator’s ability to exercise the powers granted to it hereunder with respect to the 423 Component (or any successor rule or provision or any applicable law or regulation), the Company shall obtain stockholder approval in such a manner and to such a degree as so required.

(b)    Without stockholder consent and without regard to whether any Participant rights may be considered to have been adversely affected, the Administrator shall be entitled to change the Offering Periods, limit the frequency and/or number of changes in the amount withheld during an Offering Period, establish the exchange ratio applicable to amounts withheld in a currency other than U.S. dollars, permit payroll withholding in excess of the amount designated by a Participant in order to adjust for delays or mistakes in the Company’s processing of properly completed withholding elections, establish reasonable waiting and adjustment periods and/or accounting and crediting procedures to ensure that amounts applied toward the purchase of Common Stock for each Participant properly correspond with amounts withheld from the Participant’s Compensation, and establish such other limitations or procedures as the Administrator determines in its sole discretion advisable which are consistent with the Plan.
22.    Notices. All notices or other communications by a Participant to the Company under or in connection with the Plan shall be deemed to have been duly given when received in the form specified by the Company at the location, or by the person, designated by the Company for the receipt thereof.
23.    Conditions Upon Issuance of Shares. Notwithstanding any other provision of the Plan, unless there is an available exemption from any registration, qualification or other legal requirement applicable to the Shares, the Company will not be required to deliver any Shares issuable upon exercise of an optionAwards granted under the Plan prior to the completiondate of any registration or qualificationsuch termination.

(c) Effect of the Shares under any local, state, federal or foreign securities or exchange control law or under rulings or regulations of any governmental regulatory body, or prior to obtaining any approval or other clearance from any local, state, federal or foreign governmental agency, which registration, qualification or approvalPlan on Other Arrangements.    Neither the Administrator shall, in its absolute discretion, deem necessary or advisable. The Company is under no obligation to register or qualify the Shares with any state or foreign securities commission, or to seek approval or clearance from any governmental authority for the issuance or saleadoption of the Shares. If,Plan by the Board or a Committee nor the submission of the Plan to the stockholders of the Company for approval shall be construed as creating any limitations on the power of the Board or any Committee to adopt such other incentive arrangements as it or they may deem desirable, including without limitation, the granting of restricted stock or stock options otherwise than under the Plan, and such arrangements may be either generally applicable or applicable only in specific cases. The value of Awards granted pursuant to this Section 23, the Administrator determines that the SharesPlan will not be issued toincluded as compensation, earnings, salaries or other similar terms used when calculating an Awardee’s benefits under any Participant, any Contributions credited to such Participant’s account will be promptly refunded, without interest, to the Participant, without any liability toemployee benefit plan sponsored by the Company or any Subsidiary except as such plan otherwise expressly provides.

15. Designation of its SubsidiariesBeneficiary.

(a) An Awardee may file a written designation of a beneficiary who is to receive the Awardee’s rights pursuant to Awardee’s Award or Affiliates.

Asthe Awardee may include his or her Awards in an omnibus beneficiary designation for all benefits under the Plan. To the extent that Awardee has completed a conditiondesignation of beneficiary while employed with the Company, such beneficiary designation shall remain in effect with respect to any Award hereunder until changed by the Awardee to the exerciseextent enforceable under Applicable Law.

(b) Such designation of beneficiary may be changed by the Awardee at any time by written notice. In the event of the death of an option,Awardee and in the Company may requireabsence of a beneficiary validly designated under the person exercising such option to represent and warrantPlan who is living at the time of any such exercise that the Shares are being purchased only for investment and without any present intention to sell or distribute such Shares if, in the opinion of counsel forAwardee’s death, the Company such a representation is required by Applicable Laws.

24.    Effective Date. The Plan originally became effective on May 20, 2011. This amendment and restatementshall allow the executor or administrator of the Planestate of the Awardee to exercise the Award, or if no such executor or administrator has been appointed (to the knowledge of the Company), the Company, in its discretion, may allow the spouse or one or more dependents or relatives of the Awardee to exercise the Award to the extent permissible under Applicable Law or if no spouse, dependent or relative is effective May __, 2019.known to the Company, then to such other person as the Company may designate.

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25.    Miscellaneous Provisions.
(a)A Participant

APPENDIX A

16. No Right to Awards or to Employment.

No person shall have any claim or right to be granted an Award and the grant of any Award shall not be deemed to beconstrued as giving an Awardee the holder of, or to have any of the rights of a holder with respect to, Shares subject to options unless and until the Participant’s Shares acquired upon exercise of options under the Plan are recorded in the books of the Company (or its transfer agent).

(b)The Plan does not constitute an employment contract. Nothing in the Plan shall in any way alter the at will nature of an Employee’s employment or be deemed to create in any way whatsoever any obligation on the part of any Employeeright to continue in the employ of the Company or a Subsidiaryits Affiliates. Further, the Company and its Affiliates expressly reserve the right, at any time, to dismiss any Employee, Consultant or Affiliate,Awardee at any time without liability or onany claim under the partPlan, except as provided herein or in any Award Agreement entered into hereunder.

17. Legal Compliance.

Shares shall not be issued pursuant to the exercise of an Option or Stock Award unless the exercise of such Option or Stock Award and the issuance and delivery of such Shares shall comply with Applicable Laws and shall be further subject to the approval of counsel for the Company with respect to such compliance.

18. Reservation of Shares.

The Company, during the term of this Plan, will at all times reserve and keep available such number of Shares as shall be sufficient to satisfy the requirements of the Plan.

19. Notice.

Any written notice to the Company required by any provisions of this Plan shall be addressed to the Secretary of the Company or a Subsidiary or Affiliate to continue the employmentand shall be effective when received.

20. Governing Law; Interpretation of an Employee.

(c)The provisions of the Plan and Awards.

(a) This Plan and all determinations made and actions taken pursuant hereto shall be governed by the substantive laws, but not the choice of law rules, of the state of Delaware.

(b) In the event that any provision of the Plan or any Award granted under the Plan is declared to be illegal, invalid or otherwise unenforceable by a court of competent jurisdiction, such provision shall be reformed, if possible, to the extent necessary to render it legal, valid and enforceable, or otherwise deleted, and the remainder of the terms of the Plan and/or Award shall not be affected except to the extent necessary to reform or delete such illegal, invalid or unenforceable provision.

(c) The headings preceding the text of the sections hereof are inserted solely for convenience of reference, and shall not constitute a part of the Plan, nor shall they affect its meaning, construction or effect.

(d) The terms of the Plan and any Award shall inure to the benefit of and be binding upon the parties hereto and their respective permitted heirs, beneficiaries, successors and assigns.

(e) All questions arising under the Plan or under any Award shall be decided by the Administrator in its total and absolute discretion. In the event the Participant believes that a decision by the Administrator with respect to such person was arbitrary or capricious, the Participant may request arbitration with respect to such decision. The review by the arbitrator shall be limited to determining whether the Administrator’s decision was arbitrary or capricious. This arbitration shall be the sole and exclusive review permitted of the Administrator’s decision, and the Awardee shall as a condition to the receipt of an Award be deemed to explicitly waive any right to judicial review.

(f) Notice of demand for arbitration shall be made in writing to the Administrator within thirty (30) days after the applicable decision by the Administrator. The arbitrator shall be selected from amongst those members of the Board who are neither Administrators nor Employees. If there are no such members of the Board, the arbitrator shall be selected by the Board. The arbitrator shall be an individual who is an attorney licensed to practice law in the State of WashingtonWashington. Such arbitrator shall be neutral within the meaning of the Commercial Rules of Dispute Resolution of the American Arbitration Association;provided, however, that the arbitration shall not be administered by the American Arbitration Association. Any challenge to the neutrality of the arbitrator shall be resolved by the arbitrator whose decision shall be final and conclusive. The arbitration shall be administered and conducted by the arbitrator pursuant to the Commercial Rules of Dispute Resolution of the American Arbitration Association. The decision of the arbitrator on the issue(s) presented for arbitration shall be final and conclusive and may be enforced in any court of competent jurisdiction.

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APPENDIX A

21. Limitation on Liability.

The Company and any Affiliate which is in existence or hereafter comes into existence shall not be liable to a Participant, an Employee, an Awardee or any other persons as to:

(a) TheNon-Issuance of Shares.    Thenon-issuance or sale of Shares (including under Section 17 above) as to which the Company has been unable, or the Administrator deems it infeasible, to obtain from any regulatory body having jurisdiction the authority deemed by the Company’s counsel to be necessary to the lawful issuance and sale of any shares hereunder; and

(b) Tax Consequences.    Any tax consequence realized by any Participant, Employee, Awardee or other person due to the receipt, vesting, exercise or settlement of any Option or other Award granted hereunder or due to the transfer of any Shares issued hereunder. The Participant is responsible for, and by accepting an Award under the Plan agrees to bear, all taxes of any nature that are legally imposed upon the Participant in connection with an Award, and the Company does not assume, and will not be liable to any party for, any cost or liability arising in connection with such tax liability legally imposed on the Participant. In particular, Awards issued under the Plan may be characterized by the Internal Revenue Service (the “IRS”) as “deferred compensation” under the Code resulting in additional taxes, including in some cases interest and penalties. In the event the IRS determines that an Award constitutes deferred compensation under the Code or challenges any good faith characterization made by the Company or any other party of the tax treatment applicable to an Award, the Participant will be responsible for the additional taxes, and interest and penalties, if any, that are determined to apply if such challenge succeeds, and the Company will not reimburse the Participant for the amount of any additional taxes, penalties or interest that result.

(c) Forfeiture.    The requirement that Participant forfeit an Award, or the benefits received or to be received under an Award, pursuant to any Applicable Law.

22. Unfunded Plan.

Insofar as it provides for Awards, the Plan shall be unfunded. Although bookkeeping accounts may be established with respect to Awardees who are granted Stock Awards under this Plan, any such accounts will be used merely as a bookkeeping convenience. The Company shall not be required to segregate any assets which may at any time be represented by Awards, nor shall this Plan be construed as providing for such segregation, nor shall the Company nor the Administrator be deemed to be a trustee of stock or cash to be awarded under the Plan. Any liability of the Company to any Participant with respect to an Award shall be based solely upon any contractual obligations which may be created by the Plan; no such obligation of the Company shall be deemed to be secured by any pledge or other encumbrance on any property of the Company. Neither the Company nor the Administrator shall be required to give any security or bond for the performance of any obligation which may be created by this Plan.

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Small steps make an impact. Help the environment by consenting to receive electronic delivery, sign up at www.envisionreports.com/SGEN Notice of 2020 Annual Meeting of Shareholders Proxy Solicited by Board of Directors for Annual Meeting — May 15, 2020 The undersigned hereby appoints Clay B. Siegall and Jean I. Liu, and each of them, with power to act without resortthe other and with power of substitution, as proxies and attorneys-in-fact and hereby authorizes them to that state’s conflictsrepresent and vote, as provided below, all the shares of laws rules.Seattle Genetics, Inc. Common Stock which the undersigned is entitled to vote, and, in their discretion, to vote upon such other business as may properly come before the 2020 Annual Meeting of Shareholders of Seattle Genetics, Inc. (the “Meeting”) to be held on Friday, May 15, 2020 at 11:00 a.m. Pacific Time and or at any adjournment or postponement thereof, with all powers which the undersigned would possess if present at the Meeting. UNLESS A CONTRARY DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED “FOR” ALL OF THE NOMINEES FOR DIRECTOR LISTED IN PROPOSAL NO. 1, AND “FOR” PROPOSAL NOS. 2, 3 AND 4, AS MORE SPECIFICALLY DESCRIBED IN THE PROXY STATEMENT. IF SPECIFIC INSTRUCTIONS ARE INDICATED, THIS PROXY WILL BE VOTED IN ACCORDANCE THEREWITH. IN THEIR DISCRETION, THE PROXIES OF THE UNDERSIGNED ARE AUTHORIZED TO VOTE UPON ANY AND ALL OTHER MATTERS THAT MAY PROPERLY COME BEFORE THE MEETING. (Items to be voted appear on reverse side) Proxy - SEATTLE GENETICS, INC. qIF VOTING BY MAIL, SIGN, DETACH AND RETURN THE BOTTOM PORTION IN THE ENCLOSED ENVELOPE.q Change of Address — Please print new address below. Comments — Please print your comments below. C Non-Voting Items Important notice regarding the Internet availability of proxy materials for the Annual Meeting of Shareholders. The material is available at: www.envisionreports.com/SGEN 2020 Annual Meeting of Seattle Genetics, Inc. Shareholders May 15, 2020 at 11:00 A.M. Pacific Time



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Small steps make an impact. Help the environment by consenting to receive electronic delivery, sign up at www.envisionreports.com/SGEN Notice of 2020 Annual Meeting of Shareholders Proxy Solicited by Board of Directors for Annual Meeting — May 15, 2020 The undersigned hereby appoints Clay B. Siegall and Jean I. Liu, and each of them, with power to act without the other and with power of substitution, as proxies and attorneys-in-fact and hereby authorizes them to represent and vote, as provided below, all the shares of Seattle Genetics, Inc. Common Stock which the undersigned is entitled to vote, and, in their discretion, to vote upon such other business as may properly come before the 2020 Annual Meeting of Shareholders of Seattle Genetics, Inc. (the “Meeting”) to be held on Friday, May 15, 2020 at 11:00 a.m. Pacific Time and or at any adjournment or postponement thereof, with all powers which the undersigned would possess if present at the Meeting. UNLESS A CONTRARY DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED “FOR” ALL OF THE NOMINEES FOR DIRECTOR LISTED IN PROPOSAL NO. 1, AND “FOR” PROPOSAL NOS. 2, 3 AND 4, AS MORE SPECIFICALLY DESCRIBED IN THE PROXY STATEMENT. IF SPECIFIC INSTRUCTIONS ARE INDICATED, THIS PROXY WILL BE VOTED IN ACCORDANCE THEREWITH. IN THEIR DISCRETION, THE PROXIES OF THE UNDERSIGNED ARE AUTHORIZED TO VOTE UPON ANY AND ALL OTHER MATTERS THAT MAY PROPERLY COME BEFORE THE MEETING. (Items to be voted appear on reverse side) Proxy - SEATTLE GENETICS, INC. qIF VOTING BY MAIL, SIGN, DETACH AND RETURN THE BOTTOM PORTION IN THE ENCLOSED ENVELOPE.q Change of Address — Please print new address below. Comments — Please print your comments below. C Non-Voting Items Important notice regarding the Internet availability of proxy materials for the Annual Meeting of Shareholders. The material is available at: www.envisionreports.com/SGEN 2020 Annual Meeting of Seattle Genetics, Inc. Shareholders May 15, 2020 at 11:00 A.M. Pacific Time



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